6EYZ

PI3 kinase delta in complex with 4-Fluorophenyl 5-(4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazol-6-yl)-2-methoxynicotinate

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PI3K_C2	e6eyzA3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: C2 domain (From Topology)	T: C2 domain	F: PI3K_C2	ECOD (1.6)
A	PI3Ka	e6eyzA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PI3Ka	ECOD (1.6)
A	PI3K_rbd	e6eyzA4	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: PI3K_rbd	ECOD (1.6)
A	PI3_PI4_kinase	e6eyzA2	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: PI3_PI4_kinase	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00613	Phosphoinositide 3-kinase family, accessory domain (PIK domain) (PI3Ka)	Phosphoinositide 3-kinase family, accessory domain (PIK domain)	-	Repeat
A	PF02192	PI3-kinase family, p85-binding domain (PI3K_p85B)	PI3-kinase family, p85-binding domain	-	Family
A	PF00792	Phosphoinositide 3-kinase C2 (PI3K_C2)	Phosphoinositide 3-kinase C2	Phosphoinositide 3-kinase region postulated to contain a C2 domain. Outlier of Pfam:PF00168 family.	Domain
A	PF00454	Phosphatidylinositol 3- and 4-kinase (PI3_PI4_kinase)	Phosphatidylinositol 3- and 4-kinase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups phosphatidylinositol kinase activity lipid kinase activity 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity phosphotransferase activity, alcohol group as acceptor 1-phosphatidylinositol-3-kinase activity 1-phosphatidylinositol-4-phosphate 3-kinase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups phosphatidylinositol kinase activity lipid kinase activity 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity phosphotransferase activity, alcohol group as acceptor 1-phosphatidylinositol-3-kinase activity 1-phosphatidylinositol-4-phosphate 3-kinase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding	multicellular organismal process regulation of cellular process homeostatic process leukocyte apoptotic process positive regulation of biological process regulation of programmed cell death regulation of neutrophil apoptotic process positive regulation of myeloid cell apoptotic process positive regulation of neutrophil apoptotic process regulation of immune system process myeloid cell homeostasis positive regulation of leukocyte apoptotic process positive regulation of immune system process positive regulation of cellular process multicellular organismal process regulation of cellular process homeostatic process leukocyte apoptotic process positive regulation of biological process regulation of programmed cell death regulation of neutrophil apoptotic process positive regulation of myeloid cell apoptotic process positive regulation of neutrophil apoptotic process regulation of immune system process myeloid cell homeostasis positive regulation of leukocyte apoptotic process positive regulation of immune system process positive regulation of cellular process regulation of leukocyte apoptotic process myeloid cell apoptotic process regulation of biological process positive regulation of programmed cell death regulation of apoptotic process biological regulation cell death positive regulation of apoptotic process neutrophil homeostasis neutrophil apoptotic process multicellular organismal-level homeostasis leukocyte homeostasis immune system process inflammatory cell apoptotic process cellular process homeostasis of number of cells apoptotic process programmed cell death regulation of myeloid cell apoptotic process developmental process cellular developmental process cell differentiation cellular biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process phospholipid metabolic process organic substance metabolic process organic substance biosynthetic process phosphate-containing compound metabolic process phosphorus metabolic process phosphatidylinositol metabolic process glycerophospholipid biosynthetic process phosphatidylinositol-3-phosphate biosynthetic process cellular metabolic process primary metabolic process phosphatidylinositol phosphate biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process metabolic process glycerolipid metabolic process lipid metabolic process positive regulation of locomotion regulation of cell motility endothelial cell migration positive regulation of cell migration positive regulation of epithelial cell migration tissue migration ameboidal-type cell migration positive regulation of cell motility regulation of cell migration regulation of endothelial cell migration cell migration regulation of multicellular organismal process epithelial cell migration cell motility regulation of epithelial cell migration locomotion epithelium migration regulation of locomotion positive regulation of endothelial cell migration response to stimulus immune response adaptive immune response cellular response to stimulus signaling intracellular signal transduction cell communication intracellular signaling cassette signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of biosynthetic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression positive regulation of gene expression regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process B cell activation cell activation lymphocyte activation leukocyte activation biological process involved in interspecies interaction between organisms response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to other organism response to stress innate immune response response to external biotic stimulus B cell homeostasis lymphocyte homeostasis positive regulation of epithelial tube formation regulation of developmental process tube formation positive regulation of developmental process epithelial tube formation multicellular organism development tube morphogenesis positive regulation of morphogenesis of an epithelium anatomical structure development regulation of morphogenesis of an epithelium regulation of epithelial tube formation epithelial tube morphogenesis regulation of anatomical structure morphogenesis epithelium development regulation of multicellular organismal development tube development morphogenesis of an epithelium tissue development tissue morphogenesis anatomical structure morphogenesis anatomical structure formation involved in morphogenesis positive regulation of multicellular organismal process chemotaxis taxis response to chemical cellular response to growth factor stimulus cell surface receptor protein tyrosine kinase signaling pathway cellular response to endogenous stimulus enzyme-linked receptor protein signaling pathway cell surface receptor signaling pathway response to endogenous stimulus positive regulation of cell migration by vascular endothelial growth factor signaling pathway vascular endothelial growth factor signaling pathway cellular response to vascular endothelial growth factor stimulus response to growth factor angiogenesis regulation of vasculature development blood vessel development system development blood vessel morphogenesis positive regulation of angiogenesis vasculature development circulatory system development positive regulation of vasculature development regulation of angiogenesis defense response to fungus response to fungus phosphorylation inflammatory response negative regulation of biological process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process cell population proliferation positive regulation of cell population proliferation endothelial cell proliferation positive regulation of epithelial cell proliferation regulation of endothelial cell proliferation regulation of cell population proliferation positive regulation of endothelial cell proliferation regulation of epithelial cell proliferation epithelial cell proliferation	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane protein-containing complex catalytic complex phosphatidylinositol 3-kinase complex, class I membrane protein complex transferase complex phosphatidylinositol 3-kinase complex, class IA phosphatidylinositol 3-kinase complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane protein-containing complex catalytic complex phosphatidylinositol 3-kinase complex, class I membrane protein complex transferase complex phosphatidylinositol 3-kinase complex, class IA phosphatidylinositol 3-kinase complex transferase complex, transferring phosphorus-containing groups extrinsic component of membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR015433	Phosphatidylinositol kinase	Family
A	IPR016024	Armadillo-type fold	Homologous Superfamily
A	IPR002420	C2 phosphatidylinositol 3-kinase-type domain	Domain
A	IPR018936	Phosphatidylinositol 3/4-kinase, conserved site	Conserved Site
A	IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain	Domain
A	IPR001263	Phosphoinositide 3-kinase, accessory (PIK) domain	Domain
A	IPR037703	PI3Kdelta, catalytic domain	Domain
A	IPR042236	Phosphoinositide 3-kinase, accessory (PIK) domain superfamily	Homologous Superfamily
A	IPR036940	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily	Homologous Superfamily
A	IPR003113	Phosphatidylinositol 3-kinase, adaptor-binding domain	Domain
A	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A	IPR000341	Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain	Domain
A	IPR035892	C2 domain superfamily	Homologous Superfamily
A	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.