6EWX

Structure of Pragmin pseudo-kinase reveals a dimerization mechanism to regulate protein tyrosine phosphorylation and nuclear transcription

External Resource: Annotation

Domain Annotation: ECOD Classification
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e6ewxA2	A: alpha duplicates or obligate multimers	X: split helical dimerization (SHED) domain (From Topology)	H: split helical dimerization (SHED) domain (From Topology)	T: split helical dimerization (SHED) domain	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF00069	e6ewxA1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: PF00069	ECOD (1.6)
B	F_UNCLASSIFIED	e6ewxB1	A: alpha duplicates or obligate multimers	X: split helical dimerization (SHED) domain (From Topology)	H: split helical dimerization (SHED) domain (From Topology)	T: split helical dimerization (SHED) domain	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF00069	e6ewxB2	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: PF00069	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	PEAK1-related kinase-activating pseudokinase 1	catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups identical protein binding protein binding binding	developmental process regulation of biological process regulation of developmental process biological regulation regulation of cell shape cell morphogenesis regulation of cell morphogenesis anatomical structure morphogenesis anatomical structure development regulation of biological quality regulation of anatomical structure morphogenesis cellular response to stimulus regulation of signaling regulation of cellular process developmental process regulation of biological process regulation of developmental process biological regulation regulation of cell shape cell morphogenesis regulation of cell morphogenesis anatomical structure morphogenesis anatomical structure development regulation of biological quality regulation of anatomical structure morphogenesis cellular response to stimulus regulation of signaling regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling regulation of signal transduction cell communication Notch signaling pathway regulation of response to stimulus regulation of Notch signaling pathway regulation of cell communication cellular process signal transduction regulation of cell motility regulation of locomotion cell motility locomotion positive regulation of cell communication small GTPase-mediated signal transduction positive regulation of signal transduction regulation of small GTPase mediated signal transduction positive regulation of biological process intracellular signal transduction Rho protein signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette positive regulation of cellular process positive regulation of intracellular signal transduction regulation of Rho protein signal transduction positive regulation of Rho protein signal transduction positive regulation of small GTPase mediated signal transduction positive regulation of signaling regulation of neuron projection development multicellular organismal process regulation of cellular component organization cellular developmental process cell projection organization negative regulation of biological process cell development neuron projection development cellular component organization neurogenesis multicellular organism development neuron differentiation cell differentiation negative regulation of cellular process cellular component organization or biogenesis negative regulation of cell projection organization system development plasma membrane bounded cell projection organization negative regulation of cellular component organization regulation of cell projection organization nervous system development negative regulation of neuron projection development generation of neurons neuron development regulation of plasma membrane bounded cell projection organization cell migration	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction intracellular anatomical structure cytoplasm membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR008266	Tyrosine-protein kinase, active site	Active Site
A, B	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, B	IPR000719	Protein kinase domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.