6DNF

Cryo-EM structure of the mitochondrial calcium uniporter MCU from the fungus Cyphellophora europaea

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	MCU_C	e6dnfA1	A: alpha arrays	X: Mitochondrial calcium uniporter (MCU) (From Topology)	H: Mitochondrial calcium uniporter (MCU) (From Topology)	T: Mitochondrial calcium uniporter (MCU)	F: MCU_C	ECOD (1.6)
A	UNK_F_TYPE	e6dnfA2	A: a+b two layers	X: beta-Grasp	H: Mitochondrial calcium uniporter N-terminal domain (From Topology)	T: Mitochondrial calcium uniporter N-terminal domain	F: UNK_F_TYPE	ECOD (1.6)
B	MCU_C	e6dnfB2	A: alpha arrays	X: Mitochondrial calcium uniporter (MCU) (From Topology)	H: Mitochondrial calcium uniporter (MCU) (From Topology)	T: Mitochondrial calcium uniporter (MCU)	F: MCU_C	ECOD (1.6)
B	UNK_F_TYPE	e6dnfB1	A: a+b two layers	X: beta-Grasp	H: Mitochondrial calcium uniporter N-terminal domain (From Topology)	T: Mitochondrial calcium uniporter N-terminal domain	F: UNK_F_TYPE	ECOD (1.6)
C	MCU_C	e6dnfC2	A: alpha arrays	X: Mitochondrial calcium uniporter (MCU) (From Topology)	H: Mitochondrial calcium uniporter (MCU) (From Topology)	T: Mitochondrial calcium uniporter (MCU)	F: MCU_C	ECOD (1.6)
C	UNK_F_TYPE	e6dnfC1	A: a+b two layers	X: beta-Grasp	H: Mitochondrial calcium uniporter N-terminal domain (From Topology)	T: Mitochondrial calcium uniporter N-terminal domain	F: UNK_F_TYPE	ECOD (1.6)
D	MCU_C	e6dnfD1	A: alpha arrays	X: Mitochondrial calcium uniporter (MCU) (From Topology)	H: Mitochondrial calcium uniporter (MCU) (From Topology)	T: Mitochondrial calcium uniporter (MCU)	F: MCU_C	ECOD (1.6)
D	UNK_F_TYPE	e6dnfD2	A: a+b two layers	X: beta-Grasp	H: Mitochondrial calcium uniporter N-terminal domain (From Topology)	T: Mitochondrial calcium uniporter N-terminal domain	F: UNK_F_TYPE	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF04678	Mitochondrial calcium uniporter (MCU)	Mitochondrial calcium uniporter	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Mitochondrial calcium uniporter MCU	active transmembrane transporter activity transporter activity uniporter activity transmembrane transporter activity secondary active transmembrane transporter activity calcium channel activity monoatomic cation transmembrane transporter activity monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity active transmembrane transporter activity transporter activity uniporter activity transmembrane transporter activity secondary active transmembrane transporter activity calcium channel activity monoatomic cation transmembrane transporter activity monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity metal ion transmembrane transporter activity identical protein binding protein binding binding	mitochondrial calcium ion homeostasis inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis	membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane cellular anatomical entity intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope mitochondrial envelope organelle cytoplasm membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane cellular anatomical entity intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope mitochondrial envelope organelle cytoplasm organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR039055	MCU family	Family
A, B, C, D	IPR006769	Calcium uniporter protein, C-terminal	Domain

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D	OPM				Mitochondrial calcium uniporter

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D	MemProtMD	Annotated as membrane protein by MemProtMD

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.