Annotations: 6C6R

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF08491	e6c6rA2	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: PF08491	ECOD (1.6)
A	PF08491	e6c6rA1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: PF08491	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF13450	NAD(P)-binding Rossmann-like domain (NAD_binding_8)	NAD(P)-binding Rossmann-like domain	-	Domain
A, B	PF08491	Squalene epoxidase (SE)	Squalene epoxidase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Squalene monooxygenase	FAD binding flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding squalene monooxygenase activity oxidoreductase activity monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen FAD binding flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding squalene monooxygenase activity oxidoreductase activity monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen catalytic activity	response to organic substance response to stimulus response to chemical regulation of biological process cell population proliferation regulation of cellular process regulation of cell population proliferation biological regulation cellular process organic hydroxy compound metabolic process steroid metabolic process sterol metabolic process lipid biosynthetic process primary metabolic process response to organic substance response to stimulus response to chemical regulation of biological process cell population proliferation regulation of cellular process regulation of cell population proliferation biological regulation cellular process organic hydroxy compound metabolic process steroid metabolic process sterol metabolic process lipid biosynthetic process primary metabolic process organic cyclic compound metabolic process organic substance metabolic process sterol biosynthetic process biosynthetic process organic hydroxy compound biosynthetic process organic cyclic compound biosynthetic process organic substance biosynthetic process metabolic process steroid biosynthetic process lipid metabolic process cholesterol metabolic process alcohol metabolic process secondary alcohol metabolic process small molecule metabolic process organelle assembly non-membrane-bounded organelle assembly lipid storage lipid localization lipid droplet formation maintenance of location cellular component organization cellular component biogenesis localization organelle organization cellular component assembly macromolecule localization lipid droplet organization cellular component organization or biogenesis	membrane cellular anatomical entity membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle intracellular membrane-bounded organelle endoplasmic reticulum cytoplasm endomembrane system organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network organelle membrane membrane cellular anatomical entity membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle intracellular membrane-bounded organelle endoplasmic reticulum cytoplasm endomembrane system organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network organelle membrane endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR013698	Squalene epoxidase	Domain
A, B	IPR036188	FAD/NAD(P)-binding domain superfamily	Homologous Superfamily
A, B	IPR040125	Squalene monooxygenase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q14534	Liver Neoplasms, Experimental medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor atypical teratoid rhabdoid tumor tinea pedis breast carcinoma dermatophytosis of scalp or beard large cell medulloblastoma lymphoplasmacytic lymphoma malignant mesothelioma non-small cell lung carcinoma pancreatic ductal adenocarcinoma Pick disease Liver Neoplasms, Experimental medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor atypical teratoid rhabdoid tumor tinea pedis breast carcinoma dermatophytosis of scalp or beard large cell medulloblastoma lymphoplasmacytic lymphoma malignant mesothelioma non-small cell lung carcinoma pancreatic ductal adenocarcinoma Pick disease psoriasis B-cell chronic lymphocytic leukemia ulcerative colitis Crohn disease ductal breast carcinoma in situ malignant colon neoplasm malignant pancreatic neoplasm osteosarcoma pancreatic intraductal papillary-mucinous carcinoma pityriasis versicolor tinea corporis breast cancer dermatophytosis of groin and perianal area invasive ductal breast carcinoma lung cancer malignant ependymoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.