Annotations: 6DT0

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF04678	e6dt0A1	A: alpha arrays	X: Mitochondrial calcium uniporter (MCU) (From Topology)	H: Mitochondrial calcium uniporter (MCU) (From Topology)	T: Mitochondrial calcium uniporter (MCU)	F: PF04678	ECOD (1.6)
A	F_UNCLASSIFIED	e6dt0A2	A: a+b two layers	X: beta-Grasp	H: Mitochondrial calcium uniporter N-terminal domain (From Topology)	T: Mitochondrial calcium uniporter N-terminal domain	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF04678	e6dt0B2	A: alpha arrays	X: Mitochondrial calcium uniporter (MCU) (From Topology)	H: Mitochondrial calcium uniporter (MCU) (From Topology)	T: Mitochondrial calcium uniporter (MCU)	F: PF04678	ECOD (1.6)
B	F_UNCLASSIFIED	e6dt0B1	A: a+b two layers	X: beta-Grasp	H: Mitochondrial calcium uniporter N-terminal domain (From Topology)	T: Mitochondrial calcium uniporter N-terminal domain	F: F_UNCLASSIFIED	ECOD (1.6)
C	PF04678	e6dt0C1	A: alpha arrays	X: Mitochondrial calcium uniporter (MCU) (From Topology)	H: Mitochondrial calcium uniporter (MCU) (From Topology)	T: Mitochondrial calcium uniporter (MCU)	F: PF04678	ECOD (1.6)
C	F_UNCLASSIFIED	e6dt0C2	A: a+b two layers	X: beta-Grasp	H: Mitochondrial calcium uniporter N-terminal domain (From Topology)	T: Mitochondrial calcium uniporter N-terminal domain	F: F_UNCLASSIFIED	ECOD (1.6)
D	PF04678	e6dt0D2	A: alpha arrays	X: Mitochondrial calcium uniporter (MCU) (From Topology)	H: Mitochondrial calcium uniporter (MCU) (From Topology)	T: Mitochondrial calcium uniporter (MCU)	F: PF04678	ECOD (1.6)
D	F_UNCLASSIFIED	e6dt0D1	A: a+b two layers	X: beta-Grasp	H: Mitochondrial calcium uniporter N-terminal domain (From Topology)	T: Mitochondrial calcium uniporter N-terminal domain	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF04678	Mitochondrial calcium uniporter (MCU)	Mitochondrial calcium uniporter	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Mitochondrial calcium uniporter	active transmembrane transporter activity transporter activity uniporter activity transmembrane transporter activity secondary active transmembrane transporter activity calcium channel activity monoatomic cation transmembrane transporter activity monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity active transmembrane transporter activity transporter activity uniporter activity transmembrane transporter activity secondary active transmembrane transporter activity calcium channel activity monoatomic cation transmembrane transporter activity monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity metal ion transmembrane transporter activity identical protein binding protein binding binding	transport monoatomic ion transmembrane transport inorganic ion transmembrane transport mitochondrial transmembrane transport establishment of localization calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization import into the mitochondrion mitochondrial calcium ion transmembrane transport monoatomic ion transport transport monoatomic ion transmembrane transport inorganic ion transmembrane transport mitochondrial transmembrane transport establishment of localization calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization import into the mitochondrion mitochondrial calcium ion transmembrane transport monoatomic ion transport cellular process calcium import into the mitochondrion monoatomic cation transport calcium ion transmembrane transport mitochondrial transport mitochondrial calcium ion homeostasis inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis	membrane-bounded organelle protein-containing complex intracellular anatomical structure mitochondrial membrane organelle inner membrane mitochondrion membrane protein complex transporter complex intracellular organelle organelle envelope uniplex complex mitochondrial protein-containing complex membrane cation channel complex membrane-bounded organelle protein-containing complex intracellular anatomical structure mitochondrial membrane organelle inner membrane mitochondrion membrane protein complex transporter complex intracellular organelle organelle envelope uniplex complex mitochondrial protein-containing complex membrane cation channel complex cellular anatomical entity intracellular membrane-bounded organelle mitochondrial inner membrane inner mitochondrial membrane protein complex transmembrane transporter complex organelle mitochondrial envelope cytoplasm organelle membrane calcium channel complex monoatomic ion channel complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR039055	MCU family	Family
A, B, C, D	IPR006769	Calcium uniporter protein, C-terminal	Domain

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D	OPM				Mitochondrial calcium uniporter

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Channels: Calcium Ion-Selective	Mitochondrial calcium uniporter (MCU), full length

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.