Annotations: 6FG9

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e6fg9A4	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF00801	e6fg9A2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00801	ECOD (1.6)
A	PF15902	e6fg9A1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 10-bladed	F: PF15902	ECOD (1.6)
A	F_UNCLASSIFIED	e6fg9A3	A: a+b two layers	X: Alpha-beta plaits	H: RNA-binding domain, RBD (From Topology)	T: RNA-binding domain, RBD	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF15901	e6fg9A6	A: few secondary structure elements	X: Sortilin C-terminal domain (From Topology)	H: Sortilin C-terminal domain (From Topology)	T: Sortilin C-terminal domain	F: PF15901	ECOD (1.6)
B	F_UNCLASSIFIED	e6fg9B4	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF00801	e6fg9B2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00801	ECOD (1.6)
B	PF15902	e6fg9B1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 10-bladed	F: PF15902	ECOD (1.6)
B	F_UNCLASSIFIED	e6fg9B3	A: a+b two layers	X: Alpha-beta plaits	H: RNA-binding domain, RBD (From Topology)	T: RNA-binding domain, RBD	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF15901	e6fg9B6	A: few secondary structure elements	X: Sortilin C-terminal domain (From Topology)	H: Sortilin C-terminal domain (From Topology)	T: Sortilin C-terminal domain	F: PF15901	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF15902	Sortilin, neurotensin receptor 3, (Sortilin-Vps10)	Sortilin, neurotensin receptor 3,	-	Repeat
A, B	PF15901	Sortilin, neurotensin receptor 3, C-terminal (Sortilin_C)	Sortilin, neurotensin receptor 3, C-terminal	Sortilin_C is the C-terminal cytoplasmic tail of sortilin, a Vps10p domain-containing family of proteins [1,2]. Most sortilin is expressed within intracellular compartments, where it chaperones diverse ligands, including proBDNF and acid hydrolases. ...	Sortilin_C is the C-terminal cytoplasmic tail of sortilin, a Vps10p domain-containing family of proteins [1,2]. Most sortilin is expressed within intracellular compartments, where it chaperones diverse ligands, including proBDNF and acid hydrolases. The sortilin cytoplasmic tail is homologous to mannose 6-phosphate receptor and is required for the intracellular trafficking of cargo proteins via interactions with distinct adaptor molecules [3,4]. In addition to mediating lysosomal targeting of specific acid hydrolases, the sortilin cytoplasmic tail also directs trafficking of BDNF to the secretory pathway in neurons, where it can be released in response to depolarisation to modulate cell survival and synaptic plasticity [5].	Domain
A, B	PF18911	PKD domain (PKD_4)	PKD domain	This entry is composed of PKD domains found in bacterial surface proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	VPS10 domain-containing receptor SorCS2	-	protein localization cellular localization establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization cellular process protein localization cellular localization establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization cellular process intracellular protein transport regulation of cellular process negative regulation of signaling signaling modulation of chemical synaptic transmission negative regulation of biological process negative regulation of synaptic transmission negative regulation of cell communication cell communication synaptic signaling negative regulation of cellular process regulation of biological quality regulation of synaptic plasticity trans-synaptic signaling regulation of signaling regulation of biological process biological regulation cell-cell signaling chemical synaptic transmission regulation of trans-synaptic signaling long-term synaptic depression anterograde trans-synaptic signaling regulation of cell communication	postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane cellular anatomical entity postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse neuron to neuron synapse organelle cell junction postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane cellular anatomical entity postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse neuron to neuron synapse organelle cell junction postsynaptic membrane asymmetric synapse plasma membrane region somatodendritic compartment cell body perikaryon neuronal cell body endosome membrane membrane-bounded organelle intracellular anatomical structure endosome intracellular vesicle intracellular membrane-bounded organelle recycling endosome endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle recycling endosome membrane vesicle membrane cytoplasmic vesicle cytoplasm vesicle organelle membrane early endosome early endosome membrane neuron spine neuron projection dendritic spine plasma membrane bounded cell projection cell projection dendrite dendritic tree cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR000601	PKD domain	Domain
A, B	IPR031777	Sortilin, C-terminal	Domain
A, B	IPR006581	VPS10	Domain
A, B	IPR035986	PKD domain superfamily	Homologous Superfamily
A, B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B	IPR031778	Sortilin, N-terminal	Domain
A, B	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.