6C46

Crystal structure of dTDP-4-dehydrorhamnose 3,5-epimerase from Elizabethkingia anophelis NUHP1

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6c46a1	All beta proteins	Double-stranded beta-helix	RmlC-like cupins	automated matches	automated matches	(Elizabethkingia anophelis NUHP1 ) [TaxId: 1338011 ],	SCOPe (2.08)
A	d6c46a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Elizabethkingia anophelis NUHP1 ) [TaxId: 1338011 ],	SCOPe (2.08)
B	d6c46b1	All beta proteins	Double-stranded beta-helix	RmlC-like cupins	automated matches	automated matches	(Elizabethkingia anophelis NUHP1 ) [TaxId: 1338011 ],	SCOPe (2.08)
B	d6c46b2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Elizabethkingia anophelis NUHP1 ) [TaxId: 1338011 ],	SCOPe (2.08)
C	d6c46c1	All beta proteins	Double-stranded beta-helix	RmlC-like cupins	automated matches	automated matches	(Elizabethkingia anophelis NUHP1 ) [TaxId: 1338011 ],	SCOPe (2.08)
C	d6c46c2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Elizabethkingia anophelis NUHP1 ) [TaxId: 1338011 ],	SCOPe (2.08)
D	d6c46d1	All beta proteins	Double-stranded beta-helix	RmlC-like cupins	automated matches	automated matches	(Elizabethkingia anophelis NUHP1 ) [TaxId: 1338011 ],	SCOPe (2.08)
D	d6c46d2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Elizabethkingia anophelis NUHP1 ) [TaxId: 1338011 ],	SCOPe (2.08)
E	d6c46e1	All beta proteins	Double-stranded beta-helix	RmlC-like cupins	automated matches	automated matches	(Elizabethkingia anophelis NUHP1 ) [TaxId: 1338011 ],	SCOPe (2.08)
E	d6c46e2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Elizabethkingia anophelis NUHP1 ) [TaxId: 1338011 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	dTDP-sugar isomerase	8063623	4002863	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	RmlC-like cupins	8063624	3001825	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	RmlC-like cupins	8063624	3001825	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	RmlC-like cupins	8063624	3001825	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	RmlC-like cupins	8063624	3001825	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	RmlC-like cupins	8063624	3001825	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	dTDP_sugar_isom	e6c46A1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: dTDP_sugar_isom	ECOD (1.6)
B	dTDP_sugar_isom	e6c46B1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: dTDP_sugar_isom	ECOD (1.6)
C	dTDP_sugar_isom	e6c46C1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: dTDP_sugar_isom	ECOD (1.6)
D	dTDP_sugar_isom	e6c46D1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: dTDP_sugar_isom	ECOD (1.6)
E	dTDP_sugar_isom	e6c46E1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: dTDP_sugar_isom	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.10	Mainly Beta	Sandwich	Jelly Rolls	Jelly Rolls	CATH (4.3.0)
B	2.60.120.10	Mainly Beta	Sandwich	Jelly Rolls	Jelly Rolls	CATH (4.3.0)
C	2.60.120.10	Mainly Beta	Sandwich	Jelly Rolls	Jelly Rolls	CATH (4.3.0)
D	2.60.120.10	Mainly Beta	Sandwich	Jelly Rolls	Jelly Rolls	CATH (4.3.0)
E	2.60.120.10	Mainly Beta	Sandwich	Jelly Rolls	Jelly Rolls	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E	PF00908	dTDP-4-dehydrorhamnose 3,5-epimerase (dTDP_sugar_isom)	dTDP-4-dehydrorhamnose 3,5-epimerase	This family catalyse the isomerisation of dTDP-4-dehydro-6-deoxy -D-glucose with dTDP-4-dehydro-6-deoxy-L-mannose. The EC number of this enzyme is 5.1.3.13.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E	dTDP-4-dehydrorhamnose 3,5-epimerase	isomerase activity racemase and epimerase activity dTDP-4-dehydrorhamnose 3,5-epimerase activity racemase and epimerase activity, acting on carbohydrates and derivatives catalytic activity	carbohydrate derivative biosynthetic process nucleotide-sugar metabolic process carbohydrate derivative metabolic process primary metabolic process dTDP-rhamnose biosynthetic process nucleobase-containing compound biosynthetic process dTDP-rhamnose metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process nucleobase-containing small molecule metabolic process organic cyclic compound biosynthetic process organic substance biosynthetic process carbohydrate derivative biosynthetic process nucleotide-sugar metabolic process carbohydrate derivative metabolic process primary metabolic process dTDP-rhamnose biosynthetic process nucleobase-containing compound biosynthetic process dTDP-rhamnose metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process nucleobase-containing small molecule metabolic process organic cyclic compound biosynthetic process organic substance biosynthetic process small molecule metabolic process metabolic process nucleotide-sugar biosynthetic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E	IPR000888	dTDP-4-dehydrorhamnose 3,5-epimerase-like	Family
A, B, C, D, E	IPR011051	RmlC-like cupin domain superfamily	Homologous Superfamily
A, B, C, D, E	IPR014710	RmlC-like jelly roll fold	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.