6G2D

Citrate-induced acetyl-CoA carboxylase (ACC-Cit) filament at 5.4 A resolution

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	ACC_central_1st_1	e6g2dB2	A: alpha bundles	X: Bromodomain-like	H: Four-helical bundle in acetyl-CoA carboxylase (From Topology)	T: Four-helical bundle in acetyl-CoA carboxylase	F: ACC_central_1st_1	ECOD (1.6)
A [auth B]	ACC_central_1st	e6g2dB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Helical domain in acetyl-CoA carboxylase (From Topology)	T: Helical domain in acetyl-CoA carboxylase	F: ACC_central_1st	ECOD (1.6)
A [auth B]	ACC_central_2nd	e6g2dB4	A: a/b three-layered sandwiches	X: Restriction endonuclease-like	H: Acetyl-CoA carboxylase AC4 and AC5 domains (From Topology)	T: Acetyl-CoA carboxylase AC4 and AC5 domains	F: ACC_central_2nd	ECOD (1.6)
B [auth C]	ACC_central_1st	e6g2dC5	A: alpha superhelices	X: Repetitive alpha hairpins	H: Helical domain in acetyl-CoA carboxylase (From Topology)	T: Helical domain in acetyl-CoA carboxylase	F: ACC_central_1st	ECOD (1.6)
B [auth C]	KOG0368	e6g2dC3	A: a+b two layers	X: Methylcrotonyl-CoA carboxylase alpha-subunit BT domain-related (From Homology)	H: Methylcrotonyl-CoA carboxylase alpha-subunit BT domain-related	T: Barrel domain in methylcrotonyl-CoA carboxylase alpha-subunit	F: KOG0368	ECOD (1.6)
B [auth C]	ATP-grasp	e6g2dC8	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: ATP-grasp	F: ATP-grasp	ECOD (1.6)
B [auth C]	Biotin_carb_C	e6g2dC1	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: CO dehydrogenase molybdoprotein N-domain-like	F: Biotin_carb_C	ECOD (1.6)
B [auth C]	Biotin_lipoyl	e6g2dC9	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: Biotin_lipoyl	ECOD (1.6)
B [auth C]	Biotin_carb_N	e6g2dC4	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: PreATP-grasp domain	F: Biotin_carb_N	ECOD (1.6)
B [auth C]	ACC_central_2nd	e6g2dC2	A: a/b three-layered sandwiches	X: Restriction endonuclease-like	H: Acetyl-CoA carboxylase AC4 and AC5 domains (From Topology)	T: Acetyl-CoA carboxylase AC4 and AC5 domains	F: ACC_central_2nd	ECOD (1.6)
B [auth C]	Carboxyl_trans_C	e6g2dC6	A: a/b three-layered sandwiches	X: ClpP/crotonase (From Topology)	H: ClpP/crotonase (From Topology)	T: ClpP/crotonase	F: Carboxyl_trans_C	ECOD (1.6)
C [auth D]	ACC_central_1st	e6g2dD1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Helical domain in acetyl-CoA carboxylase (From Topology)	T: Helical domain in acetyl-CoA carboxylase	F: ACC_central_1st	ECOD (1.6)
C [auth D]	KOG0368	e6g2dD8	A: a+b two layers	X: Methylcrotonyl-CoA carboxylase alpha-subunit BT domain-related (From Homology)	H: Methylcrotonyl-CoA carboxylase alpha-subunit BT domain-related	T: Barrel domain in methylcrotonyl-CoA carboxylase alpha-subunit	F: KOG0368	ECOD (1.6)
C [auth D]	ATP-grasp	e6g2dD3	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: ATP-grasp	F: ATP-grasp	ECOD (1.6)
C [auth D]	Biotin_carb_C	e6g2dD4	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: CO dehydrogenase molybdoprotein N-domain-like	F: Biotin_carb_C	ECOD (1.6)
C [auth D]	Biotin_lipoyl	e6g2dD9	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: Biotin_lipoyl	ECOD (1.6)
C [auth D]	Biotin_carb_N	e6g2dD2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: PreATP-grasp domain	F: Biotin_carb_N	ECOD (1.6)
C [auth D]	ACC_central_2nd	e6g2dD6	A: a/b three-layered sandwiches	X: Restriction endonuclease-like	H: Acetyl-CoA carboxylase AC4 and AC5 domains (From Topology)	T: Acetyl-CoA carboxylase AC4 and AC5 domains	F: ACC_central_2nd	ECOD (1.6)
C [auth D]	Carboxyl_trans_C	e6g2dD5	A: a/b three-layered sandwiches	X: ClpP/crotonase (From Topology)	H: ClpP/crotonase (From Topology)	T: ClpP/crotonase	F: Carboxyl_trans_C	ECOD (1.6)
D [auth F]	ACC_central_1st_1	e6g2dF1	A: alpha bundles	X: Bromodomain-like	H: Four-helical bundle in acetyl-CoA carboxylase (From Topology)	T: Four-helical bundle in acetyl-CoA carboxylase	F: ACC_central_1st_1	ECOD (1.6)
D [auth F]	ACC_central_1st	e6g2dF2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Helical domain in acetyl-CoA carboxylase (From Topology)	T: Helical domain in acetyl-CoA carboxylase	F: ACC_central_1st	ECOD (1.6)
D [auth F]	ACC_central_2nd	e6g2dF4	A: a/b three-layered sandwiches	X: Restriction endonuclease-like	H: Acetyl-CoA carboxylase AC4 and AC5 domains (From Topology)	T: Acetyl-CoA carboxylase AC4 and AC5 domains	F: ACC_central_2nd	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth C], C [auth D], D [auth F]	PF21385	Acetyl-CoA carboxylase, BT domain (ACCA_BT)	Acetyl-CoA carboxylase, BT domain	This is the BC-CT interaction domain (BT) which is between the BC (biotin carboxylase, which catalyses the MgATP-dependent carboxylation of N1' atom of biotin) and BCCP (biotin carboxyl carrier protein) domains of Acetyl-CoA carboxylase. This domain ...	This is the BC-CT interaction domain (BT) which is between the BC (biotin carboxylase, which catalyses the MgATP-dependent carboxylation of N1' atom of biotin) and BCCP (biotin carboxyl carrier protein) domains of Acetyl-CoA carboxylase. This domain helps to mediate interactions between the BC and CT (carboxyltransferase) domains [1-3].	Domain
A [auth B], B [auth C], C [auth D], D [auth F]	PF00364	Biotin-requiring enzyme (Biotin_lipoyl)	Biotin-requiring enzyme	This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognise the Glycine cleavage system H proteins.	Domain
A [auth B], B [auth C], C [auth D], D [auth F]	PF02786	Carbamoyl-phosphate synthase L chain, ATP binding domain (CPSase_L_D2)	Carbamoyl-phosphate synthase L chain, ATP binding domain	Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from glutamine or ammonia and bicarbonate. This important enzyme initiates both the urea cycle and the biosynthesis of arginine and/or pyrimidines [2]. The c ...	Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from glutamine or ammonia and bicarbonate. This important enzyme initiates both the urea cycle and the biosynthesis of arginine and/or pyrimidines [2]. The carbamoyl-phosphate synthase (CPS) enzyme in prokaryotes is a heterodimer of a small and large chain. The small chain promotes the hydrolysis of glutamine to ammonia, which is used by the large chain to synthesise carbamoyl phosphate. See Pfam:PF00988. The small chain has a GATase domain in the carboxyl terminus. See Pfam:PF00117. The ATP binding domain (this one) has an ATP-grasp fold.	Domain
A [auth B], B [auth C], C [auth D], D [auth F]	PF00289	Biotin carboxylase, N-terminal domain (Biotin_carb_N)	Biotin carboxylase, N-terminal domain	This domain is structurally related to the PreATP-grasp domain. The family contains the N-terminus of biotin carboxylase enzymes [1,3], and propionyl-CoA carboxylase A chain [2].	Domain
A [auth B], B [auth C], C [auth D], D [auth F]	PF08326	Acetyl-CoA carboxylase, central region (ACC_central)	Acetyl-CoA carboxylase, central region	-	Family
A [auth B], B [auth C], C [auth D], D [auth F]	PF02785	Biotin carboxylase C-terminal domain (Biotin_carb_C)	Biotin carboxylase C-terminal domain	Biotin carboxylase is a component of the acetyl-CoA carboxylase multi-component enzyme which catalyses the first committed step in fatty acid synthesis in animals, plants and bacteria. Most of the active site residues reported in reference [1] are i ...	Biotin carboxylase is a component of the acetyl-CoA carboxylase multi-component enzyme which catalyses the first committed step in fatty acid synthesis in animals, plants and bacteria. Most of the active site residues reported in reference [1] are in this C-terminal domain.	Domain
A [auth B], B [auth C], C [auth D], D [auth F]	PF01039	Carboxyl transferase domain (Carboxyl_trans)	Carboxyl transferase domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth C], C [auth D], D [auth F]	Acetyl-CoA carboxylase 1	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding CoA carboxylase activity acetyl-CoA carboxylase activity ligase activity, forming carbon-carbon bonds catalytic activity ligase activity cation binding metal ion binding identical protein binding protein binding	nucleoside bisphosphate metabolic process ribonucleoside bisphosphate biosynthetic process malonyl-CoA metabolic process nucleotide biosynthetic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process nucleobase-containing compound metabolic process ribonucleotide biosynthetic process malonyl-CoA biosynthetic process phosphate-containing compound metabolic process organic substance biosynthetic process small molecule metabolic process sulfur compound metabolic process nucleoside bisphosphate metabolic process ribonucleoside bisphosphate biosynthetic process malonyl-CoA metabolic process nucleotide biosynthetic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process nucleobase-containing compound metabolic process ribonucleotide biosynthetic process malonyl-CoA biosynthetic process phosphate-containing compound metabolic process organic substance biosynthetic process small molecule metabolic process sulfur compound metabolic process thioester metabolic process phosphorus metabolic process ribose phosphate biosynthetic process nucleoside phosphate metabolic process cellular metabolic process primary metabolic process amide biosynthetic process nucleotide metabolic process organic cyclic compound metabolic process sulfur compound biosynthetic process biosynthetic process organophosphate biosynthetic process organic cyclic compound biosynthetic process nucleoside phosphate biosynthetic process metabolic process purine ribonucleotide metabolic process purine nucleotide biosynthetic process ribose phosphate metabolic process purine nucleoside bisphosphate metabolic process ribonucleoside bisphosphate metabolic process thioester biosynthetic process cellular biosynthetic process purine nucleotide metabolic process organic substance metabolic process acyl-CoA metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process acyl-CoA biosynthetic process purine nucleoside bisphosphate biosynthetic process amide metabolic process carbohydrate derivative biosynthetic process organonitrogen compound metabolic process nucleoside bisphosphate biosynthetic process nucleobase-containing compound biosynthetic process purine-containing compound metabolic process organophosphate metabolic process cellular process chemical homeostasis homeostatic process lipid homeostasis protein-containing complex organization protein homotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis fatty-acyl-CoA metabolic process lipid biosynthetic process fatty-acyl-CoA biosynthetic process fatty acid derivative biosynthetic process fatty acid derivative metabolic process lipid metabolic process cellular response to stimulus response to organic substance response to ketone response to prostaglandin response to lipid response to stimulus cellular response to endogenous stimulus response to hormone response to prostaglandin E cellular response to organic substance cellular response to ketone cellular response to hormone stimulus response to endogenous stimulus response to alcohol cellular response to prostaglandin stimulus response to oxygen-containing compound cellular response to oxygen-containing compound cellular response to prostaglandin E stimulus cellular response to chemical stimulus cellular response to alcohol response to chemical cellular response to lipid fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process carboxylic acid metabolic process organic acid biosynthetic process organic acid metabolic process fatty acid biosynthetic process carboxylic acid biosynthetic process cellular lipid metabolic process monocarboxylic acid metabolic process protein metabolic process macromolecule metabolic process multicellular organismal process multicellular organismal-level homeostasis anatomical structure homeostasis tissue homeostasis acetyl-CoA metabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytoskeleton intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle cytosol nucleus membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytoskeleton intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle cytosol nucleus membrane-enclosed lumen nucleolus intracellular organelle lumen organelle lumen fibrillar center nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth C], C [auth D], D [auth F]	IPR011763	Acetyl-coenzyme A carboxyltransferase, C-terminal	Domain
A [auth B], B [auth C], C [auth D], D [auth F]	IPR029045	ClpP/crotonase-like domain superfamily	Homologous Superfamily
A [auth B], B [auth C], C [auth D], D [auth F]	IPR011762	Acetyl-coenzyme A carboxyltransferase, N-terminal	Domain
A [auth B], B [auth C], C [auth D], D [auth F]	IPR049074	Acetyl-CoA carboxylase, BT domain	Domain
A [auth B], B [auth C], C [auth D], D [auth F]	IPR011764	Biotin carboxylation domain	Domain
A [auth B], B [auth C], C [auth D], D [auth F]	IPR034733	Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta	Domain
A [auth B], B [auth C], C [auth D], D [auth F]	IPR049076	Acetyl-CoA carboxylase	Family
A [auth B], B [auth C], C [auth D], D [auth F]	IPR011054	Rudiment single hybrid motif	Homologous Superfamily
A [auth B], B [auth C], C [auth D], D [auth F]	IPR013537	Acetyl-CoA carboxylase, central domain	Domain
A [auth B], B [auth C], C [auth D], D [auth F]	IPR011053	Single hybrid motif	Homologous Superfamily
A [auth B], B [auth C], C [auth D], D [auth F]	IPR001882	Biotin-binding site	Binding Site
A [auth B], B [auth C], C [auth D], D [auth F]	IPR000089	Biotin/lipoyl attachment	Domain
A [auth B], B [auth C], C [auth D], D [auth F]	IPR005481	Biotin carboxylase-like, N-terminal domain	Domain
A [auth B], B [auth C], C [auth D], D [auth F]	IPR011761	ATP-grasp fold	Domain
A [auth B], B [auth C], C [auth D], D [auth F]	IPR013815	ATP-grasp fold, subdomain 1	Homologous Superfamily
A [auth B], B [auth C], C [auth D], D [auth F]	IPR005482	Biotin carboxylase, C-terminal	Domain
A [auth B], B [auth C], C [auth D], D [auth F]	IPR005479	Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain	Domain
A [auth B], B [auth C], C [auth D], D [auth F]	IPR016185	Pre-ATP-grasp domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth B], B [auth C], C [auth D], D [auth F]	Pharos: Q13085	acetyl-coa carboxylase deficiency congestive heart failure Heart Decompensation hepatocellular carcinoma malignant mesothelioma spina bifida colorectal cancer heart failure interstitial cystitis large cell medulloblastoma lung cancer pituitary cancer