Annotations: 6FLK

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	C2_2	e6flkA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: C2 domain (From Topology)	T: C2 domain	F: C2_2	ECOD (1.6)
B	C2_2	e6flkB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: C2 domain (From Topology)	T: C2 domain	F: C2_2	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00168	C2 domain (C2)	C2 domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Cep120	-	microtubule cytoskeleton organization astral microtubule organization cytoplasmic microtubule organization cellular component organization organelle organization cellular process microtubule-based process cell cycle cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization spindle organization cell cycle process developmental process microtubule cytoskeleton organization astral microtubule organization cytoplasmic microtubule organization cellular component organization organelle organization cellular process microtubule-based process cell cycle cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization spindle organization cell cycle process developmental process multicellular organismal process head development forebrain development animal organ development brain development nervous system development pallium development cerebral cortex development multicellular organism development central nervous system development anatomical structure development telencephalon development system development neurogenesis cellular developmental process cell differentiation regulation of cellular process regulation of cellular component organization positive regulation of centrosome duplication positive regulation of biological process centrosome duplication centrosome cycle positive regulation of cell cycle process regulation of cell cycle positive regulation of cellular process regulation of biological process microtubule organizing center organization regulation of centrosome cycle regulation of cell cycle process regulation of microtubule-based process biological regulation positive regulation of cell cycle regulation of centrosome duplication positive regulation of organelle organization regulation of cytoskeleton organization positive regulation of centriole elongation positive regulation of cellular component organization non-membrane-bounded organelle assembly cellular component biogenesis cellular component assembly regulation of centriole replication centriole replication centriole assembly centriole elongation organelle assembly positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization regulation of cellular component biogenesis regulation of centriole elongation regulation of organelle organization regulation of organelle assembly positive regulation of centriole replication positive regulation of organelle assembly cell projection organization plasma membrane bounded cell projection assembly cilium assembly positive regulation of cell projection organization cilium organization plasma membrane bounded cell projection organization regulation of cell projection organization regulation of cell projection assembly regulation of plasma membrane bounded cell projection assembly positive regulation of cilium assembly regulation of cilium assembly cell projection assembly regulation of plasma membrane bounded cell projection organization positive regulation of plasma membrane bounded cell projection assembly establishment of organelle localization cellular localization transport localization organelle localization establishment of localization in cell nuclear migration cell proliferation in forebrain cell population proliferation nucleus localization intracellular transport establishment of localization interkinetic nuclear migration neural precursor cell proliferation protein localization regulation of localization establishment of protein localization regulation of protein localization regulation of establishment of protein localization positive regulation of establishment of protein localization regulation of cellular localization cellular macromolecule localization macromolecule localization positive regulation of protein localization	intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle centriole cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR022136	Domain of unknown function DUF3668	Domain
A, B	IPR000008	C2 domain	Domain
A, B	IPR035892	C2 domain superfamily	Homologous Superfamily
A, B	IPR039893	Centrosomal protein of 120kDa-like	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q8N960	Jeune syndrome short-rib thoracic dysplasia 13 with or without polydactyly short rib-polydactyly syndrome Joubert syndrome 31 Ciliopathies Joubert syndrome large cell medulloblastoma osteosarcoma polydactyly ovarian cancer primitive neuroectodermal tumor Joubert syndrome with ocular defect medulloblastoma plasma cell myeloma tuberculosis

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.