6C95

The Human NatA (Naa10/Naa15) amino-terminal acetyltransferase complex bound to HYPK

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d6c95b_	Alpha and beta proteins (a+b)	Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Acyl-CoA N-acyltransferases (Nat)	8098678	3000403	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF12569	e6c95A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF12569	ECOD (1.6)
B	PF00583	e6c95B1	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: PF00583	ECOD (1.6)
C [auth D]	PF19026	e6c95D1	A: alpha arrays	X: RuvA-C	H: RuvA-C, UBA, CRAL/TRIO-N, HBS1 (From Topology)	T: RuvA-C, UBA, CRAL/TRIO-N, HBS1	F: PF19026	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF13181	Tetratricopeptide repeat (TPR_8)	Tetratricopeptide repeat	-	Repeat
A	PF12569	N-terminal acetyltransferase A, auxiliary subunit (NatA_aux_su)	N-terminal acetyltransferase A, auxiliary subunit	-	Repeat
B	PF00583	Acetyltransferase (GNAT) family (Acetyltransf_1)	Acetyltransferase (GNAT) family	-	Family
C [auth D]	PF19026	HYPK UBA domain (HYPK_UBA)	HYPK UBA domain	This entry represents the UBA domain [1] found at the C-terminus of the HYPK protein and its homologues. This domain in HYPK mediates a protein interaction with the Naa15 C-terminus [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	N-alpha-acetyltransferase 15, NatA auxiliary subunit	ribonucleoprotein complex binding protein-containing complex binding binding ribosome binding RNA binding organic cyclic compound binding nucleic acid binding	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein acylation protein maturation protein acetylation organic substance metabolic process biosynthetic process N-terminal protein amino acid modification macromolecule modification N-terminal protein amino acid acetylation organic substance biosynthetic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein acylation protein maturation protein acetylation organic substance metabolic process biosynthetic process N-terminal protein amino acid modification macromolecule modification N-terminal protein amino acid acetylation organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process developmental process cellular developmental process cell differentiation regulation of protein stability biological regulation regulation of biological quality protein stabilization multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis anatomical structure development anatomical structure formation involved in morphogenesis blood vessel development system development regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process	membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol protein-containing complex transcription regulator complex NatA complex catalytic complex N-terminal protein acetyltransferase complex transferase complex acetyltransferase complex protein acetyltransferase complex intracellular protein-containing complex membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol protein-containing complex transcription regulator complex NatA complex catalytic complex N-terminal protein acetyltransferase complex transferase complex acetyltransferase complex protein acetyltransferase complex intracellular protein-containing complex membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nuclear body nucleoplasm organelle lumen nuclear lumen
B	N-alpha-acetyltransferase 10	acetyltransferase activity N-acetyltransferase activity acyltransferase activity peptide-serine-alpha-N-acetyltransferase activity peptide alpha-N-acetyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity peptide N-acetyltransferase activity catalytic activity N-acyltransferase activity peptide-glutamate-alpha-N-acetyltransferase activity	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein acylation protein maturation protein acetylation organic substance metabolic process biosynthetic process N-terminal protein amino acid modification macromolecule modification N-terminal protein amino acid acetylation organic substance biosynthetic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein acylation protein maturation protein acetylation organic substance metabolic process biosynthetic process N-terminal protein amino acid modification macromolecule modification N-terminal protein amino acid acetylation organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process cellular component organization organelle organization chromosome organization cellular component organization or biogenesis internal protein amino acid acetylation regulation of maintenance of mitotic sister chromatid cohesion negative regulation of maintenance of sister chromatid cohesion regulation of cellular component organization regulation of cellular process negative regulation of maintenance of mitotic sister chromatid cohesion mitotic sister chromatid cohesion negative regulation of biological process negative regulation of cell cycle maintenance of sister chromatid cohesion regulation of maintenance of mitotic sister chromatid cohesion, centromeric centromeric sister chromatid cohesion negative regulation of sister chromatid cohesion negative regulation of chromosome organization maintenance of mitotic sister chromatid cohesion regulation of centromeric sister chromatid cohesion negative regulation of cellular process cell cycle regulation of cell cycle cell cycle process regulation of biological process negative regulation of cellular component organization regulation of cell cycle process biological regulation sister chromatid cohesion regulation of chromosome organization negative regulation of cell cycle process negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric regulation of organelle organization regulation of maintenance of sister chromatid cohesion maintenance of mitotic sister chromatid cohesion, centromeric negative regulation of organelle organization regulation of sister chromatid cohesion mitotic sister chromatid cohesion, centromeric	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane cytoplasm cytosol protein-containing complex NatA complex catalytic complex N-terminal protein acetyltransferase complex transferase complex acetyltransferase complex protein acetyltransferase complex intracellular protein-containing complex
C [auth D]	Huntingtin-interacting protein K	protein folding chaperone	regulation of protein stability biological regulation regulation of biological quality protein stabilization regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process cellular process regulation of protein stability biological regulation regulation of biological quality protein stabilization regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process cellular process apoptotic process programmed cell death	intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A	IPR021183	N-terminal acetyltransferase A, auxiliary subunit	Family
A	IPR019734	Tetratricopeptide repeat	Repeat
B	IPR045047	N-acetyltransferase Ard1-like	Family
B	IPR000182	GNAT domain	Domain
B	IPR016181	Acyl-CoA N-acyltransferase	Homologous Superfamily
C [auth D]	IPR044034	Nascent polypeptide-associated complex subunit alpha-like, UBA domain	Domain
C [auth D]	IPR038922	Huntingtin-interacting protein K, UBA-like domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9BXJ9	intellectual disability acute myeloid leukemia Mental deficiency oligodendroglioma ulcerative colitis astrocytic tumor intellectual disability, autosomal dominant 50 osteosarcoma psoriasis atopic eczema limb-girdle muscular dystrophy Ogden syndrome ovarian cancer rheumatoid arthritis
B	Pharos: P41227	Ogden syndrome microphthalmia, syndromic 1 microphthalmia Adenocarcinoma of Lung lung adenocarcinoma rheumatoid arthritis celiac disease lung cancer microphthalmia, Lenz type osteosarcoma Sjogren syndrome coloboma intellectual disability malignant colon neoplasm ovarian cancer Ogden syndrome microphthalmia, syndromic 1 microphthalmia Adenocarcinoma of Lung lung adenocarcinoma rheumatoid arthritis celiac disease lung cancer microphthalmia, Lenz type osteosarcoma Sjogren syndrome coloboma intellectual disability malignant colon neoplasm ovarian cancer systemic lupus erythematosus
C [auth D]	Pharos: Q9NX55	metabolic syndrome X Ogden syndrome

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
B	ACE	RESID: AA0041 , AA0042 , AA0043 , AA0044 , AA0045 , AA0046 , AA0049 , AA0050 , AA0051 , AA0052 , AA0053 , AA0054 , AA0354 PSI-MOD : N-acetyl-L-alanine MOD:00050 , N-acetyl-L-aspartic acid MOD:00051 , N-acetyl-L-cysteine MOD:00052 , N-acetyl-S-archeol-cysteine MOD:00897 , N-acetyl-L-glutamic acid MOD:00053 , N-acetyl-L-glutamine MOD:00054 , N-acetylglycine MOD:00055 , N-acetyl-L-methionine MOD:00058 , N-acetyl-L-proline MOD:00059 , N-acetyl-L-serine MOD:00060 , N,O-diacetylated L-serine MOD:00648 , N-acetyl-L-threonine MOD:00061 , N-acetyl-L-tyrosine MOD:00062 , N-acetyl-L-valine MOD:00063 , N2-acetyl-L-arginine MOD:00359

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.