6EKK
Crystal structure of GEF domain of DENND 1A in complex with Rab GTPase Rab35-GDP bound state.
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
C | d6ekkc_ | Alpha and beta proteins (a/b) | P-loop containing nucleoside triphosphate hydrolases | P-loop containing nucleoside triphosphate hydrolases | automated matches | automated matches | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
D | d6ekkd_ | Alpha and beta proteins (a/b) | P-loop containing nucleoside triphosphate hydrolases | P-loop containing nucleoside triphosphate hydrolases | automated matches | automated matches | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | uDENN | e6ekkA1 | A: a+b three layers | X: Profilin-like | H: profilin-like (From Topology) | T: profilin-like | F: uDENN | ECOD (1.6) |
A | DENN | e6ekkA2 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: Differentially expressed in normal cells and neoplasia (DENN) domain (From Topology) | T: Differentially expressed in normal cells and neoplasia (DENN) domain | F: DENN | ECOD (1.6) |
B | uDENN | e6ekkB1 | A: a+b three layers | X: Profilin-like | H: profilin-like (From Topology) | T: profilin-like | F: uDENN | ECOD (1.6) |
B | DENN | e6ekkB2 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: Differentially expressed in normal cells and neoplasia (DENN) domain (From Topology) | T: Differentially expressed in normal cells and neoplasia (DENN) domain | F: DENN | ECOD (1.6) |
C | Ras | e6ekkC1 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: Ras | ECOD (1.6) |
D | Ras | e6ekkD1 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: Ras | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
C | 3.40.50.300 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | P-loop containing nucleotide triphosphate hydrolases | CATH (4.3.0) |
D | 3.40.50.300 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | P-loop containing nucleotide triphosphate hydrolases | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF02141 | DENN (AEX-3) domain (DENN) | DENN (AEX-3) domain | - | Family | |
PF03455 | dDENN domain (dDENN) | dDENN domain | This region is always found associated with Pfam:PF02141. It is predicted to form a globular domain [1]. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family [1]. This N ... | Domain | |
PF03456 | uDENN domain (uDENN) | uDENN domain | This region is always found associated with Pfam:PF02141. It is predicted to form an all beta domain [1]. | Domain | |
PF00071 | Ras family (Ras) | Ras family | Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motil ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR005113 | uDENN domain | Domain | |
IPR037516 | Tripartite DENN domain | Domain | |
IPR005112 | dDENN domain | Domain | |
IPR043153 | DENN domain, C-terminal lobe | Homologous Superfamily | |
IPR040032 | DENN domain-containing protein 1A/1B/1C | Family | |
IPR001194 | cDENN domain | Domain | |
IPR027417 | P-loop containing nucleoside triphosphate hydrolase | Homologous Superfamily | |
IPR001806 | Small GTPase | Family | |
IPR041815 | Rab35 | Family | |
IPR005225 | Small GTP-binding protein domain | Domain |