6FNY

CRYSTAL STRUCTURE OF A CHOLINE SULFATASE FROM SINORHIZOBIUM MELLILOTI

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Arylsulfatase C-terminal domain-like	8091466	3002305	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Alkaline phosphatase-like	8091465	3001353	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Alkaline phosphatase-like	8091465	3001353	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Arylsulfatase C-terminal domain-like	8091466	3002305	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Alkaline phosphatase-like	8091465	3001353	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Arylsulfatase C-terminal domain-like	8091466	3002305	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Alkaline phosphatase-like	8091465	3001353	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Arylsulfatase C-terminal domain-like	8091466	3002305	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Alkaline phosphatase-like	8091465	3001353	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Arylsulfatase C-terminal domain-like	8091466	3002305	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Arylsulfatase C-terminal domain-like	8091466	3002305	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Alkaline phosphatase-like	8091465	3001353	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Alkaline phosphatase-like	8091465	3001353	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Arylsulfatase C-terminal domain-like	8091466	3002305	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Arylsulfatase C-terminal domain-like	8091466	3002305	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Alkaline phosphatase-like	8091465	3001353	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00884,PF12411	e6fnyA1	A: a/b three-layered sandwiches	X: Alkaline phosphatase-like (From Topology)	H: Alkaline phosphatase-like (From Topology)	T: Alkaline phosphatase-like	F: PF00884,PF12411	ECOD (1.6)
B	PF00884,PF12411	e6fnyB1	A: a/b three-layered sandwiches	X: Alkaline phosphatase-like (From Topology)	H: Alkaline phosphatase-like (From Topology)	T: Alkaline phosphatase-like	F: PF00884,PF12411	ECOD (1.6)
C	PF00884,PF12411	e6fnyC1	A: a/b three-layered sandwiches	X: Alkaline phosphatase-like (From Topology)	H: Alkaline phosphatase-like (From Topology)	T: Alkaline phosphatase-like	F: PF00884,PF12411	ECOD (1.6)
D	PF00884,PF12411	e6fnyD1	A: a/b three-layered sandwiches	X: Alkaline phosphatase-like (From Topology)	H: Alkaline phosphatase-like (From Topology)	T: Alkaline phosphatase-like	F: PF00884,PF12411	ECOD (1.6)
E	PF00884,PF12411	e6fnyE1	A: a/b three-layered sandwiches	X: Alkaline phosphatase-like (From Topology)	H: Alkaline phosphatase-like (From Topology)	T: Alkaline phosphatase-like	F: PF00884,PF12411	ECOD (1.6)
F	PF00884,PF12411	e6fnyF1	A: a/b three-layered sandwiches	X: Alkaline phosphatase-like (From Topology)	H: Alkaline phosphatase-like (From Topology)	T: Alkaline phosphatase-like	F: PF00884,PF12411	ECOD (1.6)
G	PF00884,PF12411	e6fnyG1	A: a/b three-layered sandwiches	X: Alkaline phosphatase-like (From Topology)	H: Alkaline phosphatase-like (From Topology)	T: Alkaline phosphatase-like	F: PF00884,PF12411	ECOD (1.6)
H	PF00884,PF12411	e6fnyH1	A: a/b three-layered sandwiches	X: Alkaline phosphatase-like (From Topology)	H: Alkaline phosphatase-like (From Topology)	T: Alkaline phosphatase-like	F: PF00884,PF12411	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF12411	Choline sulfatase enzyme C terminal (Choline_sulf_C)	Choline sulfatase enzyme C terminal	-	Family
A, B, C, D, E A, B, C, D, E, F, G, H	PF00884	Sulfatase (Sulfatase)	Sulfatase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Choline-sulfatase	cation binding ion binding binding metal ion binding small molecule binding hydrolase activity, acting on ester bonds choline-sulfatase activity hydrolase activity catalytic activity sulfuric ester hydrolase activity	organonitrogen compound metabolic process choline biosynthetic process organonitrogen compound biosynthetic process ammonium ion metabolic process biogenic amine biosynthetic process amine metabolic process organic substance metabolic process biosynthetic process amine biosynthetic process choline metabolic process organic substance biosynthetic process metabolic process biogenic amine metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR017785	Choline-sulfatase	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR024607	Sulfatase, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G, H	IPR025863	Choline sulfatase enzyme C-terminal domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR000917	Sulfatase, N-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR017850	Alkaline-phosphatase-like, core domain superfamily	Homologous Superfamily

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A, B, C, D, E A, B, C, D, E, F, G, H	DDZ	Parent Component: ALA RESID: AA0492 PSI-MOD : L-3,3-dihydroxyoalanine (Cys) MOD:01444 , L-3,3-dihydroxyoalanine (Ser) MOD:01445 , L-3,3-dihydroxyoalanine MOD:01448

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.