6F9I

Crystal structure of KLC2 bound to the second tryptophan-acidic motif peptide from calsyntenin-1

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF13424	e6f9iA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF13424	ECOD (1.6)
C [auth B]	PF13424	e6f9iB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF13424	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C [auth B]	PF13424	Tetratricopeptide repeat (TPR_12)	Tetratricopeptide repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth B]	Kinesin light chain 2	-	localization organelle localization lysosome localization vacuolar localization	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle intracellular organelle mitochondrion organelle intracellular membrane-bounded organelle protein-containing complex cytoskeleton intracellular non-membrane-bounded organelle microtubule associated complex kinesin complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle intracellular organelle mitochondrion organelle intracellular membrane-bounded organelle protein-containing complex cytoskeleton intracellular non-membrane-bounded organelle microtubule associated complex kinesin complex microtubule cytoskeleton non-membrane-bounded organelle cell periphery plasma membrane membrane nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer supramolecular complex
B [auth X], D [auth C]	Calsyntenin-1	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding amide binding amyloid-beta binding peptide binding cytoskeletal protein binding protein binding kinesin binding X11-like protein binding	protein localization cellular localization establishment of protein localization nitrogen compound transport protein localization to synapse transport neurotransmitter receptor transport to postsynaptic membrane establishment of protein localization to postsynaptic membrane vesicle-mediated transport neurotransmitter receptor transport to plasma membrane localization cellular macromolecule localization regulation of biological quality protein localization to cell periphery protein localization cellular localization establishment of protein localization nitrogen compound transport protein localization to synapse transport neurotransmitter receptor transport to postsynaptic membrane establishment of protein localization to postsynaptic membrane vesicle-mediated transport neurotransmitter receptor transport to plasma membrane localization cellular macromolecule localization regulation of biological quality protein localization to cell periphery protein localization to postsynaptic membrane neurotransmitter receptor transport establishment of protein localization to membrane organic substance transport biological regulation localization within membrane protein localization to membrane establishment of localization protein-containing complex localization vesicle-mediated transport to the plasma membrane regulation of postsynaptic membrane neurotransmitter receptor levels protein transport macromolecule localization cellular process protein localization to postsynapse protein localization to cell junction receptor localization to synapse positive regulation of nervous system development multicellular organismal process positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization regulation of developmental process positive regulation of biological process regulation of nervous system development positive regulation of developmental process cellular component organization cellular component biogenesis multicellular organism development cellular component assembly cell junction assembly anatomical structure development regulation of multicellular organismal process regulation of synapse structure or activity synapse organization cellular component organization or biogenesis regulation of synapse assembly positive regulation of cellular process system development developmental process regulation of multicellular organismal development regulation of biological process positive regulation of cellular component biogenesis nervous system development regulation of cellular component biogenesis regulation of cell junction assembly positive regulation of cell junction assembly regulation of synapse organization cell junction organization positive regulation of multicellular organismal process synapse assembly positive regulation of synapse assembly regulation of growth growth regulation of cell growth cell growth inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis vesicle-mediated transport in synapse developmental maturation synapse maturation regulation of synapse maturation trans-synaptic signaling synaptic signaling signaling anterograde trans-synaptic signaling cell-cell signaling chemical synaptic transmission cell communication cell adhesion cell-cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules homophilic cell adhesion via plasma membrane adhesion molecules positive regulation of cell communication regulation of signaling modulation of chemical synaptic transmission positive regulation of synaptic transmission regulation of trans-synaptic signaling regulation of cell communication positive regulation of signaling	postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane cellular anatomical entity postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse neuron to neuron synapse organelle cell junction postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane cellular anatomical entity postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse neuron to neuron synapse organelle cell junction postsynaptic membrane asymmetric synapse plasma membrane region cell surface GABA-ergic synapse glutamatergic synapse membrane-bounded organelle intracellular anatomical structure organelle subcompartment intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum membrane neuron spine neuron projection dendritic spine plasma membrane bounded cell projection somatodendritic compartment cell projection bounding membrane of organelle spine apparatus dendrite dendritic tree spine apparatus membrane endosome intracellular vesicle postsynaptic endosome cytoplasmic vesicle vesicle extracellular region Golgi membrane Golgi apparatus nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth B]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A, C [auth B]	IPR019734	Tetratricopeptide repeat	Repeat
A, C [auth B]	IPR002151	Kinesin light chain	Family
A, C [auth B]	IPR015792	Kinesin light chain repeat	Repeat
B [auth X], D [auth C]	IPR045588	Calsyntenin, C-terminal	Domain
B [auth X], D [auth C]	IPR015919	Cadherin-like superfamily	Homologous Superfamily
B [auth X], D [auth C]	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
B [auth X], D [auth C]	IPR026914	Calsyntenin	Unknown
B [auth X], D [auth C]	IPR002126	Cadherin-like	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.