6D84

Structure of the cargo bound AP-1:Arf1:tetherin-Nef (L164A, L165A) dileucine mutant dimer

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth B]	SCOP2B Superfamily	ARM repeat-like	8082787	3000116	SCOP2B (2022-06-29)
K [auth F]	SCOP2B Superfamily	ARM repeat-like	8082787	3000116	SCOP2B (2022-06-29)
D [auth C]	SCOP2B Superfamily	Ras-like P-loop GTPases	8089848	3002022	SCOP2B (2022-06-29)
F [auth H]	SCOP2B Superfamily	Ras-like P-loop GTPases	8089848	3002022	SCOP2B (2022-06-29)
L [auth I]	SCOP2B Superfamily	Ras-like P-loop GTPases	8089848	3002022	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	Ras-like P-loop GTPases	8089848	3002022	SCOP2B (2022-06-29)
E [auth G]	SCOP2B Superfamily	ARM repeat-like	8078176	3000116	SCOP2B (2022-06-29)
M [auth K]	SCOP2B Superfamily	ARM repeat-like	8078176	3000116	SCOP2B (2022-06-29)
G [auth M]	SCOP2B Superfamily	mu adaptin domain-like	8083652	3000810	SCOP2B (2022-06-29)
O [auth P]	SCOP2B Superfamily	mu adaptin domain-like	8083652	3000810	SCOP2B (2022-06-29)
P [auth Q]	SCOP2B Superfamily	SNARE-like	8082711	3001113	SCOP2B (2022-06-29)
H [auth S]	SCOP2B Superfamily	SNARE-like	8082711	3001113	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth B]	PF01602	e6d84B1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF01602	ECOD (1.6)
K [auth F]	PF01602	e6d84F1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF01602	ECOD (1.6)
D [auth C]	PF00025	e6d84C1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00025	ECOD (1.6)
F [auth H]	PF00025	e6d84H1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00025	ECOD (1.6)
L [auth I]	PF00025	e6d84I1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00025	ECOD (1.6)
N	PF00025	e6d84N1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00025	ECOD (1.6)
E [auth G]	PF01602	e6d84G1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF01602	ECOD (1.6)
M [auth K]	PF01602	e6d84K1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF01602	ECOD (1.6)
G [auth M]	PF00928	e6d84M1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: PF00928	ECOD (1.6)
G [auth M]	PF01217	e6d84M2	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: PF01217	ECOD (1.6)
O [auth P]	PF00928	e6d84P3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: PF00928	ECOD (1.6)
O [auth P]	PF01217	e6d84P2	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: PF01217	ECOD (1.6)
P [auth Q]	PF01217	e6d84Q1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: PF01217	ECOD (1.6)
H [auth S]	PF01217	e6d84S1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: PF01217	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth T], B [auth L], I [auth R], J [auth O]	PF00469	Negative factor, (F-Protein) or Nef (F-protein)	Negative factor, (F-Protein) or Nef	-	Family
C [auth B], K [auth F]	PF01602	Adaptin N terminal region (Adaptin_N)	Adaptin N terminal region	-	Repeat
D [auth C], F [auth H], L [auth I], N	PF00025	ADP-ribosylation factor family (Arf)	ADP-ribosylation factor family	Pfam combines a number of different Prosite families together	Domain
E [auth G], M [auth K]	PF01602	Adaptin N terminal region (Adaptin_N)	Adaptin N terminal region	-	Repeat
G [auth M], O [auth P]	PF00928	Adaptor complexes medium subunit family (Adap_comp_sub)	Adaptor complexes medium subunit family	-	Family
H [auth S], P [auth Q]	PF01217	Clathrin adaptor complex small chain (Clat_adaptor_s)	Clathrin adaptor complex small chain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth T], B [auth L], I [auth R], J [auth O]	Bone marrow stromal antigen 2,Protein Nef	protein binding binding signaling receptor binding thioesterase binding enzyme binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding protein binding binding signaling receptor binding thioesterase binding enzyme binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding SH3 domain binding protein domain specific binding CD4 receptor binding kinase binding protein kinase binding MHC class I protein binding MHC protein binding ATPase binding RNA binding nucleic acid binding enzyme regulator activity molecular function inhibitor activity peptidase regulator activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity metalloendopeptidase inhibitor activity endopeptidase inhibitor activity identical protein binding protein homodimerization activity protein dimerization activity	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein trimerization protein complex oligomerization protein-containing complex assembly cellular process cellular component organization or biogenesis viral process viral life cycle symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein trimerization protein complex oligomerization protein-containing complex assembly cellular process cellular component organization or biogenesis viral process viral life cycle symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism response to external stimulus response to biotic stimulus biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated suppression of host immune response modulation by symbiont of host process response to host immune response symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I symbiont-mediated suppression of host antigen processing and presentation response to host response to external biotic stimulus modulation of process of another organism symbiont-mediated suppression of host adaptive immune response symbiont-mediated suppression of host T-cell mediated immune response regulation of CD4 production regulation of cellular process cellular biosynthetic process organonitrogen compound biosynthetic process negative regulation of biological process carbohydrate derivative metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process organic substance metabolic process organic substance biosynthetic process negative regulation of cellular process protein metabolic process regulation of glycoprotein biosynthetic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process carbohydrate derivative biosynthetic process regulation of biosynthetic process negative regulation of glycoprotein biosynthetic process negative regulation of glycoprotein metabolic process regulation of biological process organonitrogen compound metabolic process negative regulation of CD4 production cellular metabolic process regulation of protein metabolic process negative regulation of metabolic process biological regulation glycoprotein biosynthetic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process glycoprotein metabolic process macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of glycoprotein metabolic process regulation of cellular biosynthetic process biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process CD4 biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process cellular response to stimulus regulation of signaling signaling regulation of signal transduction intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus calcium-mediated signaling intracellular signaling cassette regulation of calcium-mediated signaling regulation of cell communication signal transduction modulation by virus of host process virus-mediated perturbation of host defense response perturbation by virus of host immune response modulation by virus of host cellular process suppression by virus of host autophagy modulation by virus of host autophagy symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class II positive regulation of cell communication positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction positive regulation of biological process positive regulation of response to stimulus positive regulation of cellular process positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction positive regulation of signaling negative regulation of viral life cycle negative regulation of intracellular transport of viral material regulation of viral life cycle regulation of viral process negative regulation of viral process intracellular transport of virus transport of virus regulation of intracellular transport of viral material regulation of immune effector process multicellular organismal process negative regulation of dendritic cell cytokine production dendritic cell cytokine production cytokine production leukocyte mediated immunity regulation of immune system process regulation of plasmacytoid dendritic cell cytokine production negative regulation of cytokine production involved in immune response regulation of cytokine production involved in immune response immune response negative regulation of immune effector process immune effector process regulation of gene expression regulation of leukocyte mediated immunity negative regulation of production of molecular mediator of immune response negative regulation of gene expression plasmacytoid dendritic cell cytokine production regulation of production of molecular mediator of immune response negative regulation of plasmacytoid dendritic cell cytokine production negative regulation of multicellular organismal process regulation of dendritic cell cytokine production regulation of cytokine production regulation of multicellular organismal process cytokine production involved in immune response production of molecular mediator of immune response negative regulation of cytokine production gene expression negative regulation of immune system process immune system process negative regulation of leukocyte mediated immunity regulation of cytoskeleton organization regulation of cellular component organization regulation of actin filament-based process actin cytoskeleton organization regulation of organelle organization organelle organization regulation of actin cytoskeleton organization actin filament-based process cytoskeleton organization B cell activation cell activation lymphocyte activation leukocyte activation defense response defense response to symbiont defense response to other organism response to stress innate immune response regulation of growth growth negative regulation of cell growth regulation of cell growth cell growth negative regulation of growth response to organic substance response to type II interferon response to cytokine response to chemical negative regulation of locomotion regulation of cell motility regulation of locomotion regulation of cell migration negative regulation of cell motility cell migration cell motility negative regulation of cell migration locomotion negative regulation of viral genome replication viral genome replication regulation of viral genome replication response to virus response to interferon-alpha response to interferon-beta defense response to virus regulation of leukocyte proliferation cell population proliferation positive regulation of cell population proliferation leukocyte proliferation regulation of cell population proliferation positive regulation of leukocyte proliferation	membrane cellular anatomical entity host cell plasma membrane host cellular component host cell part host cell membrane extracellular region virion component host intracellular part host cell Golgi membrane host cell Golgi apparatus host cell cytoplasm part host cell cytoplasm host cell endomembrane system membrane cellular anatomical entity host cell plasma membrane host cellular component host cell part host cell membrane extracellular region virion component host intracellular part host cell Golgi membrane host cell Golgi apparatus host cell cytoplasm part host cell cytoplasm host cell endomembrane system host intracellular region cell periphery apical part of cell plasma membrane plasma membrane region apical plasma membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure intracellular vesicle lytic vacuole endomembrane system intracellular organelle bounding membrane of organelle vesicle membrane cytoplasmic vesicle lysosome vacuolar membrane azurophil granule vacuole intracellular membrane-bounded organelle lytic vacuole membrane cytoplasmic vesicle membrane lysosomal membrane secretory granule primary lysosome secretory vesicle azurophil granule membrane cytoplasm organelle membrane secretory granule membrane cell surface membrane microdomain membrane raft endosome late endosome multivesicular body side of membrane Golgi apparatus
C [auth B], K [auth F]	AP-1 complex subunit beta-1	clathrin binding protein binding binding kinase binding enzyme binding protein kinase binding	developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development protein localization establishment of protein localization cellular localization nitrogen compound transport transport secretion developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development protein localization establishment of protein localization cellular localization nitrogen compound transport transport secretion organic substance transport basolateral protein secretion establishment of protein localization to extracellular region export from cell protein secretion establishment of localization protein localization to extracellular region localization secretion by cell protein transport cellular macromolecule localization macromolecule localization cellular process determination of bilateral symmetry pattern specification process determination of left/right symmetry left/right pattern formation regionalization specification of symmetry intracellular transport establishment of localization in cell intracellular protein transport organelle assembly cellular pigmentation pigment granule organization vesicle organization cellular component organization cellular component biogenesis melanosome organization organelle organization pigmentation cellular component assembly cellular component organization or biogenesis melanosome assembly vesicle-mediated transport platelet dense granule organization secretory granule organization endomembrane system organization kidney development renal system development	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle protein-containing complex vesicle coat intracellular vesicle membrane protein complex transport vesicle membrane clathrin coat of trans-Golgi network vesicle endomembrane system intracellular organelle membrane coat intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle protein-containing complex vesicle coat intracellular vesicle membrane protein complex transport vesicle membrane clathrin coat of trans-Golgi network vesicle endomembrane system intracellular organelle membrane coat bounding membrane of organelle trans-Golgi network transport vesicle membrane trans-Golgi network transport vesicle AP-type membrane coat adaptor complex AP-1 adaptor complex vesicle membrane cytoplasmic vesicle clathrin-coated vesicle clathrin vesicle coat coated vesicle Golgi-associated vesicle vesicle clathrin-coated vesicle membrane transport vesicle Golgi apparatus membrane intracellular membrane-bounded organelle coated membrane clathrin coat coated vesicle membrane cytoplasmic vesicle membrane organelle Golgi-associated vesicle membrane organelle membrane clathrin adaptor complex early endosome endosome vacuolar membrane lytic vacuole vacuole lytic vacuole membrane lysosomal membrane lysosome Golgi membrane Golgi apparatus subcompartment organelle subcompartment trans-Golgi network membrane trans-Golgi network
D [auth C], F [auth H], L [auth I], N	ADP-ribosylation factor 1	protein binding binding protein domain specific binding RNA binding organic cyclic compound binding nucleic acid binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding protein binding binding protein domain specific binding RNA binding organic cyclic compound binding nucleic acid binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cation binding magnesium ion binding metal ion binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	inorganic ion homeostasis homeostatic process intracellular copper ion homeostasis copper ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis regulation of localization import into cell regulation of biological process inorganic ion homeostasis homeostatic process intracellular copper ion homeostasis copper ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis regulation of localization import into cell regulation of biological process regulation of cellular process regulation of cellular component organization receptor internalization regulation of transport transport regulation of receptor-mediated endocytosis biological regulation regulation of vesicle-mediated transport regulation of receptor internalization establishment of localization vesicle-mediated transport cellular component organization localization cellular process cellular component organization or biogenesis endocytosis receptor-mediated endocytosis regulation of endocytosis protein localization cellular localization establishment of protein localization nitrogen compound transport organic substance transport intracellular transport protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization intracellular protein transport cell junction organization dendritic spine organization postsynapse organization plasma membrane bounded cell projection organization cell projection organization neuron projection organization synapse organization negative regulation of signaling signaling modulation of chemical synaptic transmission negative regulation of biological process negative regulation of synaptic transmission negative regulation of cell communication cell communication synaptic signaling negative regulation of cellular process regulation of biological quality regulation of synaptic plasticity trans-synaptic signaling regulation of signaling cell-cell signaling chemical synaptic transmission regulation of trans-synaptic signaling long-term synaptic depression anterograde trans-synaptic signaling regulation of cell communication membrane organization cytoskeleton-dependent cytokinesis mitotic cytokinetic process cleavage furrow ingression mitotic cytokinesis cytokinesis mitotic cleavage furrow ingression mitotic cell cycle mitotic cell cycle process cytokinetic process membrane invagination cell cycle cell division plasma membrane invagination cell cycle process regulation of Arp2/3 complex-mediated actin nucleation regulation of cytoskeleton organization regulation of actin filament-based process regulation of actin nucleation actin filament-based process regulation of actin filament organization actin cytoskeleton organization actin filament organization Arp2/3 complex-mediated actin nucleation regulation of organelle organization organelle organization regulation of actin cytoskeleton organization regulation of supramolecular fiber organization actin nucleation supramolecular fiber organization cytoskeleton organization cellular response to virus biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to external stimulus response to external biotic stimulus response to virus response to biotic stimulus	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol cell leading edge cell periphery plasma membrane membrane protein-containing complex cell projection neuron projection plasma membrane bounded cell projection sarcomere intracellular organelle intracellular non-membrane-bounded organelle contractile muscle fiber supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle Golgi membrane Golgi apparatus intracellular membrane-bounded organelle endomembrane system bounding membrane of organelle organelle membrane postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization synapse asymmetric synapse
E [auth G], M [auth K]	AP-1 complex subunit gamma-1	small GTPase binding protein binding binding enzyme binding GTPase binding GTP-dependent protein binding cytoskeletal protein binding kinesin binding cargo adaptor activity clathrin adaptor activity protein-macromolecule adaptor activity molecular adaptor activity	regulation of immune effector process lymphocyte mediated immunity positive regulation of leukocyte mediated immunity positive regulation of response to biotic stimulus regulation of cellular process response to stimulus response to biotic stimulus positive regulation of leukocyte mediated cytotoxicity positive regulation of immune response positive regulation of natural killer cell mediated immunity leukocyte mediated immunity regulation of immune system process natural killer cell mediated immunity positive regulation of immune system process regulation of immune effector process lymphocyte mediated immunity positive regulation of leukocyte mediated immunity positive regulation of response to biotic stimulus regulation of cellular process response to stimulus response to biotic stimulus positive regulation of leukocyte mediated cytotoxicity positive regulation of immune response positive regulation of natural killer cell mediated immunity leukocyte mediated immunity regulation of immune system process natural killer cell mediated immunity positive regulation of immune system process regulation of biological process regulation of natural killer cell mediated immunity immune response response to other organism regulation of innate immune response response to external stimulus leukocyte mediated cytotoxicity immune effector process regulation of leukocyte mediated immunity regulation of response to stimulus defense response to other organism positive regulation of defense response natural killer cell mediated cytotoxicity regulation of immune response positive regulation of natural killer cell mediated cytotoxicity regulation of cell killing positive regulation of cell killing regulation of defense response regulation of response to biotic stimulus regulation of natural killer cell mediated cytotoxicity biological process involved in interspecies interaction between organisms regulation of response to external stimulus positive regulation of lymphocyte mediated immunity positive regulation of biological process positive regulation of response to stimulus positive regulation of response to external stimulus response to stress regulation of response to stress innate immune response positive regulation of immune effector process response to external biotic stimulus positive regulation of cellular process positive regulation of innate immune response defense response regulation of leukocyte mediated cytotoxicity biological regulation defense response to symbiont regulation of lymphocyte mediated immunity immune system process cellular process cell killing cellular localization post-Golgi vesicle-mediated transport transport intracellular transport establishment of localization vesicle-mediated transport Golgi to vacuole transport localization establishment of localization in cell vacuolar transport Golgi vesicle transport protein localization establishment of protein localization nitrogen compound transport secretion organic substance transport basolateral protein secretion establishment of protein localization to extracellular region export from cell protein secretion protein localization to extracellular region secretion by cell protein transport cellular macromolecule localization macromolecule localization cellular response to stimulus pigment cell differentiation cellular developmental process developmental pigmentation cellular pigmentation endosome to pigment granule transport pigmentation cell differentiation cellular pigment accumulation developmental process endosome to melanosome transport pigment accumulation developmental maturation pigment granule maturation lysosomal transport cytosolic transport Golgi to lysosome transport intracellular protein transport organelle assembly pigment granule organization vesicle organization cellular component organization cellular component biogenesis melanosome organization organelle organization cellular component assembly cellular component organization or biogenesis melanosome assembly multicellular organismal process regulation of localization regulated exocytosis cell activation involved in immune response leukocyte degranulation positive regulation of leukocyte degranulation positive regulation of regulated secretory pathway natural killer cell activation regulation of secretion positive regulation of natural killer cell degranulation regulation of natural killer cell degranulation exocytosis natural killer cell degranulation positive regulation of secretion by cell lymphocyte activation positive regulation of exocytosis leukocyte activation regulation of regulated secretory pathway regulation of secretion by cell positive regulation of secretion natural killer cell activation involved in immune response leukocyte activation involved in immune response regulation of leukocyte degranulation lymphocyte activation involved in immune response regulation of transport cell activation regulation of vesicle-mediated transport positive regulation of transport regulation of exocytosis platelet dense granule organization secretory granule organization endomembrane system organization	clathrin-coated pit membrane cellular anatomical entity endomembrane system membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle clathrin-coated vesicle coated vesicle cytoplasm clathrin-coated pit membrane cellular anatomical entity endomembrane system membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle clathrin-coated vesicle coated vesicle cytoplasm vesicle cytosol protein-containing complex vesicle coat membrane protein complex transport vesicle membrane clathrin coat of trans-Golgi network vesicle membrane coat bounding membrane of organelle trans-Golgi network transport vesicle membrane trans-Golgi network transport vesicle AP-type membrane coat adaptor complex AP-1 adaptor complex vesicle membrane clathrin vesicle coat Golgi-associated vesicle clathrin-coated vesicle membrane transport vesicle Golgi apparatus coated membrane clathrin coat coated vesicle membrane cytoplasmic vesicle membrane Golgi-associated vesicle membrane organelle membrane clathrin adaptor complex early endosome endosome vacuolar membrane lytic vacuole vacuole lytic vacuole membrane lysosomal membrane lysosome Golgi apparatus subcompartment organelle subcompartment trans-Golgi network recycling endosome trans-Golgi network membrane perinuclear region of cytoplasm
G [auth M], O [auth P]	AP-1 complex subunit mu-1	cargo adaptor activity clathrin adaptor activity protein-macromolecule adaptor activity molecular adaptor activity	protein localization cellular localization establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization cellular process protein localization cellular localization establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization cellular process intracellular protein transport vesicle organization cellular component organization melanosome organization organelle organization pigmentation cellular pigmentation cellular component organization or biogenesis pigment granule organization organelle assembly cellular component biogenesis cellular component assembly melanosome assembly vesicle-mediated transport platelet dense granule organization secretory granule organization endomembrane system organization cellular response to stimulus pigment cell differentiation response to stimulus cellular developmental process developmental pigmentation endosome to pigment granule transport cell differentiation cellular pigment accumulation developmental process endosome to melanosome transport pigment accumulation response to external stimulus developmental maturation pigment granule maturation	membrane-bounded organelle intracellular anatomical structure early endosome endosome intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle vacuolar membrane membrane-bounded organelle intracellular anatomical structure early endosome endosome intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle vacuolar membrane membrane lytic vacuole vacuole lytic vacuole membrane bounding membrane of organelle lysosomal membrane organelle membrane lysosome Golgi apparatus subcompartment Golgi apparatus organelle subcompartment trans-Golgi network clathrin-coated vesicle coated vesicle cytosol trans-Golgi network membrane protein-containing complex vesicle coat membrane protein complex transport vesicle membrane clathrin coat of trans-Golgi network vesicle membrane coat trans-Golgi network transport vesicle membrane trans-Golgi network transport vesicle AP-type membrane coat adaptor complex AP-1 adaptor complex vesicle membrane clathrin vesicle coat Golgi-associated vesicle clathrin-coated vesicle membrane transport vesicle coated membrane clathrin coat coated vesicle membrane cytoplasmic vesicle membrane Golgi-associated vesicle membrane clathrin adaptor complex
H [auth S], P [auth Q]	AP-1 complex subunit sigma-3	cargo adaptor activity clathrin adaptor activity protein-macromolecule adaptor activity molecular adaptor activity	protein localization cellular localization establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization cellular process protein localization cellular localization establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization cellular process intracellular protein transport organelle assembly cellular pigmentation pigment granule organization vesicle organization cellular component organization cellular component biogenesis melanosome organization organelle organization pigmentation cellular component assembly cellular component organization or biogenesis melanosome assembly protein targeting vesicle-mediated transport platelet dense granule organization secretory granule organization endomembrane system organization	membrane-bounded organelle intracellular anatomical structure membrane intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle organelle cytoplasm vesicle organelle membrane membrane-bounded organelle intracellular anatomical structure membrane intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle organelle cytoplasm vesicle organelle membrane early endosome endosome endomembrane system clathrin-coated pit vacuolar membrane lytic vacuole vacuole lytic vacuole membrane bounding membrane of organelle lysosomal membrane lysosome Golgi membrane Golgi apparatus cytosol Golgi apparatus subcompartment organelle subcompartment trans-Golgi network membrane trans-Golgi network protein-containing complex vesicle coat membrane protein complex transport vesicle membrane clathrin coat of trans-Golgi network vesicle membrane coat trans-Golgi network transport vesicle membrane trans-Golgi network transport vesicle AP-type membrane coat adaptor complex AP-1 adaptor complex clathrin-coated vesicle clathrin vesicle coat coated vesicle Golgi-associated vesicle clathrin-coated vesicle membrane transport vesicle coated membrane clathrin coat coated vesicle membrane Golgi-associated vesicle membrane clathrin adaptor complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth T], B [auth L], I [auth R], J [auth O]	IPR001558	HIV negative factor Nef	Family
A [auth T], B [auth L], I [auth R], J [auth O]	IPR027481	HIV-1 Nef protein, core domain superfamily	Homologous Superfamily
A [auth T], B [auth L], I [auth R], J [auth O]	IPR027480	HIV-1 Nef protein, anchor domain superfamily	Homologous Superfamily
A [auth T], B [auth L], I [auth R], J [auth O]	IPR024886	Bone marrow stromal antigen 2	Family
C [auth B], K [auth F]	IPR016024	Armadillo-type fold	Homologous Superfamily
C [auth B], K [auth F]	IPR013037	Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain	Homologous Superfamily
C [auth B], K [auth F]	IPR000225	Armadillo	Repeat
C [auth B], K [auth F]	IPR026739	AP complex subunit beta	Family
C [auth B], K [auth F]	IPR011989	Armadillo-like helical	Homologous Superfamily
C [auth B], K [auth F]	IPR012295	TBP domain superfamily	Homologous Superfamily
C [auth B], K [auth F]	IPR002553	Clathrin/coatomer adaptor, adaptin-like, N-terminal	Domain
C [auth B], K [auth F]	IPR015151	Beta-adaptin appendage, C-terminal subdomain	Domain
C [auth B], K [auth F]	IPR013041	Clathrin adaptor, appendage, Ig-like subdomain superfamily	Homologous Superfamily
C [auth B], K [auth F]	IPR008152	Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain	Domain
C [auth B], K [auth F]	IPR009028	Coatomer/calthrin adaptor appendage, C-terminal subdomain	Homologous Superfamily
C [auth B], K [auth F]	IPR016342	AP-1/2/4 complex subunit beta	Family
D [auth C], F [auth H], L [auth I], N	IPR045872	ADP-ribosylation factor 1-5	Family
D [auth C], F [auth H], L [auth I], N	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
D [auth C], F [auth H], L [auth I], N	IPR005225	Small GTP-binding protein domain	Domain
D [auth C], F [auth H], L [auth I], N	IPR006689	Small GTPase superfamily, ARF/SAR type	Family
E [auth G], M [auth K]	IPR016024	Armadillo-type fold	Homologous Superfamily
E [auth G], M [auth K]	IPR017107	Adaptor protein complex AP-1, gamma subunit	Family
E [auth G], M [auth K]	IPR011989	Armadillo-like helical	Homologous Superfamily
E [auth G], M [auth K]	IPR008153	Gamma-adaptin ear (GAE) domain	Domain
E [auth G], M [auth K]	IPR002553	Clathrin/coatomer adaptor, adaptin-like, N-terminal	Domain
E [auth G], M [auth K]	IPR013041	Clathrin adaptor, appendage, Ig-like subdomain superfamily	Homologous Superfamily
E [auth G], M [auth K]	IPR008152	Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain	Domain
G [auth M], O [auth P]	IPR011012	Longin-like domain superfamily	Homologous Superfamily
G [auth M], O [auth P]	IPR022775	AP complex, mu/sigma subunit	Domain
G [auth M], O [auth P]	IPR036168	AP-2 complex subunit mu, C-terminal superfamily	Homologous Superfamily
G [auth M], O [auth P]	IPR028565	Mu homology domain	Domain
G [auth M], O [auth P]	IPR018240	Clathrin adaptor, mu subunit, conserved site	Conserved Site
G [auth M], O [auth P]	IPR001392	Clathrin adaptor, mu subunit	Family
H [auth S], P [auth Q]	IPR016635	Adaptor protein complex, sigma subunit	Family
H [auth S], P [auth Q]	IPR011012	Longin-like domain superfamily	Homologous Superfamily
H [auth S], P [auth Q]	IPR044733	AP-1 complex subunit sigma	Family
H [auth S], P [auth Q]	IPR000804	Clathrin adaptor complex, small chain	Conserved Site
H [auth S], P [auth Q]	IPR022775	AP complex, mu/sigma subunit	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth T], B [auth L], I [auth R], J [auth O]	Pharos: Q10589	ovarian cancer pituitary cancer rheumatoid arthritis ulcerative colitis acute myeloid leukemia breast cancer cystic fibrosis esophageal adenocarcinoma large cell medulloblastoma malignant mesothelioma multiple sclerosis pancreatic ductal adenocarcinoma plasma cell myeloma subependymal giant cell astrocytoma AIDS ovarian cancer pituitary cancer rheumatoid arthritis ulcerative colitis acute myeloid leukemia breast cancer cystic fibrosis esophageal adenocarcinoma large cell medulloblastoma malignant mesothelioma multiple sclerosis pancreatic ductal adenocarcinoma plasma cell myeloma subependymal giant cell astrocytoma AIDS Crohn disease dermatomyositis glioblastoma lung cancer malignant pancreatic neoplasm nasopharyngeal carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis tuberculosis astrocytic tumor cutaneous lupus erythematosus diabetes mellitus juvenile dermatomyositis lung carcinoma medulloblastoma
C [auth B], K [auth F]	Pharos: Q10567	astrocytic tumor osteosarcoma
D [auth C], F [auth H], L [auth I], N	Pharos: P84077	breast carcinoma Neoplasm Invasiveness acute myeloid leukemia idiopathic scoliosis atypical teratoid rhabdoid tumor diabetes mellitus large cell medulloblastoma ovarian cancer breast cancer glioblastoma malignant glioma plasma cell myeloma
H [auth S], P [auth Q]	Pharos: Q96PC3	psoriasis pustulosis palmaris et plantaris psoriasis 15, pustular, susceptibility to tuberculosis Acrodermatitis continua of Hallopeau malignant glioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm spina bifida ulcerative colitis atopic eczema interstitial cystitis malignant pancreatic neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis pustulosis palmaris et plantaris psoriasis 15, pustular, susceptibility to tuberculosis Acrodermatitis continua of Hallopeau malignant glioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm spina bifida ulcerative colitis atopic eczema interstitial cystitis malignant pancreatic neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia transitional cell carcinoma atypical teratoid rhabdoid tumor large cell medulloblastoma medulloblastoma pancreatic intraductal papillary-mucinous carcinoma