6DW1

Cryo-EM structure of the benzodiazepine-sensitive alpha1beta1gamma2S tri-heteromeric GABAA receptor in complex with GABA (ECD map)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth D]	d6dw1d_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	automated matches	automated matches	Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
B [auth C]	d6dw1c_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	automated matches	automated matches	Rat (Rattus norvegicus ) [TaxId: 10116 ], Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
C [auth A]	d6dw1a_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	automated matches	automated matches	Rat (Rattus norvegicus ) [TaxId: 10116 ], Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
E [auth B]	d6dw1b_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	automated matches	automated matches	Rat (Rattus norvegicus ) [TaxId: 10116 ], Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
D [auth E]	d6dw1e_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	automated matches	automated matches	Rat (Rattus norvegicus ) [TaxId: 10116 ], Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth D]	PF02931	e6dw1D1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: PF02931	ECOD (1.6)
B [auth C]	PF02931	e6dw1C1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: PF02931	ECOD (1.6)
C [auth A]	PF02931	e6dw1A1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: PF02931	ECOD (1.6)
E [auth B]	PF02931	e6dw1B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: PF02931	ECOD (1.6)
D [auth E]	PF02931	e6dw1E1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: PF02931	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth D]	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (utative)
B [auth C]	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (utative)
C [auth A]	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (utative)
E [auth B]	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (utative)
D [auth E]	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth D]	PF02931	Neurotransmitter-gated ion-channel ligand binding domain (Neur_chan_LBD)	Neurotransmitter-gated ion-channel ligand binding domain	-	Family
B [auth C], C [auth A]	PF02931	Neurotransmitter-gated ion-channel ligand binding domain (Neur_chan_LBD)	Neurotransmitter-gated ion-channel ligand binding domain	-	Family
D [auth E], E [auth B]	PF02931	Neurotransmitter-gated ion-channel ligand binding domain (Neur_chan_LBD)	Neurotransmitter-gated ion-channel ligand binding domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth D]	Gamma-aminobutyric acid receptor subunit gamma-2	gated channel activity monoatomic ion channel activity inhibitory extracellular ligand-gated monoatomic ion channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity passive transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity transmitter-gated monoatomic ion channel activity monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity gated channel activity monoatomic ion channel activity inhibitory extracellular ligand-gated monoatomic ion channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity passive transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity transmitter-gated monoatomic ion channel activity monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity molecular transducer activity neurotransmitter receptor activity inorganic molecular entity transmembrane transporter activity GABA-gated chloride ion channel activity signaling receptor activity ligand-gated monoatomic anion channel activity transmitter-gated channel activity monoatomic anion channel activity inorganic anion transmembrane transporter activity chloride channel activity GABA-A receptor activity GABA receptor activity transmembrane signaling receptor activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential postsynaptic neurotransmitter receptor activity neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	transport monoatomic ion transmembrane transport inorganic ion transmembrane transport inorganic anion transmembrane transport establishment of localization chloride transport transmembrane transport localization chloride transmembrane transport monoatomic anion transport monoatomic anion transmembrane transport monoatomic ion transport cellular process inorganic anion transport transport monoatomic ion transmembrane transport inorganic ion transmembrane transport inorganic anion transmembrane transport establishment of localization chloride transport transmembrane transport localization chloride transmembrane transport monoatomic anion transport monoatomic anion transmembrane transport monoatomic ion transport cellular process inorganic anion transport cellular response to stimulus cellular response to nitrogen compound response to organic substance response to stimulus response to organonitrogen compound response to endogenous stimulus cellular response to organic cyclic compound response to nitrogen compound cellular response to endogenous stimulus cellular response to chemical stimulus response to histamine cellular response to organonitrogen compound response to chemical cellular response to histamine cellular response to organic substance response to organic cyclic compound behavior adult behavior multicellular organismal process regulation of biological process signaling biological regulation cell-cell signaling gamma-aminobutyric acid signaling pathway cell communication regulation of postsynaptic membrane potential regulation of biological quality regulation of membrane potential developmental process inhibitory synapse assembly nervous system development cellular component organization cellular component biogenesis multicellular organism development cell junction organization cellular component assembly cell junction assembly anatomical structure development synapse organization cellular component organization or biogenesis synapse assembly system development trans-synaptic signaling synaptic signaling anterograde trans-synaptic signaling chemical synaptic transmission synaptic transmission, GABAergic post-embryonic development	protein-containing complex transmembrane transporter complex membrane chloride channel complex membrane protein complex cellular anatomical entity transporter complex monoatomic ion channel complex GABA receptor complex receptor complex cell periphery plasma membrane postsynaptic specialization membrane postsynaptic specialization protein-containing complex transmembrane transporter complex membrane chloride channel complex membrane protein complex cellular anatomical entity transporter complex monoatomic ion channel complex GABA receptor complex receptor complex cell periphery plasma membrane postsynaptic specialization membrane postsynaptic specialization synapse synaptic membrane postsynapse organelle postsynaptic membrane cell junction plasma membrane region GABA-A receptor complex GABA-ergic synapse glutamatergic synapse cell projection neuron projection plasma membrane bounded cell projection membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle cytoplasm vesicle organelle membrane cell leading edge leading edge membrane somatodendritic compartment neuron projection membrane dendrite membrane dendrite dendritic tree cell projection membrane axon inhibitory synapse
B [auth C], C [auth A]	Gamma-aminobutyric acid receptor subunit alpha-1,Gamma-aminobutyric acid receptor subunit alpha-1	gated channel activity monoatomic ion channel activity inhibitory extracellular ligand-gated monoatomic ion channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity passive transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity transmitter-gated monoatomic ion channel activity monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity gated channel activity monoatomic ion channel activity inhibitory extracellular ligand-gated monoatomic ion channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity passive transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity transmitter-gated monoatomic ion channel activity monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity molecular transducer activity neurotransmitter receptor activity inorganic molecular entity transmembrane transporter activity GABA-gated chloride ion channel activity signaling receptor activity ligand-gated monoatomic anion channel activity transmitter-gated channel activity monoatomic anion channel activity inorganic anion transmembrane transporter activity chloride channel activity ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential GABA-A receptor activity GABA receptor activity transmembrane signaling receptor activity binding organic cyclic compound binding diazepam binding transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential postsynaptic neurotransmitter receptor activity neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	transport monoatomic ion transmembrane transport inorganic ion transmembrane transport inorganic anion transmembrane transport establishment of localization chloride transport transmembrane transport localization chloride transmembrane transport monoatomic anion transport monoatomic anion transmembrane transport monoatomic ion transport cellular process inorganic anion transport transport monoatomic ion transmembrane transport inorganic ion transmembrane transport inorganic anion transmembrane transport establishment of localization chloride transport transmembrane transport localization chloride transmembrane transport monoatomic anion transport monoatomic anion transmembrane transport monoatomic ion transport cellular process inorganic anion transport cellular response to stimulus cellular response to nitrogen compound response to organic substance response to stimulus response to organonitrogen compound response to endogenous stimulus cellular response to organic cyclic compound response to nitrogen compound cellular response to endogenous stimulus cellular response to chemical stimulus response to histamine cellular response to organonitrogen compound response to chemical cellular response to histamine cellular response to organic substance response to organic cyclic compound regulation of biological process signaling biological regulation cell-cell signaling gamma-aminobutyric acid signaling pathway cell communication regulation of postsynaptic membrane potential regulation of biological quality regulation of membrane potential developmental process multicellular organismal process inhibitory synapse assembly nervous system development cellular component organization cellular component biogenesis multicellular organism development cell junction organization cellular component assembly cell junction assembly anatomical structure development synapse organization cellular component organization or biogenesis synapse assembly system development trans-synaptic signaling synaptic transmission, GABAergic chemical synaptic transmission synaptic signaling anterograde trans-synaptic signaling	protein-containing complex transmembrane transporter complex membrane chloride channel complex membrane protein complex cellular anatomical entity transporter complex monoatomic ion channel complex GABA receptor complex receptor complex cell periphery plasma membrane postsynaptic specialization membrane postsynaptic specialization protein-containing complex transmembrane transporter complex membrane chloride channel complex membrane protein complex cellular anatomical entity transporter complex monoatomic ion channel complex GABA receptor complex receptor complex cell periphery plasma membrane postsynaptic specialization membrane postsynaptic specialization synapse synaptic membrane postsynapse organelle postsynaptic membrane cell junction plasma membrane region GABA-A receptor complex GABA-ergic synapse cell projection neuron projection plasma membrane bounded cell projection membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle cytoplasm vesicle organelle membrane cell leading edge leading edge membrane somatodendritic compartment neuron projection membrane dendrite membrane dendrite dendritic tree cell projection membrane
D [auth E], E [auth B]	Gamma-aminobutyric acid receptor subunit beta-1,Gamma-aminobutyric acid receptor subunit beta-1	ligand-gated channel activity ligand-gated monoatomic ion channel activity passive transmembrane transporter activity gated channel activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity neurotransmitter receptor activity molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity ligand-gated channel activity ligand-gated monoatomic ion channel activity passive transmembrane transporter activity gated channel activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity neurotransmitter receptor activity molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity G protein-coupled neurotransmitter receptor activity G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential transmitter-gated monoatomic ion channel activity monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity inorganic molecular entity transmembrane transporter activity GABA-gated chloride ion channel activity ligand-gated monoatomic anion channel activity extracellular ligand-gated monoatomic ion channel activity transmitter-gated channel activity monoatomic anion channel activity inorganic anion transmembrane transporter activity chloride channel activity ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential protein binding binding signaling receptor binding GABA receptor binding GABA-A receptor activity GABA receptor activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential postsynaptic neurotransmitter receptor activity neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	developmental process multicellular organismal process cellular developmental process central nervous system neuron development cell development nervous system development generation of neurons central nervous system neuron differentiation multicellular organism development neurogenesis central nervous system development neuron differentiation cell differentiation neuron development anatomical structure development developmental process multicellular organismal process cellular developmental process central nervous system neuron development cell development nervous system development generation of neurons central nervous system neuron differentiation multicellular organism development neurogenesis central nervous system development neuron differentiation cell differentiation neuron development anatomical structure development cellular process system development transport monoatomic ion transmembrane transport inorganic ion transmembrane transport inorganic anion transmembrane transport establishment of localization chloride transport transmembrane transport localization chloride transmembrane transport monoatomic anion transport monoatomic anion transmembrane transport monoatomic ion transport inorganic anion transport response to organic substance response to ketone response to lipid response to stimulus response to endogenous stimulus response to progesterone response to oxygen-containing compound response to hormone response to steroid hormone response to chemical response to organic cyclic compound cellular response to stimulus cellular response to nitrogen compound response to organonitrogen compound cellular response to organic cyclic compound response to nitrogen compound cellular response to endogenous stimulus cellular response to chemical stimulus response to histamine cellular response to organonitrogen compound cellular response to histamine cellular response to organic substance regulation of biological process signaling biological regulation cell-cell signaling gamma-aminobutyric acid signaling pathway cell communication response to toxic substance ovulation cycle rhythmic process reproductive process multicellular organismal reproductive process	protein-containing complex transmembrane transporter complex membrane chloride channel complex membrane protein complex cellular anatomical entity transporter complex monoatomic ion channel complex membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope protein-containing complex transmembrane transporter complex membrane chloride channel complex membrane protein complex cellular anatomical entity transporter complex monoatomic ion channel complex membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system cell periphery plasma membrane postsynaptic specialization membrane postsynaptic specialization synapse synaptic membrane postsynapse postsynaptic membrane cell junction plasma membrane region somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection GABA receptor complex GABA-A receptor complex receptor complex GABA-ergic synapse presynaptic active zone membrane presynaptic membrane presynapse presynaptic active zone Schaffer collateral - CA1 synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth D]	IPR005437	Gamma-aminobutyric acid receptor subunit gamma-1/4	Family
A [auth D]	IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain	Domain
A [auth D]	IPR036719	Neurotransmitter-gated ion-channel transmembrane domain superfamily	Homologous Superfamily
A [auth D]	IPR006028	Gamma-aminobutyric acid A receptor/Glycine receptor alpha	Family
A [auth D]	IPR005439	Gamma-aminobutyric-acid A receptor, gamma 2 subunit	Family
A [auth D]	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain	Domain
A [auth D]	IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily	Homologous Superfamily
A [auth D]	IPR018000	Neurotransmitter-gated ion-channel, conserved site	Conserved Site
A [auth D]	IPR038050	Neuronal acetylcholine receptor	Homologous Superfamily
A [auth D]	IPR006201	Neurotransmitter-gated ion-channel	Family
B [auth C], C [auth A]	IPR001390	Gamma-aminobutyric-acid A receptor, alpha subunit	Family
B [auth C], C [auth A]	IPR005431	Gamma-aminobutyric-acid A receptor, alpha 1 subunit	Family
B [auth C], C [auth A]	IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain	Domain
B [auth C], C [auth A]	IPR036719	Neurotransmitter-gated ion-channel transmembrane domain superfamily	Homologous Superfamily
B [auth C], C [auth A]	IPR006028	Gamma-aminobutyric acid A receptor/Glycine receptor alpha	Family
B [auth C], C [auth A]	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain	Domain
B [auth C], C [auth A]	IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily	Homologous Superfamily
B [auth C], C [auth A]	IPR018000	Neurotransmitter-gated ion-channel, conserved site	Conserved Site
B [auth C], C [auth A]	IPR038050	Neuronal acetylcholine receptor	Homologous Superfamily
B [auth C], C [auth A]	IPR047024	Gamma-aminobutyric acid receptor subunit alpha 1-6, transmembrane domain	Domain
B [auth C], C [auth A]	IPR047079	Gamma-aminobutyric acid receptor subunit alpha-1, extracellular domain	Domain
B [auth C], C [auth A]	IPR006201	Neurotransmitter-gated ion-channel	Family
D [auth E], E [auth B]	IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain	Domain
D [auth E], E [auth B]	IPR036719	Neurotransmitter-gated ion-channel transmembrane domain superfamily	Homologous Superfamily
D [auth E], E [auth B]	IPR006028	Gamma-aminobutyric acid A receptor/Glycine receptor alpha	Family
D [auth E], E [auth B]	IPR002289	Gamma-aminobutyric-acid A receptor, beta subunit	Family
D [auth E], E [auth B]	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain	Domain
D [auth E], E [auth B]	IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily	Homologous Superfamily
D [auth E], E [auth B]	IPR018000	Neurotransmitter-gated ion-channel, conserved site	Conserved Site
D [auth E], E [auth B]	IPR038050	Neuronal acetylcholine receptor	Homologous Superfamily
D [auth E], E [auth B]	IPR006201	Neurotransmitter-gated ion-channel	Family

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A [auth D], B [auth C], C [auth A], D [auth E], E [auth B]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Cys-Loop Receptor Family	Benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABA_A receptor