6CE7
Insulin Receptor ectodomain in complex with one insulin molecule
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A [auth B] | SCOP2B Superfamily | L domain-like | 8032830 | 3001010 | SCOP2B (2022-06-29) |
A [auth B] | SCOP2B Superfamily | L domain-like | 8032832 | 3001010 | SCOP2B (2022-06-29) |
A [auth B] | SCOP2B Superfamily | Growth factor receptor domain-like | 8032837 | 3000398 | SCOP2B (2022-06-29) |
B [auth A] | SCOP2B Superfamily | L domain-like | 8032830 | 3001010 | SCOP2B (2022-06-29) |
B [auth A] | SCOP2B Superfamily | L domain-like | 8032832 | 3001010 | SCOP2B (2022-06-29) |
C [auth N] | SCOP2B Superfamily | Insulin-like | 8038024 | 3000307 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A [auth B] | F_UNCLASSIFIED | e6ce7B3 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: F_UNCLASSIFIED | ECOD (1.6) |
A [auth B] | PF00041 | e6ce7B2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF00041 | ECOD (1.6) |
A [auth B] | PF01030 | e6ce7B1 | A: beta duplicates or obligate multimers | X: Single-stranded right-handed beta-helix | H: Leucine-rich repeats (From Topology) | T: Leucine-rich repeats | F: PF01030 | ECOD (1.6) |
A [auth B] | PF00757 | e6ce7B4 | A: few secondary structure elements | X: EGF-like | H: Growth factor receptor domain (From Topology) | T: Growth factor receptor domain | F: PF00757 | ECOD (1.6) |
B [auth A] | F_UNCLASSIFIED | e6ce7A1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: F_UNCLASSIFIED | ECOD (1.6) |
B [auth A] | PF01030 | e6ce7A3 | A: beta duplicates or obligate multimers | X: Single-stranded right-handed beta-helix | H: Leucine-rich repeats (From Topology) | T: Leucine-rich repeats | F: PF01030 | ECOD (1.6) |
B [auth A] | PF00757 | e6ce7A4 | A: few secondary structure elements | X: EGF-like | H: Growth factor receptor domain (From Topology) | T: Growth factor receptor domain | F: PF00757 | ECOD (1.6) |
C [auth N] | PF00049 | e6ce7N1 | A: few secondary structure elements | X: Insulin-like (From Topology) | H: Insulin-like (From Topology) | T: Insulin-like | F: PF00049 | ECOD (1.6) |
D [auth O] | PF00049 | e6ce7O1 | A: few secondary structure elements | X: Insulin-like (From Topology) | H: Insulin-like (From Topology) | T: Insulin-like | F: PF00049 | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A [auth B], B [auth A] | PF00757 | Furin-like cysteine rich region (Furin-like) | Furin-like cysteine rich region | - | Domain |
A [auth B], B [auth A] | PF01030 | Receptor L domain (Recep_L_domain) | Receptor L domain | - | Repeat |
C [auth N] | PF00049 | Insulin/IGF/Relaxin family (Insulin) | Insulin/IGF/Relaxin family | Superfamily includes insulins; relaxins; insulin-like growth factor; and bombyxin. All are secreted regulatory hormones. Disulfide rich, all-alpha fold. Alignment includes B chain, linker (which is processed out of the final product), and A chain. | Domain |
D [auth O] | PF00049 | Insulin/IGF/Relaxin family (Insulin) | Insulin/IGF/Relaxin family | Superfamily includes insulins; relaxins; insulin-like growth factor; and bombyxin. All are secreted regulatory hormones. Disulfide rich, all-alpha fold. Alignment includes B chain, linker (which is processed out of the final product), and A chain. | Domain |