Annotations: 6F4A

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e6f4aA4	A: beta barrels	X: SH3	H: SH3	T: SH3	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF00773	e6f4aA1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF00773	ECOD (1.6)
A	F_UNCLASSIFIED	e6f4aA2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF12513	e6f4aB3	A: alpha bundles	X: Spectrin repeat-like	H: MIT domain (From Topology)	T: MIT domain	F: PF12513	ECOD (1.6)
B	F_UNCLASSIFIED	e6f4aB6	A: alpha bundles	X: immunoglobulin/albumin-binding domain-like	H: Phosphoprotein XD domain (From Topology)	T: Phosphoprotein XD domain	F: F_UNCLASSIFIED	ECOD (1.6)
B	F_UNCLASSIFIED	e6f4aB1	A: alpha complex topology	X: Sigma2 domain-like	H: Sigma2 domain of RNA polymerase sigma factors (From Topology)	T: Sigma2 domain of RNA polymerase sigma factors	F: F_UNCLASSIFIED	ECOD (1.6)
B	F_UNCLASSIFIED	e6f4aB5	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF00271	e6f4aB2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00271	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00773	RNB domain (RNB)	RNB domain	This domain is the catalytic domain of ribonuclease II [1].	Domain
B	PF00270	DEAD/DEAH box helicase (DEAD)	DEAD/DEAH box helicase	Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome ...	Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.	Domain
B	PF12513	Mitochondrial degradasome RNA helicase subunit C terminal (SUV3_C)	Mitochondrial degradasome RNA helicase subunit C terminal	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Exoribonuclease II, mitochondrial	3'-5'-RNA exonuclease activity catalytic activity, acting on RNA RNA exonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on a nucleic acid 3'-5' exonuclease activity RNA exonuclease activity RNA nuclease activity hydrolase activity exoribonuclease II activity exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters nuclease activity hydrolase activity, acting on ester bonds exonuclease activity catalytic activity 3'-5'-RNA exonuclease activity catalytic activity, acting on RNA RNA exonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on a nucleic acid 3'-5' exonuclease activity RNA exonuclease activity RNA nuclease activity hydrolase activity exoribonuclease II activity exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters nuclease activity hydrolase activity, acting on ester bonds exonuclease activity catalytic activity RNA binding binding organic cyclic compound binding nucleic acid binding	catabolic process RNA metabolic process primary metabolic process nucleic acid metabolic process macromolecule catabolic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process nucleic acid catabolic process metabolic process mitochondrial RNA metabolic process macromolecule metabolic process catabolic process RNA metabolic process primary metabolic process nucleic acid metabolic process macromolecule catabolic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process nucleic acid catabolic process metabolic process mitochondrial RNA metabolic process macromolecule metabolic process mitochondrial RNA catabolic process organic substance catabolic process RNA catabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial protein-containing complex protein-containing complex catalytic complex cytoplasmic exosome (RNase complex) exosome (RNase complex) mitochondrial degradosome membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial protein-containing complex protein-containing complex catalytic complex cytoplasmic exosome (RNase complex) exosome (RNase complex) mitochondrial degradosome exoribonuclease complex
B	Suv3 helicase	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding nucleic acid binding 3'-5'-RNA exonuclease activity catalytic activity, acting on RNA RNA exonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on a nucleic acid 3'-5' exonuclease activity RNA exonuclease activity RNA nuclease activity hydrolase activity exoribonuclease II activity exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters nuclease activity hydrolase activity, acting on ester bonds exonuclease activity catalytic activity helicase activity RNA helicase activity ATP-dependent activity, acting on RNA ATP-dependent activity hydrolase activity, acting on acid anhydrides	catabolic process RNA metabolic process primary metabolic process nucleic acid metabolic process macromolecule catabolic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process nucleic acid catabolic process metabolic process mitochondrial RNA metabolic process macromolecule metabolic process catabolic process RNA metabolic process primary metabolic process nucleic acid metabolic process macromolecule catabolic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process nucleic acid catabolic process metabolic process mitochondrial RNA metabolic process macromolecule metabolic process mitochondrial RNA catabolic process organic substance catabolic process RNA catabolic process Group I intron splicing RNA splicing RNA splicing, via transesterification reactions with guanosine as nucleophile cellular biosynthetic process cellular metabolic process gene expression macromolecule biosynthetic process RNA splicing, via transesterification reactions biosynthetic process organic substance biosynthetic process cellular process RNA processing DNA-templated DNA replication DNA metabolic process mitochondrial genome maintenance mitochondrial DNA metabolic process cellular component organization organelle organization DNA replication mitochondrial DNA replication cellular component organization or biogenesis mitochondrion organization	membrane-bounded organelle mitochondrial chromosome intracellular anatomical structure mitochondrion membrane-enclosed lumen chromosome nucleoid cellular anatomical entity intracellular membrane-bounded organelle mitochondrial matrix intracellular organelle lumen intracellular organelle organelle lumen organelle membrane-bounded organelle mitochondrial chromosome intracellular anatomical structure mitochondrion membrane-enclosed lumen chromosome nucleoid cellular anatomical entity intracellular membrane-bounded organelle mitochondrial matrix intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle cytoplasm mitochondrial nucleoid non-membrane-bounded organelle mitochondrial protein-containing complex protein-containing complex catalytic complex cytoplasmic exosome (RNase complex) exosome (RNase complex) mitochondrial degradosome exoribonuclease complex
C	RNA (5'-R(PAPGPAPUPAPC)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001900	Ribonuclease II/R	Domain
A	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
B	IPR001650	Helicase, C-terminal domain-like	Domain
B	IPR014001	Helicase superfamily 1/2, ATP-binding domain	Domain
B	IPR044774	Suv3, DEXQ-box helicase domain	Domain
B	IPR022192	Mitochondrial degradasome RNA helicase subunit, C-terminal domain	Domain
B	IPR011545	DEAD/DEAH box helicase domain	Domain
B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.