Annotations: 6EYC

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth 2]	PF17207	e6eyc21	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
A [auth 2]	PF17855	e6eyc24	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17855	ECOD (1.6)
A [auth 2]	PF14551	e6eyc22	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
A [auth 2]	PF00493	e6eyc25	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00493	ECOD (1.6)
A [auth 2]	F_UNCLASSIFIED	e6eyc23	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)
B [auth 3]	PF17207	e6eyc35	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
B [auth 3]	PF17855	e6eyc31	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17855	ECOD (1.6)
B [auth 3]	PF14551	e6eyc33	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
B [auth 3]	PF00493	e6eyc34	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00493	ECOD (1.6)
B [auth 3]	F_UNCLASSIFIED	e6eyc32	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)
C [auth 4]	PF17207	e6eyc43	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
C [auth 4]	PF17855	e6eyc42	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17855	ECOD (1.6)
C [auth 4]	PF14551	e6eyc41	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
C [auth 4]	PF00493	e6eyc44	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00493	ECOD (1.6)
C [auth 4]	PF17207	e6eyc45	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: PF17207	ECOD (1.6)
D [auth 5]	PF17207	e6eyc55	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
D [auth 5]	PF17855	e6eyc51	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17855	ECOD (1.6)
D [auth 5]	PF14551	e6eyc53	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
D [auth 5]	PF00493	e6eyc52	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00493	ECOD (1.6)
D [auth 5]	F_UNCLASSIFIED	e6eyc54	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)
E [auth 6]	PF17207	e6eyc62	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
E [auth 6]	PF17855	e6eyc65	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17855	ECOD (1.6)
E [auth 6]	PF14551	e6eyc64	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
E [auth 6]	PF00493	e6eyc63	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00493	ECOD (1.6)
E [auth 6]	PF17207	e6eyc61	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: PF17207	ECOD (1.6)
F [auth 7]	PF17207	e6eyc74	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
F [auth 7]	PF17855	e6eyc71	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17855	ECOD (1.6)
F [auth 7]	PF14551	e6eyc75	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
F [auth 7]	PF00493	e6eyc73	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00493	ECOD (1.6)
F [auth 7]	F_UNCLASSIFIED	e6eyc72	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth 2]	PF14551	MCM N-terminal domain (MCM_N)	MCM N-terminal domain	This family contains the N-terminal domain of MCM proteins.	Domain
A [auth 2]	PF00493	MCM P-loop domain (MCM)	MCM P-loop domain	-	Domain
A [auth 2]	PF17855	MCM AAA-lid domain (MCM_lid)	MCM AAA-lid domain	This entry represents the AAA-lid domain found in MCM proteins.	Domain
A [auth 2]	PF17207	MCM OB domain (MCM_OB)	MCM OB domain	This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif [2].	Domain
B [auth 3]	PF14551	MCM N-terminal domain (MCM_N)	MCM N-terminal domain	This family contains the N-terminal domain of MCM proteins.	Domain
B [auth 3]	PF00493	MCM P-loop domain (MCM)	MCM P-loop domain	-	Domain
B [auth 3]	PF17855	MCM AAA-lid domain (MCM_lid)	MCM AAA-lid domain	This entry represents the AAA-lid domain found in MCM proteins.	Domain
B [auth 3]	PF17207	MCM OB domain (MCM_OB)	MCM OB domain	This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif [2].	Domain
C [auth 4]	PF14551	MCM N-terminal domain (MCM_N)	MCM N-terminal domain	This family contains the N-terminal domain of MCM proteins.	Domain
C [auth 4]	PF00493	MCM P-loop domain (MCM)	MCM P-loop domain	-	Domain
C [auth 4]	PF17855	MCM AAA-lid domain (MCM_lid)	MCM AAA-lid domain	This entry represents the AAA-lid domain found in MCM proteins.	Domain
C [auth 4]	PF17207	MCM OB domain (MCM_OB)	MCM OB domain	This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif [2].	Domain
D [auth 5]	PF00493	MCM P-loop domain (MCM)	MCM P-loop domain	-	Domain
D [auth 5]	PF17855	MCM AAA-lid domain (MCM_lid)	MCM AAA-lid domain	This entry represents the AAA-lid domain found in MCM proteins.	Domain
D [auth 5]	PF17207	MCM OB domain (MCM_OB)	MCM OB domain	This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif [2].	Domain
E [auth 6]	PF14551	MCM N-terminal domain (MCM_N)	MCM N-terminal domain	This family contains the N-terminal domain of MCM proteins.	Domain
E [auth 6]	PF00493	MCM P-loop domain (MCM)	MCM P-loop domain	-	Domain
E [auth 6]	PF17855	MCM AAA-lid domain (MCM_lid)	MCM AAA-lid domain	This entry represents the AAA-lid domain found in MCM proteins.	Domain
E [auth 6]	PF17207	MCM OB domain (MCM_OB)	MCM OB domain	This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif [2].	Domain
F [auth 7]	PF14551	MCM N-terminal domain (MCM_N)	MCM N-terminal domain	This family contains the N-terminal domain of MCM proteins.	Domain
F [auth 7]	PF00493	MCM P-loop domain (MCM)	MCM P-loop domain	-	Domain
F [auth 7]	PF17855	MCM AAA-lid domain (MCM_lid)	MCM AAA-lid domain	This entry represents the AAA-lid domain found in MCM proteins.	Domain
F [auth 7]	PF17207	MCM OB domain (MCM_OB)	MCM OB domain	This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth 2]	DNA replication licensing factor MCM2	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity protein-containing complex binding chromatin binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity protein-containing complex binding chromatin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides cation binding metal ion binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process DNA-templated DNA replication sexual reproduction reproductive process meiotic cell cycle nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process DNA-templated DNA replication sexual reproduction reproductive process meiotic cell cycle nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process meiotic cell cycle process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process premeiotic DNA replication metabolic process macromolecule metabolic process cell cycle cell cycle process pre-replicative complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis pre-replicative complex assembly involved in nuclear cell cycle DNA replication protein-containing complex organization pre-replicative complex assembly involved in cell cycle DNA replication protein-DNA complex assembly double-strand break repair DNA recombination double-strand break repair via break-induced replication recombinational repair double-strand break repair via homologous recombination DNA repair DNA strand elongation DNA strand elongation involved in DNA replication mitotic DNA replication DNA replication initiation cell cycle DNA replication initiation mitotic DNA replication initiation mitotic cell cycle nuclear cell cycle DNA replication initiation mitotic cell cycle process DNA duplex unwinding DNA geometric change chromosome organization DNA conformation change DNA unwinding involved in DNA replication organelle organization	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle replication fork protection complex nuclear replication fork replication fork cytoplasm MCM complex pre-replicative complex nuclear pre-replicative complex
B [auth 3]	DNA replication licensing factor MCM3	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity protein-containing complex binding MCM complex binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity protein-containing complex binding MCM complex binding chromatin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides single-stranded DNA binding	DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process sexual reproduction reproductive process meiotic cell cycle DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process sexual reproduction reproductive process meiotic cell cycle nuclear DNA replication cell cycle DNA replication meiotic cell cycle process premeiotic DNA replication cellular process cell cycle cell cycle process pre-replicative complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis pre-replicative complex assembly involved in nuclear cell cycle DNA replication protein-containing complex organization pre-replicative complex assembly involved in cell cycle DNA replication protein-DNA complex assembly regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process silent mating-type cassette heterochromatin formation negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process regulation of metabolic process cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair DNA strand elongation DNA strand elongation involved in DNA replication subtelomeric heterochromatin formation telomere organization chromosome organization organelle organization mitotic DNA replication cell cycle DNA replication initiation mitotic DNA replication initiation mitotic cell cycle nuclear cell cycle DNA replication initiation mitotic cell cycle process DNA duplex unwinding DNA geometric change DNA conformation change DNA unwinding involved in DNA replication	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle replication fork protection complex nuclear replication fork replication fork cytoplasm MCM complex pre-replicative complex nuclear pre-replicative complex chromosome, telomeric region chromosomal region
C [auth 4]	DNA replication licensing factor MCM4	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity ATP-dependent activity, acting on DNA DNA helicase activity DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity ATP-dependent activity, acting on DNA DNA helicase activity catalytic activity, acting on DNA adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides single-stranded DNA binding	DNA-templated DNA replication nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process cellular process macromolecule metabolic process cell cycle DNA-templated DNA replication nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process cellular process macromolecule metabolic process cell cycle cell cycle process DNA replication initiation sexual reproduction reproductive process meiotic cell cycle meiotic cell cycle process premeiotic DNA replication pre-replicative complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis pre-replicative complex assembly involved in nuclear cell cycle DNA replication protein-containing complex organization pre-replicative complex assembly involved in cell cycle DNA replication protein-DNA complex assembly cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair DNA strand elongation DNA strand elongation involved in DNA replication mitotic DNA replication cell cycle DNA replication initiation mitotic DNA replication initiation mitotic cell cycle nuclear cell cycle DNA replication initiation mitotic cell cycle process DNA duplex unwinding DNA geometric change chromosome organization DNA conformation change DNA unwinding involved in DNA replication organelle organization	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle MCM core complex replication fork protection complex nuclear replication fork replication fork cytoplasm MCM complex pre-replicative complex nuclear pre-replicative complex
D [auth 5]	Minichromosome maintenance protein 5	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity protein-containing complex binding chromatin binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity protein-containing complex binding chromatin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides	DNA-templated DNA replication nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process cellular process macromolecule metabolic process cell cycle DNA-templated DNA replication nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process cellular process macromolecule metabolic process cell cycle cell cycle process DNA replication initiation sexual reproduction reproductive process meiotic cell cycle meiotic cell cycle process premeiotic DNA replication pre-replicative complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis pre-replicative complex assembly involved in nuclear cell cycle DNA replication protein-containing complex organization pre-replicative complex assembly involved in cell cycle DNA replication protein-DNA complex assembly regulation of DNA-templated DNA replication initiation regulation of biological process biological regulation regulation of macromolecule metabolic process regulation of primary metabolic process regulation of DNA-templated DNA replication regulation of nucleobase-containing compound metabolic process regulation of metabolic process regulation of DNA replication regulation of DNA metabolic process cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair subtelomeric heterochromatin formation regulation of cellular process cellular biosynthetic process negative regulation of biological process telomere organization negative regulation of cellular metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling negative regulation of macromolecule metabolic process regulation of biosynthetic process heterochromatin formation epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process chromosome organization regulation of cellular metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organelle organization negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process DNA duplex unwinding DNA geometric change DNA conformation change DNA unwinding involved in DNA replication	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle replication fork protection complex nuclear replication fork replication fork cytoplasm MCM complex pre-replicative complex nuclear pre-replicative complex chromosome, telomeric region chromosomal region
E [auth 6]	DNA replication licensing factor MCM6	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity ATP-dependent activity, acting on DNA DNA helicase activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid single-stranded DNA helicase activity helicase activity single-stranded DNA binding	DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process sexual reproduction reproductive process meiotic cell cycle DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process sexual reproduction reproductive process meiotic cell cycle nuclear DNA replication cell cycle DNA replication meiotic cell cycle process premeiotic DNA replication cellular process cell cycle cell cycle process pre-replicative complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis pre-replicative complex assembly involved in nuclear cell cycle DNA replication protein-containing complex organization pre-replicative complex assembly involved in cell cycle DNA replication protein-DNA complex assembly cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair mitotic DNA replication mitotic cell cycle mitotic cell cycle process DNA strand elongation DNA strand elongation involved in DNA replication DNA duplex unwinding DNA geometric change chromosome organization DNA conformation change DNA unwinding involved in DNA replication organelle organization	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle MCM core complex replication fork protection complex nuclear replication fork replication fork cytoplasm MCM complex pre-replicative complex nuclear pre-replicative complex
F [auth 7]	DNA replication licensing factor MCM7	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding protein-containing complex binding MCM complex binding chromatin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding protein-containing complex binding MCM complex binding chromatin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity ATP-dependent activity, acting on DNA DNA helicase activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid single-stranded DNA helicase activity helicase activity	DNA-templated DNA replication nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process cellular process macromolecule metabolic process cell cycle DNA-templated DNA replication nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process cellular process macromolecule metabolic process cell cycle cell cycle process DNA replication initiation sexual reproduction reproductive process meiotic cell cycle meiotic cell cycle process premeiotic DNA replication pre-replicative complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis pre-replicative complex assembly involved in nuclear cell cycle DNA replication protein-containing complex organization pre-replicative complex assembly involved in cell cycle DNA replication protein-DNA complex assembly regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process silent mating-type cassette heterochromatin formation negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process regulation of metabolic process cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair DNA strand elongation DNA strand elongation involved in DNA replication subtelomeric heterochromatin formation telomere organization chromosome organization organelle organization DNA duplex unwinding DNA geometric change DNA conformation change DNA unwinding involved in DNA replication	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle MCM core complex replication fork protection complex nuclear replication fork replication fork cytoplasm MCM complex pre-replicative complex nuclear pre-replicative complex chromosome, telomeric region chromosomal region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth 2]	IPR031327	Mini-chromosome maintenance protein	Family
A [auth 2]	IPR018525	Mini-chromosome maintenance, conserved site	Conserved Site
A [auth 2]	IPR001208	MCM domain	Domain
A [auth 2]	IPR041562	MCM, AAA-lid domain	Domain
A [auth 2]	IPR008045	DNA replication licensing factor Mcm2	Family
A [auth 2]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A [auth 2]	IPR027925	MCM, N-terminal domain	Domain
A [auth 2]	IPR033762	MCM OB domain	Domain
A [auth 2]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
B [auth 3]	IPR031327	Mini-chromosome maintenance protein	Family
B [auth 3]	IPR018525	Mini-chromosome maintenance, conserved site	Conserved Site
B [auth 3]	IPR003593	AAA+ ATPase domain	Domain
B [auth 3]	IPR001208	MCM domain	Domain
B [auth 3]	IPR041562	MCM, AAA-lid domain	Domain
B [auth 3]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B [auth 3]	IPR027925	MCM, N-terminal domain	Domain
B [auth 3]	IPR008046	DNA replication licensing factor Mcm3	Family
B [auth 3]	IPR033762	MCM OB domain	Domain
B [auth 3]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
C [auth 4]	IPR031327	Mini-chromosome maintenance protein	Family
C [auth 4]	IPR018525	Mini-chromosome maintenance, conserved site	Conserved Site
C [auth 4]	IPR001208	MCM domain	Domain
C [auth 4]	IPR041562	MCM, AAA-lid domain	Domain
C [auth 4]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
C [auth 4]	IPR027925	MCM, N-terminal domain	Domain
C [auth 4]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
C [auth 4]	IPR008047	Mini-chromosome maintenance complex protein 4	Family
C [auth 4]	IPR033762	MCM OB domain	Domain
C [auth 4]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
D [auth 5]	IPR031327	Mini-chromosome maintenance protein	Family
D [auth 5]	IPR018525	Mini-chromosome maintenance, conserved site	Conserved Site
D [auth 5]	IPR001208	MCM domain	Domain
D [auth 5]	IPR041562	MCM, AAA-lid domain	Domain
D [auth 5]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
D [auth 5]	IPR027925	MCM, N-terminal domain	Domain
D [auth 5]	IPR033762	MCM OB domain	Domain
D [auth 5]	IPR008048	DNA replication licensing factor Mcm5	Family
D [auth 5]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
E [auth 6]	IPR008049	DNA replication licensing factor Mcm6	Family
E [auth 6]	IPR041024	Mcm6, C-terminal winged-helix domain	Domain
E [auth 6]	IPR031327	Mini-chromosome maintenance protein	Family
E [auth 6]	IPR018525	Mini-chromosome maintenance, conserved site	Conserved Site
E [auth 6]	IPR001208	MCM domain	Domain
E [auth 6]	IPR041562	MCM, AAA-lid domain	Domain
E [auth 6]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
E [auth 6]	IPR027925	MCM, N-terminal domain	Domain
E [auth 6]	IPR033762	MCM OB domain	Domain
E [auth 6]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
F [auth 7]	IPR031327	Mini-chromosome maintenance protein	Family
F [auth 7]	IPR008050	DNA replication licensing factor Mcm7	Family
F [auth 7]	IPR018525	Mini-chromosome maintenance, conserved site	Conserved Site
F [auth 7]	IPR003593	AAA+ ATPase domain	Domain
F [auth 7]	IPR001208	MCM domain	Domain
F [auth 7]	IPR041562	MCM, AAA-lid domain	Domain
F [auth 7]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
F [auth 7]	IPR027925	MCM, N-terminal domain	Domain
F [auth 7]	IPR033762	MCM OB domain	Domain
F [auth 7]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily