Annotations: 6CLZ

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6clza_	All beta proteins	4-bladed beta-propeller	Hemopexin-like domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Apolipoprotein	8072930	3001489	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Apolipoprotein	8072930	3001489	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Hemopexin-like domain	8073685	3001566	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Apolipoprotein	e6clzB1	A: alpha bundles	X: Four-helical up-and-down bundle	H: Apolipoprotein (From Topology)	T: Apolipoprotein	F: Apolipoprotein	ECOD (1.6)
C	Apolipoprotein	e6clzC1	A: alpha bundles	X: Four-helical up-and-down bundle	H: Apolipoprotein (From Topology)	T: Apolipoprotein	F: Apolipoprotein	ECOD (1.6)
A	Hemopexin	e6clzA1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 4-bladed	F: Hemopexin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.110.10.10	Mainly Beta	4 Propeller	Hemopexin	Hemopexin-like domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B, C	PF01442	Apolipoprotein A1/A4/E domain (Apolipoprotein)	Apolipoprotein A1/A4/E domain	These proteins contain several 22 residue repeats which form a pair of alpha helices. This family includes: Swiss:P02647 Apolipoprotein A-I. Swiss:P06727 Apolipoprotein A-IV. Swiss:P02649 Apolipoprotein E.	Domain
A	PF00045	Hemopexin (Hemopexin)	Hemopexin	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B, C	Apolipoprotein A-I	amide binding amyloid-beta binding binding peptide binding high-density lipoprotein particle receptor binding protein binding signaling receptor binding lipoprotein particle receptor binding heat shock protein binding phospholipid binding lipid binding sterol transfer activity lipid transporter activity lipid transfer activity amide binding amyloid-beta binding binding peptide binding high-density lipoprotein particle receptor binding protein binding signaling receptor binding lipoprotein particle receptor binding heat shock protein binding phospholipid binding lipid binding sterol transfer activity lipid transporter activity lipid transfer activity transporter activity cholesterol transfer activity apolipoprotein A-I receptor binding apolipoprotein receptor binding lipoprotein particle binding protein-containing complex binding protein-lipid complex binding high-density lipoprotein particle binding identical protein binding enzyme regulator activity enzyme activator activity molecular function activator activity molecular function regulator activity phosphatidylcholine-sterol O-acyltransferase activator activity sterol binding organic cyclic compound binding alcohol binding steroid binding cholesterol binding small molecule binding protein homodimerization activity protein dimerization activity signaling receptor regulator activity chemorepellent activity receptor ligand activity signaling receptor activator activity enzyme binding	positive regulation of cholesterol efflux regulation of localization transport positive regulation of sterol transport positive regulation of biological process regulation of lipid transport organic hydroxy compound transport localization regulation of cholesterol efflux sterol transport regulation of cholesterol transport positive regulation of cholesterol transport regulation of sterol transport regulation of biological process positive regulation of cholesterol efflux regulation of localization transport positive regulation of sterol transport positive regulation of biological process regulation of lipid transport organic hydroxy compound transport localization regulation of cholesterol efflux sterol transport regulation of cholesterol transport positive regulation of cholesterol transport regulation of sterol transport regulation of biological process regulation of transport organic substance transport biological regulation lipid localization lipid transport positive regulation of lipid localization establishment of localization positive regulation of lipid transport positive regulation of transport regulation of lipid localization macromolecule localization cholesterol transport cholesterol efflux vitamin transport regulation of protein stability regulation of biological quality protein stabilization phospholipid homeostasis chemical homeostasis homeostatic process lipid homeostasis reverse cholesterol transport regulation of CoA-transferase activity regulation of molecular function positive regulation of molecular function positive regulation of transferase activity regulation of catalytic activity positive regulation of CoA-transferase activity positive regulation of catalytic activity regulation of transferase activity triglyceride homeostasis acylglycerol homeostasis epithelium migration multicellular organismal process tissue migration endothelial cell migration ameboidal-type cell migration blood vessel endothelial cell migration epithelial cell migration cell migration cellular process cell motility organonitrogen compound metabolic process cellular metabolic process glycerophospholipid metabolic process primary metabolic process phospholipid metabolic process organic substance metabolic process organophosphate metabolic process cellular lipid metabolic process phosphate-containing compound metabolic process phosphatidylcholine metabolic process metabolic process glycerolipid metabolic process phosphorus metabolic process lipid metabolic process import into cell positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization vesicle-mediated transport cellular component organization positive regulation of endocytosis phagocytosis cellular component organization or biogenesis positive regulation of cellular process regulation of endocytosis regulation of phagocytosis regulation of vesicle-mediated transport positive regulation of phagocytosis endocytosis regulation of immune effector process response to stimulus negative regulation of biological process negative regulation of cellular metabolic process cytokine production organic substance biosynthetic process regulation of immune system process negative regulation of cytokine production involved in immune response regulation of cytokine production involved in immune response immune response negative regulation of metabolic process negative regulation of immune effector process regulation of cellular metabolic process negative regulation of cellular biosynthetic process immune effector process regulation of gene expression negative regulation of production of molecular mediator of immune response negative regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of production of molecular mediator of immune response negative regulation of multicellular organismal process regulation of metabolic process cellular biosynthetic process negative regulation of cellular process regulation of cytokine production regulation of multicellular organismal process cytokine production involved in immune response negative regulation of macromolecule metabolic process production of molecular mediator of immune response regulation of biosynthetic process negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process negative regulation of immune system process negative regulation of biosynthetic process immune system process positive regulation of substrate adhesion-dependent cell spreading regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of substrate adhesion-dependent cell spreading regulation of cell adhesion cell-substrate adhesion cell adhesion positive regulation of cell-substrate adhesion substrate adhesion-dependent cell spreading embryo development negative regulation of cell adhesion regulation of cell-cell adhesion involved in gastrulation heterotypic cell-cell adhesion multicellular organism development cell-cell adhesion anatomical structure development regulation of cell-cell adhesion regulation of heterotypic cell-cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules developmental process cell-cell adhesion involved in gastrulation embryonic morphogenesis gastrulation anatomical structure morphogenesis negative regulation of heterotypic cell-cell adhesion negative regulation of cell-cell adhesion chemotaxis negative chemotaxis taxis response to chemical response to external stimulus locomotion protein-containing complex remodeling protein-lipid complex organization very-low-density lipoprotein particle remodeling protein-lipid complex remodeling negative regulation of very-low-density lipoprotein particle remodeling plasma lipoprotein particle organization negative regulation of cellular component organization protein-containing complex organization plasma lipoprotein particle remodeling regulation of plasma lipoprotein particle levels regulation of very-low-density lipoprotein particle remodeling triglyceride-rich lipoprotein particle remodeling peptidyl-methionine modification macromolecule modification peptidyl-amino acid modification protein metabolic process protein modification process system process regulation of intestinal absorption digestive system process regulation of system process lipid digestion regulation of digestive system process intestinal lipid absorption digestion intestinal absorption regulation of intestinal lipid absorption intestinal cholesterol absorption regulation of intestinal cholesterol absorption protein oxidation cholesterol import cell population proliferation endothelial cell proliferation epithelial cell proliferation lipoprotein biosynthetic process lipoprotein metabolic process organonitrogen compound biosynthetic process cellular component biogenesis cellular component assembly high-density lipoprotein particle assembly protein-containing complex assembly plasma lipoprotein particle assembly protein-lipid complex assembly lipid biosynthetic process glycerophospholipid biosynthetic process phospholipid biosynthetic process glycerolipid biosynthetic process organophosphate biosynthetic process phosphatidylcholine biosynthetic process glucocorticoid metabolic process organic cyclic compound metabolic process steroid metabolic process phospholipid transport organophosphate ester transport phospholipid efflux cellular response to stimulus regulation of signaling small GTPase-mediated signal transduction signaling regulation of small GTPase mediated signal transduction regulation of signal transduction regulation of Cdc42 protein signal transduction regulation of Rho protein signal transduction intracellular signal transduction Rho protein signal transduction Cdc42 protein signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette regulation of cell communication signal transduction integrin-mediated signaling pathway cell surface receptor signaling pathway regulation of defense response regulation of response to external stimulus negative regulation of inflammatory response defense response negative regulation of response to stimulus regulation of inflammatory response response to stress negative regulation of response to external stimulus regulation of response to stress negative regulation of defense response inflammatory response interleukin-1 production regulation of interleukin-1 beta production negative regulation of interleukin-1 beta production negative regulation of interleukin-1 production regulation of interleukin-1 production interleukin-1 beta production positive regulation of cell communication positive regulation of signal transduction positive regulation of response to stimulus positive regulation of intracellular signal transduction positive regulation of Rho protein signal transduction positive regulation of small GTPase mediated signal transduction positive regulation of signaling regulation of cholesterol metabolic process organic hydroxy compound metabolic process sterol metabolic process regulation of lipid metabolic process cholesterol metabolic process alcohol metabolic process regulation of primary metabolic process positive regulation of metabolic process regulation of small molecule metabolic process positive regulation of lipid metabolic process small molecule metabolic process regulation of steroid metabolic process secondary alcohol metabolic process positive regulation of cholesterol metabolic process positive regulation of steroid metabolic process positive regulation of small molecule metabolic process sterol homeostasis cholesterol homeostasis steroid biosynthetic process secondary alcohol biosynthetic process small molecule biosynthetic process cholesterol biosynthetic process sterol biosynthetic process organic hydroxy compound biosynthetic process organic cyclic compound biosynthetic process alcohol biosynthetic process regulation of cell adhesion molecule production negative regulation of cell adhesion molecule production cell adhesion molecule production high-density lipoprotein particle clearance plasma lipoprotein particle clearance adrenal gland development endocrine system development gland development animal organ development system development high-density lipoprotein particle remodeling lipid storage maintenance of location response to organic substance response to cytokine regulation of response to cytokine stimulus negative regulation of response to cytokine stimulus regulation of protein modification process regulation of protein phosphorylation regulation of phosphate metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process regulation of phosphorylation regulation of phosphorus metabolic process G protein-coupled receptor signaling pathway regulation of phospholipid transport positive regulation of phospholipid efflux regulation of phospholipid efflux positive regulation of phospholipid transport negative regulation of signaling negative regulation of cell communication cytokine-mediated signaling pathway cellular response to tumor necrosis factor tumor necrosis factor-mediated signaling pathway cellular response to cytokine stimulus cellular response to organic substance regulation of tumor necrosis factor-mediated signaling pathway regulation of cytokine-mediated signaling pathway negative regulation of tumor necrosis factor-mediated signaling pathway negative regulation of signal transduction cellular response to chemical stimulus negative regulation of cytokine-mediated signaling pathway response to tumor necrosis factor positive regulation of organelle organization regulation of cytoskeleton organization regulation of actin filament-based process regulation of actin filament bundle assembly positive regulation of actin filament bundle assembly actin filament bundle organization positive regulation of stress fiber assembly actin filament-based process stress fiber assembly regulation of actin filament organization actin cytoskeleton organization actomyosin structure organization positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization actin filament organization regulation of cellular component biogenesis positive regulation of supramolecular fiber organization regulation of organelle organization regulation of stress fiber assembly organelle organization contractile actin filament bundle assembly regulation of actomyosin structure organization actin filament bundle assembly regulation of actin cytoskeleton organization regulation of supramolecular fiber organization supramolecular fiber organization cytoskeleton organization positive regulation of hydrolase activity regulation of hydrolase activity	protein-containing complex extracellular region plasma lipoprotein particle high-density lipoprotein particle extracellular space cellular anatomical entity lipoprotein particle protein-lipid complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle vesicle protein-containing complex extracellular region plasma lipoprotein particle high-density lipoprotein particle extracellular space cellular anatomical entity lipoprotein particle protein-lipid complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle vesicle extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix intracellular anatomical structure cytoplasm cytosol intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle endocytic vesicle membrane-enclosed lumen endomembrane system intracellular organelle lumen endoplasmic reticulum lumen organelle lumen endoplasmic reticulum spherical high-density lipoprotein particle plasma membrane membrane early endosome endosome blood microparticle vesicle lumen cytoplasmic vesicle lumen secretory granule lumen secretory granule secretory vesicle endocytic vesicle lumen very-low-density lipoprotein particle triglyceride-rich plasma lipoprotein particle
A	Matrix metalloproteinase-14	peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity metalloendopeptidase activity metallopeptidase activity aminopeptidase activity metalloaminopeptidase activity exopeptidase activity metalloexopeptidase activity peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity metalloendopeptidase activity metallopeptidase activity aminopeptidase activity metalloaminopeptidase activity exopeptidase activity metalloexopeptidase activity cell adhesion molecule binding protein-containing complex binding protein binding binding integrin binding signaling receptor binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development system development cellular developmental process glial cell migration nervous system development neurogenesis gliogenesis cell differentiation astrocyte cell migration cellular process cell migration cell motility epithelium development tube development branching morphogenesis of an epithelial tube morphogenesis of an epithelium tissue development tissue morphogenesis anatomical structure morphogenesis tube morphogenesis morphogenesis of a branching structure epithelial tube morphogenesis morphogenesis of a branching epithelium skeletal system development cellular component organization extracellular matrix organization cellular component organization or biogenesis extracellular structure organization external encapsulating structure organization endochondral ossification replacement ossification endochondral bone morphogenesis ossification skeletal system morphogenesis animal organ morphogenesis bone morphogenesis bone development cell population proliferation chondrocyte proliferation female gonad development female sex differentiation development of primary female sexual characteristics ovarian follicle development regulation of cellular process regulation of developmental process positive regulation of biological process regulation of cell differentiation regulation of striated muscle cell differentiation muscle cell differentiation myotube differentiation muscle structure development positive regulation of developmental process positive regulation of myotube differentiation positive regulation of cell differentiation positive regulation of striated muscle cell differentiation regulation of myotube differentiation positive regulation of cellular process regulation of biological process biological regulation positive regulation of muscle cell differentiation regulation of muscle cell differentiation striated muscle cell differentiation craniofacial suture morphogenesis cranial skeletal system development response to decreased oxygen levels response to stimulus response to hypoxia response to stress response to oxygen levels response to abiotic stimulus protein localization regulation of localization cellular localization protein localization to cell periphery regulation of protein localization protein localization to plasma membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane localization regulation of cellular localization cellular macromolecule localization macromolecule localization regulation of protein localization to plasma membrane regulation of protein localization to membrane regulation of leukocyte differentiation regulation of leukocyte activation regulation of cell activation mononuclear cell differentiation positive regulation of B cell differentiation lymphocyte differentiation regulation of cell development positive regulation of cell activation positive regulation of leukocyte activation regulation of immune system process positive regulation of immune system process positive regulation of cell development positive regulation of multicellular organismal process leukocyte differentiation cell development lymphocyte activation leukocyte activation positive regulation of lymphocyte activation regulation of B cell differentiation B cell differentiation positive regulation of hemopoiesis regulation of B cell activation regulation of multicellular organismal process regulation of lymphocyte differentiation regulation of multicellular organismal development hemopoiesis B cell activation cell activation positive regulation of B cell activation immune system process regulation of hemopoiesis positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation regulation of lymphocyte activation response to chemical response to odorant endothelial cell proliferation epithelial cell proliferation regulation of growth regulation of cellular component organization growth positive regulation of cell growth regulation of cell growth cell growth positive regulation of growth collagen catabolic process catabolic process metabolic process collagen metabolic process cell-substrate junction assembly negative regulation of biological process negative regulation of cell-substrate junction organization negative regulation of cell-matrix adhesion negative regulation of cell adhesion cellular component biogenesis cell adhesion cellular component assembly negative regulation of cell junction assembly cell junction assembly negative regulation of cellular process regulation of cell-substrate junction organization focal adhesion assembly negative regulation of cellular component organization regulation of cell-substrate adhesion regulation of cell adhesion cell-substrate adhesion regulation of cellular component biogenesis negative regulation of focal adhesion assembly regulation of cell junction assembly cell junction organization cell-matrix adhesion regulation of cell-matrix adhesion cell-substrate junction organization negative regulation of cell-substrate adhesion regulation of focal adhesion assembly regulation of cell-substrate junction assembly response to organic substance response to hormone response to endogenous stimulus response to estrogen blood vessel morphogenesis angiogenesis vasculature development circulatory system development anatomical structure formation involved in morphogenesis blood vessel development head development embryonic organ morphogenesis embryonic cranial skeleton morphogenesis chordate embryonic development embryonic morphogenesis embryo development embryo development ending in birth or egg hatching embryonic skeletal system development embryonic organ development embryonic skeletal system morphogenesis formation of primary germ layer gastrulation endoderm development endoderm formation endodermal cell differentiation respiratory tube development lung development respiratory system development regulation of protein maturation positive regulation of protein maturation cellular biosynthetic process positive regulation of protein metabolic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of protein processing protein maturation regulation of primary metabolic process positive regulation of metabolic process organic substance metabolic process regulation of proteolysis positive regulation of biosynthetic process proteolysis organic substance biosynthetic process positive regulation of macromolecule metabolic process protein metabolic process regulation of biosynthetic process organonitrogen compound metabolic process cellular metabolic process regulation of protein metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression positive regulation of proteolysis regulation of protein processing protein processing regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process tissue remodeling cellular component disassembly extracellular matrix disassembly positive regulation of locomotion regulation of cell motility macrophage migration positive regulation of cell migration regulation of macrophage migration positive regulation of cell motility regulation of cell migration myeloid leukocyte migration positive regulation of mononuclear cell migration regulation of mononuclear cell migration locomotion positive regulation of macrophage migration regulation of leukocyte migration positive regulation of leukocyte migration leukocyte migration regulation of locomotion mononuclear cell migration cellular response to stimulus negative regulation of signaling signaling regulation of signal transduction negative regulation of cell communication cell communication signal transduction regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of signal transduction Notch signaling pathway negative regulation of Notch signaling pathway regulation of response to stimulus regulation of Notch signaling pathway regulation of cell communication response to mechanical stimulus response to external stimulus response to oxidative stress response to organic cyclic compound zymogen activation	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle endosome intracellular vesicle intracellular membrane-bounded organelle macropinosome endomembrane system intracellular organelle cytoplasmic vesicle organelle vesicle intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle endosome intracellular vesicle intracellular membrane-bounded organelle macropinosome endomembrane system intracellular organelle cytoplasmic vesicle organelle vesicle pinosome cytoskeleton intracellular non-membrane-bounded organelle non-membrane-bounded organelle intermediate filament cytoskeleton extracellular region extracellular space anchoring junction cell junction focal adhesion cell-substrate junction pigment granule melanosome cell periphery plasma membrane membrane extracellular matrix external encapsulating structure Golgi apparatus membrane-enclosed lumen intracellular organelle lumen Golgi lumen organelle lumen nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B, C	IPR000074	Apolipoprotein A/E	Family
A	IPR021158	Peptidase M10A, cysteine switch, zinc binding site	Binding Site
A	IPR021190	Peptidase M10A	Family
A	IPR002477	Peptidoglycan binding-like	Domain
A	IPR006026	Peptidase, metallopeptidase	Domain
A	IPR033739	Peptidase M10A, catalytic domain	Domain
A	IPR018486	Hemopexin, conserved site	Conserved Site
A	IPR036375	Hemopexin-like domain superfamily	Homologous Superfamily
A	IPR036365	PGBD-like superfamily	Homologous Superfamily
A	IPR001818	Peptidase M10, metallopeptidase	Domain
A	IPR021805	Peptidase M10A, matrix metallopeptidase, C-terminal	Domain
A	IPR024079	Metallopeptidase, catalytic domain superfamily	Homologous Superfamily
A	IPR018487	Hemopexin-like repeats	Repeat
A	IPR000585	Hemopexin-like domain	Domain
A	IPR036366	PGBD superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B, C	Pharos: P02647	familial visceral amyloidosis hypertensive disorder membranous glomerulonephritis coronary artery disease Behcet disease Hypoxia acute lung injury amyloidosis HIV infectious disease peripheral neuropathy cerebrovascular disorder Tangier disease hypoalphalipoproteinemia, primary, 1 inherited lipid metabolism disorder adenocarcinoma familial visceral amyloidosis hypertensive disorder membranous glomerulonephritis coronary artery disease Behcet disease Hypoxia acute lung injury amyloidosis HIV infectious disease peripheral neuropathy cerebrovascular disorder Tangier disease hypoalphalipoproteinemia, primary, 1 inherited lipid metabolism disorder adenocarcinoma granular cell carcinoma hypoalphalipoproteinemia tubular adenocarcinoma malignant mesothelioma atherosclerosis psoriasis type 2 diabetes mellitus abdominal aortic aneurysm drug-induced liver injury lung benign neoplasm familial isolated deficiency of vitamin E gastric neoplasm metabolic disease non-alcoholic fatty liver disease hereditary diffuse gastric adenocarcinoma hypertrophic pyloric stenosis cribriform carcinoma idiopathic membranous glomerulonephritis acquired metabolic disease metabolic syndrome X obesity disorder periodic fever syndrome cribriform carcinoma of breast inborn carbohydrate metabolic disorder lung adenocarcinoma gastric cancer heart disease hepatocellular carcinoma ovarian cancer apolipoprotein A-I deficiency peripheral nervous system disease
A	Pharos: P50281	Winchester syndrome abdominal aortic aneurysm Neoplasm Invasiveness breast carcinoma tubular adenocarcinoma esophageal cancer adenocarcinoma breast cancer granular cell carcinoma lung carcinoma malignant mesothelioma non-small cell lung carcinoma pilocytic astrocytoma prostate carcinoma cribriform carcinoma Winchester syndrome abdominal aortic aneurysm Neoplasm Invasiveness breast carcinoma tubular adenocarcinoma esophageal cancer adenocarcinoma breast cancer granular cell carcinoma lung carcinoma malignant mesothelioma non-small cell lung carcinoma pilocytic astrocytoma prostate carcinoma cribriform carcinoma hypertensive disorder malignant ependymoma neoplasm of esophagus osteosarcoma plantar fibromatosis atypical teratoid rhabdoid tumor psoriasis cancer cribriform carcinoma of breast glioblastoma lung adenocarcinoma malignant glioma malignant pancreatic neoplasm medulloblastoma pancreatic ductal adenocarcinoma Torg-Winchester syndrome chronic obstructive pulmonary disease cystic fibrosis

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.