Annotations: 6EJF

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth G]	F_UNCLASSIFIED	e6ejfG2	A: alpha arrays	X: MshE c-di-GMP-binding domain (From Topology)	H: MshE c-di-GMP-binding domain (From Topology)	T: MshE c-di-GMP-binding domain	F: F_UNCLASSIFIED	ECOD (1.6)
A [auth G]	PF05157	e6ejfG1	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: GSPII protein E N-terminal domain-like (From Topology)	T: GSPII protein E N-terminal domain-like	F: PF05157	ECOD (1.6)
F [auth I]	F_UNCLASSIFIED	e6ejfI2	A: alpha arrays	X: MshE c-di-GMP-binding domain (From Topology)	H: MshE c-di-GMP-binding domain (From Topology)	T: MshE c-di-GMP-binding domain	F: F_UNCLASSIFIED	ECOD (1.6)
F [auth I]	PF05157	e6ejfI1	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: GSPII protein E N-terminal domain-like (From Topology)	T: GSPII protein E N-terminal domain-like	F: PF05157	ECOD (1.6)
G [auth M]	F_UNCLASSIFIED	e6ejfM2	A: alpha arrays	X: MshE c-di-GMP-binding domain (From Topology)	H: MshE c-di-GMP-binding domain (From Topology)	T: MshE c-di-GMP-binding domain	F: F_UNCLASSIFIED	ECOD (1.6)
G [auth M]	PF05157	e6ejfM1	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: GSPII protein E N-terminal domain-like (From Topology)	T: GSPII protein E N-terminal domain-like	F: PF05157	ECOD (1.6)
K [auth Q]	F_UNCLASSIFIED	e6ejfQ2	A: alpha arrays	X: MshE c-di-GMP-binding domain (From Topology)	H: MshE c-di-GMP-binding domain (From Topology)	T: MshE c-di-GMP-binding domain	F: F_UNCLASSIFIED	ECOD (1.6)
K [auth Q]	PF05157	e6ejfQ1	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: GSPII protein E N-terminal domain-like (From Topology)	T: GSPII protein E N-terminal domain-like	F: PF05157	ECOD (1.6)
L [auth R]	F_UNCLASSIFIED	e6ejfR2	A: alpha arrays	X: MshE c-di-GMP-binding domain (From Topology)	H: MshE c-di-GMP-binding domain (From Topology)	T: MshE c-di-GMP-binding domain	F: F_UNCLASSIFIED	ECOD (1.6)
L [auth R]	PF05157	e6ejfR1	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: GSPII protein E N-terminal domain-like (From Topology)	T: GSPII protein E N-terminal domain-like	F: PF05157	ECOD (1.6)
E [auth H]	F_UNCLASSIFIED	e6ejfH1	A: alpha arrays	X: MshE c-di-GMP-binding domain (From Topology)	H: MshE c-di-GMP-binding domain (From Topology)	T: MshE c-di-GMP-binding domain	F: F_UNCLASSIFIED	ECOD (1.6)
E [auth H]	PF05157	e6ejfH2	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: GSPII protein E N-terminal domain-like (From Topology)	T: GSPII protein E N-terminal domain-like	F: PF05157	ECOD (1.6)
B [auth J]	F_UNCLASSIFIED	e6ejfJ1	A: alpha arrays	X: MshE c-di-GMP-binding domain (From Topology)	H: MshE c-di-GMP-binding domain (From Topology)	T: MshE c-di-GMP-binding domain	F: F_UNCLASSIFIED	ECOD (1.6)
B [auth J]	PF05157	e6ejfJ2	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: GSPII protein E N-terminal domain-like (From Topology)	T: GSPII protein E N-terminal domain-like	F: PF05157	ECOD (1.6)
D [auth L]	F_UNCLASSIFIED	e6ejfL2	A: alpha arrays	X: MshE c-di-GMP-binding domain (From Topology)	H: MshE c-di-GMP-binding domain (From Topology)	T: MshE c-di-GMP-binding domain	F: F_UNCLASSIFIED	ECOD (1.6)
D [auth L]	PF05157	e6ejfL1	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: GSPII protein E N-terminal domain-like (From Topology)	T: GSPII protein E N-terminal domain-like	F: PF05157	ECOD (1.6)
H [auth N]	F_UNCLASSIFIED	e6ejfN1	A: alpha arrays	X: MshE c-di-GMP-binding domain (From Topology)	H: MshE c-di-GMP-binding domain (From Topology)	T: MshE c-di-GMP-binding domain	F: F_UNCLASSIFIED	ECOD (1.6)
H [auth N]	PF05157	e6ejfN2	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: GSPII protein E N-terminal domain-like (From Topology)	T: GSPII protein E N-terminal domain-like	F: PF05157	ECOD (1.6)
I [auth O]	F_UNCLASSIFIED	e6ejfO1	A: alpha arrays	X: MshE c-di-GMP-binding domain (From Topology)	H: MshE c-di-GMP-binding domain (From Topology)	T: MshE c-di-GMP-binding domain	F: F_UNCLASSIFIED	ECOD (1.6)
I [auth O]	PF05157	e6ejfO2	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: GSPII protein E N-terminal domain-like (From Topology)	T: GSPII protein E N-terminal domain-like	F: PF05157	ECOD (1.6)
J [auth P]	F_UNCLASSIFIED	e6ejfP1	A: alpha arrays	X: MshE c-di-GMP-binding domain (From Topology)	H: MshE c-di-GMP-binding domain (From Topology)	T: MshE c-di-GMP-binding domain	F: F_UNCLASSIFIED	ECOD (1.6)
J [auth P]	PF05157	e6ejfP2	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: GSPII protein E N-terminal domain-like (From Topology)	T: GSPII protein E N-terminal domain-like	F: PF05157	ECOD (1.6)
C [auth K]	F_UNCLASSIFIED	e6ejfK2	A: alpha arrays	X: MshE c-di-GMP-binding domain (From Topology)	H: MshE c-di-GMP-binding domain (From Topology)	T: MshE c-di-GMP-binding domain	F: F_UNCLASSIFIED	ECOD (1.6)
C [auth K]	PF05157	e6ejfK1	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: GSPII protein E N-terminal domain-like (From Topology)	T: GSPII protein E N-terminal domain-like	F: PF05157	ECOD (1.6)
N [auth B]	PF00437	e6ejfB1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00437	ECOD (1.6)
O [auth C]	PF00437	e6ejfC1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00437	ECOD (1.6)
P [auth D]	PF00437	e6ejfD1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00437	ECOD (1.6)
Q [auth E]	PF00437	e6ejfE1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00437	ECOD (1.6)
R [auth F]	PF00437	e6ejfF1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00437	ECOD (1.6)
M [auth A]	PF00437	e6ejfA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00437	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth G], E [auth H], F [auth I], G [auth M], K [auth Q], A [auth G], E [auth H], F [auth I], G [auth M], K [auth Q], L [auth R]	PF05157	MshEN domain (MshEN)	MshEN domain	This domain is found at the N-terminus of the Type II secretion secretion system protein E (GspE) and type IV pilus extensin ATPase PilB and near the C-terminus of the glycosyltransferase NfrB. A variant of this domain, called MshEN, binds cyclic di- ...	This domain is found at the N-terminus of the Type II secretion secretion system protein E (GspE) and type IV pilus extensin ATPase PilB and near the C-terminus of the glycosyltransferase NfrB. A variant of this domain, called MshEN, binds cyclic di-GMP [4,6,7], which modulates the activity of the respective protein. The structure of this domain is now known [1,2,4].	Domain
B [auth J], C [auth K], D [auth L], H [auth N], I [auth O], B [auth J], C [auth K], D [auth L], H [auth N], I [auth O], J [auth P]	PF05157	MshEN domain (MshEN)	MshEN domain	This domain is found at the N-terminus of the Type II secretion secretion system protein E (GspE) and type IV pilus extensin ATPase PilB and near the C-terminus of the glycosyltransferase NfrB. A variant of this domain, called MshEN, binds cyclic di- ...	This domain is found at the N-terminus of the Type II secretion secretion system protein E (GspE) and type IV pilus extensin ATPase PilB and near the C-terminus of the glycosyltransferase NfrB. A variant of this domain, called MshEN, binds cyclic di-GMP [4,6,7], which modulates the activity of the respective protein. The structure of this domain is now known [1,2,4].	Domain
M [auth A], N [auth B], O [auth C], P [auth D], Q [auth E], M [auth A], N [auth B], O [auth C], P [auth D], Q [auth E], R [auth F]	PF00437	Type II/IV secretion system protein (T2SSE)	Type II/IV secretion system protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth G], E [auth H], F [auth I], G [auth M], K [auth Q], A [auth G], E [auth H], F [auth I], G [auth M], K [auth Q], L [auth R]	Type IV pilus assembly protein PilF	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cation binding metal ion binding	-	intracellular anatomical structure cytoplasm cellular anatomical entity
B [auth J], C [auth K], D [auth L], H [auth N], I [auth O], B [auth J], C [auth K], D [auth L], H [auth N], I [auth O], J [auth P]	Type IV pilus assembly protein PilF	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cation binding metal ion binding	-	intracellular anatomical structure cytoplasm cellular anatomical entity
M [auth A], N [auth B], O [auth C], P [auth D], Q [auth E], M [auth A], N [auth B], O [auth C], P [auth D], Q [auth E], R [auth F]	Type IV pilus assembly protein PilF	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cation binding metal ion binding	-	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth G], E [auth H], F [auth I], G [auth M], K [auth Q], A [auth G], E [auth H], F [auth I], G [auth M], K [auth Q], L [auth R]	IPR001482	Type II/IV secretion system domain	Domain
A [auth G], E [auth H], F [auth I], G [auth M], K [auth Q], A [auth G], E [auth H], F [auth I], G [auth M], K [auth Q], L [auth R]	IPR037257	Type II secretion system protein GspE, N-terminal superfamily	Homologous Superfamily
A [auth G], E [auth H], F [auth I], G [auth M], K [auth Q], A [auth G], E [auth H], F [auth I], G [auth M], K [auth Q], L [auth R]	IPR007831	Type II secretion system protein GspE, N-terminal	Domain
A [auth G], E [auth H], F [auth I], G [auth M], K [auth Q], A [auth G], E [auth H], F [auth I], G [auth M], K [auth Q], L [auth R]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B [auth J], C [auth K], D [auth L], H [auth N], I [auth O], B [auth J], C [auth K], D [auth L], H [auth N], I [auth O], J [auth P]	IPR001482	Type II/IV secretion system domain	Domain
B [auth J], C [auth K], D [auth L], H [auth N], I [auth O], B [auth J], C [auth K], D [auth L], H [auth N], I [auth O], J [auth P]	IPR037257	Type II secretion system protein GspE, N-terminal superfamily	Homologous Superfamily
B [auth J], C [auth K], D [auth L], H [auth N], I [auth O], B [auth J], C [auth K], D [auth L], H [auth N], I [auth O], J [auth P]	IPR007831	Type II secretion system protein GspE, N-terminal	Domain
B [auth J], C [auth K], D [auth L], H [auth N], I [auth O], B [auth J], C [auth K], D [auth L], H [auth N], I [auth O], J [auth P]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
M [auth A], N [auth B], O [auth C], P [auth D], Q [auth E], M [auth A], N [auth B], O [auth C], P [auth D], Q [auth E], R [auth F]	IPR001482	Type II/IV secretion system domain	Domain
M [auth A], N [auth B], O [auth C], P [auth D], Q [auth E], M [auth A], N [auth B], O [auth C], P [auth D], Q [auth E], R [auth F]	IPR037257	Type II secretion system protein GspE, N-terminal superfamily	Homologous Superfamily
M [auth A], N [auth B], O [auth C], P [auth D], Q [auth E], M [auth A], N [auth B], O [auth C], P [auth D], Q [auth E], R [auth F]	IPR007831	Type II secretion system protein GspE, N-terminal	Domain
M [auth A], N [auth B], O [auth C], P [auth D], Q [auth E], M [auth A], N [auth B], O [auth C], P [auth D], Q [auth E], R [auth F]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily