6FDD

Crystal Structure of the HHD2 Domain of Whirlin

External Resource: Annotation

Domain Annotation: ECOD Classification
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e6fddA1	A: alpha bundles	X: PAH2 domain (From Topology)	H: PAH2 domain (From Topology)	T: PAH2 domain	F: F_UNCLASSIFIED	ECOD (1.6)
B	F_UNCLASSIFIED	e6fddB1	A: alpha bundles	X: PAH2 domain (From Topology)	H: PAH2 domain (From Topology)	T: PAH2 domain	F: F_UNCLASSIFIED	ECOD (1.6)
C	F_UNCLASSIFIED	e6fddC1	A: alpha bundles	X: PAH2 domain (From Topology)	H: PAH2 domain (From Topology)	T: PAH2 domain	F: F_UNCLASSIFIED	ECOD (1.6)
D	F_UNCLASSIFIED	e6fddD1	A: alpha bundles	X: PAH2 domain (From Topology)	H: PAH2 domain (From Topology)	T: PAH2 domain	F: F_UNCLASSIFIED	ECOD (1.6)
E	F_UNCLASSIFIED	e6fddE1	A: alpha bundles	X: PAH2 domain (From Topology)	H: PAH2 domain (From Topology)	T: PAH2 domain	F: F_UNCLASSIFIED	ECOD (1.6)
F	F_UNCLASSIFIED	e6fddF1	A: alpha bundles	X: PAH2 domain (From Topology)	H: PAH2 domain (From Topology)	T: PAH2 domain	F: F_UNCLASSIFIED	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Whirlin	protein binding binding protein domain specific binding identical protein binding	multicellular organismal process inner ear receptor cell development cell projection organization sensory organ development epidermis development auditory receptor cell stereocilium organization neuron projection development epithelial cell differentiation hair cell differentiation multicellular organism development neuron differentiation cell differentiation inner ear development anatomical structure development multicellular organismal process inner ear receptor cell development cell projection organization sensory organ development epidermis development auditory receptor cell stereocilium organization neuron projection development epithelial cell differentiation hair cell differentiation multicellular organism development neuron differentiation cell differentiation inner ear development anatomical structure development animal organ morphogenesis system development developmental process embryonic organ morphogenesis mechanoreceptor differentiation epithelium development epidermal cell differentiation ear development embryonic morphogenesis nervous system development tissue development inner ear receptor cell differentiation generation of neurons auditory receptor cell development cellular developmental process cell development embryo development cell morphogenesis cellular component organization neurogenesis cellular component organization or biogenesis auditory receptor cell morphogenesis embryonic organ development ear morphogenesis plasma membrane bounded cell projection organization animal organ development inner ear auditory receptor cell differentiation cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis sensory organ morphogenesis neuron development inner ear morphogenesis cellular process inner ear receptor cell stereocilium organization protein localization localization establishment of protein localization cellular localization cellular macromolecule localization macromolecule localization establishment of localization multicellular organismal-level homeostasis homeostatic process anatomical structure homeostasis tissue homeostasis retina homeostasis cerebellar cortex morphogenesis hindbrain morphogenesis cerebellar Purkinje cell layer formation cerebellar Purkinje cell layer development metencephalon development cerebellar Purkinje cell layer morphogenesis cerebellar cortex formation cerebellum morphogenesis head development brain development cerebellar cortex development cerebellum development central nervous system development anatomical structure formation involved in morphogenesis hindbrain development regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process sensory perception of light stimulus system process sensory perception nervous system process cell junction maintenance cell junction organization cellular component maintenance paranodal junction maintenance cell-cell junction maintenance cell-cell junction organization establishment of localization in cell detection of external stimulus response to stimulus detection of mechanical stimulus involved in sensory perception of sound response to mechanical stimulus response to external stimulus detection of mechanical stimulus involved in sensory perception sensory perception of mechanical stimulus detection of abiotic stimulus detection of stimulus detection of mechanical stimulus response to abiotic stimulus detection of stimulus involved in sensory perception sensory perception of sound	membrane-bounded organelle cell projection organelle cilium cellular anatomical entity plasma membrane bounded cell projection photoreceptor inner segment protein-containing complex stereocilia ankle link stereocilia ankle link complex stereocilium bundle stereocilia coupling link cluster of actin-based cell projections stereocilium membrane-bounded organelle cell projection organelle cilium cellular anatomical entity plasma membrane bounded cell projection photoreceptor inner segment protein-containing complex stereocilia ankle link stereocilia ankle link complex stereocilium bundle stereocilia coupling link cluster of actin-based cell projections stereocilium actin-based cell projection stereocilium tip neuron projection ciliary transition zone non-motile cilium 9+0 non-motile cilium photoreceptor cell cilium photoreceptor connecting cilium intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane presynapse synapse cell junction USH2 complex growth cone axon distal axon site of polarized growth axon collateral somatodendritic compartment dendrite dendritic tree dendritic shaft perinuclear region of cytoplasm polymeric cytoskeletal fiber actin filament actin cytoskeleton intracellular organelle cytoskeleton intracellular non-membrane-bounded organelle supramolecular fiber supramolecular polymer supramolecular complex non-membrane-bounded organelle cell body neuronal cell body plasma membrane region periciliary membrane compartment apical dendrite postsynapse ciliary basal body microtubule organizing center microtubule cytoskeleton

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR033028	Whirlin, harmonin_N-like domain 2	Domain
A, B, C, D, E A, B, C, D, E, F	IPR036034	PDZ superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR047056	Whirlin, harmonin_N-like domain 1	Domain
A, B, C, D, E A, B, C, D, E, F	IPR001478	PDZ domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.