Annotations: 6F1D

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00431	e6f1dA1	A: beta sandwiches	X: jelly-roll	H: Spermadhesin, CUB domain (From Topology)	T: Spermadhesin, CUB domain	F: PF00431	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.290	Mainly Beta	Sandwich	Jelly Rolls	Spermadhesin, CUB domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00431	CUB domain (CUB)	CUB domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Complement C1r subcomponent	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity molecular sequestering activity identical protein binding protein binding	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity humoral immune response response to stimulus positive regulation of biological process positive regulation of response to stimulus complement activation humoral immune response mediated by circulating immunoglobulin positive regulation of immune response leukocyte mediated immunity regulation of immune system process positive regulation of immune system process complement activation, classical pathway regulation of biological process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity humoral immune response response to stimulus positive regulation of biological process positive regulation of response to stimulus complement activation humoral immune response mediated by circulating immunoglobulin positive regulation of immune response leukocyte mediated immunity regulation of immune system process positive regulation of immune system process complement activation, classical pathway regulation of biological process immune response biological regulation immunoglobulin mediated immune response adaptive immune response immune effector process regulation of response to stimulus immune system process B cell mediated immunity regulation of immune response activation of immune response biological process involved in interspecies interaction between organisms response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to other organism response to stress innate immune response response to external biotic stimulus zymogen activation organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process biosynthetic process proteolysis organic substance biosynthetic process protein processing metabolic process cellular process protein metabolic process macromolecule metabolic process	extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle blood microparticle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR018097	EGF-like calcium-binding, conserved site	Conserved Site
A	IPR035914	Spermadhesin, CUB domain superfamily	Homologous Superfamily
A	IPR000436	Sushi/SCR/CCP domain	Domain
A	IPR000859	CUB domain	Domain
A	IPR000742	EGF-like domain	Domain
A	IPR035976	Sushi/SCR/CCP superfamily	Homologous Superfamily
A	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
A	IPR001314	Peptidase S1A, chymotrypsin family	Family
A	IPR033116	Serine proteases, trypsin family, serine active site	Active Site
A	IPR001254	Serine proteases, trypsin domain	Domain
A	IPR001881	EGF-like calcium-binding domain	Domain
A	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
A	IPR024175	Peptidase S1A, complement C1r/C1S/mannan-binding	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P00736	Ehlers-Danlos syndrome cystic fibrosis endometriosis paratuberculosis Ehlers-Danlos syndrome, periodontal type 1 large cell medulloblastoma lung carcinoma malignant ependymoma malignant pancreatic neoplasm adrenal cortex carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm Duchenne muscular dystrophy pilocytic astrocytoma subependymal giant cell astrocytoma Ehlers-Danlos syndrome cystic fibrosis endometriosis paratuberculosis Ehlers-Danlos syndrome, periodontal type 1 large cell medulloblastoma lung carcinoma malignant ependymoma malignant pancreatic neoplasm adrenal cortex carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm Duchenne muscular dystrophy pilocytic astrocytoma subependymal giant cell astrocytoma Ehlers-Danlos syndrome, periodontitis type glioblastoma invasive ductal breast carcinoma limb-girdle muscular dystrophy Lupus Erythematosus, Systemic malignant glioma medulloblastoma Becker muscular dystrophy pancreatic ductal adenocarcinoma dermatomyositis pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia pituitary cancer ulcerative colitis facioscapulohumeral muscular dystrophy heart disease juvenile dermatomyositis lung cancer malignant colon neoplasm malignant mesothelioma myopathy complement component C1r/C1s deficiency pancreatic intraductal papillary-mucinous carcinoma diabetes mellitus Sjogren syndrome gastric carcinoma interstitial cystitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.