6FEY

Crystal structure of Drosophila neural ectodermal development factor Imp-L2 with Drosophila DILP5 insulin

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e6feyA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF07679	e6feyA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07679	ECOD (1.6)
B	F_UNCLASSIFIED	e6feyB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF07679	e6feyB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07679	ECOD (1.6)
C [auth D]	F_UNCLASSIFIED	e6feyD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: F_UNCLASSIFIED	ECOD (1.6)
C [auth D]	PF07679	e6feyD2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07679	ECOD (1.6)
D [auth C]	F_UNCLASSIFIED	e6feyC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: F_UNCLASSIFIED	ECOD (1.6)
D [auth C]	PF07679	e6feyC2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07679	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C [auth D], D [auth C]	PF07679	Immunoglobulin I-set domain (I-set)	Immunoglobulin I-set domain	-	Domain
E, G, I, K	PF00049	Insulin/IGF/Relaxin family (Insulin)	Insulin/IGF/Relaxin family	Superfamily includes insulins; relaxins; insulin-like growth factor; and bombyxin. All are secreted regulatory hormones. Disulfide rich, all-alpha fold. Alignment includes B chain, linker (which is processed out of the final product), and A chain.	Domain
F, H, J, L	PF00049	Insulin/IGF/Relaxin family (Insulin)	Insulin/IGF/Relaxin family	Superfamily includes insulins; relaxins; insulin-like growth factor; and bombyxin. All are secreted regulatory hormones. Disulfide rich, all-alpha fold. Alignment includes B chain, linker (which is processed out of the final product), and A chain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C [auth D], D [auth C]	Neural/ectodermal development factor IMP-L2	cell adhesion molecule binding protein binding binding cell adhesion mediator activity cell-cell adhesion mediator activity amide binding peptide hormone binding hormone binding insulin binding	cellular response to stimulus cellular response to nitrogen compound positive regulation of cell communication response to organic substance regulation of cellular process positive regulation of signal transduction response to stimulus signaling response to peptide hormone positive regulation of biological process regulation of signal transduction insulin receptor signaling pathway regulation of cellular response to insulin stimulus cell surface receptor protein tyrosine kinase signaling pathway cell communication cellular response to stimulus cellular response to nitrogen compound positive regulation of cell communication response to organic substance regulation of cellular process positive regulation of signal transduction response to stimulus signaling response to peptide hormone positive regulation of biological process regulation of signal transduction insulin receptor signaling pathway regulation of cellular response to insulin stimulus cell surface receptor protein tyrosine kinase signaling pathway cell communication positive regulation of response to stimulus cellular response to endogenous stimulus response to hormone cellular response to organic substance signal transduction enzyme-linked receptor protein signaling pathway positive regulation of cellular process cellular response to hormone stimulus positive regulation of cellular response to insulin stimulus regulation of biological process regulation of signaling cell surface receptor signaling pathway response to endogenous stimulus response to organonitrogen compound regulation of insulin receptor signaling pathway positive regulation of insulin receptor signaling pathway biological regulation response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to organonitrogen compound regulation of response to stimulus response to chemical response to insulin regulation of cell communication cellular process cellular response to insulin stimulus positive regulation of signaling developmental process neuron recognition multicellular organismal process cellular developmental process cell development nervous system development generation of neurons neurogenesis multicellular organism development neuron differentiation cell differentiation neuron development dendrite self-avoidance anatomical structure development cell recognition system development determination of adult lifespan axonogenesis cell projection organization plasma membrane bounded cell projection morphogenesis neuron projection development cell morphogenesis cellular component organization cell projection morphogenesis neuron projection morphogenesis cellular component organization or biogenesis plasma membrane bounded cell projection organization axon guidance axon development cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis neuron projection guidance cell adhesion cell-cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules homophilic cell adhesion via plasma membrane adhesion molecules regulation of localization lipid storage negative regulation of biological process lipid localization negative regulation of lipid localization maintenance of location localization regulation of lipid storage regulation of lipid localization negative regulation of lipid storage macromolecule localization regulation of entry into reproductive diapause regulation of developmental process positive regulation of developmental process positive regulation of entry into reproductive diapause entry into reproductive diapause entry into diapause dormancy process response to nutrient levels response to stress response to starvation negative regulation of signaling negative regulation of cell communication negative regulation of cellular process negative regulation of response to stimulus negative regulation of signal transduction negative regulation of cellular response to insulin stimulus negative regulation of insulin receptor signaling pathway	cell periphery plasma membrane membrane cellular anatomical entity axon cell projection neuron projection plasma membrane bounded cell projection extracellular region extracellular space
E, G, I, K	Probable insulin-like peptide 5	hormone activity protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity insulin receptor binding	multicellular organismal process sleep behavior locomotory behavior cellular response to stimulus cellular response to nitrogen compound response to organic substance regulation of cellular process response to stimulus signaling response to peptide hormone insulin receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cell communication multicellular organismal process sleep behavior locomotory behavior cellular response to stimulus cellular response to nitrogen compound response to organic substance regulation of cellular process response to stimulus signaling response to peptide hormone insulin receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cell communication cellular response to endogenous stimulus response to hormone cellular response to organic substance signal transduction enzyme-linked receptor protein signaling pathway cellular response to hormone stimulus regulation of biological process cell surface receptor signaling pathway response to endogenous stimulus response to organonitrogen compound biological regulation response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to organonitrogen compound response to chemical response to insulin cellular process cellular response to insulin stimulus reproductive process multicellular organismal reproductive process female mating behavior reproductive behavior mating behavior developmental process regulation of entry into reproductive diapause regulation of developmental process negative regulation of developmental process negative regulation of biological process entry into reproductive diapause entry into diapause negative regulation of entry into reproductive diapause dormancy process chemical homeostasis homeostatic process carbohydrate homeostasis	extracellular region cellular anatomical entity extracellular space
F, H, J, L	Probable insulin-like peptide 5	hormone activity protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity insulin receptor binding	multicellular organismal process sleep behavior locomotory behavior cellular response to stimulus cellular response to nitrogen compound response to organic substance regulation of cellular process response to stimulus signaling response to peptide hormone insulin receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cell communication multicellular organismal process sleep behavior locomotory behavior cellular response to stimulus cellular response to nitrogen compound response to organic substance regulation of cellular process response to stimulus signaling response to peptide hormone insulin receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cell communication cellular response to endogenous stimulus response to hormone cellular response to organic substance signal transduction enzyme-linked receptor protein signaling pathway cellular response to hormone stimulus regulation of biological process cell surface receptor signaling pathway response to endogenous stimulus response to organonitrogen compound biological regulation response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to organonitrogen compound response to chemical response to insulin cellular process cellular response to insulin stimulus reproductive process multicellular organismal reproductive process female mating behavior reproductive behavior mating behavior developmental process regulation of entry into reproductive diapause regulation of developmental process negative regulation of developmental process negative regulation of biological process entry into reproductive diapause entry into diapause negative regulation of entry into reproductive diapause dormancy process chemical homeostasis homeostatic process carbohydrate homeostasis	extracellular region cellular anatomical entity extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C [auth D], D [auth C]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A, B, C [auth D], D [auth C]	IPR003599	Immunoglobulin subtype	Domain
A, B, C [auth D], D [auth C]	IPR003598	Immunoglobulin subtype 2	Domain
A, B, C [auth D], D [auth C]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B, C [auth D], D [auth C]	IPR007110	Immunoglobulin-like domain	Domain
A, B, C [auth D], D [auth C]	IPR013098	Immunoglobulin I-set	Domain
E, G, I, K	IPR022352	Insulin family	Family
E, G, I, K	IPR016179	Insulin-like	Domain
E, G, I, K	IPR022353	Insulin, conserved site	Conserved Site
E, G, I, K	IPR036438	Insulin-like superfamily	Homologous Superfamily
E, G, I, K	IPR040228	Insulin-related peptide, invertebrates	Family
F, H, J, L	IPR022352	Insulin family	Family
F, H, J, L	IPR016179	Insulin-like	Domain
F, H, J, L	IPR022353	Insulin, conserved site	Conserved Site
F, H, J, L	IPR036438	Insulin-like superfamily	Homologous Superfamily
F, H, J, L	IPR040228	Insulin-related peptide, invertebrates	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.