6FEC

Human cap-dependent 48S pre-initiation complex

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
F [auth 6]	SCOP2B Superfamily	Winged helix DNA-binding domain	8002864	3000034	SCOP2B (2022-06-29)
F [auth 6]	SCOP2B Superfamily	ARM repeat-like	8002866	3000116	SCOP2B (2022-06-29)
L [auth G]	SCOP2B Superfamily	Nucleic acid-binding proteins	8052717	3000135	SCOP2B (2022-06-29)
L [auth G]	SCOP2B Superfamily	Ribosomal S17 N-terminal domain-like	8052715	3002138	SCOP2B (2022-06-29)
O [auth J]	SCOP2B Superfamily	Glucocorticoid receptor-like (DNA-binding domain)	8052572	3000068	SCOP2B (2022-06-29)
Q [auth L]	SCOP2B Superfamily	S13-like H2TH domain	8101555	3000053	SCOP2B (2022-06-29)
X [auth V]	SCOP2B Superfamily	Ribosomal protein S30e-like	8053453	3002190	SCOP2B (2022-06-29)
Y [auth W]	SCOP2B Superfamily	Winged helix DNA-binding domain	8090992	3000034	SCOP2B (2022-06-29)
CA [auth a]	SCOP2B Superfamily	Ribosomal protein S8	8095469	3000709	SCOP2B (2022-06-29)
HA [auth f]	SCOP2B Superfamily	SIS domain/Ribosomal protein S2-like	8052791	3001397	SCOP2B (2022-06-29)
JA [auth h]	SCOP2B Superfamily	Ribosomal protein S10	8098806	3001336	SCOP2B (2022-06-29)
KA [auth i]	SCOP2B Superfamily	Ribosomal S3Ae-like	8053212	3002166	SCOP2B (2022-06-29)
NA [auth l]	SCOP2B Superfamily	Nucleic acid-binding proteins	8063426	3000135	SCOP2B (2022-06-29)
SA [auth q]	SCOP2B Superfamily	GS N-terminal domain-like	8053171	3000408	SCOP2B (2022-06-29)
TA [auth r]	SCOP2B Superfamily	L30e-like	8063978	3001739	SCOP2B (2022-06-29)
M [auth H]	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8082685	3000100	SCOP2B (2022-06-29)
N [auth I]	SCOP2B Superfamily	Alpha-L RNA-binding motif	8052755	3001473	SCOP2B (2022-06-29)
N [auth I]	SCOP2B Superfamily	Nucleic acid-binding proteins	8052756	3000135	SCOP2B (2022-06-29)
N [auth I]	SCOP2B Superfamily	Translation proteins SH3-like KOW motif containing domain	8052757	3000334	SCOP2B (2022-06-29)
W [auth U]	SCOP2B Superfamily	Ribosomal protein S7	8066003	3000799	SCOP2B (2022-06-29)
BA [auth Z]	SCOP2B Superfamily	S15/NS1 RNA-binding domain	8052959	3001284	SCOP2B (2022-06-29)
BA [auth Z]	SCOP2B Superfamily	Homeodomain-like	8052958	3000001	SCOP2B (2022-06-29)
C [auth 3]	SCOP2B Superfamily	TPR-like	8091483	3001345	SCOP2B (2022-06-29)
C [auth 3]	SCOP2B Superfamily	Winged helix DNA-binding domain	8091486	3000034	SCOP2B (2022-06-29)
IA [auth g]	SCOP2B Superfamily	Prokaryotic type KH domain (KH-domain type II)	8043545	3001043	SCOP2B (2022-06-29)
LA [auth j]	SCOP2B Superfamily	Translational machinery components	8098844	3000571	SCOP2B (2022-06-29)
QA [auth o]	SCOP2B Superfamily	50S Ribosomal protein L14-like	8053077	3000433	SCOP2B (2022-06-29)
VA [auth t]	SCOP2B Superfamily	Winged helix DNA-binding domain	8055714	3000034	SCOP2B (2022-06-29)
WA [auth u]	SCOP2B Superfamily	RNA-binding domain RBD	8043568	3000110	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D [auth 4]	JAB_1	e6fec42	A: a+b three layers	X: Cytidine deaminase-like (From Topology)	H: Cytidine deaminase-like (From Topology)	T: Cytidine deaminase-like	F: JAB_1	ECOD (1.6)
D [auth 4]	MitMem_reg	e6fec41	A: extended segments	X: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain (From Topology)	H: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain (From Topology)	T: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain	F: MitMem_reg	ECOD (1.6)
F [auth 6]	CSN8_PSD8_EIF3K_C	e6fec62	A: alpha arrays	X: HTH	H: HTH	T: winged	F: CSN8_PSD8_EIF3K_C	ECOD (1.6)
F [auth 6]	SAC3_GANP_1st	e6fec61	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: SAC3_GANP_1st	ECOD (1.6)
L [auth G]	Ribosomal_S17_1	e6fecG1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: Ribosomal_S17_1	ECOD (1.6)
O [auth J]	Ribosomal_S14_2	e6fecJ1	A: few secondary structure elements	X: Glucocorticoid receptor-like	H: LIM domain-like	T: LIM domain-like	F: Ribosomal_S14_2	ECOD (1.6)
P [auth K]	S4	e6fecK1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Alpha-L RNA-binding motif	F: S4	ECOD (1.6)
Q [auth L]	Ribosomal_S13	e6fecL1	A: alpha arrays	X: HhH/H2TH	H: H2TH (From Topology)	T: H2TH	F: Ribosomal_S13	ECOD (1.6)
T [auth Q]	Ribosom_S12_S23	e6fecQ1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: Ribosom_S12_S23	ECOD (1.6)
U [auth R]	Ribosomal_S19e	e6fecR1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: Ribosomal_S19e	ECOD (1.6)
X [auth V]	Ribosomal_S30	e6fecV1	A: extended segments	X: 40S ribosomal protein S30 (S30e) (From Topology)	H: 40S ribosomal protein S30 (S30e) (From Topology)	T: 40S ribosomal protein S30 (S30e)	F: Ribosomal_S30	ECOD (1.6)
Y [auth W]	Ribosomal_S25	e6fecW1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: Ribosomal_S25	ECOD (1.6)
Z [auth X]	Ribosomal_S7e_N	e6fecX2	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: 40S ribosomal protein S7-A (From Topology)	T: 40S ribosomal protein S7-A	F: Ribosomal_S7e_N	ECOD (1.6)
Z [auth X]	Ribosomal_S7e_C_1	e6fecX1	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: 40S ribosomal protein S7-A (From Topology)	T: 40S ribosomal protein S7-A	F: Ribosomal_S7e_C_1	ECOD (1.6)
AA [auth Y]	Ribosomal_S27e	e6fecY1	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: Ribosomal_S27e	ECOD (1.6)
CA [auth a]	Ribosomal_S8_N_1	e6feca1	A: a+b two layers	X: R3H domain-like	H: Ribosomal protein S8, N-terminal domain (From Topology)	T: Ribosomal protein S8, N-terminal domain	F: Ribosomal_S8_N_1	ECOD (1.6)
CA [auth a]	Ribosomal_S8_C_1	e6feca2	A: a+b two layers	X: Ribosomal protein S8, C-terminal domain (From Topology)	H: Ribosomal protein S8, C-terminal domain (From Topology)	T: Ribosomal protein S8, C-terminal domain	F: Ribosomal_S8_C_1	ECOD (1.6)
DA [auth b]	Ribosomal_S21e	e6fecb1	A: a+b two layers	X: 40S ribosomal protein rpS21 (S21e) (From Topology)	H: 40S ribosomal protein rpS21 (S21e) (From Topology)	T: 40S ribosomal protein rpS21 (S21e)	F: Ribosomal_S21e	ECOD (1.6)
HA [auth f]	Ribosomal_S2_2	e6fecf1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Ribosomal protein S2/SIS domain (From Topology)	T: Ribosomal protein S2/SIS domain	F: Ribosomal_S2_2	ECOD (1.6)
JA [auth h]	Ribosomal_S10_1	e6fech1	A: a+b two layers	X: Alpha-beta plaits	H: Ribosomal protein S10 (From Topology)	T: Ribosomal protein S10	F: Ribosomal_S10_1	ECOD (1.6)
KA [auth i]	Ribosomal_S3Ae_N	e6feci1	A: beta barrels	X: Ribosomal protein L25-like	H: 40S ribosomal protein S3A N-terminal domain (From Topology)	T: 40S ribosomal protein S3A N-terminal domain	F: Ribosomal_S3Ae_N	ECOD (1.6)
KA [auth i]	Ribosomal_S3Ae_C	e6feci2	A: a+b two layers	X: T-fold	H: 40S ribosomal protein S3A C-terminal domain (From Topology)	T: 40S ribosomal protein S3A C-terminal domain	F: Ribosomal_S3Ae_C	ECOD (1.6)
NA [auth l]	Ribosomal_S28e	e6fecl1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: Ribosomal_S28e	ECOD (1.6)
SA [auth q]	Ribosomal_S6e	e6fecq1	A: beta barrels	X: Ribosomal protein L25-like	H: Ribosomal protein L25-like (From Topology)	T: Ribosomal protein L25-like	F: Ribosomal_S6e	ECOD (1.6)
TA [auth r]	Ribosomal_L7Ae	e6fecr1	A: a+b three layers	X: Bacillus chorismate mutase-like	H: L30e-like (From Topology)	T: L30e-like	F: Ribosomal_L7Ae	ECOD (1.6)
UA [auth s]	Ribosomal_S24e	e6fecs1	A: a+b two layers	X: Alpha-beta plaits	H: Ribosomal proteins S24e, L23 and L15e (From Topology)	T: Ribosomal proteins S24e, L23 and L15e	F: Ribosomal_S24e	ECOD (1.6)
M [auth H]	Ribosomal_S9	e6fecH1	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: Ribosomal_S9	ECOD (1.6)
N [auth I]	Ribosomal_S4e	e6fecI2	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: Ribosomal_S4e	ECOD (1.6)
N [auth I]	40S_S4_C	e6fecI1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: 40S_S4_C	ECOD (1.6)
N [auth I]	RS4NT	e6fecI3	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Alpha-L RNA-binding motif	F: RS4NT	ECOD (1.6)
S [auth P]	S1_1	e6fecP2	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: S1_1	ECOD (1.6)
S [auth P]	EIF_2_alpha_N	e6fecP1	A: alpha arrays	X: HhH/H2TH	H: eIF2alpha middle domain (From Topology)	T: eIF2alpha middle domain	F: EIF_2_alpha_N	ECOD (1.6)
S [auth P]	EIF_2_alpha_C	e6fecP3	A: a+b two layers	X: Alpha-beta plaits	H: eIF-2-alpha, C-terminal domain (From Topology)	T: eIF-2-alpha, C-terminal domain	F: EIF_2_alpha_C	ECOD (1.6)
V [auth S]	GTP_EFTU_D2_2	e6fecS3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: GTP_EFTU_D2_2	ECOD (1.6)
V [auth S]	eIF2_C	e6fecS1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Aminomethyltransferase beta-barrel domain	F: eIF2_C	ECOD (1.6)
V [auth S]	MnmE_helical_2nd	e6fecS4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: MnmE_helical_2nd	ECOD (1.6)
V [auth S]	KOG0466	e6fecS2	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: KOG0466	ECOD (1.6)
W [auth U]	Ribosomal_S7_1	e6fecU1	A: alpha arrays	X: Ribosomal protein S7 (From Topology)	H: Ribosomal protein S7 (From Topology)	T: Ribosomal protein S7	F: Ribosomal_S7_1	ECOD (1.6)
BA [auth Z]	Ribosomal_S13_N	e6fecZ1	A: alpha arrays	X: HTH	H: 40S ribosomal protein S13 N-terminal domain (From Topology)	T: 40S ribosomal protein S13 N-terminal domain	F: Ribosomal_S13_N	ECOD (1.6)
BA [auth Z]	Ribosomal_S15_2	e6fecZ2	A: alpha arrays	X: S15/NS1 RNA-binding domain (From Topology)	H: S15/NS1 RNA-binding domain (From Topology)	T: S15/NS1 RNA-binding domain	F: Ribosomal_S15_2	ECOD (1.6)
C [auth 3]	PCI	e6fec32	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PCI	ECOD (1.6)
C [auth 3]	eIF3_N	e6fec31	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: eIF3_N	ECOD (1.6)
C [auth 3]	KOG2758	e6fec33	A: extended segments	X: 26S proteasome regulatory subunits C-terminal helices	H: 26S proteasome regulatory subunit RPN7 C-terminal helix (From Topology)	T: 26S proteasome regulatory subunit RPN7 C-terminal helix	F: KOG2758	ECOD (1.6)
EA [auth c]	Ribosomal_S5_C_1	e6fecc3	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: Ribosomal_S5_C_1	ECOD (1.6)
EA [auth c]	Ribosomal_S5_3	e6fecc2	A: a+b two layers	X: dsRBD-like	H: dsRNA-binding domain-like (From Topology)	T: dsRNA-binding domain-like	F: Ribosomal_S5_3	ECOD (1.6)
EA [auth c]	Ribosomal_S5_2	e6fecc1	A: extended segments	X: N-terminal region in 40S ribosomal protein rpS2 (S5p) (From Topology)	H: N-terminal region in 40S ribosomal protein rpS2 (S5p) (From Topology)	T: N-terminal region in 40S ribosomal protein rpS2 (S5p)	F: Ribosomal_S5_2	ECOD (1.6)
GA [auth e]	Ribosomal_S17e	e6fece1	A: alpha arrays	X: HTH	H: HTH	T: FF domain	F: Ribosomal_S17e	ECOD (1.6)
IA [auth g]	Ribosomal_S3_C	e6fecg2	A: a+b two layers	X: T-fold	H: Ribosomal protein S3-C (From Topology)	T: Ribosomal protein S3-C	F: Ribosomal_S3_C	ECOD (1.6)
IA [auth g]	KH_2_3	e6fecg1	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: KH-domains	T: Prokaryotic type KH domain (KH-domain type II)	F: KH_2_3	ECOD (1.6)
LA [auth j]	Ribosomal_S11	e6fecj1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Ribosomal_S11	ECOD (1.6)
MA [auth k]	Ribosomal_S26e	e6feck1	A: few secondary structure elements	X: Glucocorticoid receptor-like	H: LIM domain-like	T: LIM domain-like	F: Ribosomal_S26e	ECOD (1.6)
OA [auth m]	DUF1899	e6fecm1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: DUF1899	ECOD (1.6)
PA [auth n]	Ribosomal_S19	e6fecn1	A: a+b two layers	X: Ribosomal protein S19 (From Topology)	H: Ribosomal protein S19 (From Topology)	T: Ribosomal protein S19	F: Ribosomal_S19	ECOD (1.6)
QA [auth o]	Ribosomal_S8e	e6feco1	A: beta barrels	X: Ribosomal protein L14-like	H: Ribosomal protein L14-related (From Topology)	T: Ribosomal protein L14-related	F: Ribosomal_S8e	ECOD (1.6)
RA [auth p]	Ribosomal_S27	e6fecp1	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: Ribosomal_S27	ECOD (1.6)
VA [auth t]	S10_plectin	e6fect1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: S10_plectin	ECOD (1.6)
WA [auth u]	RRM_1_4	e6fecu1	A: a+b two layers	X: Alpha-beta plaits	H: RNA-binding domain, RBD (From Topology)	T: RNA-binding domain, RBD	F: RRM_1_4	ECOD (1.6)
E [auth 5]	JAB_1	e6fec51	A: a+b three layers	X: Cytidine deaminase-like (From Topology)	H: Cytidine deaminase-like (From Topology)	T: Cytidine deaminase-like	F: JAB_1	ECOD (1.6)
E [auth 5]	KOG1560	e6fec52	A: extended segments	X: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain (From Topology)	H: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain (From Topology)	T: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain	F: KOG1560	ECOD (1.6)
I [auth 9]	eIF-3_zeta	e6fec91	A: a/b three-layered sandwiches	X: Restriction endonuclease-like	H: Restriction endonuclease-like (From Topology)	T: Restriction endonuclease-like	F: eIF-3_zeta	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
F [auth 6]	PF10075	CSN8/PSMD8/EIF3K family (CSN8_PSD8_EIF3K)	CSN8/PSMD8/EIF3K family	-	Family
H [auth 8]	PF18005	eIF3 subunit M, C-terminal helix (eIF3m_C_helix)	eIF3 subunit M, C-terminal helix	This is the C-terminal helix domain found in Eukaryotic translation initiation factor 3 subunit M (eIF3m). In mammalian eIF3a, the C-terminal helix following the PCI domain is involved in interactions with other core subunits [1].	Domain
H [auth 8]	PF01399	PCI domain (PCI)	PCI domain	This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [1].	Domain
L [auth G]	PF00366	Ribosomal protein S17 (Ribosomal_S17)	Ribosomal protein S17	-	Domain
L [auth G]	PF16205	Ribosomal_S17 N-terminal (Ribosomal_S17_N)	Ribosomal_S17 N-terminal	-	Family
O [auth J]	PF00253	Ribosomal protein S14p/S29e (Ribosomal_S14)	Ribosomal protein S14p/S29e	-	Family
P [auth K]	PF00163	Ribosomal protein S4/S9 N-terminal domain (Ribosomal_S4)	Ribosomal protein S4/S9 N-terminal domain	-	Family
P [auth K]	PF01479	S4 domain (S4)	S4 domain	The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast pro ...	The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast protein containing a pseudouridine synthetase and a deaminase domain, bacterial tyrosyl-tRNA synthetases, and a number of uncharacterized, small proteins that may be involved in translation regulation [1]. The S4 domain probably mediates binding to RNA.	Domain
Q [auth L]	PF00416	Ribosomal protein S13/S18 (Ribosomal_S13)	Ribosomal protein S13/S18	-	Family
T [auth Q]	PF00164	Ribosomal protein S12/S23 (Ribosom_S12_S23)	Ribosomal protein S12/S23	-	Family
X [auth V]	PF04758	Ribosomal protein S30 (Ribosomal_S30)	Ribosomal protein S30	-	Family
Y [auth W]	PF03297	S25 ribosomal protein (Ribosomal_S25)	S25 ribosomal protein	-	Family
Z [auth X]	PF01251	Ribosomal protein S7e (Ribosomal_S7e)	Ribosomal protein S7e	-	Family
AA [auth Y]	PF01667	Ribosomal protein S27 (Ribosomal_S27e)	Ribosomal protein S27	-	Family
CA [auth a]	PF00410	Ribosomal protein S8 (Ribosomal_S8)	Ribosomal protein S8	-	Domain
HA [auth f]	PF00318	Ribosomal protein S2 (Ribosomal_S2)	Ribosomal protein S2	-	Family
HA [auth f]	PF16122	40S ribosomal protein SA C-terminus (40S_SA_C)	40S ribosomal protein SA C-terminus	-	Family
JA [auth h]	PF00338	Ribosomal protein S10p/S20e (Ribosomal_S10)	Ribosomal protein S10p/S20e	This family includes small ribosomal subunit S10 from prokaryotes and S20 from eukaryotes.	Domain
KA [auth i]	PF01015	Ribosomal S3Ae family (Ribosomal_S3Ae)	Ribosomal S3Ae family	-	Family
NA [auth l]	PF01200	Ribosomal protein S28e (Ribosomal_S28e)	Ribosomal protein S28e	-	Family
SA [auth q]	PF01092	Ribosomal protein S6e (Ribosomal_S6e)	Ribosomal protein S6e	-	Family
TA [auth r]	PF01248	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family (Ribosomal_L7Ae)	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family	This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD11 ...	This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118 [1].	Domain
UA [auth s]	PF01282	Ribosomal protein S24e (Ribosomal_S24e)	Ribosomal protein S24e	-	Family
M [auth H]	PF00380	Ribosomal protein S9/S16 (Ribosomal_S9)	Ribosomal protein S9/S16	-	Family
N [auth I]	PF00900	Ribosomal family S4e (Ribosomal_S4e)	Ribosomal family S4e	-	Family
N [auth I]	PF16121	40S ribosomal protein S4 C-terminus (40S_S4_C)	40S ribosomal protein S4 C-terminus	-	Family
N [auth I]	PF08071	RS4NT (NUC023) domain (RS4NT)	RS4NT (NUC023) domain	This is the N-terminal domain of Ribosomal S4 / S4e proteins. This domain is associated with S4 and KOW domains [1].	Domain
N [auth I]	PF00467	KOW motif (KOW)	KOW motif	-	Family
V [auth S]	PF00009	Elongation factor Tu GTP binding domain (GTP_EFTU)	Elongation factor Tu GTP binding domain	This domain contains a P-loop motif, also found in several other families such as Pfam:PF00071, Pfam:PF00025 and Pfam:PF00063. Elongation factor Tu consists of three structural domains, this plus two C-terminal beta barrel domains.	Domain
V [auth S]	PF03144	Elongation factor Tu domain 2 (GTP_EFTU_D2)	Elongation factor Tu domain 2	Elongation factor Tu consists of three structural domains, this is the second domain. This domain adopts a beta barrel structure. This the second domain is involved in binding to charged tRNA [1]. This domain is also found in other proteins such as e ...	Elongation factor Tu consists of three structural domains, this is the second domain. This domain adopts a beta barrel structure. This the second domain is involved in binding to charged tRNA [1]. This domain is also found in other proteins such as elongation factor G and translation initiation factor IF-2. This domain is structurally related to Pfam:PF03143, and in fact has weak sequence matches to this domain.	Domain
V [auth S]	PF09173	Initiation factor eIF2 gamma, C terminal (eIF2_C)	Initiation factor eIF2 gamma, C terminal	Members of this family, which are found in the initiation factors eIF2 and EF-Tu, adopt a structure consisting of a beta barrel with Greek key topology. They are required for formation of the ternary complex with GTP and initiator tRNA [1].	Domain
W [auth U]	PF00177	Ribosomal protein S7p/S5e (Ribosomal_S7)	Ribosomal protein S7p/S5e	This family contains ribosomal protein S7 from prokaryotes and S5 from eukaryotes.	Domain
BA [auth Z]	PF08069	Ribosomal S13/S15 N-terminal domain (Ribosomal_S13_N)	Ribosomal S13/S15 N-terminal domain	This domain is found at the N-terminus of ribosomal S13 and S15 proteins. This domain is also identified as NUC021 [1].	Domain
BA [auth Z]	PF00312	Ribosomal protein S15 (Ribosomal_S15)	Ribosomal protein S15	-	Domain
C [auth 3]	PF09440	eIF3 subunit 6 N terminal domain (eIF3_N)	eIF3 subunit 6 N terminal domain	This is the N terminal domain of subunit 6 translation initiation factor eIF3.	Domain
C [auth 3]	PF21357	Eukaryotic translation initiation factor 3 subunit E, C-terminal (EIF3E_C)	Eukaryotic translation initiation factor 3 subunit E, C-terminal	Eukaryotic translation initiation factor 3 subunit E (EIF3E) is a component of the EIF3 complex, involved in protein synthesis. This is the C-terminal helical tail of EIF3E [1].	Domain
C [auth 3]	PF01399	PCI domain (PCI)	PCI domain	This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [1].	Domain
GA [auth e]	PF00833	Ribosomal S17 (Ribosomal_S17e)	Ribosomal S17	-	Family
IA [auth g]	PF07650	KH domain (KH_2)	KH domain	-	Domain
IA [auth g]	PF00189	Ribosomal protein S3, C-terminal domain (Ribosomal_S3_C)	Ribosomal protein S3, C-terminal domain	This family contains a central domain Pfam:PF00013, hence the amino and carboxyl terminal domains are stored separately. This is a minimal carboxyl-terminal domain. Some are much longer.	Domain
LA [auth j]	PF00411	Ribosomal protein S11 (Ribosomal_S11)	Ribosomal protein S11	-	Family
OA [auth m]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
PA [auth n]	PF00203	Ribosomal protein S19 (Ribosomal_S19)	Ribosomal protein S19	-	Domain
QA [auth o]	PF01201	Ribosomal protein S8e (Ribosomal_S8e)	Ribosomal protein S8e	-	Family
RA [auth p]	PF01599	Ribosomal protein S27a (Ribosomal_S27)	Ribosomal protein S27a	This family of ribosomal proteins consists mainly of the 40S ribosomal protein S27a which is synthesised as a C-terminal extension of ubiquitin (CEP). The S27a domain compromises the C-terminal half of the protein. The synthesis of ribosomal proteins ...	This family of ribosomal proteins consists mainly of the 40S ribosomal protein S27a which is synthesised as a C-terminal extension of ubiquitin (CEP). The S27a domain compromises the C-terminal half of the protein. The synthesis of ribosomal proteins as extensions of ubiquitin promotes their incorporation into nascent ribosomes by a transient metabolic stabilisation and is required for efficient ribosome biogenesis [3]. The ribosomal extension protein S27a contains a basic region that is proposed to form a zinc finger; its fusion gene is proposed as a mechanism to maintain a fixed ratio between ubiquitin necessary for degrading proteins and ribosomes a source of proteins [2].	Domain
VA [auth t]	PF03501	Plectin/S10 domain (S10_plectin)	Plectin/S10 domain	This presumed domain is found at the N-terminus of some isoforms of the cytoskeletal muscle protein plectin as well as the ribosomal S10 protein. This domain may be involved in RNA binding.	Domain
WA [auth u]	PF00076	RNA recognition motif (RRM_1)	RNA recognition motif	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and pro ...	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (Swiss:P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (Swiss:P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.	Domain
G [auth 7]	PF10255	RNA polymerase I-associated factor PAF67 (Paf67)	RNA polymerase I-associated factor PAF67	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B [auth 2]	Eukaryotic translation initiation factor 3 subunit C	-	-	-
D [auth 4]	Eukaryotic translation initiation factor 3 subunit F	-	-	-
F [auth 6]	Eukaryotic translation initiation factor 3 subunit K	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding ribonucleoprotein complex binding protein-containing complex binding ribosome binding RNA binding	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process translational initiation metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process translational initiation metabolic process cellular process protein metabolic process macromolecule metabolic process regulation of cellular process regulation of primary metabolic process post-transcriptional regulation of gene expression regulation of biosynthetic process regulation of biological process regulation of translational initiation regulation of protein metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process regulation of cellular biosynthetic process regulation of gene expression regulation of translation regulation of macromolecule biosynthetic process regulation of metabolic process ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization formation of cytoplasmic translation initiation complex cytoplasmic translation cytoplasmic translational initiation	protein-containing complex translation preinitiation complex intracellular anatomical structure eukaryotic 43S preinitiation complex ribonucleoprotein complex cytoplasm cellular anatomical entity membrane eukaryotic translation initiation factor 3 complex cytosol eukaryotic 48S preinitiation complex membrane-bounded organelle intracellular organelle organelle protein-containing complex translation preinitiation complex intracellular anatomical structure eukaryotic 43S preinitiation complex ribonucleoprotein complex cytoplasm cellular anatomical entity membrane eukaryotic translation initiation factor 3 complex cytosol eukaryotic 48S preinitiation complex membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
H [auth 8]	Eukaryotic translation initiation factor 3 subunit M	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding protein binding translation initiation factor binding	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process translational initiation metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process translational initiation metabolic process cellular process protein metabolic process macromolecule metabolic process cytoplasmic translation cytoplasmic translational initiation ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization formation of cytoplasmic translation initiation complex	protein-containing complex translation preinitiation complex intracellular anatomical structure eukaryotic 43S preinitiation complex ribonucleoprotein complex cytoplasm cellular anatomical entity eukaryotic translation initiation factor 3 complex cytosol eukaryotic 48S preinitiation complex eukaryotic translation initiation factor 3 complex, eIF3m
L [auth G]	40S ribosomal protein S11	RNA binding binding organic cyclic compound binding rRNA binding nucleic acid binding structural molecule activity structural constituent of ribosome	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process protein metabolic process macromolecule metabolic process cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis ribosomal small subunit biogenesis	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane cytosolic ribosome ribosome cytoplasm cytosol preribosome protein-containing complex ribonucleoprotein complex small-subunit processome extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle synapse cytosolic small ribosomal subunit small ribosomal subunit ribosomal subunit nucleoplasm
O [auth J]	40S ribosomal protein S29	cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding structural molecule activity structural constituent of ribosome	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process protein metabolic process macromolecule metabolic process	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction protein-containing complex intracellular anatomical structure small ribosomal subunit ribosomal subunit intracellular organelle organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction protein-containing complex intracellular anatomical structure small ribosomal subunit ribosomal subunit intracellular organelle organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome non-membrane-bounded organelle extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle organelle subcompartment cytoplasmic side of membrane membrane intracellular membrane-bounded organelle endomembrane system side of membrane cytoplasmic side of rough endoplasmic reticulum membrane rough endoplasmic reticulum endoplasmic reticulum subcompartment bounding membrane of organelle rough endoplasmic reticulum membrane nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasmic side of endoplasmic reticulum membrane cytoplasm organelle membrane endoplasmic reticulum membrane cytosol cytosolic small ribosomal subunit cytosolic ribosome nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
P [auth K]	40S ribosomal protein S9	translation regulator activity RNA binding binding organic cyclic compound binding rRNA binding nucleic acid binding structural molecule activity structural constituent of ribosome	regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation regulation of cell population proliferation biological regulation positive regulation of biological process cellular process positive regulation of cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation regulation of cell population proliferation biological regulation positive regulation of biological process cellular process positive regulation of cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process protein metabolic process macromolecule metabolic process cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis ribosomal small subunit biogenesis	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol nucleoplasm ribosome cytosolic ribosome preribosome protein-containing complex ribonucleoprotein complex small-subunit processome synapse cytosolic small ribosomal subunit small ribosomal subunit ribosomal subunit
Q [auth L]	40S ribosomal protein S18	RNA binding binding organic cyclic compound binding rRNA binding nucleic acid binding structural molecule activity structural constituent of ribosome	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process protein metabolic process macromolecule metabolic process	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction protein-containing complex intracellular anatomical structure small ribosomal subunit ribosomal subunit intracellular organelle organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction protein-containing complex intracellular anatomical structure small ribosomal subunit ribosomal subunit intracellular organelle organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome non-membrane-bounded organelle membrane cytosolic ribosome cytoplasm cytosol extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization synapse asymmetric synapse cytosolic small ribosomal subunit nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
R [auth N]	Transfer RNA (75-MER)	-	-	-
T [auth Q]	40S ribosomal protein S23	RNA binding binding organic cyclic compound binding nucleic acid binding structural molecule activity structural constituent of ribosome	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process protein metabolic process macromolecule metabolic process cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis ribosomal small subunit biogenesis cellular component organization organelle organization cellular component assembly stress granule assembly organelle assembly non-membrane-bounded organelle assembly maintenance of translational fidelity	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane cytosolic ribosome ribosome cytoplasm cytosol preribosome protein-containing complex ribonucleoprotein complex small-subunit processome synapse cell junction cytosolic small ribosomal subunit small ribosomal subunit ribosomal subunit nucleoplasm rough endoplasmic reticulum endoplasmic reticulum endomembrane system
U [auth R]	40S ribosomal protein S19	-	-	-
X [auth V]	40S ribosomal protein S30	RNA binding binding organic cyclic compound binding nucleic acid binding structural molecule activity structural constituent of ribosome	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process protein metabolic process macromolecule metabolic process biological process involved in interspecies interaction between organisms innate immune response in mucosa response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus mucosal immune response organ or tissue specific immune response humoral immune response antimicrobial humoral response antimicrobial humoral immune response mediated by antimicrobial peptide antibacterial humoral response defense response to bacterium response to bacterium defense response to Gram-positive bacterium	protein-containing complex intracellular anatomical structure small ribosomal subunit cellular anatomical entity ribosomal subunit intracellular organelle organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome non-membrane-bounded organelle cytosolic ribosome cytoplasm cytosol protein-containing complex intracellular anatomical structure small ribosomal subunit cellular anatomical entity ribosomal subunit intracellular organelle organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome non-membrane-bounded organelle cytosolic ribosome cytoplasm cytosol cytosolic small ribosomal subunit extracellular region extracellular space membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
Y [auth W]	40S ribosomal protein S25	RNA binding binding organic cyclic compound binding nucleic acid binding structural molecule activity structural constituent of ribosome	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process protein metabolic process macromolecule metabolic process cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis ribosomal small subunit biogenesis RNA metabolic process rRNA processing nucleobase-containing compound metabolic process RNA processing rRNA metabolic process nucleic acid metabolic process organic cyclic compound metabolic process ncRNA metabolic process nucleic acid catabolic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle protein-containing complex small ribosomal subunit ribosomal subunit ribonucleoprotein complex ribosome cytosolic ribosome cytoplasm cytosol extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization synapse cell junction asymmetric synapse cytosolic small ribosomal subunit nucleoplasm
Z [auth X]	40S ribosomal protein S7	mRNA 3'-UTR binding RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding structural molecule activity structural constituent of ribosome protein binding kinase binding enzyme binding protein kinase binding enzyme regulator activity molecular function inhibitor activity mRNA 3'-UTR binding RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding structural molecule activity structural constituent of ribosome protein binding kinase binding enzyme binding protein kinase binding enzyme regulator activity molecular function inhibitor activity ubiquitin-protein transferase regulator activity ubiquitin-protein transferase inhibitor activity ubiquitin ligase inhibitor activity molecular function regulator activity enzyme inhibitor activity mRNA 5'-UTR binding	regulation of protein stability biological regulation regulation of biological quality protein stabilization developmental process neural crest cell differentiation cellular developmental process animal organ development mesenchyme development tissue development stem cell differentiation cell differentiation anatomical structure development cellular process regulation of protein stability biological regulation regulation of biological quality protein stabilization developmental process neural crest cell differentiation cellular developmental process animal organ development mesenchyme development tissue development stem cell differentiation cell differentiation anatomical structure development cellular process mesenchymal cell differentiation regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process catabolic process negative regulation of proteolysis negative regulation of proteolysis involved in protein catabolic process proteolysis involved in protein catabolic process negative regulation of biological process regulation of ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of primary metabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis modification-dependent macromolecule catabolic process proteolysis protein metabolic process negative regulation of protein metabolic process negative regulation of ubiquitin-dependent protein catabolic process negative regulation of macromolecule metabolic process organonitrogen compound catabolic process negative regulation of catabolic process organonitrogen compound metabolic process regulation of protein metabolic process negative regulation of metabolic process primary metabolic process regulation of catabolic process protein catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process organic substance catabolic process ribonucleoprotein complex biogenesis RNA metabolic process rRNA processing nucleobase-containing compound metabolic process cellular component biogenesis ribosome biogenesis cellular component organization or biogenesis RNA processing rRNA metabolic process nucleic acid metabolic process organic cyclic compound metabolic process ncRNA metabolic process nucleic acid catabolic process cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus signaling positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator regulation of signal transduction regulation of programmed cell death regulation of intrinsic apoptotic signaling pathway intracellular signal transduction cell communication positive regulation of apoptotic signaling pathway positive regulation of response to stimulus regulation of intracellular signal transduction regulation of signal transduction by p53 class mediator positive regulation of signal transduction by p53 class mediator signal transduction intrinsic apoptotic signaling pathway regulation of signaling positive regulation of programmed cell death regulation of apoptotic process positive regulation of intracellular signal transduction signal transduction by p53 class mediator cell death positive regulation of apoptotic process apoptotic signaling pathway regulation of response to stimulus regulation of cell communication intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of intrinsic apoptotic signaling pathway apoptotic process regulation of intrinsic apoptotic signaling pathway by p53 class mediator programmed cell death regulation of apoptotic signaling pathway positive regulation of signaling multicellular organismal process embryonic epithelial tube formation chordate embryonic development tube formation embryo development multicellular organism development epithelial tube formation tube morphogenesis primary neural tube formation embryo development ending in birth or egg hatching epithelial tube morphogenesis system development morphogenesis of embryonic epithelium epithelium development neural tube development tube development embryonic morphogenesis morphogenesis of an epithelium nervous system development anatomical structure morphogenesis tissue morphogenesis neural tube closure neural tube formation anatomical structure formation involved in morphogenesis tube closure organonitrogen compound biosynthetic process translation cytoplasmic translation ribosomal small subunit biogenesis negative regulation of post-translational protein modification negative regulation of ubiquitin protein ligase activity regulation of protein modification process regulation of catalytic activity regulation of protein ubiquitination negative regulation of catalytic activity regulation of transferase activity regulation of ubiquitin protein ligase activity negative regulation of ubiquitin-protein transferase activity protein ubiquitination negative regulation of transferase activity negative regulation of protein modification process regulation of ubiquitin-protein transferase activity negative regulation of protein ubiquitination regulation of protein modification by small protein conjugation or removal protein modification process negative regulation of protein modification by small protein conjugation or removal regulation of post-translational protein modification negative regulation of molecular function regulation of molecular function macromolecule modification post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton cytoplasm cytosol nucleoplasm ribosome protein-containing complex cytosolic ribosome preribosome ribonucleoprotein complex small-subunit processome synapse cytosolic small ribosomal subunit small ribosomal subunit ribosomal subunit endoplasmic reticulum endomembrane system
AA [auth Y]	40S ribosomal protein S27	DNA binding binding organic cyclic compound binding nucleic acid binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding RNA binding structural molecule activity structural constituent of ribosome	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process protein metabolic process macromolecule metabolic process cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis ribosomal small subunit biogenesis RNA metabolic process rRNA processing nucleobase-containing compound metabolic process RNA processing rRNA metabolic process nucleic acid metabolic process organic cyclic compound metabolic process ncRNA metabolic process nucleic acid catabolic process organelle assembly protein-containing complex organization non-membrane-bounded organelle assembly ribosomal small subunit assembly protein-RNA complex assembly cellular component organization organelle organization protein-RNA complex organization cellular component assembly protein-containing complex assembly ribosome assembly	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle cytosolic ribosome ribosome cytoplasm cytosol preribosome protein-containing complex ribonucleoprotein complex small-subunit processome postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization synapse cell junction asymmetric synapse cytosolic small ribosomal subunit small ribosomal subunit ribosomal subunit nucleoplasm
CA [auth a]	40S ribosomal protein S15a	RNA binding binding organic cyclic compound binding nucleic acid binding structural molecule activity structural constituent of ribosome	regulation of biological process regulation of cellular process biological regulation positive regulation of biological process cellular process cell cycle regulation of cell cycle positive regulation of cell cycle positive regulation of cellular process cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation organonitrogen compound metabolic process cellular biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process cellular process cell cycle regulation of cell cycle positive regulation of cell cycle positive regulation of cellular process cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process protein metabolic process macromolecule metabolic process cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis ribosomal small subunit biogenesis biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to external stimulus response to external biotic stimulus response to virus response to biotic stimulus	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane cytosolic ribosome ribosome cytoplasm cytosol preribosome protein-containing complex ribonucleoprotein complex small-subunit processome extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle synapse cell junction cytosolic small ribosomal subunit small ribosomal subunit ribosomal subunit nucleoplasm
DA [auth b]	40S ribosomal protein S21	-	-	-
HA [auth f]	40S ribosomal protein SA	protein binding binding virus receptor activity exogenous protein binding RNA binding organic cyclic compound binding nucleic acid binding structural molecule activity structural constituent of ribosome extracellular matrix binding laminin binding cell adhesion molecule binding laminin receptor activity cell adhesion mediator activity protein binding binding virus receptor activity exogenous protein binding RNA binding organic cyclic compound binding nucleic acid binding structural molecule activity structural constituent of ribosome extracellular matrix binding laminin binding cell adhesion molecule binding laminin receptor activity cell adhesion mediator activity ribonucleoprotein complex binding protein-containing complex binding ribosome binding	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process protein metabolic process macromolecule metabolic process ribonucleoprotein complex biogenesis organelle assembly protein-containing complex organization non-membrane-bounded organelle assembly ribosomal small subunit assembly protein-RNA complex assembly ribosomal small subunit biogenesis cellular component organization cellular component biogenesis ribosome biogenesis organelle organization protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis ribosome assembly	membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen cytosolic ribosome intracellular non-membrane-bounded organelle ribosome non-membrane-bounded organelle cytosolic small ribosomal subunit protein-containing complex small ribosomal subunit ribosomal subunit ribonucleoprotein complex
JA [auth h]	40S ribosomal protein S20	enzyme regulator activity molecular function inhibitor activity ubiquitin-protein transferase regulator activity ubiquitin-protein transferase inhibitor activity ubiquitin ligase inhibitor activity molecular function regulator activity enzyme inhibitor activity protein binding binding MDM2/MDM4 family protein binding RNA binding organic cyclic compound binding nucleic acid binding structural molecule activity enzyme regulator activity molecular function inhibitor activity ubiquitin-protein transferase regulator activity ubiquitin-protein transferase inhibitor activity ubiquitin ligase inhibitor activity molecular function regulator activity enzyme inhibitor activity protein binding binding MDM2/MDM4 family protein binding RNA binding organic cyclic compound binding nucleic acid binding structural molecule activity structural constituent of ribosome	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction regulation of signal transduction by p53 class mediator positive regulation of signal transduction by p53 class mediator cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction regulation of signal transduction by p53 class mediator positive regulation of signal transduction by p53 class mediator signal transduction positive regulation of cellular process regulation of biological process regulation of signaling biological regulation positive regulation of intracellular signal transduction signal transduction by p53 class mediator regulation of response to stimulus regulation of cell communication cellular process positive regulation of signaling organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process protein metabolic process macromolecule metabolic process	membrane cellular anatomical entity intracellular organelle intracellular anatomical structure cytosolic ribosome organelle intracellular non-membrane-bounded organelle ribosome cytoplasm cytosol non-membrane-bounded organelle extracellular exosome membrane-bounded organelle extracellular vesicle membrane cellular anatomical entity intracellular organelle intracellular anatomical structure cytosolic ribosome organelle intracellular non-membrane-bounded organelle ribosome cytoplasm cytosol non-membrane-bounded organelle extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle synapse cell junction cytosolic small ribosomal subunit protein-containing complex small ribosomal subunit ribosomal subunit ribonucleoprotein complex nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
KA [auth i]	40S ribosomal protein S3a	RNA binding binding organic cyclic compound binding nucleic acid binding structural molecule activity structural constituent of ribosome mRNA 5'-UTR binding mRNA binding	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process translational initiation metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process translational initiation metabolic process cellular process protein metabolic process macromolecule metabolic process developmental process cellular developmental process cell differentiation regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death cytoplasmic translation cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis ribosomal small subunit biogenesis	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol nucleoplasm cytosolic ribosome ribosome preribosome protein-containing complex ribonucleoprotein complex small-subunit processome synapse cytosolic small ribosomal subunit small ribosomal subunit ribosomal subunit endoplasmic reticulum endomembrane system
NA [auth l]	40S ribosomal protein S28	RNA binding binding organic cyclic compound binding nucleic acid binding structural molecule activity structural constituent of ribosome	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process protein metabolic process macromolecule metabolic process cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis ribosomal small subunit biogenesis RNA metabolic process rRNA processing nucleobase-containing compound metabolic process RNA processing rRNA metabolic process nucleic acid metabolic process organic cyclic compound metabolic process ncRNA metabolic process nucleic acid catabolic process organelle assembly protein-containing complex organization non-membrane-bounded organelle assembly ribosomal small subunit assembly protein-RNA complex assembly cellular component organization organelle organization protein-RNA complex organization cellular component assembly protein-containing complex assembly ribosome assembly maturation of SSU-rRNA	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle protein-containing complex small ribosomal subunit ribosomal subunit ribonucleoprotein complex ribosome preribosome small-subunit processome extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle synapse cell junction organelle subcompartment cytoplasmic side of membrane membrane endomembrane system side of membrane cytoplasmic side of rough endoplasmic reticulum membrane rough endoplasmic reticulum endoplasmic reticulum subcompartment bounding membrane of organelle rough endoplasmic reticulum membrane nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasmic side of endoplasmic reticulum membrane cytoplasm organelle membrane endoplasmic reticulum membrane cytosol cytosolic small ribosomal subunit cytosolic ribosome nucleoplasm
SA [auth q]	40S ribosomal protein S6	RNA binding binding organic cyclic compound binding nucleic acid binding structural molecule activity structural constituent of ribosome protein binding kinase binding enzyme binding protein kinase binding	regulation of biological process positive regulation of programmed cell death regulation of cellular process regulation of apoptotic process biological regulation positive regulation of biological process regulation of programmed cell death cell death positive regulation of apoptotic process cellular process apoptotic process programmed cell death positive regulation of cellular process ribonucleoprotein complex biogenesis regulation of biological process positive regulation of programmed cell death regulation of cellular process regulation of apoptotic process biological regulation positive regulation of biological process regulation of programmed cell death cell death positive regulation of apoptotic process cellular process apoptotic process programmed cell death positive regulation of cellular process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process rRNA processing nucleobase-containing compound metabolic process cellular component biogenesis ribosome biogenesis organic substance metabolic process organic substance biosynthetic process cellular component organization or biogenesis RNA processing rRNA metabolic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process ncRNA metabolic process nucleic acid catabolic process metabolic process macromolecule metabolic process cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation organonitrogen compound metabolic process organonitrogen compound biosynthetic process translation cytoplasmic translation protein metabolic process ribosomal small subunit biogenesis cellular response to stimulus TOR signaling response to stimulus signaling intracellular signal transduction cell communication signal transduction chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane cytoplasm cytosol somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection nucleoplasm cytoplasmic ribonucleoprotein granule supramolecular complex ribonucleoprotein granule protein-containing complex small ribosomal subunit ribosomal subunit ribonucleoprotein complex ribosome cytosolic ribosome preribosome small-subunit processome cell body cytosolic small ribosomal subunit endoplasmic reticulum endomembrane system
TA [auth r]	40S ribosomal protein S12	RNA binding binding organic cyclic compound binding nucleic acid binding structural molecule activity structural constituent of ribosome	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process protein metabolic process macromolecule metabolic process cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis ribosomal small subunit biogenesis cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway positive regulation of biological process regulation of signal transduction cell communication positive regulation of response to stimulus positive regulation of Wnt signaling pathway signal transduction Wnt signaling pathway positive regulation of cellular process positive regulation of canonical Wnt signaling pathway regulation of biological process regulation of signaling cell surface receptor signaling pathway regulation of Wnt signaling pathway biological regulation regulation of response to stimulus regulation of cell communication positive regulation of signaling	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane cytosolic ribosome ribosome cytoplasm cytosol Golgi apparatus endomembrane system preribosome protein-containing complex ribonucleoprotein complex small-subunit processome cytosolic small ribosomal subunit small ribosomal subunit ribosomal subunit nucleoplasm
UA [auth s]	40S ribosomal protein S24	protein binding binding translation initiation factor binding RNA binding organic cyclic compound binding nucleic acid binding structural molecule activity structural constituent of ribosome	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process protein metabolic process macromolecule metabolic process cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis ribosomal small subunit biogenesis RNA metabolic process rRNA processing nucleobase-containing compound metabolic process RNA processing rRNA metabolic process nucleic acid metabolic process organic cyclic compound metabolic process ncRNA metabolic process nucleic acid catabolic process multicellular organismal process multicellular organismal-level homeostasis homeostatic process immune system process homeostasis of number of cells myeloid cell homeostasis erythrocyte homeostasis	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle protein-containing complex small ribosomal subunit ribosomal subunit ribonucleoprotein complex ribosome membrane cytosolic ribosome cytoplasm cytosol preribosome small-subunit processome cytosolic small ribosomal subunit nucleoplasm endoplasmic reticulum endomembrane system
A [auth 1]	Eukaryotic translation initiation factor 3 subunit A	-	-	-
J [auth A]	18S ribosomal RNA	-	-	-
K [auth F]	Messenger RNA (26-MER)	-	-	-
M [auth H]	40S ribosomal protein S16	RNA binding binding organic cyclic compound binding nucleic acid binding structural molecule activity structural constituent of ribosome	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process protein metabolic process macromolecule metabolic process ribonucleoprotein complex biogenesis RNA metabolic process rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cellular component biogenesis nucleobase-containing compound metabolic process ribosome biogenesis maturation of SSU-rRNA cellular component organization or biogenesis RNA processing rRNA metabolic process ribosomal small subunit biogenesis nucleic acid metabolic process organic cyclic compound metabolic process ncRNA metabolic process nucleic acid catabolic process cellular response to stimulus response to organic substance response to stimulus response to cytokine response to leukemia inhibitory factor cellular response to leukemia inhibitory factor cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular response to organic substance	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle protein-containing complex small ribosomal subunit ribosomal subunit ribonucleoprotein complex ribosome membrane cytosolic ribosome cytoplasm cytosol preribosome small-subunit processome extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle synapse cytosolic small ribosomal subunit nucleoplasm
N [auth I]	40S ribosomal protein S4, X isoform	RNA binding binding organic cyclic compound binding rRNA binding nucleic acid binding structural molecule activity structural constituent of ribosome	regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation regulation of cell population proliferation biological regulation positive regulation of biological process cellular process positive regulation of cellular process cellular biosynthetic process positive regulation of protein metabolic process organonitrogen compound biosynthetic process positive regulation of translation positive regulation of cellular metabolic process regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation regulation of cell population proliferation biological regulation positive regulation of biological process cellular process positive regulation of cellular process cellular biosynthetic process positive regulation of protein metabolic process organonitrogen compound biosynthetic process positive regulation of translation positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process protein metabolic process regulation of biosynthetic process organonitrogen compound metabolic process cellular metabolic process regulation of protein metabolic process regulation of cellular metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of translation regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process cytoplasmic translation cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis ribosomal small subunit biogenesis	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol nucleoplasm ribosome cytoplasmic ribonucleoprotein granule supramolecular complex ribonucleoprotein granule protein-containing complex small ribosomal subunit ribosomal subunit ribonucleoprotein complex cytosolic ribosome preribosome small-subunit processome synapse cytosolic small ribosomal subunit
S [auth P]	Eukaryotic translation initiation factor 2 subunit 1	-	-	-
V [auth S]	Eukaryotic translation initiation factor 2 subunit 3	RNA binding binding organic cyclic compound binding tRNA binding nucleic acid binding methionyl-initiator methionine tRNA binding translation regulator activity translation regulator activity, nucleic acid binding translation initiation factor activity translation factor activity, RNA binding cell adhesion molecule binding cadherin binding protein binding guanyl nucleotide binding RNA binding binding organic cyclic compound binding tRNA binding nucleic acid binding methionyl-initiator methionine tRNA binding translation regulator activity translation regulator activity, nucleic acid binding translation initiation factor activity translation factor activity, RNA binding cell adhesion molecule binding cadherin binding protein binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process translational initiation metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process translational initiation metabolic process cellular process protein metabolic process macromolecule metabolic process ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis formation of translation preinitiation complex protein-containing complex organization cytoplasmic translation cytoplasmic translational initiation	extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol protein-containing complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol protein-containing complex eukaryotic translation initiation factor 2 complex
W [auth U]	40S ribosomal protein S5	RNA binding binding organic cyclic compound binding rRNA binding nucleic acid binding structural molecule activity structural constituent of ribosome mRNA binding	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process translational initiation metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process translational initiation metabolic process cellular process protein metabolic process macromolecule metabolic process biological regulation regulation of biological quality regulation of translational fidelity cytoplasmic translation cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis ribosomal small subunit biogenesis organelle assembly protein-containing complex organization non-membrane-bounded organelle assembly ribosomal small subunit assembly protein-RNA complex assembly cellular component organization organelle organization protein-RNA complex organization cellular component assembly protein-containing complex assembly ribosome assembly	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol nucleoplasm ribosome cytosolic ribosome preribosome protein-containing complex ribonucleoprotein complex small-subunit processome synapse cytosolic small ribosomal subunit small ribosomal subunit ribosomal subunit
BA [auth Z]	40S ribosomal protein S13	RNA binding binding organic cyclic compound binding nucleic acid binding structural molecule activity structural constituent of ribosome mRNA binding small ribosomal subunit rRNA binding rRNA binding mRNA 5'-UTR binding	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process protein metabolic process macromolecule metabolic process regulation of cellular process negative regulation of biological process RNA metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process RNA processing regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process RNA splicing negative regulation of metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process regulation of RNA splicing negative regulation of cellular biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of RNA splicing regulation of gene expression organic cyclic compound metabolic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of metabolic process negative regulation of RNA metabolic process cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis ribosomal small subunit biogenesis	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol nucleoplasm ribosome cytosolic ribosome preribosome protein-containing complex ribonucleoprotein complex small-subunit processome postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization synapse asymmetric synapse cytosolic small ribosomal subunit small ribosomal subunit ribosomal subunit
C [auth 3]	Eukaryotic translation initiation factor 3 subunit E	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding RNA binding cell adhesion molecule binding cadherin binding protein binding	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process translational initiation metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process translational initiation metabolic process cellular process protein metabolic process macromolecule metabolic process positive regulation of mRNA binding positive regulation of molecular function regulation of molecular function positive regulation of RNA binding regulation of binding biological regulation regulation of mRNA binding positive regulation of binding regulation of RNA binding regulation of cellular process positive regulation of protein metabolic process positive regulation of biological process positive regulation of translation positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process regulation of protein metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process regulation of cellular biosynthetic process regulation of gene expression positive regulation of gene expression regulation of translation regulation of macromolecule biosynthetic process regulation of metabolic process positive regulation of cellular biosynthetic process regulation of translational initiation negative regulation of biological process negative regulation of cellular metabolic process negative regulation of translation negative regulation of cellular process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of translational initiation negative regulation of cellular biosynthetic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process catabolic process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay RNA metabolic process macromolecule catabolic process nucleobase-containing compound metabolic process RNA catabolic process mRNA catabolic process nuclear-transcribed mRNA catabolic process mRNA metabolic process nucleic acid metabolic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process organic cyclic compound metabolic process nucleic acid catabolic process organic substance catabolic process ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization formation of cytoplasmic translation initiation complex cytoplasmic translation cytoplasmic translational initiation	membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle eukaryotic translation initiation factor 3 complex protein-containing complex intracellular anatomical structure membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle eukaryotic translation initiation factor 3 complex protein-containing complex intracellular anatomical structure cytoplasm cytosol nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle translation preinitiation complex eukaryotic 43S preinitiation complex ribonucleoprotein complex postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization synapse cell junction asymmetric synapse eukaryotic 48S preinitiation complex eukaryotic translation initiation factor 3 complex, eIF3e nuclear body PML body
EA [auth c]	40S ribosomal protein S2	-	-	-
FA [auth d]	EUKARYOTIC TRANSLATION INITIATION FACTOR 2 BETA SUBUNIT (eIF2-Beta)	-	-	-
GA [auth e]	40S ribosomal protein S17	RNA binding binding organic cyclic compound binding nucleic acid binding structural molecule activity structural constituent of ribosome	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process translational initiation metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process translational initiation metabolic process cellular process protein metabolic process macromolecule metabolic process cytoplasmic translation cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis ribosomal small subunit biogenesis RNA metabolic process rRNA processing nucleobase-containing compound metabolic process RNA processing rRNA metabolic process nucleic acid metabolic process organic cyclic compound metabolic process ncRNA metabolic process nucleic acid catabolic process multicellular organismal process multicellular organismal-level homeostasis homeostatic process immune system process homeostasis of number of cells myeloid cell homeostasis erythrocyte homeostasis	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane cytosolic ribosome ribosome cytoplasm cytosol preribosome protein-containing complex ribonucleoprotein complex small-subunit processome synapse cytosolic small ribosomal subunit small ribosomal subunit ribosomal subunit nucleoplasm
IA [auth g]	40S ribosomal protein S3	DNA binding oxidized DNA binding oxidized pyrimidine DNA binding binding organic cyclic compound binding damaged DNA binding nucleic acid binding structural molecule activity structural constituent of ribosome ubiquitin-like protein conjugating enzyme binding protein binding enzyme binding cytoskeletal protein binding microtubule binding DNA binding oxidized DNA binding oxidized pyrimidine DNA binding binding organic cyclic compound binding damaged DNA binding nucleic acid binding structural molecule activity structural constituent of ribosome ubiquitin-like protein conjugating enzyme binding protein binding enzyme binding cytoskeletal protein binding microtubule binding tubulin binding RNA binding mRNA binding double-stranded DNA binding supercoiled DNA binding protein-containing complex binding DNA-(apurinic or apyrimidinic site) endonuclease activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid class I DNA-(apurinic or apyrimidinic site) endonuclease activity lyase activity catalytic activity carbon-oxygen lyase activity oxidized purine DNA binding small ribosomal subunit rRNA binding rRNA binding protein kinase A binding iron-sulfur cluster binding metal cluster binding small molecule binding Hsp90 protein binding heat shock protein binding DNA endonuclease activity endonuclease activity nuclease activity hydrolase activity, acting on ester bonds hydrolase activity DNA nuclease activity Hsp70 protein binding protein-folding chaperone binding kinase binding protein kinase binding transcription factor binding DNA-binding transcription factor binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process translational initiation metabolic process protein metabolic process macromolecule metabolic process positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process regulation of cellular response to stress regulation of signal transduction regulation of intrinsic apoptotic signaling pathway in response to DNA damage regulation of programmed cell death regulation of intrinsic apoptotic signaling pathway intracellular signal transduction cell communication positive regulation of apoptotic signaling pathway positive regulation of response to stimulus regulation of intracellular signal transduction regulation of response to stress intrinsic apoptotic signaling pathway in response to DNA damage signal transduction intrinsic apoptotic signaling pathway positive regulation of cellular process regulation of biological process regulation of signaling positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of programmed cell death regulation of apoptotic process biological regulation positive regulation of intracellular signal transduction cell death positive regulation of apoptotic process apoptotic signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of intrinsic apoptotic signaling pathway apoptotic process programmed cell death regulation of apoptotic signaling pathway positive regulation of signaling regulation of primary metabolic process nucleobase-containing compound metabolic process regulation of base-excision repair positive regulation of metabolic process positive regulation of DNA repair base-excision repair positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process DNA repair positive regulation of nucleobase-containing compound metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process regulation of DNA repair organic cyclic compound metabolic process positive regulation of DNA metabolic process positive regulation of base-excision repair regulation of metabolic process regulation of DNA metabolic process cell division negative regulation of post-translational protein modification regulation of protein modification process negative regulation of biological process regulation of protein ubiquitination protein ubiquitination negative regulation of protein modification process negative regulation of protein ubiquitination regulation of protein modification by small protein conjugation or removal protein modification process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of protein modification by small protein conjugation or removal regulation of post-translational protein modification regulation of protein metabolic process negative regulation of metabolic process macromolecule modification post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process regulation of biosynthetic process regulation of cellular metabolic process regulation of cellular biosynthetic process regulation of gene expression positive regulation of gene expression regulation of macromolecule biosynthetic process positive regulation of cellular biosynthetic process cell cycle chromosome segregation cell cycle process positive regulation of cellular component organization regulation of cellular component organization protein-containing complex organization positive regulation of cellular component biogenesis regulation of cellular component biogenesis cellular component organization cellular component biogenesis positive regulation of protein-containing complex assembly regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly cellular component organization or biogenesis response to chemical response to TNF agonist immune response-regulating cell surface receptor signaling pathway positive regulation of T cell receptor signaling pathway regulation of antigen receptor-mediated signaling pathway immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process positive regulation of immune system process cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway immune response regulation of T cell receptor signaling pathway T cell receptor signaling pathway immune system process regulation of immune response antigen receptor-mediated signaling pathway activation of immune response positive regulation of antigen receptor-mediated signaling pathway positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity RNA metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process regulation of molecular function regulation of DNA-binding transcription factor activity organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of organelle organization regulation of cytoskeleton organization regulation of microtubule polymerization or depolymerization microtubule cytoskeleton organization microtubule polymerization or depolymerization positive regulation of protein polymerization protein polymerization positive regulation of microtubule polymerization or depolymerization positive regulation of cytoskeleton organization regulation of microtubule-based process microtubule polymerization positive regulation of supramolecular fiber organization regulation of organelle organization organelle organization positive regulation of microtubule polymerization regulation of protein polymerization regulation of microtubule polymerization regulation of supramolecular fiber organization microtubule-based process supramolecular fiber organization cytoskeleton organization regulation of microtubule cytoskeleton organization positive regulation of phosphorylation regulation of catalytic activity regulation of transferase activity positive regulation of phosphate metabolic process regulation of MAP kinase activity positive regulation of protein serine/threonine kinase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process intracellular signaling cassette phosphorus metabolic process positive regulation of protein phosphorylation positive regulation of MAP kinase activity protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation positive regulation of MAPK cascade positive regulation of JUN kinase activity regulation of MAPK cascade positive regulation of kinase activity regulation of kinase activity regulation of protein serine/threonine kinase activity regulation of phosphorus metabolic process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of protein modification process positive regulation of protein kinase activity positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity regulation of JUN kinase activity MAPK cascade regulation of phosphorylation positive regulation of peptidase activity positive regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of proteolysis proteolysis regulation of endopeptidase activity regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis regulation of cysteine-type endopeptidase activity regulation of peptidase activity positive regulation of hydrolase activity positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis positive regulation of cysteine-type endopeptidase activity regulation of hydrolase activity positive regulation of endopeptidase activity positive regulation of proteolysis negative regulation of cellular metabolic process post-transcriptional regulation of gene expression negative regulation of translation negative regulation of cellular process negative regulation of cellular biosynthetic process negative regulation of gene expression negative regulation of biosynthetic process regulation of translation negative regulation of macromolecule biosynthetic process negative regulation of DNA repair negative regulation of nucleobase-containing compound metabolic process negative regulation of response to stimulus negative regulation of DNA metabolic process organelle assembly non-membrane-bounded organelle assembly spindle assembly spindle organization regulation of endodeoxyribonuclease activity regulation of deoxyribonuclease activity regulation of nuclease activity positive regulation of endodeoxyribonuclease activity positive regulation of deoxyribonuclease activity positive regulation of nuclease activity cellular response to oxidative stress response to oxygen-containing compound cellular response to chemical stress cellular response to oxygen-containing compound cellular response to hydrogen peroxide response to reactive oxygen species response to inorganic substance response to hydrogen peroxide response to oxidative stress cellular response to reactive oxygen species cellular response to chemical stimulus response to organic substance response to cytokine cellular response to tumor necrosis factor cellular response to cytokine stimulus cellular response to organic substance response to tumor necrosis factor multicellular organismal process positive regulation of cell population proliferation regulation of leukocyte activation regulation of cell activation positive regulation of cell activation T cell activation lymphocyte proliferation positive regulation of leukocyte activation regulation of leukocyte proliferation cell population proliferation positive regulation of T cell activation positive regulation of lymphocyte proliferation positive regulation of T cell proliferation positive regulation of activated T cell proliferation regulation of cell population proliferation mononuclear cell proliferation regulation of leukocyte cell-cell adhesion positive regulation of leukocyte proliferation positive regulation of multicellular organismal process regulation of activated T cell proliferation positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation activated T cell proliferation positive regulation of cell-cell adhesion positive regulation of lymphocyte activation cell adhesion cell-cell adhesion positive regulation of mononuclear cell proliferation regulation of multicellular organismal process regulation of cell-cell adhesion T cell proliferation regulation of lymphocyte proliferation positive regulation of cell adhesion regulation of cell adhesion cell activation regulation of T cell activation regulation of T cell proliferation regulation of mononuclear cell proliferation regulation of lymphocyte activation cytoplasmic translation regulation of cytokine production cytokine production regulation of interleukin-2 production interleukin-2 production positive regulation of interleukin-2 production positive regulation of cytokine production regulation of non-canonical NF-kappaB signal transduction non-canonical NF-kappaB signal transduction positive regulation of non-canonical NF-kappaB signal transduction	membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol intracellular organelle protein-containing complex NF-kappaB complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane mitochondrion mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane anchoring junction cell junction focal adhesion cell-substrate junction membrane-enclosed lumen nucleolus intracellular organelle lumen organelle lumen intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle ruffle cell leading edge plasma membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection ruffle membrane plasma membrane region cell projection membrane mitotic spindle cytoskeleton spindle microtubule cytoskeleton nucleoplasm ribosome cytosolic ribosome postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization synapse asymmetric synapse cytosolic small ribosomal subunit small ribosomal subunit ribosomal subunit ribonucleoprotein complex mitochondrial matrix endoplasmic reticulum endomembrane system
LA [auth j]	40S ribosomal protein S14	translation regulator activity RNA binding binding organic cyclic compound binding nucleic acid binding structural molecule activity structural constituent of ribosome mRNA 5'-UTR binding mRNA binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process rRNA processing cellular component biogenesis nucleobase-containing compound metabolic process ribosome biogenesis organic substance metabolic process maturation of SSU-rRNA organic substance biosynthetic process cellular component organization or biogenesis RNA processing rRNA metabolic process cellular metabolic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process rRNA processing cellular component biogenesis nucleobase-containing compound metabolic process ribosome biogenesis organic substance metabolic process maturation of SSU-rRNA organic substance biosynthetic process cellular component organization or biogenesis RNA processing rRNA metabolic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process ribosomal small subunit biogenesis nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process ncRNA metabolic process nucleic acid catabolic process cellular process metabolic process macromolecule metabolic process organonitrogen compound metabolic process organonitrogen compound biosynthetic process translation cytoplasmic translation protein metabolic process developmental process multicellular organismal process cellular developmental process homeostatic process hemopoiesis cell development erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation immune system process cell differentiation anatomical structure development homeostasis of number of cells myeloid cell homeostasis erythrocyte homeostasis organelle assembly protein-containing complex organization non-membrane-bounded organelle assembly ribosomal small subunit assembly protein-RNA complex assembly cellular component organization organelle organization protein-RNA complex organization cellular component assembly protein-containing complex assembly ribosome assembly regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription regulation of biological process negative regulation of transcription by RNA polymerase II negative regulation of metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process regulation of gene expression negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process regulation of cellular biosynthetic process negative regulation of biosynthetic process	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol nucleoplasm cytosolic ribosome ribosome preribosome protein-containing complex ribonucleoprotein complex small-subunit processome postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization synapse asymmetric synapse cytosolic small ribosomal subunit small ribosomal subunit ribosomal subunit
MA [auth k]	40S ribosomal protein S26	-	-	-
OA [auth m]	Receptor of activated protein C kinase 1	molecular function inhibitor activity channel regulator activity transporter inhibitor activity ion channel inhibitor activity ion channel regulator activity molecular function regulator activity transporter regulator activity channel inhibitor activity protein phosphatase binding phosphatase binding protein binding binding enzyme binding death domain binding molecular function inhibitor activity channel regulator activity transporter inhibitor activity ion channel inhibitor activity ion channel regulator activity molecular function regulator activity transporter regulator activity channel inhibitor activity protein phosphatase binding phosphatase binding protein binding binding enzyme binding death domain binding BH3 domain binding BH domain binding protein domain specific binding cell adhesion molecule binding cadherin binding enzyme regulator activity enzyme activator activity peptidase regulator activity molecular function activator activity cysteine-type endopeptidase activator activity involved in apoptotic process cysteine-type endopeptidase regulator activity involved in apoptotic process peptidase activator activity peptidase activator activity involved in apoptotic process molecular adaptor activity protein tyrosine kinase binding kinase binding signaling receptor binding receptor tyrosine kinase binding protein kinase binding translation regulator activity protein-macromolecule adaptor activity signaling adaptor activity SH2 domain binding cyclin binding RNA binding organic cyclic compound binding nucleic acid binding identical protein binding protein homodimerization activity protein dimerization activity protein kinase inhibitor activity protein tyrosine kinase inhibitor activity enzyme inhibitor activity protein kinase regulator activity kinase inhibitor activity kinase regulator activity ribonucleoprotein complex binding protein-containing complex binding ribosome binding protein kinase C binding	protein localization positive regulation of protein localization to plasma membrane regulation of localization Golgi to plasma membrane transport establishment of protein localization nitrogen compound transport regulation of cellular process establishment of protein localization to plasma membrane positive regulation of establishment of protein localization Golgi to plasma membrane protein transport vesicle-mediated transport localization cellular macromolecule localization positive regulation of protein localization to cell periphery protein localization positive regulation of protein localization to plasma membrane regulation of localization Golgi to plasma membrane transport establishment of protein localization nitrogen compound transport regulation of cellular process establishment of protein localization to plasma membrane positive regulation of establishment of protein localization Golgi to plasma membrane protein transport vesicle-mediated transport localization cellular macromolecule localization positive regulation of protein localization to cell periphery positive regulation of Golgi to plasma membrane protein transport regulation of biological process protein localization to cell periphery establishment of protein localization to membrane organic substance transport positive regulation of protein localization to membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane establishment of localization regulation of Golgi to plasma membrane protein transport positive regulation of protein localization Golgi vesicle transport cellular localization post-Golgi vesicle-mediated transport regulation of protein localization transport positive regulation of biological process positive regulation of protein transport regulation of protein localization to membrane positive regulation of cellular process regulation of transport protein localization to plasma membrane biological regulation regulation of establishment of protein localization regulation of protein transport regulation of vesicle-mediated transport vesicle-mediated transport to the plasma membrane positive regulation of transport protein transport regulation of cellular localization macromolecule localization cellular process regulation of protein localization to plasma membrane regulation of protein binding regulation of molecular function negative regulation of protein binding negative regulation of binding regulation of binding negative regulation of molecular function cellular biosynthetic process rescue of stalled ribosome organonitrogen compound biosynthetic process cellular component organization organic substance metabolic process organelle disassembly organic substance biosynthetic process cellular component organization or biogenesis protein metabolic process cellular component disassembly organonitrogen compound metabolic process ribosome disassembly cellular metabolic process primary metabolic process translation gene expression macromolecule biosynthetic process organelle organization biosynthetic process translational elongation metabolic process macromolecule metabolic process developmental process multicellular organismal process regulation of embryonic development regulation of multicellular organismal development regulation of gastrulation regulation of developmental process embryonic morphogenesis positive regulation of gastrulation embryo development gastrulation positive regulation of developmental process multicellular organism development anatomical structure morphogenesis anatomical structure development positive regulation of embryonic development positive regulation of multicellular organismal process regulation of multicellular organismal process regulation of anatomical structure morphogenesis positive regulation of cellular component organization regulation of cellular component organization protein-containing complex organization positive regulation of cellular component biogenesis regulation of cellular component biogenesis cellular component biogenesis positive regulation of protein-containing complex assembly regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death regulation of growth negative regulation of biological process growth negative regulation of cell growth regulation of cell growth cell growth negative regulation of growth negative regulation of cellular process regulation of mitochondrial depolarization positive regulation of membrane depolarization positive regulation of mitochondrial depolarization mitochondrial depolarization regulation of membrane depolarization regulation of mitochondrial membrane potential membrane depolarization regulation of biological quality regulation of membrane potential positive regulation of proteasomal protein catabolic process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process proteolysis positive regulation of macromolecule metabolic process organonitrogen compound catabolic process regulation of protein metabolic process proteasomal protein catabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process regulation of metabolic process organic substance catabolic process regulation of protein catabolic process protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal cellular response to stimulus regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction intracellular signaling cassette signal transduction regulation of signaling negative regulation of response to stimulus negative regulation of signal transduction regulation of response to stimulus regulation of cell communication phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of molecular function positive regulation of hydrolase activity positive regulation of cyclic-nucleotide phosphodiesterase activity regulation of catalytic activity regulation of hydrolase activity positive regulation of catalytic activity regulation of cyclic-nucleotide phosphodiesterase activity positive regulation of cell communication positive regulation of signal transduction regulation of intrinsic apoptotic signaling pathway positive regulation of apoptotic signaling pathway positive regulation of response to stimulus intrinsic apoptotic signaling pathway positive regulation of intracellular signal transduction apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway regulation of apoptotic signaling pathway positive regulation of signaling cell division regulation of cell division pigmentation response to organic substance regulation of cellular response to stress endoplasmic reticulum unfolded protein response regulation of response to endoplasmic reticulum stress regulation of endoplasmic reticulum unfolded protein response cellular response to stress response to stress regulation of response to stress cellular response to organic substance negative regulation of endoplasmic reticulum unfolded protein response response to endoplasmic reticulum stress negative regulation of response to endoplasmic reticulum stress cellular response to topologically incorrect protein cellular response to unfolded protein response to unfolded protein cellular response to chemical stimulus response to chemical response to topologically incorrect protein negative regulation of Wnt signaling pathway Wnt signaling pathway cell surface receptor signaling pathway regulation of Wnt signaling pathway negative regulation of cellular metabolic process post-transcriptional regulation of gene expression negative regulation of translation negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression negative regulation of biosynthetic process regulation of translation negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process positive regulation of peptidase activity positive regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of endopeptidase activity activation of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity regulation of peptidase activity positive regulation of cysteine-type endopeptidase activity positive regulation of endopeptidase activity homeostatic process response to monosaccharide response to carbohydrate carbohydrate homeostasis cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus response to oxygen-containing compound cellular response to glucose stimulus intracellular glucose homeostasis cellular response to oxygen-containing compound response to hexose cellular response to carbohydrate stimulus cellular homeostasis chemical homeostasis response to glucose glucose homeostasis regulation of GTPase activity positive regulation of GTPase activity regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process regulation of peptidyl-serine phosphorylation peptidyl-serine modification peptidyl-serine phosphorylation regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process peptidyl-amino acid modification phosphorus metabolic process negative regulation of peptidyl-serine phosphorylation protein phosphorylation phosphorylation negative regulation of protein phosphorylation negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process negative regulation of phosphorylation regulation of hydrogen peroxide-mediated programmed cell death programmed cell death in response to reactive oxygen species negative regulation of apoptotic signaling pathway negative regulation of programmed cell death negative regulation of apoptotic process intrinsic apoptotic signaling pathway in response to oxidative stress regulation of oxidative stress-induced intrinsic apoptotic signaling pathway cellular response to oxidative stress cellular response to chemical stress negative regulation of hydrogen peroxide-mediated programmed cell death cellular response to reactive oxygen species hydrogen peroxide-mediated programmed cell death negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway intrinsic apoptotic signaling pathway in response to hydrogen peroxide response to reactive oxygen species negative regulation of intrinsic apoptotic signaling pathway response to oxidative stress negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide negative regulation of smoothened signaling pathway regulation of smoothened signaling pathway smoothened signaling pathway cell cycle cytoplasmic translation rhythmic process cellular response to endogenous stimulus cellular response to growth factor stimulus response to endogenous stimulus response to growth factor positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion import into cell negative regulation of transport negative regulation of endocytosis negative regulation of phagocytosis phagocytosis regulation of endocytosis negative regulation of cellular component organization regulation of phagocytosis endocytosis positive regulation of phosphorylation positive regulation of cellular metabolic process positive regulation of phosphate metabolic process positive regulation of protein modification process positive regulation of protein phosphorylation positive regulation of phosphorus metabolic process regulation of cell cycle regulation of establishment of cell polarity regulation of establishment or maintenance of cell polarity establishment of cell polarity establishment or maintenance of cell polarity	somatodendritic compartment cell body perikaryon neuronal cell body cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle somatodendritic compartment cell body perikaryon neuronal cell body cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection protein-containing complex small ribosomal subunit ribosomal subunit intracellular organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome non-membrane-bounded organelle IRE1-RACK1-PP2A complex perinuclear region of cytoplasm phagocytic cup cell periphery plasma membrane membrane mitochondrion intracellular membrane-bounded organelle midbody nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen cytosolic small ribosomal subunit cytosolic ribosome
PA [auth n]	40S ribosomal protein S15	protein binding binding MDM2/MDM4 family protein binding RNA binding organic cyclic compound binding nucleic acid binding structural molecule activity structural constituent of ribosome DNA binding enzyme regulator activity molecular function inhibitor activity ubiquitin-protein transferase regulator activity ubiquitin-protein transferase inhibitor activity ubiquitin ligase inhibitor activity protein binding binding MDM2/MDM4 family protein binding RNA binding organic cyclic compound binding nucleic acid binding structural molecule activity structural constituent of ribosome DNA binding enzyme regulator activity molecular function inhibitor activity ubiquitin-protein transferase regulator activity ubiquitin-protein transferase inhibitor activity ubiquitin ligase inhibitor activity molecular function regulator activity enzyme inhibitor activity	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction regulation of signal transduction by p53 class mediator positive regulation of signal transduction by p53 class mediator cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction regulation of signal transduction by p53 class mediator positive regulation of signal transduction by p53 class mediator signal transduction positive regulation of cellular process regulation of biological process regulation of signaling biological regulation positive regulation of intracellular signal transduction signal transduction by p53 class mediator regulation of response to stimulus regulation of cell communication cellular process positive regulation of signaling developmental process multicellular organismal process cellular developmental process ossification cell differentiation osteoblast differentiation establishment of organelle localization cellular localization ribonucleoprotein complex biogenesis nucleocytoplasmic transport transport nuclear transport ribosomal subunit export from nucleus intracellular transport establishment of localization protein-containing complex localization cellular component biogenesis localization ribosome biogenesis ribosomal small subunit export from nucleus organelle localization establishment of localization in cell cellular component organization or biogenesis nuclear export ribosome localization cellular biosynthetic process RNA metabolic process rRNA processing nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process RNA processing rRNA metabolic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process ncRNA metabolic process nucleic acid catabolic process metabolic process macromolecule metabolic process gland development animal organ development animal organ regeneration liver development regeneration multicellular organism development hepaticobiliary system development anatomical structure development liver regeneration system development organonitrogen compound metabolic process organonitrogen compound biosynthetic process translation cytoplasmic translation protein metabolic process ribosomal small subunit biogenesis organelle assembly protein-containing complex organization non-membrane-bounded organelle assembly ribosomal small subunit assembly protein-RNA complex assembly cellular component organization organelle organization protein-RNA complex organization cellular component assembly protein-containing complex assembly ribosome assembly	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cytosolic ribosome intracellular non-membrane-bounded organelle ribosome non-membrane-bounded organelle synapse cytosolic small ribosomal subunit protein-containing complex small ribosomal subunit ribosomal subunit ribonucleoprotein complex
QA [auth o]	40S ribosomal protein S8	RNA binding binding organic cyclic compound binding nucleic acid binding structural molecule activity structural constituent of ribosome	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process protein metabolic process macromolecule metabolic process ribonucleoprotein complex biogenesis RNA metabolic process rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cellular component biogenesis nucleobase-containing compound metabolic process ribosome biogenesis maturation of SSU-rRNA cellular component organization or biogenesis RNA processing rRNA metabolic process ribosomal small subunit biogenesis nucleic acid metabolic process organic cyclic compound metabolic process ncRNA metabolic process nucleic acid catabolic process	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane cytosolic ribosome ribosome cytoplasm cytosol preribosome protein-containing complex ribonucleoprotein complex small-subunit processome extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosolic small ribosomal subunit small ribosomal subunit ribosomal subunit nucleoplasm endoplasmic reticulum endomembrane system
RA [auth p]	Ubiquitin-40S ribosomal protein S27a	RNA binding binding organic cyclic compound binding nucleic acid binding structural molecule activity structural constituent of ribosome protein tag activity molecular tag activity ubiquitin protein ligase binding protein binding ubiquitin-like protein ligase binding enzyme binding cation binding ion binding RNA binding binding organic cyclic compound binding nucleic acid binding structural molecule activity structural constituent of ribosome protein tag activity molecular tag activity ubiquitin protein ligase binding protein binding ubiquitin-like protein ligase binding enzyme binding cation binding ion binding metal ion binding small molecule binding	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process translation gene expression macromolecule biosynthetic process biosynthetic process organic substance biosynthetic process cytoplasmic translation cellular process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane vesicle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle cytoplasm cytosol cell periphery plasma membrane nucleoplasm organelle subcompartment endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane intracellular vesicle cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane endocytic vesicle membrane endocytic vesicle cytosolic ribosome ribosome preribosome protein-containing complex ribonucleoprotein complex small-subunit processome synapse cell junction endosome membrane endosome mitochondrial membrane mitochondrion organelle outer membrane organelle envelope mitochondrial envelope mitochondrial outer membrane outer membrane cytosolic small ribosomal subunit small ribosomal subunit ribosomal subunit
VA [auth t]	40S ribosomal protein S10	RNA binding binding organic cyclic compound binding nucleic acid binding structural molecule activity structural constituent of ribosome	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process protein metabolic process macromolecule metabolic process	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane cytosolic ribosome ribosome cytoplasm cytosol cytosolic small ribosomal subunit protein-containing complex small ribosomal subunit ribosomal subunit ribonucleoprotein complex nucleoplasm
WA [auth u]	Eukaryotic translation initiation factor 4B	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding RNA binding	regulation of cellular process cellular biosynthetic process organonitrogen compound biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression organic substance metabolic process organic substance biosynthetic process translational initiation protein metabolic process regulation of biosynthetic process regulation of biological process organonitrogen compound metabolic process regulation of translational initiation cellular metabolic process regulation of cellular process cellular biosynthetic process organonitrogen compound biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression organic substance metabolic process organic substance biosynthetic process translational initiation protein metabolic process regulation of biosynthetic process regulation of biological process organonitrogen compound metabolic process regulation of translational initiation cellular metabolic process regulation of protein metabolic process biological regulation regulation of cellular metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process regulation of translation regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex eukaryotic translation initiation factor 4F complex RNA cap binding complex intracellular protein-containing complex
E [auth 5]	Eukaryotic translation initiation factor 3 subunit H	-	-	-
XA [auth w]	Eukaryotic translation initiation factor 3 subunit B	-	-	-
G [auth 7]	Eukaryotic translation initiation factor 3 subunit L	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding RNA binding	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process translational initiation metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process translational initiation metabolic process cellular process protein metabolic process macromolecule metabolic process viral gene expression viral process viral translational termination-reinitiation viral translation ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization formation of cytoplasmic translation initiation complex cytoplasmic translation cytoplasmic translational initiation	protein-containing complex translation preinitiation complex intracellular anatomical structure eukaryotic 43S preinitiation complex ribonucleoprotein complex cytoplasm cellular anatomical entity membrane eukaryotic translation initiation factor 3 complex synapse cell junction cytosol membrane-bounded organelle nucleus protein-containing complex translation preinitiation complex intracellular anatomical structure eukaryotic 43S preinitiation complex ribonucleoprotein complex cytoplasm cellular anatomical entity membrane eukaryotic translation initiation factor 3 complex synapse cell junction cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen fibrillar center organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle eukaryotic 48S preinitiation complex nucleoplasm
I [auth 9]	EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
F [auth 6]	IPR016024	Armadillo-type fold	Homologous Superfamily
F [auth 6]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
F [auth 6]	IPR033464	CSN8/PSMD8/EIF3K	Domain
F [auth 6]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
F [auth 6]	IPR016020	Translation initiation factor 3, subunit 12, N-terminal, eukaryotic	Homologous Superfamily
F [auth 6]	IPR000717	Proteasome component (PCI) domain	Domain
F [auth 6]	IPR009374	Eukaryotic translation initiation factor 3 subunit K	Family
H [auth 8]	IPR016024	Armadillo-type fold	Homologous Superfamily
H [auth 8]	IPR040750	eIF3 subunit M, C-terminal helix domain	Domain
H [auth 8]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
H [auth 8]	IPR027528	Eukaryotic translation initiation factor 3 subunit M	Family
H [auth 8]	IPR045237	Eukaryotic translation initiation factor 3 subunit M eIF3m/COP9 signalosome complex subunit 7 COPS7	Family
H [auth 8]	IPR000717	Proteasome component (PCI) domain	Domain
L [auth G]	IPR019979	Small ribosomal subunit protein uS17, conserved site	Conserved Site
L [auth G]	IPR032440	Small ribosomal subunit protein uS17, N-terminal	Domain
L [auth G]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
L [auth G]	IPR000266	Small ribosomal subunit protein uS17	Family
L [auth G]	IPR028333	Small ribosomal subunit protein uS17, archaeal/eukaryotic	Family
O [auth J]	IPR018271	Small ribosomal subunit protein uS14, conserved site	Conserved Site
O [auth J]	IPR043140	Small ribosomal subunit protein uS14 superfamily	Homologous Superfamily
O [auth J]	IPR001209	Small ribosomal subunit protein uS14	Family
O [auth J]	IPR039744	Small ribosomal subunit protein uS14, eukaryotes/archaea	Family
P [auth K]	IPR002942	RNA-binding S4 domain	Domain
P [auth K]	IPR022801	Small ribosomal subunit protein uS4	Family
P [auth K]	IPR018079	Small ribosomal subunit protein uS4, conserved site	Conserved Site
P [auth K]	IPR001912	Small ribosomal subunit protein uS4, N-terminal	Domain
P [auth K]	IPR005710	Small ribosomal subunit protein uS4, eukaryotic/archaeal	Family
P [auth K]	IPR036986	RNA-binding S4 domain superfamily	Homologous Superfamily
Q [auth L]	IPR018269	Small ribosomal subunit protein uS13, conserved site	Conserved Site
Q [auth L]	IPR027437	Small ribosomal subunit protein uS13, C-terminal	Homologous Superfamily
Q [auth L]	IPR001892	Small ribosomal subunit protein uS13	Family
Q [auth L]	IPR010979	Small ribosomal subunit protein uS13-like, H2TH	Homologous Superfamily
T [auth Q]	IPR006032	Small ribosomal subunit protein uS12	Family
T [auth Q]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
T [auth Q]	IPR005680	Small ribosomal subunit protein uS12, eukaryotic/archaeal	Family
X [auth V]	IPR019954	Ubiquitin conserved site	Conserved Site
X [auth V]	IPR000626	Ubiquitin-like domain	Domain
X [auth V]	IPR006846	Small ribosomal subunit protein eS30	Family
X [auth V]	IPR039415	Ubiquitin-like protein FUBI	Domain
X [auth V]	IPR019956	Ubiquitin domain	Domain
X [auth V]	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
Y [auth W]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
Y [auth W]	IPR004977	Small ribosomal subunit protein eS25	Family
Z [auth X]	IPR000554	Small ribosomal subunit protein eS7	Family
Z [auth X]	IPR047861	Small ribosomal subunit protein eS7, conserved site	Conserved Site
AA [auth Y]	IPR023407	Small ribosomal subunit protein eS27, zinc-binding domain superfamily	Homologous Superfamily
AA [auth Y]	IPR000592	Small ribosomal subunit protein eS27	Family
AA [auth Y]	IPR011332	Zinc-binding ribosomal protein	Homologous Superfamily
CA [auth a]	IPR047863	Small ribosomal subunit protein uS8, conserved site	Conserved Site
CA [auth a]	IPR000630	Small ribosomal subunit protein uS8	Family
CA [auth a]	IPR035987	Small ribosomal subunit protein uS8 superfamily	Homologous Superfamily
HA [auth f]	IPR023591	Small ribosomal subunit protein uS2, flavodoxin-like domain superfamily	Homologous Superfamily
HA [auth f]	IPR001865	Small ribosomal subunit protein uS2	Family
HA [auth f]	IPR032281	Small ribosomal subunit protein uS2, C-terminal domain	Domain
HA [auth f]	IPR027504	Small ribosomal subunit protein uS2, vertebrates	Family
HA [auth f]	IPR005707	Small ribosomal subunit protein uS2, eukaryotic/archaeal	Family
HA [auth f]	IPR018130	Small ribosomal subunit protein uS2, conserved site	Conserved Site
HA [auth f]	IPR027498	Small ribosomal subunit protein uS2, eukaryotic	Family
JA [auth h]	IPR027486	Small ribosomal subunit protein uS10 domain	Domain
JA [auth h]	IPR036838	Small ribosomal subunit protein uS10 domain superfamily	Homologous Superfamily
JA [auth h]	IPR005729	Small ribosomal subunit protein uS10, eukaryotic/archaeal	Family
JA [auth h]	IPR018268	Small ribosomal subunit protein uS10, conserved site	Conserved Site
JA [auth h]	IPR001848	Small ribosomal subunit protein uS10	Family
KA [auth i]	IPR001593	Small ribosomal subunit protein eS1	Family
KA [auth i]	IPR018281	Small ribosomal subunit protein eS1, conserved site	Conserved Site
KA [auth i]	IPR027500	Small ribosomal subunit protein eS1, eukaryotes	Family
NA [auth l]	IPR028626	Ribosomal protein eS28 conserved site	Conserved Site
NA [auth l]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
NA [auth l]	IPR000289	Small ribosomal subunit protein eS28	Family
SA [auth q]	IPR018282	Small ribosomal subunit protein eS6, conserved site	Conserved Site
SA [auth q]	IPR001377	Small ribosomal subunit protein eS6	Family
SA [auth q]	IPR014401	Small ribosomal subunit protein eS6-like	Family
TA [auth r]	IPR000530	Small ribosomal subunit protein eS12	Family
TA [auth r]	IPR004038	Ribosomal protein eL8/eL30/eS12/Gadd45	Domain
TA [auth r]	IPR047860	Small ribosomal subunit protein eS12, conserved site	Conserved Site
TA [auth r]	IPR029064	Ribosomal protein eL30-like superfamily	Homologous Superfamily
UA [auth s]	IPR001976	Small ribosomal subunit protein eS24	Family
UA [auth s]	IPR012678	Ribosomal protein uL23/eL15/eS24 core domain superfamily	Homologous Superfamily
UA [auth s]	IPR018098	Small ribosomal subunit protein eS24 conserved site	Conserved Site
M [auth H]	IPR020574	Small ribosomal subunit protein uS9, conserved site	Conserved Site
M [auth H]	IPR020568	Ribosomal protein uS5 domain 2-type superfamily	Homologous Superfamily
M [auth H]	IPR000754	Small ribosomal subunit protein uS9	Family
M [auth H]	IPR014721	Small ribosomal subunit protein uS5 domain 2-type fold, subgroup	Homologous Superfamily
N [auth I]	IPR013843	Small ribosomal subunit protein eS4, N-terminal	Domain
N [auth I]	IPR032277	Small ribosomal subunit protein eS4, C-terminal domain	Domain
N [auth I]	IPR013845	Small ribosomal subunit protein eS4, central region	Domain
N [auth I]	IPR014722	Large ribosomal subunit protein uL2, domain 2	Homologous Superfamily
N [auth I]	IPR041982	Small ribosomal subunit protein eS4, KOW domain	Domain
N [auth I]	IPR018199	Small ribosomal subunit protein eS4, N-terminal, conserved site	Conserved Site
N [auth I]	IPR002942	RNA-binding S4 domain	Domain
N [auth I]	IPR000876	Small ribosomal subunit protein eS4	Family
N [auth I]	IPR038237	Small ribosomal subunit protein eS4, central domain superfamily	Homologous Superfamily
N [auth I]	IPR036986	RNA-binding S4 domain superfamily	Homologous Superfamily
N [auth I]	IPR005824	KOW	Domain
V [auth S]	IPR000795	Translational (tr)-type GTP-binding domain	Domain
V [auth S]	IPR009001	Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal	Homologous Superfamily
V [auth S]	IPR004161	Translation elongation factor EFTu-like, domain 2	Domain
V [auth S]	IPR044128	Initiation factor eIF2 gamma, GTP-binding domain	Domain
V [auth S]	IPR015256	Initiation factor eIF2 gamma, C-terminal	Domain
V [auth S]	IPR009000	Translation protein, beta-barrel domain superfamily	Homologous Superfamily
V [auth S]	IPR044127	Initiation factor eIF2 gamma, domain 2	Domain
V [auth S]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
W [auth U]	IPR023798	Small ribosomal subunit protein uS7 domain	Domain
W [auth U]	IPR020606	Small ribosomal subunit protein uS7, conserved site	Conserved Site
W [auth U]	IPR036823	Small ribosomal subunit protein uS7 domain superfamily	Homologous Superfamily
W [auth U]	IPR000235	Small ribosomal subunit protein uS7	Family
W [auth U]	IPR005716	Ribosomal protein uS7, eukaryotic/archaeal	Family
BA [auth Z]	IPR009068	uS15/NS1, RNA-binding domain superfamily	Homologous Superfamily
BA [auth Z]	IPR000589	Small ribosomal subunit protein uS15	Family
BA [auth Z]	IPR023029	Small ribosomal subunit protein uS15, archaea/eukaryotes	Family
BA [auth Z]	IPR012606	Small ribosomal subunit protein uS15, N-terminal	Domain
C [auth 3]	IPR016650	Eukaryotic translation initiation factor 3 subunit E	Family
C [auth 3]	IPR019010	Eukaryotic translation initiation factor 3 subunit E, N-terminal	Domain
C [auth 3]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
C [auth 3]	IPR000717	Proteasome component (PCI) domain	Domain
GA [auth e]	IPR001210	Small ribosomal subunit protein eS17	Family
GA [auth e]	IPR036401	Small ribosomal subunit protein eS17 superfamily	Homologous Superfamily
GA [auth e]	IPR018273	Small ribosomal subunit protein eS17, conserved site	Conserved Site
IA [auth g]	IPR009019	K homology domain superfamily, prokaryotic type	Homologous Superfamily
IA [auth g]	IPR015946	K homology domain-like, alpha/beta	Homologous Superfamily
IA [auth g]	IPR036419	Ribosomal protein S3, C-terminal domain superfamily	Homologous Superfamily
IA [auth g]	IPR004044	K Homology domain, type 2	Domain
IA [auth g]	IPR001351	Small ribosomal subunit protein uS3, C-terminal	Domain
IA [auth g]	IPR005703	Small ribosomal subunit protein uS3, eukaryotic/archaeal	Family
IA [auth g]	IPR018280	Small ribosomal subunit protein uS3, conserved site	Conserved Site
LA [auth j]	IPR036967	Small ribosomal subunit protein uS11 superfamily	Homologous Superfamily
LA [auth j]	IPR018102	Small ribosomal subunit protein uS11, conserved site	Conserved Site
LA [auth j]	IPR001971	Small ribosomal subunit protein uS11	Family
OA [auth m]	IPR019775	WD40 repeat, conserved site	Conserved Site
OA [auth m]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
OA [auth m]	IPR045223	Small ribosomal subunit protein RACK1-like	Family
OA [auth m]	IPR020472	G-protein beta WD-40 repeat	Repeat
OA [auth m]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
OA [auth m]	IPR001680	WD40 repeat	Repeat
PA [auth n]	IPR023575	Small ribosomal subunit protein uS19, superfamily	Homologous Superfamily
PA [auth n]	IPR020934	Small ribosomal subunit protein uS19, conserved site	Conserved Site
PA [auth n]	IPR005713	Small ribosomal subunit protein uS19, eukaryotic/archaeal	Family
PA [auth n]	IPR002222	Small ribosomal subunit protein uS19	Family
QA [auth o]	IPR042563	Small ribosomal subunit protein eS8 subdomain, eukaryotes	Homologous Superfamily
QA [auth o]	IPR022309	Ribosomal protein eS8/ribosomal biogenesis NSA2	Family
QA [auth o]	IPR018283	Small ribosomal subunit protein eS8, conserved site	Conserved Site
QA [auth o]	IPR001047	Small ribosomal subunit protein eS8	Family
RA [auth p]	IPR019954	Ubiquitin conserved site	Conserved Site
RA [auth p]	IPR011332	Zinc-binding ribosomal protein	Homologous Superfamily
RA [auth p]	IPR000626	Ubiquitin-like domain	Domain
RA [auth p]	IPR038582	Small ribosomal subunit protein eS31 eukaryotic-type superfamily	Homologous Superfamily
RA [auth p]	IPR002906	Small ribosomal subunit protein eS31	Domain
RA [auth p]	IPR019956	Ubiquitin domain	Domain
RA [auth p]	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
VA [auth t]	IPR037447	Small ribosomal subunit protein eS10	Family
VA [auth t]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
VA [auth t]	IPR005326	Plectin/eS10, N-terminal	Domain
WA [auth u]	IPR033107	Eukaryotic translation initiation factor 4B, RNA recognition motif	Domain
WA [auth u]	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
WA [auth u]	IPR000504	RNA recognition motif domain	Domain
WA [auth u]	IPR035979	RNA-binding domain superfamily	Homologous Superfamily
G [auth 7]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
G [auth 7]	IPR000717	Proteasome component (PCI) domain	Domain
G [auth 7]	IPR019382	Translation initiation factor 3 complex subunit L	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
F [auth 6]	Pharos: Q9UBQ5	atypical teratoid rhabdoid tumor large cell medulloblastoma osteosarcoma plasma cell myeloma diabetes mellitus malignant glioma ovarian cancer psoriasis glioblastoma malignant mesothelioma Pick disease
H [auth 8]	Pharos: Q7L2H7	tuberculosis attention deficit hyperactivity disorder, inattentive type breast carcinoma hereditary spastic paraplegia lymphoplasmacytic lymphoma medulloblastoma pancreatic intraductal papillary-mucinous carcinoma plasma cell myeloma atypical teratoid rhabdoid tumor endometrial carcinoma large cell medulloblastoma malignant mesothelioma myopathy pancreatic intraductal papillary-mucinous neoplasm psoriasis tuberculosis attention deficit hyperactivity disorder, inattentive type breast carcinoma hereditary spastic paraplegia lymphoplasmacytic lymphoma medulloblastoma pancreatic intraductal papillary-mucinous carcinoma plasma cell myeloma atypical teratoid rhabdoid tumor endometrial carcinoma large cell medulloblastoma malignant mesothelioma myopathy pancreatic intraductal papillary-mucinous neoplasm psoriasis breast cancer glioblastoma lung cancer Malignant neoplasm of breast ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia
L [auth G]	Pharos: P62280	diabetes mellitus medulloblastoma Hodgkins lymphoma plasma cell myeloma lung cancer
O [auth J]	Pharos: P62273	Diamond-Blackfan anemia Diamond-Blackfan anemia 13 Aase Smith syndrome 2 glioblastoma lung cancer aplastic anemia hematopoietic and lymphoid system neoplasm malignant glioma congenital anemia inherited aplastic anemia ovarian cancer
P [auth K]	Pharos: P46781	alcoholic liver cirrhosis prostate carcinoma lung cancer Takayasu arteritis Malignant neoplasm of breast
Q [auth L]	Pharos: P62269	cervical cancer triple-negative breast carcinoma
T [auth Q]	Pharos: P62266	brachycephaly, trichomegaly, and developmental delay intellectual disability osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia breast carcinoma large cell medulloblastoma pancreatic intraductal papillary-mucinous carcinoma polycystic ovary syndrome cystic fibrosis medulloblastoma pancreatic intraductal papillary-mucinous neoplasm
X [auth V]	Pharos: P62861	acne lung carcinoma metabolic syndrome X
Y [auth W]	Pharos: P62851	acute myeloid leukemia heart disease
Z [auth X]	Pharos: P62081	Diamond-Blackfan anemia Diamond-Blackfan anemia 8 breast carcinoma Aase Smith syndrome 2 diabetes mellitus hematopoietic and lymphoid system neoplasm MALT lymphoma aplastic anemia congenital anemia inherited aplastic anemia breast cancer
AA [auth Y]	Pharos: P42677	Diamond-Blackfan anemia Diamond-Blackfan anemia 17 Aase Smith syndrome 2 hematopoietic and lymphoid system neoplasm aplastic anemia inherited aplastic anemia congenital anemia prostate carcinoma
CA [auth a]	Pharos: P62244	breast cancer glioblastoma medulloblastoma pancreatic intraductal papillary-mucinous neoplasm cystic fibrosis lung adenocarcinoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Diamond-Blackfan anemia malignant glioma ovarian cancer subependymal giant cell astrocytoma
HA [auth f]	Pharos: P08865	familial isolated congenital asplenia Neoplasm Invasiveness amyotrophic lateral sclerosis lung adenocarcinoma
JA [auth h]	Pharos: P60866	adenoma cutaneous lupus erythematosus glioblastoma Hereditary Nonpolyposis Colorectal Neoplasms malignant mesothelioma psoriasis atypical teratoid rhabdoid tumor cystic fibrosis lung cancer ovarian cancer systemic lupus erythematosus breast cancer familial colorectal cancer type X Lynch syndrome prostate carcinoma
NA [auth l]	Pharos: P62857	Diamond-Blackfan anemia Diamond-Blackfan anemia 15 with mandibulofacial dysostosis Weight Gain cutaneous lupus erythematosus inherited aplastic anemia metabolic syndrome X psoriasis aplastic anemia heart disease lung cancer osteosarcoma congenital anemia hematopoietic and lymphoid system neoplasm medulloblastoma ovarian cancer
SA [auth q]	Pharos: P62753	breast carcinoma breast cancer Disease Progression hepatocellular carcinoma lung cancer gastric cancer hereditary diffuse gastric adenocarcinoma gastric neoplasm pancreatic intraductal papillary-mucinous neoplasm
TA [auth r]	Pharos: P25398	diabetes mellitus
UA [auth s]	Pharos: P62847	Diamond-Blackfan anemia Diamond-Blackfan anemia 3 Aase Smith syndrome 2 lung cancer non-alcoholic fatty liver disease aplastic anemia diabetes mellitus hematopoietic and lymphoid system neoplasm lymphoplasmacytic lymphoma ovarian cancer congenital anemia inherited aplastic anemia MALT lymphoma plasma cell myeloma
M [auth H]	Pharos: P62249	atypical teratoid rhabdoid tumor lung cancer osteosarcoma plasma cell myeloma glioblastoma lymphoplasmacytic lymphoma ovarian cancer primitive neuroectodermal tumor large cell medulloblastoma medulloblastoma pancreatic intraductal papillary-mucinous neoplasm
N [auth I]	Pharos: P62701	breast carcinoma breast cancer Malignant neoplasm of breast ovarian cancer lung cancer
V [auth S]	Pharos: P41091	MEHMO syndrome intellectual disability arthrogryposis Epileptic encephalopathy juvenile dermatomyositis microcephaly osteosarcoma Duchenne muscular dystrophy facioscapulohumeral muscular dystrophy medulloblastoma myopathy ovarian cancer epilepsy obesity disorder
W [auth U]	Pharos: P46782	acute myeloid leukemia diabetes mellitus MALT lymphoma pancreatic intraductal papillary-mucinous neoplasm atypical teratoid rhabdoid tumor large cell medulloblastoma medulloblastoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia breast cancer lung cancer ovarian cancer
BA [auth Z]	Pharos: P62277	diabetes mellitus primary angle-closure glaucoma
C [auth 3]	Pharos: P60228	Adenocarcinoma of Lung lung adenocarcinoma medulloblastoma plantar fibromatosis androgenetic alopecia lung cancer ossification of the posterior longitudinal ligament of the spine plasma cell myeloma lymphoplasmacytic lymphoma ovarian cancer
GA [auth e]	Pharos: P08708	Diamond-Blackfan anemia Diamond-Blackfan anemia 4 Aase Smith syndrome 2 hematopoietic and lymphoid system neoplasm lung cancer aplastic anemia inherited aplastic anemia ovarian cancer congenital anemia large cell medulloblastoma
IA [auth g]	Pharos: P23396	melanoma Chromosomal Instability atypical teratoid rhabdoid tumor diabetes mellitus lymphoplasmacytic lymphoma Pick disease large cell medulloblastoma medulloblastoma plasma cell myeloma cutaneous melanoma lung cancer
LA [auth j]	Pharos: P62263	chromosome 5q deletion syndrome carcinoma Hypoxia sarcomatoid carcinoma neutropenia undifferentiated carcinoma congenital anemia ovarian cancer breast cancer mammary neoplasms, animal
OA [auth m]	Pharos: P63244	squamous cell carcinoma plasma cell myeloma Alcoholic Intoxication, Chronic bipolar disorder glioblastoma lymphoplasmacytic lymphoma medulloblastoma oral cavity neoplasm pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor astrocytic tumor cystic fibrosis large cell medulloblastoma malignant glioma osteosarcoma squamous cell carcinoma plasma cell myeloma Alcoholic Intoxication, Chronic bipolar disorder glioblastoma lymphoplasmacytic lymphoma medulloblastoma oral cavity neoplasm pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor astrocytic tumor cystic fibrosis large cell medulloblastoma malignant glioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm psoriasis atypical teratoid rhabdoid tumor diabetes mellitus lung cancer oligodendroglioma ovarian cancer
PA [auth n]	Pharos: P62841	B-cell chronic lymphocytic leukemia Diamond-Blackfan anemia gastric cancer hereditary diffuse gastric adenocarcinoma B-CELL MALIGNANCY, LOW-GRADE gastric neoplasm diabetes mellitus hematopoietic and lymphoid system neoplasm
QA [auth o]	Pharos: P62241	Weight Gain breast carcinoma Parkinson disease breast cancer
RA [auth p]	Pharos: P62979	acute myeloid leukemia large cell medulloblastoma Diamond-Blackfan anemia lung carcinoma hematopoietic and lymphoid system neoplasm ulcerative colitis
VA [auth t]	Pharos: P46783	Diamond-Blackfan anemia Diamond-Blackfan anemia 9 Aase Smith syndrome 2 hematopoietic and lymphoid system neoplasm aplastic anemia inherited aplastic anemia congenital anemia
WA [auth u]	Pharos: P23588	cleft lip major depressive disorder ovarian cancer Unipolar Depression large cell medulloblastoma oligodendroglioma prostate carcinoma lung cancer osteosarcoma psoriasis