6EL3

Structure of Progesterone 5beta-Reductase from Arabidopsis thaliana in complex with NADP

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF22917	e6el3A1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF22917	ECOD (1.6)
C	PF22917	e6el3C1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF22917	ECOD (1.6)
F	PF22917	e6el3F1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF22917	ECOD (1.6)
B	PF22917	e6el3B1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF22917	ECOD (1.6)
D	PF22917	e6el3D1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF22917	ECOD (1.6)
E	PF22917	e6el3E1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF22917	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
C	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
F	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
B	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
D	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
E	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01370	NAD dependent epimerase/dehydratase family (Epimerase)	NAD dependent epimerase/dehydratase family	-	Family
C	PF01370	NAD dependent epimerase/dehydratase family (Epimerase)	NAD dependent epimerase/dehydratase family	-	Family
F	PF01370	NAD dependent epimerase/dehydratase family (Epimerase)	NAD dependent epimerase/dehydratase family	-	Family
B	PF01370	NAD dependent epimerase/dehydratase family (Epimerase)	NAD dependent epimerase/dehydratase family	-	Family
D	PF01370	NAD dependent epimerase/dehydratase family (Epimerase)	NAD dependent epimerase/dehydratase family	-	Family
E	PF01370	NAD dependent epimerase/dehydratase family (Epimerase)	NAD dependent epimerase/dehydratase family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	3-oxo-Delta(4,5)-steroid 5-beta-reductase	enone reductase activity oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor Delta4-3-oxosteroid 5beta-reductase activity oxidoreductase activity, acting on the CH-CH group of donors catalytic activity protein binding binding protein dimerization activity	organic cyclic compound metabolic process organic substance metabolic process steroid metabolic process metabolic process primary metabolic process lipid metabolic process developmental process multicellular organism development multicellular organismal process xylem and phloem pattern formation anatomical structure development pattern specification process regionalization response to stimulus organic cyclic compound metabolic process organic substance metabolic process steroid metabolic process metabolic process primary metabolic process lipid metabolic process developmental process multicellular organism development multicellular organismal process xylem and phloem pattern formation anatomical structure development pattern specification process regionalization response to stimulus response to stress response to wounding	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol
C	3-oxo-Delta(4,5)-steroid 5-beta-reductase	enone reductase activity oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor Delta4-3-oxosteroid 5beta-reductase activity oxidoreductase activity, acting on the CH-CH group of donors catalytic activity protein binding binding protein dimerization activity	organic cyclic compound metabolic process organic substance metabolic process steroid metabolic process metabolic process primary metabolic process lipid metabolic process developmental process multicellular organism development multicellular organismal process xylem and phloem pattern formation anatomical structure development pattern specification process regionalization response to stimulus organic cyclic compound metabolic process organic substance metabolic process steroid metabolic process metabolic process primary metabolic process lipid metabolic process developmental process multicellular organism development multicellular organismal process xylem and phloem pattern formation anatomical structure development pattern specification process regionalization response to stimulus response to stress response to wounding	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol
F	3-oxo-Delta(4,5)-steroid 5-beta-reductase	enone reductase activity oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor Delta4-3-oxosteroid 5beta-reductase activity oxidoreductase activity, acting on the CH-CH group of donors catalytic activity protein binding binding protein dimerization activity	organic cyclic compound metabolic process organic substance metabolic process steroid metabolic process metabolic process primary metabolic process lipid metabolic process developmental process multicellular organism development multicellular organismal process xylem and phloem pattern formation anatomical structure development pattern specification process regionalization response to stimulus organic cyclic compound metabolic process organic substance metabolic process steroid metabolic process metabolic process primary metabolic process lipid metabolic process developmental process multicellular organism development multicellular organismal process xylem and phloem pattern formation anatomical structure development pattern specification process regionalization response to stimulus response to stress response to wounding	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol
B	3-oxo-Delta(4,5)-steroid 5-beta-reductase	enone reductase activity oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor Delta4-3-oxosteroid 5beta-reductase activity oxidoreductase activity, acting on the CH-CH group of donors catalytic activity protein binding binding protein dimerization activity	organic cyclic compound metabolic process organic substance metabolic process steroid metabolic process metabolic process primary metabolic process lipid metabolic process developmental process multicellular organism development multicellular organismal process xylem and phloem pattern formation anatomical structure development pattern specification process regionalization response to stimulus organic cyclic compound metabolic process organic substance metabolic process steroid metabolic process metabolic process primary metabolic process lipid metabolic process developmental process multicellular organism development multicellular organismal process xylem and phloem pattern formation anatomical structure development pattern specification process regionalization response to stimulus response to stress response to wounding	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol
D	3-oxo-Delta(4,5)-steroid 5-beta-reductase	enone reductase activity oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor Delta4-3-oxosteroid 5beta-reductase activity oxidoreductase activity, acting on the CH-CH group of donors catalytic activity protein binding binding protein dimerization activity	organic cyclic compound metabolic process organic substance metabolic process steroid metabolic process metabolic process primary metabolic process lipid metabolic process developmental process multicellular organism development multicellular organismal process xylem and phloem pattern formation anatomical structure development pattern specification process regionalization response to stimulus organic cyclic compound metabolic process organic substance metabolic process steroid metabolic process metabolic process primary metabolic process lipid metabolic process developmental process multicellular organism development multicellular organismal process xylem and phloem pattern formation anatomical structure development pattern specification process regionalization response to stimulus response to stress response to wounding	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol
E	3-oxo-Delta(4,5)-steroid 5-beta-reductase	enone reductase activity oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor Delta4-3-oxosteroid 5beta-reductase activity oxidoreductase activity, acting on the CH-CH group of donors catalytic activity protein binding binding protein dimerization activity	organic cyclic compound metabolic process organic substance metabolic process steroid metabolic process metabolic process primary metabolic process lipid metabolic process developmental process multicellular organism development multicellular organismal process xylem and phloem pattern formation anatomical structure development pattern specification process regionalization response to stimulus organic cyclic compound metabolic process organic substance metabolic process steroid metabolic process metabolic process primary metabolic process lipid metabolic process developmental process multicellular organism development multicellular organismal process xylem and phloem pattern formation anatomical structure development pattern specification process regionalization response to stimulus response to stress response to wounding	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A	IPR001509	NAD-dependent epimerase/dehydratase	Domain
C	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
C	IPR001509	NAD-dependent epimerase/dehydratase	Domain
F	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
F	IPR001509	NAD-dependent epimerase/dehydratase	Domain
B	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
B	IPR001509	NAD-dependent epimerase/dehydratase	Domain
D	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
D	IPR001509	NAD-dependent epimerase/dehydratase	Domain
E	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
E	IPR001509	NAD-dependent epimerase/dehydratase	Domain

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A	MLY	Parent Component: LYS RESID: AA0075 PSI-MOD : N6,N6-dimethyl-L-lysine MOD:00084
C	MLY	Parent Component: LYS RESID: AA0075 , AA0075 PSI-MOD : N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084
F	MLY	Parent Component: LYS RESID: AA0075 , AA0075 , AA0075 PSI-MOD : N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084
B	MLY	Parent Component: LYS RESID: AA0075 , AA0075 , AA0075 , AA0075 PSI-MOD : N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084
D	MLY	Parent Component: LYS RESID: AA0075 , AA0075 , AA0075 , AA0075 , AA0075 PSI-MOD : N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084
E	MLY	Parent Component: LYS RESID: AA0075 , AA0075 , AA0075 , AA0075 , AA0075 , AA0075 PSI-MOD : N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.