Annotations: 6FVI

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Centrosomal protein of 192 kDa	protein binding binding kinase binding enzyme binding protein kinase binding phosphatase binding	protein localization to microtubule cytoskeleton protein localization cellular localization protein localization to microtubule organizing center localization protein localization to cytoskeleton protein localization to organelle cellular macromolecule localization macromolecule localization cellular process protein localization to centrosome biological process involved in interspecies interaction between organisms response to stimulus response to other organism protein localization to microtubule cytoskeleton protein localization cellular localization protein localization to microtubule organizing center localization protein localization to cytoskeleton protein localization to organelle cellular macromolecule localization macromolecule localization cellular process protein localization to centrosome biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to bacterium response to external stimulus response to external biotic stimulus response to biotic stimulus protein polymerization protein-containing complex organization microtubule nucleation by microtubule organizing center microtubule cytoskeleton organization microtubule polymerization cellular component organization cellular component biogenesis organelle organization microtubule polymerization or depolymerization cellular component assembly microtubule nucleation protein-containing complex assembly centrosome-templated microtubule nucleation microtubule-based process cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization non-membrane-bounded organelle assembly mitotic cell cycle mitotic sister chromatid segregation cell cycle chromosome segregation microtubule cytoskeleton organization involved in mitosis spindle organization cell cycle process mitotic nuclear division organelle assembly organelle fission chromosome organization sister chromatid segregation spindle assembly mitotic spindle organization mitotic spindle assembly nuclear division mitotic cell cycle process nuclear chromosome segregation centriole assembly microtubule organizing center organization centrosome duplication centrosome cycle centriole replication	intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle pericentriolar material centriole cytoplasm cytosol intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle pericentriolar material centriole cytoplasm cytosol protein-containing complex procentriole replication complex procentriole

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR039103	Centrosomal protein Spd-2/CEP192	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q8TEP8	glioblastoma medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia progressive supranuclear palsy malignant ependymoma nasopharyngeal carcinoma pancreatic intraductal papillary-mucinous carcinoma Pick disease malignant mesothelioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm pituitary cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.