6F5F

Structure of ARTD2/PARP2 WGR domain bound to double strand DNA with 5 nucleotide overhang and 5'phosphate

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	WGR domain-like	8074102	3000760	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	WGR domain-like	8074102	3000760	SCOP2B (2022-06-29)
C	SCOP2 Family	WGR domain	8074101	4003393	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	WGR domain-like	8074102	3000760	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	WGR domain-like	8074102	3000760	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF05406	e6f5fA1	A: a+b two layers	X: WGR domain (From Topology)	H: WGR domain (From Topology)	T: WGR domain	F: PF05406	ECOD (1.6)
B	PF05406	e6f5fB1	A: a+b two layers	X: WGR domain (From Topology)	H: WGR domain (From Topology)	T: WGR domain	F: PF05406	ECOD (1.6)
C	PF05406	e6f5fC1	A: a+b two layers	X: WGR domain (From Topology)	H: WGR domain (From Topology)	T: WGR domain	F: PF05406	ECOD (1.6)
D	PF05406	e6f5fD1	A: a+b two layers	X: WGR domain (From Topology)	H: WGR domain (From Topology)	T: WGR domain	F: PF05406	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF05406	WGR domain (WGR)	WGR domain	This domain is found in a variety of polyA polymerases as well as the E. coli molybdate metabolism regulator Swiss:P33345 and other proteins of unknown function. I have called this domain WGR after the most conserved central motif of the domain. The ...	This domain is found in a variety of polyA polymerases as well as the E. coli molybdate metabolism regulator Swiss:P33345 and other proteins of unknown function. I have called this domain WGR after the most conserved central motif of the domain. The domain is found in isolation in proteins such as Swiss:Q9JN21 and is between 70 and 80 residues in length. I propose that this may be a nucleic acid binding domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Poly [ADP-ribose] polymerase 2	NAD+ ADP-ribosyltransferase activity pentosyltransferase activity glycosyltransferase activity transferase activity catalytic activity protein-containing complex binding chromatin binding binding catalytic activity, acting on a protein NAD+-protein ADP-ribosyltransferase activity DNA binding organic cyclic compound binding damaged DNA binding nucleic acid binding NAD+ ADP-ribosyltransferase activity pentosyltransferase activity glycosyltransferase activity transferase activity catalytic activity protein-containing complex binding chromatin binding binding catalytic activity, acting on a protein NAD+-protein ADP-ribosyltransferase activity DNA binding organic cyclic compound binding damaged DNA binding nucleic acid binding NAD DNA ADP-ribosyltransferase activity NAD+- protein-aspartate ADP-ribosyltransferase activity ADP-D-ribose modification-dependent protein binding poly-ADP-D-ribose modification-dependent protein binding protein binding modification-dependent protein binding poly-ADP-D-ribose binding carbohydrate derivative binding nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups NAD+-protein-glutamate ADP-ribosyltransferase activity nucleosome binding NAD+-protein-serine ADP-ribosyltransferase activity	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA modification organic substance metabolic process macromolecule modification cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA modification organic substance metabolic process macromolecule modification metabolic process macromolecule metabolic process DNA ADP-ribosylation neuron apoptotic process hippocampal neuron apoptotic process apoptotic process cell death programmed cell death DNA repair-dependent chromatin remodeling protein-containing complex organization protein-DNA complex organization cellular component organization chromatin organization chromatin remodeling cellular component organization or biogenesis regulation of biological process regulation of cellular process cell surface receptor signaling pathway signaling biological regulation extrinsic apoptotic signaling pathway cell communication apoptotic signaling pathway signal transduction response to decreased oxygen levels response to nutrient levels response to oxygen levels response to abiotic stimulus response to oxygen-glucose deprivation DNA repair developmental process multi-multicellular organism process multicellular organismal process placenta development reproductive process maternal process involved in female pregnancy multicellular organismal reproductive process animal organ development developmental process involved in reproduction tissue development maternal placenta development anatomical structure development female pregnancy multi-organism reproductive process decidualization base-excision repair regulation of growth system process regulation of cardiac muscle tissue growth developmental growth regulation of system process regulation of cell differentiation muscle cell differentiation regulation of muscle hypertrophy muscle structure development positive regulation of developmental process multicellular organism development muscle adaptation cell differentiation regulation of organ growth regulation of heart growth cardiac muscle tissue growth muscle tissue development cardiac cell development positive regulation of developmental growth positive regulation of heart growth system development heart growth positive regulation of organ growth striated muscle hypertrophy positive regulation of muscle cell differentiation regulation of muscle cell differentiation regulation of response to stimulus positive regulation of muscle hypertrophy positive regulation of cardiac muscle tissue growth positive regulation of multicellular organismal process positive regulation of cell growth involved in cardiac muscle cell development striated muscle cell differentiation regulation of cellular component organization cellular developmental process regulation of developmental process cardiac muscle cell development positive regulation of cardiac muscle hypertrophy positive regulation of biological process cell development regulation of striated muscle cell differentiation organ growth cell growth striated muscle tissue development muscle cell development positive regulation of cell differentiation positive regulation of striated muscle cell differentiation cardiac muscle hypertrophy regulation of multicellular organismal process positive regulation of cellular process muscle hypertrophy regulation of muscle adaptation heart development regulation of multicellular organismal development regulation of developmental growth cardiac muscle tissue development developmental cell growth physiological muscle hypertrophy growth cardiac muscle cell differentiation regulation of cell growth involved in cardiac muscle cell development positive regulation of cell growth regulation of cell growth muscle system process regulation of muscle system process cardiocyte differentiation regulation of cardiac muscle hypertrophy circulatory system development cell growth involved in cardiac muscle cell development positive regulation of growth physiological cardiac muscle hypertrophy double-strand break repair organonitrogen compound metabolic process protein poly-ADP-ribosylation protein metabolic process post-translational protein modification protein modification process protein auto-ADP-ribosylation	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle nucleoplasm site of DNA damage chromosome
E, F, G, H	DNA (5'-D(PCPGPGPTPCPGPCPCPTPAPTPAPGPGP*C)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR012317	Poly(ADP-ribose) polymerase, catalytic domain	Domain
A, B, C, D	IPR036616	Poly(ADP-ribose) polymerase, regulatory domain superfamily	Homologous Superfamily
A, B, C, D	IPR036930	WGR domain superfamily	Homologous Superfamily
A, B, C, D	IPR004102	Poly(ADP-ribose) polymerase, regulatory domain	Domain
A, B, C, D	IPR008893	WGR domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q9UGN5	lipodystrophy ovarian cancer atypical teratoid rhabdoid tumor glioblastoma large cell medulloblastoma Malignant epithelial tumor of ovary peripheral neuropathy Takayasu arteritis malignant glioma ovarian epithelial tumor psoriasis lung cancer peripheral nervous system disease subependymal giant cell astrocytoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.