6FS0
INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN FABCOMPLEX IN COMPLEX WITH AZD5991
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d6fs0a1 | Membrane and cell surface proteins and peptides | Toxins' membrane translocation domains | Bcl-2 inhibitors of programmed cell death | Bcl-2 inhibitors of programmed cell death | EAT/MCL-1 (Myeloid cell leukemia sequence 1) | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
A | d6fs0a2 | Artifacts | Tags | Tags | Tags | N-terminal Tags | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
B [auth H] | d6fs0h_ | All beta proteins | Immunoglobulin-like beta-sandwich | Immunoglobulin | V set domains (antibody variable domain-like) | automated matches | (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
C [auth L] | d6fs0l1 | All beta proteins | Immunoglobulin-like beta-sandwich | Immunoglobulin | automated matches | automated matches | (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | Bcl-2-like inhibitors of programmed cell death | 8083810 | 3001974 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | PF00452 | e6fs0A1 | A: alpha arrays | X: Toxins' membrane translocation domains | H: Bcl-2 inhibitors of programmed cell death (From Topology) | T: Bcl-2 inhibitors of programmed cell death | F: PF00452 | ECOD (1.6) |
B [auth H] | PF07654 | e6fs0H1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07654 | ECOD (1.6) |
B [auth H] | PF07686 | e6fs0H2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
C [auth L] | PF07654 | e6fs0L2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07654 | ECOD (1.6) |
C [auth L] | PF07686 | e6fs0L1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 1.10.437.10 | Mainly Alpha | Orthogonal Bundle | Apoptosis Regulator Bcl-x | Blc2-like | CATH (4.3.0) |
B [auth H] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (utative) |
C [auth L] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
IMGT Antibody Annotation IMGT Database Homepage
Chain | Protein Name | Description | Organism Name | Gene Allele Name(s) | Domain Name(s) | Receptor Type | Receptor Description | Provenance Source |
---|---|---|---|---|---|---|---|---|
B [auth H] | Fab AZD5991 | VH-CH1 | Homo sapiens (human) | IGHV3-21*01, IGHV3-21*02, IGHV3-21*04, IGHV3-21*03, IGHJ3*02, IGHG1*01, IGHG1*02, IGHG3*01, IGHG3*03, IGHG3*04, IGHG3*05, IGHG3*06, IGHG3*07, IGHG3*08, IGHG3*09, IGHG3*10, IGHG3*11, IGHG3*12, IGHG3*13, IGHG3*14, IGHG3*16, IGHG3*17, IGHG3*18, IGHG3*19, IGHG3*15, IGHG1*04, IGHG1*05, IGHG3*20, IGHG3*21, IGHG3*25, IGHG1*12, IGHG1*14, IGHG3*23, IGHG2*09, IGHG1*13, IGHG3*26, IGHG3*27, IGHG3*24, IGHG3*29, IGHG1*09, IGHG3*28, IGHG1*10, IGHG3*22, IGHG1*07, IGHG1*11 | V-DOMAIN VH, C-DOMAIN CH1 | IG | FAB-GAMMA-2_LAMBDA | IMGT (202416-0) |
C [auth L] | Fab AZD5991 | L-LAMBDA | Homo sapiens (human) | IGLV1-44*01, IGLJ3*02, IGLC1*02, IGLC2*01, IGLC2*02, IGLC3*02, IGLC3*03, IGLC3*04 | V-DOMAIN V-LAMBDA, C-DOMAIN C-LAMBDA | IG | FAB-GAMMA-2_LAMBDA | IMGT (202416-0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00452 | Apoptosis regulator proteins, Bcl-2 family (Bcl-2) | Apoptosis regulator proteins, Bcl-2 family | - | Family | |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR020726 | Apoptosis regulator, Bcl-2, BH2 motif, conserved site | Conserved Site | |
IPR036834 | Bcl-2-like superfamily | Homologous Superfamily | |
IPR046371 | Bcl-2, Bcl-2 homology region 1-3 | Domain | |
IPR002475 | Bcl2-like | Family | |
IPR026298 | Bcl-2 family | Family | |
IPR020717 | Apoptosis regulator, Bcl-2, BH1 motif, conserved site | Conserved Site | |
IPR013281 | Apoptosis regulator, Mcl-1 | Family | |
IPR020728 | Apoptosis regulator, Bcl-2, BH3 motif, conserved site | Conserved Site |