6CXJ

Cardiac thin filament decorated with C0C1 fragment of cardiac myosin binding protein C mode 2

External Resource: Annotation


Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APF00022e6cxjA1 A: mixed a+b and a/bX: Ribonuclease H-likeH: Ribonuclease H-like (From Topology)T: Ribonuclease H-likeF: PF00022ECOD (1.6)
BPF00022e6cxjB2 A: mixed a+b and a/bX: Ribonuclease H-likeH: Ribonuclease H-like (From Topology)T: Ribonuclease H-likeF: PF00022ECOD (1.6)
CPF00022e6cxjC2 A: mixed a+b and a/bX: Ribonuclease H-likeH: Ribonuclease H-like (From Topology)T: Ribonuclease H-likeF: PF00022ECOD (1.6)
DPF00022e6cxjD1 A: mixed a+b and a/bX: Ribonuclease H-likeH: Ribonuclease H-like (From Topology)T: Ribonuclease H-likeF: PF00022ECOD (1.6)
EPF00022e6cxjE2 A: mixed a+b and a/bX: Ribonuclease H-likeH: Ribonuclease H-like (From Topology)T: Ribonuclease H-likeF: PF00022ECOD (1.6)
F [auth G]PF07679e6cxjG1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PF07679ECOD (1.6)
G [auth H]PF07679e6cxjH1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PF07679ECOD (1.6)
H [auth I]PF07679e6cxjI1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PF07679ECOD (1.6)
I [auth J]PF07679e6cxjJ1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PF07679ECOD (1.6)
J [auth K]PF07679e6cxjK1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PF07679ECOD (1.6)
K [auth L]PF07679e6cxjL1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PF07679ECOD (1.6)
L [auth M]PF07679e6cxjM1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PF07679ECOD (1.6)
M [auth N]PF07679e6cxjN1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PF07679ECOD (1.6)
N [auth O]PF07679e6cxjO1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PF07679ECOD (1.6)
O [auth P]PF07679e6cxjP1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PF07679ECOD (1.6)
P [auth Q]PF07679e6cxjQ1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PF07679ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF00022Actin (Actin)Actin- Family
PF07679Immunoglobulin I-set domain (I-set)Immunoglobulin I-set domain- Domain
L [auth M],
M [auth N],
N [auth O],
O [auth P],
P [auth Q]		PF07679Immunoglobulin I-set domain (I-set)Immunoglobulin I-set domain- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D, E
Actin, cytoplasmic 2
Myosin-binding protein C, cardiac-type
L [auth M],
M [auth N],
N [auth O],
O [auth P],
P [auth Q]		Myosin-binding protein C, cardiac-type
Q [auth S],
R [auth T],
S [auth U],
T [auth V]		Tropomyosin---

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D, E
IPR020902Actin/actin-like conserved siteConserved Site
A, B, C, D, E
IPR004001Actin, conserved siteConserved Site
A, B, C, D, E
IPR043129ATPase, nucleotide binding domainHomologous Superfamily
A, B, C, D, E
IPR004000Actin familyFamily
IPR036179Immunoglobulin-like domain superfamilyHomologous Superfamily
IPR003599Immunoglobulin subtypeDomain
IPR003598Immunoglobulin subtype 2Domain
IPR040849MyBP-C, tri-helix bundle domainDomain
IPR013098Immunoglobulin I-setDomain
IPR003961Fibronectin type IIIDomain
IPR013783Immunoglobulin-like foldHomologous Superfamily
IPR007110Immunoglobulin-like domainDomain
IPR036116Fibronectin type III superfamilyHomologous Superfamily
L [auth M],
M [auth N],
N [auth O],
O [auth P],
P [auth Q]		IPR036179Immunoglobulin-like domain superfamilyHomologous Superfamily
L [auth M],
M [auth N],
N [auth O],
O [auth P],
P [auth Q]		IPR003599Immunoglobulin subtypeDomain
L [auth M],
M [auth N],
N [auth O],
O [auth P],
P [auth Q]		IPR003598Immunoglobulin subtype 2Domain
L [auth M],
M [auth N],
N [auth O],
O [auth P],
P [auth Q]		IPR040849MyBP-C, tri-helix bundle domainDomain
L [auth M],
M [auth N],
N [auth O],
O [auth P],
P [auth Q]		IPR013098Immunoglobulin I-setDomain
L [auth M],
M [auth N],
N [auth O],
O [auth P],
P [auth Q]		IPR003961Fibronectin type IIIDomain
L [auth M],
M [auth N],
N [auth O],
O [auth P],
P [auth Q]		IPR013783Immunoglobulin-like foldHomologous Superfamily
L [auth M],
M [auth N],
N [auth O],
O [auth P],
P [auth Q]		IPR007110Immunoglobulin-like domainDomain
L [auth M],
M [auth N],
N [auth O],
O [auth P],
P [auth Q]		IPR036116Fibronectin type III superfamilyHomologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A, B, C, D, E
Pharos:  P63261
Pharos:  Q14896
L [auth M],
M [auth N],
N [auth O],
O [auth P],
P [auth Q]		Pharos:  Q14896