6G90
Prespliceosome structure provides insight into spliceosome assembly and regulation (map A2)
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
N [auth P] | SCOP2B Superfamily | WD40 repeat-like | 8052528 | 3001694 | SCOP2B (2022-06-29) |
N [auth P] | SCOP2B Superfamily | WD40 repeat-like | 8051196 | 3001694 | SCOP2B (2022-06-29) |
N [auth P] | SCOP2B Superfamily | WD40 repeat-like | 8052528 | 3001694 | SCOP2B (2022-06-29) |
N [auth P] | SCOP2B Superfamily | WD40 repeat-like | 8052529 | 3001694 | SCOP2B (2022-06-29) |
P [auth R] | SCOP2B Superfamily | RNA-binding domain RBD | 8067306 | 3000110 | SCOP2B (2022-06-29) |
Q [auth S] | SCOP2B Superfamily | Triquetra zinc finger motif | 8051849 | 3002040 | SCOP2B (2022-06-29) |
R [auth T] | SCOP2B Superfamily | Prp9-like | 8046394 | 3002670 | SCOP2B (2022-06-29) |
R [auth T] | SCOP2B Superfamily | Prp9-like | 8046394 | 3002670 | SCOP2B (2022-06-29) |
R [auth T] | SCOP2B Superfamily | beta-beta-alpha zinc fingers | 8093057 | 3001077 | SCOP2B (2022-06-29) |
S [auth U] | SCOP2B Superfamily | Hsp20 chaperone-like | 8093058 | 3001242 | SCOP2B (2022-06-29) |
T [auth V] | SCOP2B Superfamily | Prp21-like | 8093059 | 3002671 | SCOP2B (2022-06-29) |
W [auth Y] | SCOP2B Superfamily | RNA-binding domain RBD | 8073745 | 3000110 | SCOP2B (2022-06-29) |
Y [auth b] | SCOP2B Superfamily | Sm-like ribonucleoproteins | 8077613 | 3000419 | SCOP2B (2022-06-29) |
IA [auth v] | SCOP2B Superfamily | Sm-like ribonucleoproteins | 8098694 | 3000419 | SCOP2B (2022-06-29) |
Z [auth d] | SCOP2 Family | Sm motif of small nuclear ribonucleoproteins SNRNP | 8098693 | 4001809 | SCOP2 (2022-06-29) |
Z [auth d] | SCOP2 Superfamily | Sm-like ribonucleoproteins | 8098694 | 3000419 | SCOP2 (2022-06-29) |
BA [auth f] | SCOP2B Superfamily | Sm-like ribonucleoproteins | 8043703 | 3000419 | SCOP2B (2022-06-29) |
KA [auth x] | SCOP2B Superfamily | Sm-like ribonucleoproteins | 8043703 | 3000419 | SCOP2B (2022-06-29) |
CA [auth g] | SCOP2B Superfamily | Sm-like ribonucleoproteins | 8098668 | 3000419 | SCOP2B (2022-06-29) |
LA [auth y] | SCOP2B Superfamily | Sm-like ribonucleoproteins | 8098668 | 3000419 | SCOP2B (2022-06-29) |
DA [auth h] | SCOP2B Superfamily | Sm-like ribonucleoproteins | 8082631 | 3000419 | SCOP2B (2022-06-29) |
EA [auth i] | SCOP2B Superfamily | Sm-like ribonucleoproteins | 8063490 | 3000419 | SCOP2B (2022-06-29) |
HA [auth u] | SCOP2B Superfamily | Sm-like ribonucleoproteins | 8063490 | 3000419 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
J [auth H] | PF03194 | e6g90H1 | A: few secondary structure elements | X: CCCH zinc finger | H: CCCH zinc finger (From Topology) | T: CCCH zinc finger | F: PF03194 | ECOD (1.6) |
M [auth O] | PF22646 | e6g90O1 | A: alpha superhelices | X: Repetitive alpha hairpins | H: ARM repeat (From Topology) | T: ARM repeat | F: PF22646 | ECOD (1.6) |
N [auth P] | PF03178 | e6g90P4 | A: beta duplicates or obligate multimers | X: beta-propeller-like | H: beta-propeller | T: 7-bladed | F: PF03178 | ECOD (1.6) |
N [auth P] | PF10433 | e6g90P2 | A: beta duplicates or obligate multimers | X: beta-propeller-like | H: beta-propeller | T: 7-bladed | F: PF10433 | ECOD (1.6) |
N [auth P] | PF03178 | e6g90P3 | A: alpha arrays | X: HTH | H: HTH | T: tri-helical | F: PF03178 | ECOD (1.6) |
P [auth R] | PF00076 | e6g90R2 | A: a+b two layers | X: Alpha-beta plaits | H: RNA-binding domain, RBD (From Topology) | T: RNA-binding domain, RBD | F: PF00076 | ECOD (1.6) |
Q [auth S] | F_UNCLASSIFIED | e6g90S2 | A: few secondary structure elements | X: Glucocorticoid receptor-like | H: LIM domain-like | T: LIM domain-like | F: F_UNCLASSIFIED | ECOD (1.6) |
Q [auth S] | PF03660 | e6g90S3 | A: few secondary structure elements | X: Glucocorticoid receptor-like | H: LIM domain-like | T: LIM domain-like | F: PF03660 | ECOD (1.6) |
S [auth U] | PF16835 | e6g90U1 | A: beta sandwiches | X: HSP20-like | H: Pre-mRNA-splicing factor PRP11 C-terminal domain (From Topology) | T: Pre-mRNA-splicing factor PRP11 C-terminal domain | F: PF16835 | ECOD (1.6) |
S [auth U] | PF12874 | e6g90U2 | A: few secondary structure elements | X: beta-beta-alpha zinc fingers | H: beta-beta-alpha zinc fingers (From Topology) | T: beta-beta-alpha zinc fingers | F: PF12874 | ECOD (1.6) |
T [auth V] | PF01805 | e6g90V1 | A: alpha bundles | X: Surp module (SWAP domain) (From Topology) | H: Surp module (SWAP domain) (From Topology) | T: Surp module (SWAP domain) | F: PF01805 | ECOD (1.6) |
U [auth W] | PF14580 | e6g90W1 | A: beta duplicates or obligate multimers | X: Single-stranded right-handed beta-helix | H: Leucine-rich repeats (From Topology) | T: Leucine-rich repeats | F: PF14580 | ECOD (1.6) |
W [auth Y] | PF13893 | e6g90Y1 | A: a+b two layers | X: Alpha-beta plaits | H: RNA-binding domain, RBD (From Topology) | T: RNA-binding domain, RBD | F: PF13893 | ECOD (1.6) |
X [auth Z] | PF07189 | e6g90Z1 | A: alpha arrays | X: RDS3 complex subunit 10 (From Topology) | H: RDS3 complex subunit 10 (From Topology) | T: RDS3 complex subunit 10 | F: PF07189 | ECOD (1.6) |
FA [auth s] | PF01423 | e6g90s1 | A: beta barrels | X: SH3 | H: SH3 | T: SH3 | F: PF01423 | ECOD (1.6) |
IA [auth v] | PF01423 | e6g90v1 | A: beta barrels | X: SH3 | H: SH3 | T: SH3 | F: PF01423 | ECOD (1.6) |
Z [auth d] | PF01423 | e6g90d1 | A: beta barrels | X: SH3 | H: SH3 | T: SH3 | F: PF01423 | ECOD (1.6) |
AA [auth e] | PF01423 | e6g90e1 | A: beta barrels | X: SH3 | H: SH3 | T: SH3 | F: PF01423 | ECOD (1.6) |
JA [auth w] | PF01423 | e6g90w1 | A: beta barrels | X: SH3 | H: SH3 | T: SH3 | F: PF01423 | ECOD (1.6) |
BA [auth f] | PF01423 | e6g90f1 | A: beta barrels | X: SH3 | H: SH3 | T: SH3 | F: PF01423 | ECOD (1.6) |
KA [auth x] | PF01423 | e6g90x1 | A: beta barrels | X: SH3 | H: SH3 | T: SH3 | F: PF01423 | ECOD (1.6) |
CA [auth g] | PF01423 | e6g90g1 | A: beta barrels | X: SH3 | H: SH3 | T: SH3 | F: PF01423 | ECOD (1.6) |
LA [auth y] | PF01423 | e6g90y1 | A: beta barrels | X: SH3 | H: SH3 | T: SH3 | F: PF01423 | ECOD (1.6) |
DA [auth h] | PF01423 | e6g90h1 | A: beta barrels | X: SH3 | H: SH3 | T: SH3 | F: PF01423 | ECOD (1.6) |
GA [auth t] | PF01423 | e6g90t1 | A: beta barrels | X: SH3 | H: SH3 | T: SH3 | F: PF01423 | ECOD (1.6) |
EA [auth i] | PF01423 | e6g90i1 | A: beta barrels | X: SH3 | H: SH3 | T: SH3 | F: PF01423 | ECOD (1.6) |
HA [auth u] | PF01423 | e6g90u1 | A: beta barrels | X: SH3 | H: SH3 | T: SH3 | F: PF01423 | ECOD (1.6) |
G [auth E] | F_UNCLASSIFIED | e6g90E1 | A: alpha superhelices | X: Repetitive alpha hairpins | H: ARM repeat (From Topology) | T: ARM repeat | F: F_UNCLASSIFIED | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
J [auth H] | PF03194 | LUC7 N_terminus (LUC7) | LUC7 N_terminus | - | Family |
N [auth P] | PF10433 | Mono-functional DNA-alkylating methyl methanesulfonate N-term (MMS1_N) | Mono-functional DNA-alkylating methyl methanesulfonate N-term | - | Repeat |
N [auth P] | PF03178 | CPSF A subunit region (CPSF_A) | CPSF A subunit region | - | Repeat |
O [auth Q] | PF04037 | Domain of unknown function (DUF382) (DUF382) | Domain of unknown function (DUF382) | - | Family |
O [auth Q] | PF04046 | PSP (PSP) | PSP | - | Family |
P [auth R] | PF00076 | RNA recognition motif (RRM_1) | RNA recognition motif | The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and pro ... | Domain |
Q [auth S] | PF03660 | PHF5-like protein (PHF5) | PHF5-like protein | - | Family |
R [auth T] | PF16958 | Pre-mRNA-splicing factor PRP9 N-terminus (PRP9_N) | Pre-mRNA-splicing factor PRP9 N-terminus | This is the N-terminal domain of pre-mRNA-splicing factor PRP9 [1]. | Domain |
R [auth T] | PF16837 | Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 (SF3A3) | Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 | SF3A3 is one of the components of the SF3a splicing factor complex of the mature U2 snRNP (small nuclear ribonucleoprotein particle). In yeast, SF3a shows a bifurcated assembly structure of three subunits, Prp9 (subunit 3), Prp11 (subunit 2) and Prp2 ... | Domain |
R [auth T] | PF12171 | Zinc-finger double-stranded RNA-binding (zf-C2H2_jaz) | Zinc-finger double-stranded RNA-binding | - | Family |
S [auth U] | PF12874 | Zinc-finger of C2H2 type (zf-met) | Zinc-finger of C2H2 type | This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding. | Domain |
S [auth U] | PF16835 | Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) (SF3A2) | Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) | SF3A2 is one of the components of the SF3a splicing factor complex of the mature U2 snRNP (small nuclear ribonucleoprotein particle). In yeast, SF3a shows a bifurcated assembly structure of three subunits, Prp9 (subunit 3), Prp11 (subunit 2) and Prp2 ... | Domain |
T [auth V] | PF01805 | Surp module (Surp) | Surp module | - | Family |
T [auth V] | PF12230 | Pre-mRNA splicing factor PRP21 like protein (PRP21_like_P) | Pre-mRNA splicing factor PRP21 like protein | - | Family |
U [auth W] | PF14580 | Leucine-rich repeat (LRR_9) | Leucine-rich repeat | - | Repeat |
W [auth Y] | PF13893 | RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (RRM_5) | RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) | The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The mo ... | Domain |
X [auth Z] | PF07189 | Splicing factor 3B subunit 10 (SF3b10) (SF3b10) | Splicing factor 3B subunit 10 (SF3b10) | - | Family |
FA [auth s], Y [auth b] | PF01423 | LSM domain (LSM) | LSM domain | The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ... | Domain |
IA [auth v], Z [auth d] | PF01423 | LSM domain (LSM) | LSM domain | The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ... | Domain |
AA [auth e], JA [auth w] | PF01423 | LSM domain (LSM) | LSM domain | The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ... | Domain |
BA [auth f], KA [auth x] | PF01423 | LSM domain (LSM) | LSM domain | The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ... | Domain |
CA [auth g], LA [auth y] | PF01423 | LSM domain (LSM) | LSM domain | The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ... | Domain |
DA [auth h], GA [auth t] | PF01423 | LSM domain (LSM) | LSM domain | The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ... | Domain |
EA [auth i], HA [auth u] | PF01423 | LSM domain (LSM) | LSM domain | The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ... | Domain |
D [auth B] | PF12220 | U1 small nuclear ribonucleoprotein of 70kDa MW N terminal (U1snRNP70_N) | U1 small nuclear ribonucleoprotein of 70kDa MW N terminal | - | Family |
D [auth B] | PF00076 | RNA recognition motif (RRM_1) | RNA recognition motif | The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and pro ... | Domain |
E [auth C] | PF06220 | U1 zinc finger (zf-U1) | U1 zinc finger | This family consists of several U1 small nuclear ribonucleoprotein C (U1-C) proteins. The U1 small nuclear ribonucleoprotein (U1 snRNP) binds to the pre-mRNA 5' splice site (ss) at early stages of spliceosome assembly. Recruitment of U1 to a class o ... | Domain |
H [auth F] | PF00076 | RNA recognition motif (RRM_1) | RNA recognition motif | The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and pro ... | Domain |
I [auth G] | PF19097 | Snu56-like U1 small nuclear ribonucleoprotein component (Snu56_snRNP) | Snu56-like U1 small nuclear ribonucleoprotein component | - | Family |