6F1Y

Dynein light intermediate chain region of the dynein tail/dynactin/BICDR1 complex

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth j]	DLIC	e6f1yj1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: DLIC	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth f]	PF08385	Dynein heavy chain, N-terminal region 1 (DHC_N1)	Dynein heavy chain, N-terminal region 1	-	Family
B [auth j]	PF05783	Dynein light intermediate chain (DLIC) (DLIC)	Dynein light intermediate chain (DLIC)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth f]	Cytoplasmic dynein 1 heavy chain 1,Dynein heavy chain	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding dynein light intermediate chain binding protein binding microtubule motor activity cytoskeletal motor activity minus-end-directed microtubule motor activity ATP-dependent activity dynein intermediate chain binding RNA binding nucleic acid binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	cellular process cell division establishment of organelle localization cellular localization transport nucleus localization intracellular transport establishment of localization localization organelle localization establishment of localization in cell nuclear migration cellular component biogenesis cellular component organization cellular process cell division establishment of organelle localization cellular localization transport nucleus localization intracellular transport establishment of localization localization organelle localization establishment of localization in cell nuclear migration cellular component biogenesis cellular component organization organelle organization cellular component assembly organelle assembly P-body assembly non-membrane-bounded organelle assembly cellular component organization or biogenesis stress granule assembly microtubule cytoskeleton organization spindle localization establishment of spindle localization microtubule-based process cell cycle cytoskeleton organization cell cycle process regulation of localization regulation of biological process biological regulation metaphase chromosome alignment chromosome localization nuclear chromosome segregation regulation of metaphase plate congression establishment of chromosome localization chromosome segregation positive regulation of organelle organization regulation of cytoskeleton organization regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization positive regulation of biological process positive regulation of spindle assembly positive regulation of cell cycle process regulation of cell cycle positive regulation of cellular process spindle organization regulation of cell cycle process positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization regulation of microtubule-based process regulation of spindle organization regulation of cellular component biogenesis spindle assembly regulation of organelle organization positive regulation of cell cycle regulation of spindle assembly regulation of organelle assembly regulation of microtubule cytoskeleton organization positive regulation of organelle assembly regulation of mitotic spindle organization mitotic cell cycle microtubule cytoskeleton organization involved in mitosis mitotic spindle organization mitotic cell cycle process cytoplasmic microtubule organization supramolecular fiber organization multicellular organismal process homeostatic process adaptive thermogenesis positive regulation of metabolic process multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis positive regulation of multicellular organismal process metabolic process regulation of multicellular organismal process regulation of metabolic process regulation of transport positive regulation of transport regulation of cellular localization positive regulation of intracellular transport regulation of intracellular transport retrograde axonal transport axonal transport axo-dendritic transport microtubule-based transport transport along microtubule cytoskeleton-dependent intracellular transport microtubule-based movement	membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol protein-containing complex cytoplasmic dynein complex catalytic complex dynein complex intracellular organelle cytoskeleton intracellular non-membrane-bounded organelle microtubule associated complex microtubule cytoskeleton non-membrane-bounded organelle cell projection actin-based cell projection filopodium plasma membrane bounded cell projection polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer supramolecular complex neuron projection cytoplasm axon axon cytoplasm neuron projection cytoplasmic region plasma membrane bounded cell projection cytoplasm cell periphery cell cortex centrosome microtubule organizing center lytic vacuole intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen vacuolar lumen endomembrane system intracellular organelle lumen cytoplasmic vesicle lysosome vesicle lumen azurophil granule vacuole intracellular membrane-bounded organelle secretory granule lumen azurophil granule lumen organelle lumen secretory granule primary lysosome secretory vesicle cytoplasmic microtubule
B [auth j]	Cytoplasmic dynein 1 light intermediate chain 2	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein binding dynein heavy chain binding identical protein binding	microtubule-based movement microtubule-based process cellular process localization centrosome localization microtubule organizing center localization cellular component organization organelle organization microtubule cytoskeleton organization cellular component organization or biogenesis cytoskeleton organization cellular response to endogenous stimulus cellular response to growth factor stimulus response to stimulus microtubule-based movement microtubule-based process cellular process localization centrosome localization microtubule organizing center localization cellular component organization organelle organization microtubule cytoskeleton organization cellular component organization or biogenesis cytoskeleton organization cellular response to endogenous stimulus cellular response to growth factor stimulus response to stimulus response to endogenous stimulus cellular response to nerve growth factor stimulus response to nerve growth factor response to growth factor	membrane cellular anatomical entity intracellular anatomical structure chromosome chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle membrane cellular anatomical entity intracellular anatomical structure chromosome chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton cytoplasm cytosol membrane-bounded organelle endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system cytoplasmic vesicle late endosome vesicle protein-containing complex cytoplasmic dynein complex catalytic complex dynein complex microtubule associated complex polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth f]	IPR026983	Dynein heavy chain	Family
A [auth f]	IPR013602	Dynein heavy chain, linker	Domain
A [auth f]	IPR041658	Dynein heavy chain AAA lid domain	Domain
A [auth f]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A [auth f]	IPR042222	Dynein heavy chain, domain 2, N-terminal	Homologous Superfamily
A [auth f]	IPR043160	Dynein heavy chain, C-terminal domain, barrel region	Homologous Superfamily
A [auth f]	IPR035706	Dynein heavy chain, ATP-binding dynein motor region	Domain
A [auth f]	IPR041228	Dynein heavy chain, C-terminal domain	Domain
A [auth f]	IPR003593	AAA+ ATPase domain	Domain
A [auth f]	IPR041466	Dynein heavy chain, AAA 5 extension domain	Domain
A [auth f]	IPR042228	Dynein heavy chain, linker, subdomain 3	Homologous Superfamily
A [auth f]	IPR035699	Dynein heavy chain, hydrolytic ATP-binding dynein motor region	Domain
A [auth f]	IPR042219	Dynein heavy chain AAA lid domain superfamily	Homologous Superfamily
A [auth f]	IPR024743	Dynein heavy chain, coiled coil stalk	Domain
A [auth f]	IPR013594	Dynein heavy chain, tail	Domain
A [auth f]	IPR043157	Dynein heavy chain, AAA1 domain, small subdomain	Homologous Superfamily
A [auth f]	IPR004273	Dynein heavy chain region D6 P-loop domain	Domain
A [auth f]	IPR024317	Dynein heavy chain, AAA module D4	Domain
B [auth j]	IPR022780	Dynein family light intermediate chain	Family
B [auth j]	IPR008467	Dynein 1 light intermediate chain	Family
B [auth j]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth f]	Pharos: Q14204	Charcot-Marie-Tooth disease intellectual disability, autosomal dominant 13 Charcot-Marie-Tooth disease axonal type 2O intellectual disability microcephaly autosomal dominant childhood-onset proximal spinal muscular atrophy without contractures peripheral neuropathy spinal muscular atrophy, type III Mental Retardation, Psychosocial motor peripheral neuropathy neurodegenerative disease peripheral nervous system disease astrocytic tumor cerebral cortical dysplasia lung cancer Charcot-Marie-Tooth disease intellectual disability, autosomal dominant 13 Charcot-Marie-Tooth disease axonal type 2O intellectual disability microcephaly autosomal dominant childhood-onset proximal spinal muscular atrophy without contractures peripheral neuropathy spinal muscular atrophy, type III Mental Retardation, Psychosocial motor peripheral neuropathy neurodegenerative disease peripheral nervous system disease astrocytic tumor cerebral cortical dysplasia lung cancer malignant mesothelioma osteosarcoma spinal muscular atrophy, type 1 thyroid gland papillary carcinoma diabetes mellitus familial nonmedullary thyroid carcinoma microlissencephaly ovarian cancer Pick disease spinal muscular atrophy juvenile dermatomyositis malignant ependymoma
B [auth j]	Pharos: O43237	Weight Gain juvenile dermatomyositis medulloblastoma ovarian cancer large cell medulloblastoma myopathy pancreatic ductal adenocarcinoma malignant pancreatic neoplasm osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia