6FB3

Teneurin 2 Partial Extracellular Domain

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF05593	e6fb3A2	A: beta meanders	X: Rearrangement hotspot (RHS) repeats protein (From Topology)	H: Rearrangement hotspot (RHS) repeats protein (From Topology)	T: Rearrangement hotspot (RHS) repeats protein	F: PF05593	ECOD (1.6)
A	F_UNCLASSIFIED	e6fb3A3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: F_UNCLASSIFIED	ECOD (1.6)
A	F_UNCLASSIFIED	e6fb3A4	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Prealbumin-like	F: F_UNCLASSIFIED	ECOD (1.6)
A	F_UNCLASSIFIED	e6fb3A1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: F_UNCLASSIFIED	ECOD (1.6)
A	F_UNCLASSIFIED	e6fb3A5	A: a+b two layers	X: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase (From Topology)	H: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase (From Topology)	T: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF15636	e6fb3A6	A: few secondary structure elements	X: His-Me finger endonucleases (From Homology)	H: His-Me finger endonucleases	T: Inactive Tox-GHH domain of teneurin	F: PF15636	ECOD (1.6)
B	PF05593	e6fb3B5	A: beta meanders	X: Rearrangement hotspot (RHS) repeats protein (From Topology)	H: Rearrangement hotspot (RHS) repeats protein (From Topology)	T: Rearrangement hotspot (RHS) repeats protein	F: PF05593	ECOD (1.6)
B	F_UNCLASSIFIED	e6fb3B4	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: F_UNCLASSIFIED	ECOD (1.6)
B	F_UNCLASSIFIED	e6fb3B6	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Prealbumin-like	F: F_UNCLASSIFIED	ECOD (1.6)
B	F_UNCLASSIFIED	e6fb3B3	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: F_UNCLASSIFIED	ECOD (1.6)
B	F_UNCLASSIFIED	e6fb3B1	A: a+b two layers	X: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase (From Topology)	H: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase (From Topology)	T: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF15636	e6fb3B2	A: few secondary structure elements	X: His-Me finger endonucleases (From Homology)	H: His-Me finger endonucleases	T: Inactive Tox-GHH domain of teneurin	F: PF15636	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF15636	GHH signature containing HNH/Endo VII superfamily nuclease toxin (Tox-GHH)	GHH signature containing HNH/Endo VII superfamily nuclease toxin	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Teneurin-2	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding protein binding signaling receptor binding cell adhesion molecule binding protein heterodimerization activity protein dimerization activity identical protein binding protein homodimerization activity	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules cell adhesion cell-cell adhesion cellular process cell-cell adhesion via plasma-membrane adhesion molecules multicellular organismal process axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules cell adhesion cell-cell adhesion cellular process cell-cell adhesion via plasma-membrane adhesion molecules multicellular organismal process axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development cellular component organization or biogenesis system development developmental process plasma membrane bounded cell projection organization axon guidance nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron projection guidance neuron development filopodium assembly regulation of cellular process regulation of cellular component organization positive regulation of cellular component organization positive regulation of biological process regulation of filopodium assembly plasma membrane bounded cell projection assembly cellular component biogenesis cellular component assembly positive regulation of cell projection organization positive regulation of filopodium assembly positive regulation of cellular process regulation of biological process positive regulation of cellular component biogenesis regulation of cell projection organization regulation of cell projection assembly biological regulation regulation of cellular component biogenesis regulation of plasma membrane bounded cell projection assembly cell projection assembly regulation of plasma membrane bounded cell projection organization positive regulation of plasma membrane bounded cell projection assembly negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process	cell junction cellular anatomical entity cell periphery postsynapse postsynaptic membrane synapse membrane plasma membrane plasma membrane region synaptic membrane cell-cell junction anchoring junction somatodendritic compartment cell projection cell junction cellular anatomical entity cell periphery postsynapse postsynaptic membrane synapse membrane plasma membrane plasma membrane region synaptic membrane cell-cell junction anchoring junction somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection growth cone axon distal axon site of polarized growth membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system neuron spine dendritic spine actin-based cell projection filopodium nucleus endoplasmic reticulum membrane-enclosed lumen intracellular organelle lumen nuclear body nucleoplasm organelle lumen PML body nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR011042	Six-bladed beta-propeller, TolB-like	Homologous Superfamily
A, B, C, D	IPR008969	Carboxypeptidase-like, regulatory domain superfamily	Homologous Superfamily
A, B, C, D	IPR011047	Quinoprotein alcohol dehydrogenase-like superfamily	Homologous Superfamily
A, B, C, D	IPR000742	EGF-like domain	Domain
A, B, C, D	IPR028916	Tox-GHH domain	Domain
A, B, C, D	IPR006530	YD repeat	Repeat
A, B, C, D	IPR022385	Rhs repeat-associated core	Domain
A, B, C, D	IPR001881	EGF-like calcium-binding domain	Domain
A, B, C, D	IPR009471	Teneurin intracellular, N-terminal	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.