Annotations: 6EM9

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	RecA-like P-loop NTPases	8082859	3002019	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	RecA-like P-loop NTPases	8082859	3002019	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	RecA-like P-loop NTPases	8082859	3002019	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	RecA-like P-loop NTPases	8082859	3002019	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	RecA-like P-loop NTPases	8082859	3002019	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	RecA-like P-loop NTPases	8082859	3002019	SCOP2B (2022-06-29)
I [auth H]	SCOP2B Superfamily	RecA-like P-loop NTPases	8082859	3002019	SCOP2B (2022-06-29)
J [auth L]	SCOP2B Superfamily	RecA-like P-loop NTPases	8082859	3002019	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02861	e6em9A3	A: alpha arrays	X: Histone-like	H: Histone-related	T: double Clp-N	F: PF02861	ECOD (1.6)
A	PF10431	e6em9A1	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF10431	ECOD (1.6)
A	PF17871	e6em9A2	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17871	ECOD (1.6)
A	PF00004	e6em9A4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
A	PF07724	e6em9A5	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF07724	ECOD (1.6)
B	PF02861	e6em9B5	A: alpha arrays	X: Histone-like	H: Histone-related	T: double Clp-N	F: PF02861	ECOD (1.6)
B	PF10431	e6em9B4	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF10431	ECOD (1.6)
B	PF17871	e6em9B2	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17871	ECOD (1.6)
B	PF00004	e6em9B1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
B	PF07724	e6em9B3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF07724	ECOD (1.6)
C	PF10431	e6em9C1	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF10431	ECOD (1.6)
C	PF17871	e6em9C4	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17871	ECOD (1.6)
C	PF00004	e6em9C2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
C	PF07724	e6em9C3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF07724	ECOD (1.6)
D	PF10431	e6em9D3	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF10431	ECOD (1.6)
D	PF17871	e6em9D2	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17871	ECOD (1.6)
D	PF07724	e6em9D1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF07724	ECOD (1.6)
E	PF02861	e6em9E4	A: alpha arrays	X: Histone-like	H: Histone-related	T: double Clp-N	F: PF02861	ECOD (1.6)
E	PF17871	e6em9E3	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17871	ECOD (1.6)
E	PF00004	e6em9E2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
E	PF07724	e6em9E1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF07724	ECOD (1.6)
F	PF02861	e6em9F2	A: alpha arrays	X: Histone-like	H: Histone-related	T: double Clp-N	F: PF02861	ECOD (1.6)
F	PF10431	e6em9F1	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF10431	ECOD (1.6)
F	PF17871	e6em9F5	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17871	ECOD (1.6)
F	PF00004	e6em9F4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
F	PF07724	e6em9F3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF07724	ECOD (1.6)
G	PF02861	e6em9G2	A: alpha arrays	X: Histone-like	H: Histone-related	T: double Clp-N	F: PF02861	ECOD (1.6)
G	PF10431	e6em9G5	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF10431	ECOD (1.6)
G	PF17871	e6em9G4	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17871	ECOD (1.6)
G	PF00004	e6em9G3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
G	PF07724	e6em9G1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF07724	ECOD (1.6)
H [auth I]	PF10431	e6em9I3	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF10431	ECOD (1.6)
H [auth I]	PF17871	e6em9I2	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17871	ECOD (1.6)
H [auth I]	PF07724	e6em9I1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF07724	ECOD (1.6)
I [auth H]	PF10431	e6em9H1	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF10431	ECOD (1.6)
I [auth H]	PF17871	e6em9H2	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17871	ECOD (1.6)
I [auth H]	PF00004	e6em9H3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
I [auth H]	PF07724	e6em9H4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF07724	ECOD (1.6)
J [auth L]	PF02861	e6em9L1	A: alpha arrays	X: Histone-like	H: Histone-related	T: double Clp-N	F: PF02861	ECOD (1.6)
J [auth L]	PF17871	e6em9L2	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17871	ECOD (1.6)
J [auth L]	PF00004	e6em9L4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
J [auth L]	PF07724	e6em9L3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF07724	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E, A, B, C, D, E, F, G, H [auth I], I [auth H], J [auth L]	PF10431	C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)	C-terminal, D2-small domain, of ClpB protein	This is the C-terminal domain of ClpB protein, referred to as the D2-small domain, and is a mixed alpha-beta structure. Compared with the D1-small domain (included in AAA, Pfam:PF00004) it lacks the long coiled-coil insertion, and instead of helix C4 ...	This is the C-terminal domain of ClpB protein, referred to as the D2-small domain, and is a mixed alpha-beta structure. Compared with the D1-small domain (included in AAA, Pfam:PF00004) it lacks the long coiled-coil insertion, and instead of helix C4 contains a beta-strand (e3) that is part of a three stranded beta-pleated sheet. In Thermophilus the whole protein forms a hexamer with the D1-small and D2-small domains located on the outside of the hexamer, with the long coiled-coil being exposed on the surface. The D2-small domain is essential for oligomerisation, forming a tight interface with the D2-large domain of a neighbouring subunit and thereby providing enough binding energy to stabilise the functional assembly [1]. The domain is associated with two Clp_N, Pfam:PF02861, at the N-terminus as well as AAA, Pfam:PF00004 and AAA_2, Pfam:PF07724.	Domain
A, B, C, D, E, A, B, C, D, E, F, G, H [auth I], I [auth H], J [auth L]	PF17871	AAA lid domain (AAA_lid_9)	AAA lid domain	This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.	Domain
A, B, C, D, E, A, B, C, D, E, F, G, H [auth I], I [auth H], J [auth L]	PF02861	Clp amino terminal domain, pathogenicity island component (Clp_N)	Clp amino terminal domain, pathogenicity island component	-	Family
A, B, C, D, E, A, B, C, D, E, F, G, H [auth I], I [auth H], J [auth L]	PF00004	ATPase family associated with various cellular activities (AAA) (AAA)	ATPase family associated with various cellular activities (AAA)	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	Domain
A, B, C, D, E, A, B, C, D, E, F, G, H [auth I], I [auth H], J [auth L]	PF07724	AAA domain (Cdc48 subfamily) (AAA_2)	AAA domain (Cdc48 subfamily)	This Pfam entry includes some of the AAA proteins not detected by the Pfam:PF00004 model.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E, A, B, C, D, E, F, G, H [auth I], I [auth H], J [auth L]	ATP-dependent Clp protease ATP-binding subunit ClpC	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E, A, B, C, D, E, F, G, H [auth I], I [auth H], J [auth L]	IPR001270	ClpA/B family	Family
A, B, C, D, E, A, B, C, D, E, F, G, H [auth I], I [auth H], J [auth L]	IPR018368	ClpA/B, conserved site 1	Conserved Site
A, B, C, D, E, A, B, C, D, E, F, G, H [auth I], I [auth H], J [auth L]	IPR041546	ClpA/ClpB, AAA lid domain	Domain
A, B, C, D, E, A, B, C, D, E, F, G, H [auth I], I [auth H], J [auth L]	IPR004176	Clp, repeat (R) domain	Domain
A, B, C, D, E, A, B, C, D, E, F, G, H [auth I], I [auth H], J [auth L]	IPR028299	ClpA/B, conserved site 2	Conserved Site
A, B, C, D, E, A, B, C, D, E, F, G, H [auth I], I [auth H], J [auth L]	IPR003593	AAA+ ATPase domain	Domain
A, B, C, D, E, A, B, C, D, E, F, G, H [auth I], I [auth H], J [auth L]	IPR003959	ATPase, AAA-type, core	Domain
A, B, C, D, E, A, B, C, D, E, F, G, H [auth I], I [auth H], J [auth L]	IPR001943	UVR domain	Domain
A, B, C, D, E, A, B, C, D, E, F, G, H [auth I], I [auth H], J [auth L]	IPR019489	Clp ATPase, C-terminal	Domain
A, B, C, D, E, A, B, C, D, E, F, G, H [auth I], I [auth H], J [auth L]	IPR036628	Clp, N-terminal domain superfamily	Homologous Superfamily
A, B, C, D, E, A, B, C, D, E, F, G, H [auth I], I [auth H], J [auth L]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily