6DKJ

human GIPR ECD and Fab complex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
SAbDab Antibody Annotation
Thera-SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth H]	d6dkjh_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	Human (Homo sapiens ) [TaxId: 9606 ], Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D [auth A]	d6dkja_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	Human (Homo sapiens ) [TaxId: 9606 ], Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B [auth L]	d6dkjl1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	Human (Homo sapiens ) [TaxId: 9606 ], Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B [auth L]	d6dkjl2	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	C1 set domains (antibody constant domain-like)	automated matches	Human (Homo sapiens ) [TaxId: 9606 ], Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E [auth B]	d6dkjb1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	Human (Homo sapiens ) [TaxId: 9606 ], Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E [auth B]	d6dkjb2	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	C1 set domains (antibody constant domain-like)	automated matches	Human (Homo sapiens ) [TaxId: 9606 ], Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	FnI-like domain	8086311	3000979	SCOP2B (2022-06-29)
F [auth D]	SCOP2B Superfamily	FnI-like domain	8086311	3000979	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth H]	V-set_8	e6dkjH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
A [auth H]	C1-set_1	e6dkjH2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
D [auth A]	V-set_8	e6dkjA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
D [auth A]	C1-set_1	e6dkjA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
B [auth L]	C1-set_4	e6dkjL1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
B [auth L]	V-set	e6dkjL2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
E [auth B]	C1-set_4	e6dkjB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
E [auth B]	V-set	e6dkjB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
C	HRM	e6dkjC1	A: few secondary structure elements	X: Hormone receptor domain (HRM, Pfam 02793) (From Topology)	H: Hormone receptor domain (HRM, Pfam 02793) (From Topology)	T: Hormone receptor domain (HRM, Pfam 02793)	F: HRM	ECOD (1.6)
F [auth D]	HRM	e6dkjD1	A: few secondary structure elements	X: Hormone receptor domain (HRM, Pfam 02793) (From Topology)	H: Hormone receptor domain (HRM, Pfam 02793) (From Topology)	T: Hormone receptor domain (HRM, Pfam 02793)	F: HRM	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth H]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)
D [auth A]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)
B [auth L]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)
E [auth B]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A [auth H], D [auth A]	Antibody Fab Fragment	VH-CH1	Homo sapiens (human)	IGHV3-3301, IGHV3-3304, IGHJ401, IGHJ402, IGHJ403, IGHG101, IGHG102, IGHG104, IGHG105, IGHG112, IGHG114, IGHG113, IGHG109, IGHG110, IGHG107, IGHG111	V-DOMAIN VH, C-DOMAIN CH1	IG	FAB-GAMMA-1_KAPPA	IMGT (202415-0)
B [auth L], E [auth B]	Antibody Fab Fragment	L-KAPPA	Homo sapiens (human)	IGKV3-1501, IGKV3D-1501, IGKJ401, IGKJ402, IGKC*01	V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA	IG	FAB-GAMMA-1_KAPPA	IMGT (202415-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
A [auth H], D [auth A]	Heavy Chain	IGHV3	-	gastric inhibitory polypeptide receptor	SAbDab (2024-04-19)
B [auth L], E [auth B]	Light Chain	IGKV3	Kappa	gastric inhibitory polypeptide receptor	SAbDab (2024-04-19)

Thera-SAbDab Antibody Annotation Thera-SAbDab Database Homepage

Chain	Name	Target	Provenance Source
A [auth H], D [auth A]	Maridebart	GIPR	Therapeutic SAbDab (2024-04-19)
B [auth L], E [auth B]	Maridebart	GIPR	Therapeutic SAbDab (2024-04-19)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth H], D [auth A]	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain
A [auth H], D [auth A]	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	-	Domain
B [auth L], E [auth B]	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain
B [auth L], E [auth B]	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	-	Domain
C, F [auth D]	PF02793	Hormone receptor domain (HRM)	Hormone receptor domain	-	Family
C, F [auth D]	PF00002	7 transmembrane receptor (Secretin family) (7tm_2)	7 transmembrane receptor (Secretin family)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth H], D [auth A]	Fab heavy chain	-	response to stimulus immune response immune system process adaptive immune response	cell periphery plasma membrane membrane cellular anatomical entity protein-containing complex immunoglobulin complex extracellular region
B [auth L], E [auth B]	Fab light chain	-	-	extracellular region cellular anatomical entity
C, F [auth D]	Gastric inhibitory polypeptide receptor	amide binding glucagon family peptide binding binding peptide hormone binding hormone binding molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity gastric inhibitory peptide receptor activity peptide receptor activity G protein-coupled peptide receptor activity	response to stimulus response to stress response to wounding response to axon injury positive regulation of cytosolic calcium ion concentration biological regulation regulation of biological quality response to metal ion response to chemical response to calcium ion response to inorganic substance cellular response to stimulus positive regulation of cell communication regulation of cellular process response to stimulus response to stress response to wounding response to axon injury positive regulation of cytosolic calcium ion concentration biological regulation regulation of biological quality response to metal ion response to chemical response to calcium ion response to inorganic substance cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus cAMP-mediated signaling regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of biological process regulation of signaling positive regulation of intracellular signal transduction positive regulation of cAMP-mediated signaling regulation of response to stimulus regulation of cell communication cellular process regulation of cAMP-mediated signaling positive regulation of signaling adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway negative adaptation of signaling pathway negative regulation of signaling negative regulation of biological process desensitization of G protein-coupled receptor signaling pathway negative regulation of G protein-coupled receptor signaling pathway negative regulation of cell communication negative regulation of cellular process regulation of G protein-coupled receptor signaling pathway negative regulation of response to stimulus negative regulation of signal transduction adaptation of signaling pathway cellular metabolic process metabolic process generation of precursor metabolites and energy response to hexose response to organic substance response to monosaccharide response to carbohydrate response to glucose response to oxygen-containing compound gastric inhibitory peptide signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway developmental process multicellular organism development multicellular organismal process pancreas development endocrine system development anatomical structure development animal organ development endocrine pancreas development system development protein localization regulation of localization establishment of protein localization nitrogen compound transport localization cellular macromolecule localization regulation of peptide hormone secretion regulation of hormone levels organic substance transport establishment of protein localization to extracellular region protein secretion establishment of localization regulation of protein secretion regulation of secretion cellular localization regulation of hormone secretion regulation of protein localization regulation of peptide secretion transport hormone secretion protein localization to extracellular region peptide secretion secretion by cell regulation of secretion by cell amide transport signal release secretion regulation of transport regulation of peptide transport regulation of establishment of protein localization cell-cell signaling export from cell regulation of protein transport peptide transport protein transport regulation of cellular localization regulation of insulin secretion peptide hormone secretion macromolecule localization hormone transport insulin secretion cell surface receptor signaling pathway positive regulation of adenylate cyclase activity positive regulation of cyclase activity regulation of catalytic activity positive regulation of catalytic activity positive regulation of molecular function regulation of molecular function regulation of lyase activity activation of adenylate cyclase activity regulation of adenylate cyclase activity regulation of cyclase activity positive regulation of lyase activity response to lipid response to fatty acid response to nutrient levels response to nutrient positive regulation of establishment of protein localization positive regulation of insulin secretion positive regulation of peptide hormone secretion positive regulation of protein localization positive regulation of secretion by cell positive regulation of protein transport positive regulation of hormone secretion positive regulation of secretion positive regulation of peptide secretion positive regulation of protein secretion positive regulation of transport	membrane cellular anatomical entity cell periphery plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth H], D [auth A]	IPR003597	Immunoglobulin C1-set	Domain
A [auth H], D [auth A]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A [auth H], D [auth A]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A [auth H], D [auth A]	IPR003599	Immunoglobulin subtype	Domain
A [auth H], D [auth A]	IPR013106	Immunoglobulin V-set domain	Domain
A [auth H], D [auth A]	IPR007110	Immunoglobulin-like domain	Domain
A [auth H], D [auth A]	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
B [auth L], E [auth B]	IPR003597	Immunoglobulin C1-set	Domain
B [auth L], E [auth B]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B [auth L], E [auth B]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
B [auth L], E [auth B]	IPR003599	Immunoglobulin subtype	Domain
B [auth L], E [auth B]	IPR013106	Immunoglobulin V-set domain	Domain
B [auth L], E [auth B]	IPR007110	Immunoglobulin-like domain	Domain
B [auth L], E [auth B]	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
C, F [auth D]	IPR017983	GPCR, family 2, secretin-like, conserved site	Conserved Site
C, F [auth D]	IPR036445	GPCR family 2, extracellular hormone receptor domain superfamily	Homologous Superfamily
C, F [auth D]	IPR000832	GPCR, family 2, secretin-like	Family
C, F [auth D]	IPR017981	GPCR, family 2-like, 7TM	Domain
C, F [auth D]	IPR001879	GPCR, family 2, extracellular hormone receptor domain	Domain
C, F [auth D]	IPR001749	GPCR, family 2, gastric inhibitory polypeptide receptor	Family