6DEE

Crystal structure of the C-terminus of Homo sapiens SPIN90 (SH3-protein interacting with Nck), residues 306-722

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF09431	e6deeA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF09431	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF09431	SPIN90/Ldb17, leucine-rich domain (SPIN90_LRD)	SPIN90/Ldb17, leucine-rich domain	This is the conserved leucine-rich domain (LRD) within the C-terminal domain of SPIN90 (also known as NCK interacting protein with SH3 domain (NCKIPSD)) from animals, Ldb17 from budding yeasts and Dip1 from fission yeasts [1]. Ldb17 is involved in th ...	This is the conserved leucine-rich domain (LRD) within the C-terminal domain of SPIN90 (also known as NCK interacting protein with SH3 domain (NCKIPSD)) from animals, Ldb17 from budding yeasts and Dip1 from fission yeasts [1]. Ldb17 is involved in the regulation of endocytosis in yeast [2]. SPIN90 is an F-actin binding protein that regulates actin polymerization and endocytosis [3]. It associates with and activates the Arp2/3 complex, without requiring a preformed actin filament [2,4,5]. This LRD, within the C-terminal armadillo repeat (ARM) domain of SPIN90, is important for activation of Arp2/3 complex [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	NCK-interacting protein with SH3 domain	SH3 domain binding protein binding binding protein domain specific binding cytoskeletal protein binding protein-containing complex binding Arp2/3 complex binding	regulation of neuron projection development multicellular organismal process regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization cellular developmental process cell projection organization positive regulation of biological process cell development neuron projection development cellular component organization neurogenesis multicellular organism development neuron differentiation positive regulation of neuron projection development regulation of neuron projection development multicellular organismal process regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization cellular developmental process cell projection organization positive regulation of biological process cell development neuron projection development cellular component organization neurogenesis multicellular organism development neuron differentiation positive regulation of neuron projection development cell differentiation anatomical structure development positive regulation of cell projection organization cellular component organization or biogenesis positive regulation of cellular process system development developmental process regulation of biological process plasma membrane bounded cell projection organization regulation of cell projection organization biological regulation nervous system development generation of neurons neuron development cellular process regulation of plasma membrane bounded cell projection organization organelle organization cytoskeleton organization localization import into cell transport endocytosis establishment of localization vesicle-mediated transport	polymeric cytoskeletal fiber intracellular anatomical structure cellular anatomical entity intermediate filament cytoskeleton intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle intermediate filament supramolecular fiber supramolecular polymer supramolecular complex non-membrane-bounded organelle cytoplasm polymeric cytoskeletal fiber intracellular anatomical structure cellular anatomical entity intermediate filament cytoskeleton intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle intermediate filament supramolecular fiber supramolecular polymer supramolecular complex non-membrane-bounded organelle cytoplasm cytosol membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR030125	SPIN90/Ldb17	Family
A	IPR035514	SPIN90, SH3 domain	Domain
A	IPR001452	SH3 domain	Domain
A	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A	IPR018556	SPIN90/Ldb17, leucine-rich domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9NZQ3	anorexia nervosa endogenous depression lung cancer myocardial infarction cancer inflammatory bowel disease malignant ependymoma subependymal giant cell astrocytoma Crohn disease large cell medulloblastoma medulloblastoma ulcerative colitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.