6DX7

Crystal structure of chalcone synthase from Physcomitrella patens

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6dx7a1	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	automated matches	automated matches	Moss (Physcomitrium patens ) [TaxId: 3218 ],	SCOPe (2.08)
B	d6dx7b1	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	automated matches	automated matches	Moss (Physcomitrium patens ) [TaxId: 3218 ],	SCOPe (2.08)
C	d6dx7c1	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	automated matches	automated matches	Moss (Physcomitrium patens ) [TaxId: 3218 ],	SCOPe (2.08)
D	d6dx7d1	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	automated matches	automated matches	Moss (Physcomitrium patens ) [TaxId: 3218 ],	SCOPe (2.08)
E	d6dx7e1	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	automated matches	automated matches	Moss (Physcomitrium patens ) [TaxId: 3218 ],	SCOPe (2.08)
F	d6dx7f1	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	automated matches	automated matches	Moss (Physcomitrium patens ) [TaxId: 3218 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00195	e6dx7A3	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF00195	ECOD (1.6)
A	PF02797	e6dx7A2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF02797	ECOD (1.6)
B	PF00195	e6dx7B2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF00195	ECOD (1.6)
B	PF02797	e6dx7B1	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF02797	ECOD (1.6)
C	PF00195	e6dx7C2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF00195	ECOD (1.6)
C	PF02797	e6dx7C1	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF02797	ECOD (1.6)
D	PF00195	e6dx7D2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF00195	ECOD (1.6)
D	PF02797	e6dx7D1	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF02797	ECOD (1.6)
E	PF00195	e6dx7E2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF00195	ECOD (1.6)
E	PF02797	e6dx7E1	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF02797	ECOD (1.6)
F	PF00195	e6dx7F1	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF00195	ECOD (1.6)
F	PF02797	e6dx7F2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF02797	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)
B	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)
C	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)
D	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)
E	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)
F	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF00195	Chalcone and stilbene synthases, N-terminal domain (Chal_sti_synt_N)	Chalcone and stilbene synthases, N-terminal domain	The C-terminal domain of Chalcone synthase is reported to be structurally similar to domains in thiolase and beta-ketoacyl synthase. The differences in activity are accounted for by differences in this N-terminal domain.	Domain
A, B, C, D, E A, B, C, D, E, F	PF02797	Chalcone and stilbene synthases, C-terminal domain (Chal_sti_synt_C)	Chalcone and stilbene synthases, C-terminal domain	This domain of chalcone synthase is reported to be structurally similar to domains in thiolase and beta-ketoacyl synthase. The differences in activity are accounted for by differences in the N-terminal domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Chalcone synthase	acyltransferase activity chalcone synthase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity naringenin-chalcone synthase activity	organic substance metabolic process polyketide biosynthetic process secondary metabolite biosynthetic process biosynthetic process polyketide metabolic process organic substance biosynthetic process metabolic process secondary metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR001099	Chalcone/stilbene synthase, N-terminal	Domain
A, B, C, D, E A, B, C, D, E, F	IPR016039	Thiolase-like	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR012328	Chalcone/stilbene synthase, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F	IPR011141	Polyketide synthase, type III	Family
A, B, C, D, E A, B, C, D, E, F	IPR018088	Chalcone/stilbene synthase, active site	Active Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.