Warning
You are using a web browser that we do not support. Our website will not work properly. Please update to a newer version or download a new web browser, such as Chrome or Firefox.
Contact us
Toggle navigation
RCSB PDB
Deposit
Prepare Data
PDBx/mmCIF file
pdb_extract
SF-Tool
Ligand Expo
MAXIT
Validate Data
Validation Server
Validation API
Information for Journals
Validation Task Forces
Deposit Data
wwPDB OneDep System
PDB-Dev
Help and Resources
Deposit FAQ
Validation FAQ
Tutorials
Annotation Policies
Processing Procedures
PDBx/mmCIF Dictionary
Chemical Component Dictionary
Biologically Interesting Molecule Reference Dictionary (BIRD)
BioSync/Beamlines/Facilities
Related Tools
Search
Advanced Search
Sequence Similarity Search
Structure Similarity Search
Chemical Similarity Search
Chemical Sketch Tool
Browse by Annotations
New Entries
Unreleased Entries
PDB Statistics
Visualize
Mol* (MolStar)
Sequence Annotations Viewer
Genome View
Analyze
Pairwise Structure Alignment
Symmetry Resources in the PDB
Structure Quality
Grouping Structures
PDB Citation MeSH Network Explorer
PDB Statistics
EPPIC Biological Assemblies
External Data and Resources
Integrated Resources
Additional Resources
Download
Coordinates and Experimental Data
Sequences
Ligands
File Download Services
Web Services
Learn
Training Courses
Guide to PDB Data
Molecule of the Month
Educational Resources
Curricula
Browse
News
SciArt Galleries
Irving Geis
David Goodsell
About
Contact Us
About RCSB PDB
Vision and Mission
Citation, Usage, Privacy Policies, Logo
News
PDB History
PDB50
User Community
Publications
RCSB PDB Advisory Committee
Team Members
Diversity, Equity, Inclusion, and Access
Service Status
Documentation
General Help
3D Structures in the Protein Data Bank
Computed Structure Models (CSM)
Search and Browse
Basic Search
Advanced Search
Browse Annotations
Visualize and Analyze
Sequence Viewers
Pairwise Structure Alignment
Exploring a 3D Structure
Grouping Structures
Programmatic Access
Additional Resources
Software Supporters
Deposition Resources
FAQs
Glossary
Careers
COVID-19
219,140
Structures from the PDB
1,068,577
Computed Structure Models (CSM)
Navigation Tabs
Structure Summary
Structure
Annotations
Experiment
Sequence
Genome
Versions
Display Files
FASTA Sequence
mmCIF Format
mmCIF Format (Header)
PDB Format
PDB Format (Header)
Download Files
FASTA Sequence
PDBx/mmCIF Format
PDBx/mmCIF Format (gz)
BinaryCIF Format (gz)
PDB Format
PDB Format (gz)
PDBML/XML Format (gz)
EM Map EMD-8909 (map - gz)
Validation Full PDF
Validation (XML - gz)
Validation (CIF - gz)
Biological Assembly 1 (CIF - gz)
Biological Assembly 1 (PDB - gz)
Data API
6DS5
Cryo EM structure of human SEIPIN
External Resource: Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM
Protein Family Annotation
Pfam Database Homepage
Chains
Accession
Name
Description
Comments
Source
A
,
B
,
C
,
D
,
E
A
,
B
,
C
,
D
,
E
,
F
,
G
,
H
,
I
,
J
,
K
Less
PF06775
Putative adipose-regulatory protein (Seipin) (Seipin)
Putative adipose-regulatory protein (Seipin)
-
Family
Gene Ontology: Gene Product Annotation
Gene Ontology Database Homepage
Chains
Polymer
Molecular Function
Biological Process
Cellular Component
A
,
B
,
C
,
D
,
E
A
,
B
,
C
,
D
,
E
,
F
,
G
,
H
,
I
,
J
,
K
Less
Seipin
binding
phospholipid binding
lipid binding
lipid catabolic process
organic substance metabolic process
catabolic process
primary metabolic process
metabolic process
organic substance catabolic process
lipid metabolic process
multicellular organismal process
regulation of biological process
homeostatic process
biological regulation
positive regulation of biological process
adaptive thermogenesis
positive regulation of metabolic process
lipid catabolic process
organic substance metabolic process
catabolic process
primary metabolic process
metabolic process
organic substance catabolic process
lipid metabolic process
multicellular organismal process
regulation of biological process
homeostatic process
biological regulation
positive regulation of biological process
adaptive thermogenesis
positive regulation of metabolic process
multicellular organismal-level homeostasis
regulation of cold-induced thermogenesis
cold-induced thermogenesis
temperature homeostasis
positive regulation of cold-induced thermogenesis
positive regulation of multicellular organismal process
regulation of multicellular organismal process
regulation of metabolic process
negative regulation of catabolic process
regulation of lipid metabolic process
negative regulation of metabolic process
negative regulation of biological process
regulation of catabolic process
regulation of lipid catabolic process
regulation of primary metabolic process
negative regulation of lipid metabolic process
negative regulation of lipid catabolic process
cellular component organization
organelle organization
lipid droplet organization
cellular process
cellular component organization or biogenesis
organelle assembly
non-membrane-bounded organelle assembly
lipid storage
lipid localization
lipid droplet formation
maintenance of location
cellular component biogenesis
localization
cellular component assembly
macromolecule localization
developmental process
fat cell differentiation
cellular developmental process
cell differentiation
Less
lipid droplet
intracellular organelle
intracellular anatomical structure
organelle
intracellular non-membrane-bounded organelle
cellular anatomical entity
non-membrane-bounded organelle
membrane-bounded organelle
organelle subcompartment
membrane
intracellular membrane-bounded organelle
endomembrane system
endoplasmic reticulum subcompartment
nuclear outer membrane-endoplasmic reticulum membrane network
lipid droplet
intracellular organelle
intracellular anatomical structure
organelle
intracellular non-membrane-bounded organelle
cellular anatomical entity
non-membrane-bounded organelle
membrane-bounded organelle
organelle subcompartment
membrane
intracellular membrane-bounded organelle
endomembrane system
endoplasmic reticulum subcompartment
nuclear outer membrane-endoplasmic reticulum membrane network
endoplasmic reticulum
cytoplasm
organelle membrane
endoplasmic reticulum membrane
Less
InterPro: Protein Family Classification
InterPro Database Homepage
Chains
Accession
Name
Type
A
,
B
,
C
,
D
,
E
A
,
B
,
C
,
D
,
E
,
F
,
G
,
H
,
I
,
J
,
K
Less
IPR009617
Seipin family
Family
Pharos: Disease Associations
Pharos Homepage Annotation
Chains
Drug Target  
Associated Disease
A
,
B
,
C
,
D
,
E
A
,
B
,
C
,
D
,
E
,
F
,
G
,
H
,
I
,
J
,
K
Less
Pharos
: 
Q96G97
hereditary spastic paraplegia 17
lipodystrophy
congenital generalized lipodystrophy
severe neurodegenerative syndrome with lipodystrophy
neuronopathy, distal hereditary motor, type 5A
Charcot-Marie-Tooth disease
congenital generalized lipodystrophy type 2
hereditary spastic paraplegia
oligospermia
peripheral neuropathy
Asthenozoospermia
motor peripheral neuropathy
peripheral nervous system disease
acquired metabolic disease
lipoatrophic diabetes
hereditary spastic paraplegia 17
lipodystrophy
congenital generalized lipodystrophy
severe neurodegenerative syndrome with lipodystrophy
neuronopathy, distal hereditary motor, type 5A
Charcot-Marie-Tooth disease
congenital generalized lipodystrophy type 2
hereditary spastic paraplegia
oligospermia
peripheral neuropathy
Asthenozoospermia
motor peripheral neuropathy
peripheral nervous system disease
acquired metabolic disease
lipoatrophic diabetes
neurodegenerative disease
congenital generalized lipodystrophy type 1
diabetes mellitus
paraplegia
PPARG-related familial partial lipodystrophy
intellectual disability
Less
Membrane Protein Annotation: OPM
OPM Database Homepage
Chains
External Link
Type
Class
Superfamily
Family
A
,
B
,
C
,
D
,
E
More
A
,
B
,
C
,
D
,
E
,
F
,
G
,
H
,
I
,
J
,
K
Less
OPM
Seipin
About
About Us
Citing Us
Publications
Team
Careers
Usage & Privacy
Help
Contact Us
Documentation
Website FAQ
Glossary
Service Status
RCSB PDB (
citation
) is hosted by
RCSB PDB is a member of the
RCSB Partners
Nucleic Acid Knowledgebase
wwPDB Partners
RCSB PDB
PDBe
PDBj
BMRB
EMDB