Annotations: 6DO3

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF13418	e6do3A1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF13418	ECOD (1.6)
C [auth B]	PF13418	e6do3B1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF13418	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C [auth B]	PF13418	Galactose oxidase, central domain (Kelch_4)	Galactose oxidase, central domain	-	Repeat
B [auth C], D	PF10961	Selenoprotein SelK_SelG (SelK_SelG)	Selenoprotein SelK_SelG	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth B]	Kelch domain-containing protein 2	ubiquitin-like ligase-substrate adaptor activity enzyme-substrate adaptor activity protein-macromolecule adaptor activity molecular adaptor activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process ubiquitin-dependent protein catabolic process via the C-end degron rule pathway proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process ubiquitin-dependent protein catabolic process via the C-end degron rule pathway proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen nuclear membrane membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen nuclear membrane membrane endomembrane system organelle envelope nuclear envelope organelle membrane cullin-RING ubiquitin ligase complex protein-containing complex ubiquitin ligase complex catalytic complex Cul2-RING ubiquitin ligase complex transferase complex intracellular protein-containing complex
B [auth C], D	SelK C-end Degron	identical protein binding protein binding binding	inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis endoplasmic reticulum calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis positive regulation of locomotion regulation of cell motility inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis endoplasmic reticulum calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis positive regulation of locomotion regulation of cell motility regulation of cellular process positive regulation of biological process positive regulation of cell migration positive regulation of cell motility regulation of cell migration myeloid leukocyte migration cell migration regulation of immune system process cell motility positive regulation of immune system process locomotion positive regulation of cellular process regulation of biological process regulation of leukocyte migration biological regulation positive regulation of neutrophil migration positive regulation of leukocyte migration neutrophil migration granulocyte migration leukocyte migration immune system process regulation of locomotion cellular process regulation of neutrophil migration interleukin-6 production multicellular organismal process cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of interleukin-6 production regulation of interleukin-6 production positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process regulation of cytokine production organic substance biosynthetic process cytokine production regulation of multicellular organismal process positive regulation of macromolecule metabolic process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process positive regulation of cytokine production regulation of metabolic process positive regulation of cellular biosynthetic process mononuclear cell migration lymphocyte migration T cell migration regulation of monocyte chemotactic protein-1 production positive regulation of monocyte chemotactic protein-1 production monocyte chemotactic protein-1 production regulation of chemokine production chemokine production positive regulation of chemokine production localization cellular localization establishment of localization in cell establishment of localization protein localization regulation of localization establishment of protein localization nitrogen compound transport regulation of protein localization regulation of transport transport organic substance transport regulation of establishment of protein localization regulation of protein transport protein transport regulation of cellular localization cellular macromolecule localization macromolecule localization cell population proliferation cell activation lymphocyte activation leukocyte proliferation leukocyte activation mononuclear cell proliferation T cell activation lymphocyte proliferation T cell proliferation organonitrogen compound metabolic process lipoprotein biosynthetic process lipoprotein metabolic process organonitrogen compound biosynthetic process primary metabolic process protein acylation protein lipidation protein palmitoylation macromolecule modification protein metabolic process protein modification process respiratory burst respiratory burst involved in defense response response to stimulus defense response response to stress respiratory burst after phagocytosis immune effector process regulation of lymphocyte migration positive regulation of mononuclear cell migration regulation of mononuclear cell migration positive regulation of lymphocyte migration positive regulation of T cell migration regulation of T cell migration cellular response to stimulus regulation of signaling signaling regulation of signal transduction intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus calcium-mediated signaling intracellular signaling cassette regulation of calcium-mediated signaling regulation of cell communication signal transduction intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress cell death apoptotic signaling pathway cellular response to stress apoptotic process intrinsic apoptotic signaling pathway programmed cell death response to endoplasmic reticulum stress regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus response to other organism defense response to symbiont response to external stimulus response to biotic stimulus regulation of defense response to virus defense response to virus defense response to other organism regulation of response to stress positive regulation of defense response to virus by host regulation of defense response to virus by host response to external biotic stimulus response to virus monoatomic ion transport monoatomic cation transport calcium ion transport metal ion transport developmental process foam cell differentiation cellular developmental process cell differentiation macrophage derived foam cell differentiation regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production response to oxidative stress positive regulation of cell population proliferation regulation of leukocyte activation regulation of cell activation positive regulation of cell activation positive regulation of leukocyte activation regulation of leukocyte proliferation positive regulation of T cell activation positive regulation of lymphocyte proliferation positive regulation of T cell proliferation regulation of cell population proliferation regulation of leukocyte cell-cell adhesion positive regulation of leukocyte proliferation positive regulation of leukocyte cell-cell adhesion leukocyte cell-cell adhesion positive regulation of cell-cell adhesion positive regulation of lymphocyte activation cell adhesion cell-cell adhesion positive regulation of mononuclear cell proliferation regulation of cell-cell adhesion regulation of lymphocyte proliferation positive regulation of cell adhesion regulation of cell adhesion regulation of T cell activation regulation of T cell proliferation regulation of mononuclear cell proliferation regulation of lymphocyte activation	cell periphery plasma membrane membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure organelle subcompartment intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cell periphery plasma membrane membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure organelle subcompartment intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum membrane Golgi apparatus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth B]	IPR015915	Kelch-type beta propeller	Homologous Superfamily
B [auth C], D	IPR024491	Selenoprotein SelK/SelG	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C [auth B]	Pharos: Q9Y2U9	ovarian cancer plasma cell myeloma pancreatic ductal adenocarcinoma Pick disease
B [auth C], D	Pharos: Q9Y6D0	atypical teratoid rhabdoid tumor medulloblastoma pancreatic ductal adenocarcinoma large cell medulloblastoma osteosarcoma malignant ependymoma ovarian cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.