6C24

Cryo-EM structure of PRC2 bound to cofactors AEBP2 and JARID2 in the Extended Active State

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
F [auth M]	SCOP2B Superfamily	VEFS box-like	8090819	3002459	SCOP2B (2022-06-29)
G [auth N]	SCOP2B Superfamily	WD40 repeat-like	8053350	3001694	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
F [auth M]	PF09733	e6c24M1	A: alpha arrays	X: lambda integrase-N-like	H: VEFS domain (From Topology)	T: VEFS domain	F: PF09733	ECOD (1.6)
D [auth K]	PF00856	e6c24K2	A: beta barrels	X: beta-clip	H: SET domain-like (From Topology)	T: SET domain-like	F: PF00856	ECOD (1.6)
D [auth K]	F_UNCLASSIFIED	e6c24K5	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: F_UNCLASSIFIED	ECOD (1.6)
D [auth K]	F_UNCLASSIFIED	e6c24K3	A: few secondary structure elements	X: Zn3Cys9 preSET domain-related (From Topology)	H: Zn3Cys9 preSET domain-related (From Topology)	T: Zn3Cys9 preSET domain-related	F: F_UNCLASSIFIED	ECOD (1.6)
D [auth K]	PF18264	e6c24K4	A: few secondary structure elements	X: Zn3Cys9 preSET domain-related (From Topology)	H: Zn3Cys9 preSET domain-related (From Topology)	T: Zn3Cys9 preSET domain-related	F: PF18264	ECOD (1.6)
D [auth K]	PF21358	e6c24K1	A: few secondary structure elements	X: Ezh2 MCSS domain (From Topology)	H: Ezh2 MCSS domain (From Topology)	T: Ezh2 MCSS domain	F: PF21358	ECOD (1.6)
L [auth C]	PF18118	e6c24C2	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PF18118	ECOD (1.6)
L [auth C]	PF11616	e6c24C1	A: extended segments	X: Ezh2 N-terminal domain (From Topology)	H: Ezh2 N-terminal domain (From Topology)	T: Ezh2 N-terminal domain	F: PF11616	ECOD (1.6)
E [auth L]	PF00400	e6c24L1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400	ECOD (1.6)
G [auth N]	PF00400,PF12265	e6c24N1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400,PF12265	ECOD (1.6)
I [auth P]	F_UNCLASSIFIED	e6c24P1	A: beta barrels	X: SH3	H: Chromo domain-like (From Topology)	T: Chromo domain-like	F: F_UNCLASSIFIED	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
E [auth L]	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
G [auth N]	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, F [auth M], J [auth Q]	PF09733	VEFS-Box of polycomb protein (VEFS-Box)	VEFS-Box of polycomb protein	-	Family
D [auth K], L [auth C]	PF18264	CXC domain (preSET_CXC)	CXC domain	This domain is found to the N-terminus of the SET domain in the EZH2 protein [1]. It is a zinc binding domain.	Domain
D [auth K], L [auth C]	PF00856	SET domain (SET)	SET domain	-	Family
D [auth K], L [auth C]	PF11616	WD repeat binding protein EZH2 (EZH2_WD-Binding)	WD repeat binding protein EZH2	-	Family
E [auth L]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
G [auth N]	PF12265	Histone-binding protein RBBP4 or subunit C of CAF1 complex (CAF1C_H4-bd)	Histone-binding protein RBBP4 or subunit C of CAF1 complex	-	Repeat
G [auth N]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
C [auth E]	Protein Jumonji	protein-containing complex binding chromatin binding binding protein binding ubiquitin binding ubiquitin-like protein binding DNA binding organic cyclic compound binding nucleic acid binding ubiquitin-modified protein reader activity ubiquitin-modified histone reader activity modification-dependent protein binding protein-macromolecule adaptor activity ubiquitin-like protein reader activity protein-containing complex binding chromatin binding binding protein binding ubiquitin binding ubiquitin-like protein binding DNA binding organic cyclic compound binding nucleic acid binding ubiquitin-modified protein reader activity ubiquitin-modified histone reader activity modification-dependent protein binding protein-macromolecule adaptor activity ubiquitin-like protein reader activity molecular adaptor activity protein-lysine N-methyltransferase activity histone H3 methyltransferase activity catalytic activity, acting on a protein transferase activity, transferring one-carbon groups transferase activity S-adenosylmethionine-dependent methyltransferase activity histone H3K27 methyltransferase activity histone methyltransferase activity lysine N-methyltransferase activity protein methyltransferase activity histone modifying activity N-methyltransferase activity methyltransferase activity catalytic activity	developmental process multicellular organism development multicellular organismal process hepaticobiliary system development gland development animal organ development anatomical structure development liver development system development immune system development hematopoietic or lymphoid organ development thymus development immune system process central nervous system development developmental process multicellular organism development multicellular organismal process hepaticobiliary system development gland development animal organ development anatomical structure development liver development system development immune system development hematopoietic or lymphoid organ development thymus development immune system process central nervous system development nervous system development heart development heart growth cell population proliferation developmental growth cardiac muscle tissue development cardiac muscle cell proliferation growth organ growth tissue development striated muscle tissue development circulatory system development muscle cell proliferation cellular process cardiac muscle tissue growth muscle tissue development striated muscle cell proliferation protein localization protein localization to chromatin cellular localization protein localization to chromosome, centromeric region localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to pericentric heterochromatin protein localization to heterochromatin regulation of biosynthetic process regulation of biological process regulation of cellular process cellular biosynthetic process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organic substance metabolic process biosynthetic process organic substance biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of growth regulation of cardiac muscle tissue growth regulation of developmental process negative regulation of biological process negative regulation of cardiac muscle tissue growth negative regulation of organ growth negative regulation of growth regulation of organ growth regulation of heart growth negative regulation of cellular process regulation of cardiac muscle cell proliferation regulation of multicellular organismal process negative regulation of cell population proliferation regulation of multicellular organismal development regulation of developmental growth negative regulation of heart growth negative regulation of developmental process negative regulation of developmental growth regulation of cell population proliferation negative regulation of multicellular organismal process negative regulation of cardiac muscle cell proliferation spleen development negative regulation of cellular metabolic process protein-DNA complex organization cellular component organization chromatin organization chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process heterochromatin formation protein-containing complex organization epigenetic regulation of gene expression negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process facultative heterochromatin formation negative regulation of gene expression, epigenetic muscle hypertrophy regulation of muscle adaptation system process negative regulation of muscle hypertrophy response to stimulus regulation of system process striated muscle hypertrophy regulation of muscle system process muscle system process regulation of muscle hypertrophy regulation of cardiac muscle hypertrophy muscle adaptation regulation of response to stimulus cardiac muscle hypertrophy negative regulation of cardiac muscle hypertrophy regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II primary metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process stem cell differentiation cellular developmental process cell differentiation random inactivation of X chromosome sex-chromosome dosage compensation dosage compensation by inactivation of X chromosome cellular response to stimulus response to organic substance response to cytokine response to leukemia inhibitory factor cellular response to leukemia inhibitory factor cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular response to organic substance	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex histone methyltransferase complex catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex histone methyltransferase complex catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen nucleoplasm organelle lumen methyltransferase complex nuclear lumen PcG protein complex ESC/E(Z) complex protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle
A, F [auth M], J [auth Q]	Polycomb protein SUZ12	transcription factor binding transcription coregulator binding transcription corepressor binding protein binding binding RNA binding organic cyclic compound binding lncRNA binding nucleic acid binding DNA binding sequence-specific DNA binding double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding transcription factor binding transcription coregulator binding transcription corepressor binding protein binding binding RNA binding organic cyclic compound binding lncRNA binding nucleic acid binding DNA binding sequence-specific DNA binding double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein-containing complex binding chromatin binding promoter-specific chromatin binding catalytic activity, acting on a protein transferase activity, transferring one-carbon groups protein methyltransferase activity histone modifying activity transferase activity methyltransferase activity catalytic activity histone methyltransferase activity enzyme regulator activity enzyme activator activity molecular function activator activity molecular function regulator activity chromatin DNA binding methylated histone binding modification-dependent protein binding histone binding methylation-dependent protein binding cation binding ion binding metal ion binding small molecule binding	developmental process multicellular organismal process cellular developmental process nervous system development multicellular organism development neurogenesis central nervous system development gliogenesis oligodendrocyte differentiation glial cell differentiation cell differentiation anatomical structure development cellular process system development developmental process multicellular organismal process cellular developmental process nervous system development multicellular organism development neurogenesis central nervous system development gliogenesis oligodendrocyte differentiation glial cell differentiation cell differentiation anatomical structure development cellular process system development cell population proliferation regulation of biological process regulation of cellular process positive regulation of cell population proliferation regulation of cell population proliferation biological regulation positive regulation of biological process positive regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process protein-DNA complex organization cellular component organization organic substance metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process regulation of biosynthetic process heterochromatin formation protein-containing complex organization epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process facultative heterochromatin formation negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of developmental process negative regulation of developmental process regulation of cell differentiation negative regulation of cell differentiation regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II primary metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process random inactivation of X chromosome sex-chromosome dosage compensation dosage compensation by inactivation of X chromosome	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle RSC-type complex ATPase complex protein-containing complex catalytic complex protein-DNA complex nuclear protein-containing complex chromatin chromosome SWI/SNF superfamily-type complex sex chromosome heterochromatin sex chromatin histone methyltransferase complex transferase complex PcG protein complex nucleoplasm methyltransferase complex ESC/E(Z) complex chromatin silencing complex ribonucleoprotein complex nuclear body
B	Protein Jumonji	protein-containing complex binding chromatin binding binding protein binding ubiquitin binding ubiquitin-like protein binding DNA binding organic cyclic compound binding nucleic acid binding ubiquitin-modified protein reader activity ubiquitin-modified histone reader activity modification-dependent protein binding protein-macromolecule adaptor activity ubiquitin-like protein reader activity protein-containing complex binding chromatin binding binding protein binding ubiquitin binding ubiquitin-like protein binding DNA binding organic cyclic compound binding nucleic acid binding ubiquitin-modified protein reader activity ubiquitin-modified histone reader activity modification-dependent protein binding protein-macromolecule adaptor activity ubiquitin-like protein reader activity molecular adaptor activity protein-lysine N-methyltransferase activity histone H3 methyltransferase activity catalytic activity, acting on a protein transferase activity, transferring one-carbon groups transferase activity S-adenosylmethionine-dependent methyltransferase activity histone H3K27 methyltransferase activity histone methyltransferase activity lysine N-methyltransferase activity protein methyltransferase activity histone modifying activity N-methyltransferase activity methyltransferase activity catalytic activity	developmental process multicellular organism development multicellular organismal process hepaticobiliary system development gland development animal organ development anatomical structure development liver development system development immune system development hematopoietic or lymphoid organ development thymus development immune system process central nervous system development developmental process multicellular organism development multicellular organismal process hepaticobiliary system development gland development animal organ development anatomical structure development liver development system development immune system development hematopoietic or lymphoid organ development thymus development immune system process central nervous system development nervous system development heart development heart growth cell population proliferation developmental growth cardiac muscle tissue development cardiac muscle cell proliferation growth organ growth tissue development striated muscle tissue development circulatory system development muscle cell proliferation cellular process cardiac muscle tissue growth muscle tissue development striated muscle cell proliferation protein localization protein localization to chromatin cellular localization protein localization to chromosome, centromeric region localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to pericentric heterochromatin protein localization to heterochromatin regulation of biosynthetic process regulation of biological process regulation of cellular process cellular biosynthetic process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organic substance metabolic process biosynthetic process organic substance biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of growth regulation of cardiac muscle tissue growth regulation of developmental process negative regulation of biological process negative regulation of cardiac muscle tissue growth negative regulation of organ growth negative regulation of growth regulation of organ growth regulation of heart growth negative regulation of cellular process regulation of cardiac muscle cell proliferation regulation of multicellular organismal process negative regulation of cell population proliferation regulation of multicellular organismal development regulation of developmental growth negative regulation of heart growth negative regulation of developmental process negative regulation of developmental growth regulation of cell population proliferation negative regulation of multicellular organismal process negative regulation of cardiac muscle cell proliferation spleen development negative regulation of cellular metabolic process protein-DNA complex organization cellular component organization chromatin organization chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process heterochromatin formation protein-containing complex organization epigenetic regulation of gene expression negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process facultative heterochromatin formation negative regulation of gene expression, epigenetic muscle hypertrophy regulation of muscle adaptation system process negative regulation of muscle hypertrophy response to stimulus regulation of system process striated muscle hypertrophy regulation of muscle system process muscle system process regulation of muscle hypertrophy regulation of cardiac muscle hypertrophy muscle adaptation regulation of response to stimulus cardiac muscle hypertrophy negative regulation of cardiac muscle hypertrophy regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II primary metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process stem cell differentiation cellular developmental process cell differentiation random inactivation of X chromosome sex-chromosome dosage compensation dosage compensation by inactivation of X chromosome cellular response to stimulus response to organic substance response to cytokine response to leukemia inhibitory factor cellular response to leukemia inhibitory factor cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular response to organic substance	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex histone methyltransferase complex catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex histone methyltransferase complex catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen nucleoplasm organelle lumen methyltransferase complex nuclear lumen PcG protein complex ESC/E(Z) complex protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle
D [auth K], L [auth C]	Histone-lysine N-methyltransferase EZH2	protein-lysine N-methyltransferase activity catalytic activity, acting on a protein transferase activity, transferring one-carbon groups lysine N-methyltransferase activity protein methyltransferase activity N-methyltransferase activity transferase activity methyltransferase activity catalytic activity S-adenosylmethionine-dependent methyltransferase activity RNA binding binding organic cyclic compound binding lncRNA binding protein-lysine N-methyltransferase activity catalytic activity, acting on a protein transferase activity, transferring one-carbon groups lysine N-methyltransferase activity protein methyltransferase activity N-methyltransferase activity transferase activity methyltransferase activity catalytic activity S-adenosylmethionine-dependent methyltransferase activity RNA binding binding organic cyclic compound binding lncRNA binding nucleic acid binding histone H3K27 trimethyltransferase activity histone H3 methyltransferase activity histone H3K27 methyltransferase activity histone methyltransferase activity histone modifying activity primary miRNA binding protein-containing complex binding chromatin binding promoter-specific chromatin binding DNA binding sequence-specific DNA binding double-stranded DNA binding core promoter sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding transcription factor binding transcription coregulator binding transcription corepressor binding protein binding cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding ribonucleoprotein complex binding transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity chromatin DNA binding	developmental process multicellular organismal process head development animal organ development brain development nervous system development cerebellar cortex development multicellular organism development cerebellum development central nervous system development metencephalon development anatomical structure development hindbrain development system development developmental process multicellular organismal process head development animal organ development brain development nervous system development cerebellar cortex development multicellular organism development cerebellum development central nervous system development metencephalon development anatomical structure development hindbrain development system development organic substance metabolic process organonitrogen compound metabolic process macromolecule modification metabolic process primary metabolic process protein metabolic process macromolecule metabolic process protein modification process negative regulation of stem cell differentiation regulation of biological process regulation of cellular process cellular developmental process regulation of developmental process negative regulation of developmental process biological regulation negative regulation of biological process regulation of cell differentiation stem cell differentiation cell differentiation regulation of stem cell differentiation negative regulation of cellular process cellular process negative regulation of cell differentiation cell cycle G1 to G0 transition cell cycle process negative regulation of transcription elongation by RNA polymerase II negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of DNA-templated transcription elongation negative regulation of DNA-templated transcription regulation of transcription elongation by RNA polymerase II cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process negative regulation of DNA-templated transcription, elongation organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process transcription elongation by RNA polymerase II cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process DNA-templated transcription elongation negative regulation of biosynthetic process subtelomeric heterochromatin formation telomere organization cellular component organization protein-DNA complex organization chromatin organization chromatin remodeling cellular component organization or biogenesis heterochromatin formation protein-containing complex organization epigenetic regulation of gene expression chromosome organization organelle organization negative regulation of gene expression constitutive heterochromatin formation negative regulation of gene expression, epigenetic mitotic cell cycle process cell cycle phase transition G1/S transition of mitotic cell cycle cell cycle G1/S phase transition mitotic cell cycle mitotic cell cycle phase transition cellular response to stimulus intracellular receptor signaling pathway response to stimulus signaling negative regulation of signaling regulation of retinoic acid receptor signaling pathway regulation of signal transduction negative regulation of cell communication cell communication signal transduction regulation of signaling negative regulation of response to stimulus negative regulation of retinoic acid receptor signaling pathway retinoic acid receptor signaling pathway negative regulation of signal transduction regulation of response to stimulus regulation of cell communication positive regulation of phosphorylation regulation of catalytic activity regulation of transferase activity positive regulation of phosphate metabolic process positive regulation of protein serine/threonine kinase activity positive regulation of metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process phosphorus metabolic process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process regulation of molecular function positive regulation of kinase activity regulation of kinase activity regulation of protein serine/threonine kinase activity regulation of phosphorus metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of molecular function positive regulation of protein modification process positive regulation of protein kinase activity positive regulation of cellular process positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity regulation of phosphorylation negative regulation of striated muscle cell differentiation negative regulation of muscle cell differentiation regulation of striated muscle cell differentiation muscle cell differentiation muscle structure development regulation of muscle cell differentiation striated muscle cell differentiation regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II tissue regeneration skeletal muscle tissue regeneration developmental growth skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration growth maintenance of cell number regeneration epithelium development epidermal cell differentiation epidermis development tissue development epithelial cell differentiation skin development keratinocyte differentiation forebrain development pallium development telencephalon development hippocampus development limbic system development hemopoiesis B cell activation cell activation cell development mononuclear cell differentiation lymphocyte differentiation lymphocyte activation leukocyte activation B cell differentiation immune system process leukocyte differentiation rhythmic process circadian rhythm regulation of circadian rhythm regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition mesenchyme development positive regulation of developmental process positive regulation of cell differentiation regulation of multicellular organismal process epithelial to mesenchymal transition positive regulation of multicellular organismal process mesenchymal cell differentiation positive regulation of hydrolase activity regulation of hydrolase activity regulation of GTPase activity positive regulation of GTPase activity protein localization localization protein localization to chromatin cellular localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization regulation of neurogenesis regulation of gliogenesis regulation of cell development regulation of nervous system development neurogenesis gliogenesis regulation of multicellular organismal development gland development animal organ regeneration liver development hepaticobiliary system development liver regeneration cellular response to nitrogen compound response to organic substance cellular response to trichostatin A response to endogenous stimulus response to organonitrogen compound cellular response to organic cyclic compound response to oxygen-containing compound response to nitrogen compound response to trichostatin A response to antibiotic cellular response to oxygen-containing compound cellular response to antibiotic cellular response to endogenous stimulus cellular response to chemical stimulus cellular response to organonitrogen compound response to chemical cellular response to organic substance response to organic cyclic compound cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation cellular response to oxidative stress cellular response to chemical stress cellular response to hydrogen peroxide response to reactive oxygen species response to inorganic substance response to hydrogen peroxide response to oxidative stress cellular response to reactive oxygen species cellular response to stress response to stress multicellular organismal-level homeostasis homeostatic process homeostasis of number of cells hepatocyte homeostasis regulation of epidermal cell differentiation negative regulation of keratinocyte differentiation regulation of epithelial cell differentiation negative regulation of epidermis development negative regulation of epithelial cell differentiation negative regulation of epidermal cell differentiation regulation of epidermis development negative regulation of multicellular organismal process regulation of keratinocyte differentiation positive regulation of cell communication positive regulation of signal transduction regulation of MAP kinase activity intracellular signal transduction intracellular signaling cassette positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade positive regulation of response to stimulus regulation of intracellular signal transduction MAPK cascade positive regulation of signaling facultative heterochromatin formation regulation of cell cycle phase transition negative regulation of cell cycle regulation of cell cycle G1/S phase transition negative regulation of mitotic cell cycle regulation of mitotic cell cycle negative regulation of cell cycle phase transition regulation of cell cycle negative regulation of G1/S transition of mitotic cell cycle negative regulation of mitotic cell cycle phase transition regulation of cell cycle process negative regulation of cell cycle G1/S phase transition negative regulation of cell cycle process regulation of mitotic cell cycle phase transition regulation of G1/S transition of mitotic cell cycle regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization cell projection organization neuron projection development neuron differentiation dendrite development positive regulation of neuron projection development positive regulation of cell projection organization plasma membrane bounded cell projection organization regulation of cell projection organization positive regulation of dendrite development generation of neurons regulation of dendrite development neuron development regulation of plasma membrane bounded cell projection organization positive regulation of cell cycle positive regulation of cell cycle G1/S phase transition positive regulation of cell cycle phase transition positive regulation of cell cycle process trans-synaptic signaling synaptic transmission, GABAergic cell-cell signaling chemical synaptic transmission synaptic signaling anterograde trans-synaptic signaling regulation of kidney development renal system development kidney development response to lipid response to estradiol response to tetrachloromethane muscle hypertrophy system process striated muscle adaptation striated muscle hypertrophy muscle system process muscle adaptation cardiac muscle adaptation cardiac muscle hypertrophy cardiac muscle hypertrophy in response to stress muscle hypertrophy in response to stress regulation of cytokine production involved in inflammatory response cytokine production regulation of cytokine production negative regulation of cytokine production involved in inflammatory response production of molecular mediator involved in inflammatory response defense response negative regulation of cytokine production cytokine production involved in inflammatory response inflammatory response	membrane-bounded organelle protein-containing complex histone methyltransferase complex intracellular anatomical structure catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex intracellular organelle lumen PcG protein complex intracellular organelle membrane-bounded organelle protein-containing complex histone methyltransferase complex intracellular anatomical structure catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex intracellular organelle lumen PcG protein complex intracellular organelle nucleoplasm organelle lumen organelle methyltransferase complex ESC/E(Z) complex nuclear lumen protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle chromosome, telomeric region chromosomal region pericentric heterochromatin heterochromatin chromosome, centromeric region chromatin silencing complex pronucleus synapse cell junction
E [auth L]	Polycomb protein EED	transcription factor binding transcription coregulator binding transcription corepressor binding protein binding binding catalytic activity, acting on a protein transferase activity, transferring one-carbon groups protein methyltransferase activity histone modifying activity transferase activity methyltransferase activity catalytic activity histone methyltransferase activity enzyme regulator activity transcription factor binding transcription coregulator binding transcription corepressor binding protein binding binding catalytic activity, acting on a protein transferase activity, transferring one-carbon groups protein methyltransferase activity histone modifying activity transferase activity methyltransferase activity catalytic activity histone methyltransferase activity enzyme regulator activity enzyme activator activity molecular function activator activity molecular function regulator activity protein-containing complex binding chromatin binding identical protein binding	regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process cellular process developmental process multicellular organism development multicellular organismal process spinal cord development central nervous system development anatomical structure development nervous system development system development transcription by RNA polymerase II regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II	intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome cellular anatomical entity non-membrane-bounded organelle cytoplasm cytosol membrane-bounded organelle protein-containing complex histone methyltransferase complex catalytic complex nucleus intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome cellular anatomical entity non-membrane-bounded organelle cytoplasm cytosol membrane-bounded organelle protein-containing complex histone methyltransferase complex catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle transferase complex intracellular organelle lumen PcG protein complex nucleoplasm organelle lumen methyltransferase complex ESC/E(Z) complex nuclear lumen
G [auth N]	Histone-binding protein RBBP4	protein binding binding histone binding histone deacetylase binding enzyme binding DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding protein binding binding histone binding histone deacetylase binding enzyme binding DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding	regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process cellular process DNA replication DNA metabolic process developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development regulation of developmental process cellular developmental process regulation of cell differentiation stem cell differentiation cell differentiation regulation of stem cell differentiation regulation of cell fate commitment cell fate specification regulation of cell fate specification cell fate commitment positive regulation of biological process regulation of stem cell population maintenance stem cell population maintenance positive regulation of developmental process positive regulation of stem cell population maintenance positive regulation of multicellular organismal process regulation of multicellular organismal process maintenance of cell number cell cycle protein-containing complex organization protein-DNA complex assembly protein-DNA complex organization cellular component organization cellular component biogenesis cellular component assembly chromatin organization protein-containing complex assembly chromatin remodeling cellular component organization or biogenesis nucleosome assembly nucleosome organization cellular response to stimulus negative regulation of transforming growth factor beta receptor signaling pathway cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus response to stimulus negative regulation of signaling signaling cellular response to transforming growth factor beta stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of signal transduction negative regulation of cell communication cell communication regulation of transforming growth factor beta receptor signaling pathway cellular response to endogenous stimulus signal transduction enzyme-linked receptor protein signaling pathway regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus regulation of cellular response to transforming growth factor beta stimulus response to endogenous stimulus regulation of cellular response to growth factor stimulus negative regulation of signal transduction response to transforming growth factor beta regulation of response to stimulus transforming growth factor beta receptor signaling pathway regulation of cell communication response to growth factor transforming growth factor beta receptor superfamily signaling pathway negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway DNA replication-dependent chromatin assembly negative regulation of locomotion regulation of cell motility regulation of locomotion regulation of cell migration negative regulation of cell motility cell migration cell motility negative regulation of cell migration locomotion negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process negative regulation of developmental process negative regulation of stem cell population maintenance negative regulation of multicellular organismal process transcription by RNA polymerase II regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II	protein-containing complex CAF-1 complex membrane-bounded organelle intracellular anatomical structure Sin3-type complex nucleus membrane-enclosed lumen nuclear chromosome nuclear protein-containing complex chromosome intracellular organelle lumen histone deacetylase complex intracellular organelle nucleoplasm protein-containing complex CAF-1 complex membrane-bounded organelle intracellular anatomical structure Sin3-type complex nucleus membrane-enclosed lumen nuclear chromosome nuclear protein-containing complex chromosome intracellular organelle lumen histone deacetylase complex intracellular organelle nucleoplasm non-membrane-bounded organelle catalytic complex protein-DNA complex chromatin intracellular membrane-bounded organelle cellular anatomical entity organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen cytoplasm cytosol histone methyltransferase complex transferase complex PcG protein complex methyltransferase complex ESC/E(Z) complex ATPase complex transcription regulator complex NuRD complex SWI/SNF superfamily-type complex CHD-type complex chromosome, telomeric region chromosomal region NURF complex ISWI-type complex
H [auth O]	JARID2-substrate	-	-	-
I [auth P]	Zinc finger protein AEBP2	DNA binding binding organic cyclic compound binding nucleic acid binding cation binding ion binding metal ion binding small molecule binding transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity	regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of biological process negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process protein-DNA complex organization cellular component organization protein-containing complex organization chromatin organization cellular component organization or biogenesis	membrane-bounded organelle protein-containing complex histone methyltransferase complex intracellular anatomical structure catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex intracellular organelle lumen PcG protein complex intracellular organelle membrane-bounded organelle protein-containing complex histone methyltransferase complex intracellular anatomical structure catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex intracellular organelle lumen PcG protein complex intracellular organelle nucleoplasm organelle lumen organelle methyltransferase complex ESC/E(Z) complex nuclear lumen protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle
K [auth Z]	SUZ12	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth E]	IPR003347	JmjC domain	Domain
C [auth E]	IPR003349	JmjN domain	Domain
C [auth E]	IPR001606	ARID DNA-binding domain	Domain
C [auth E]	IPR004198	Zinc finger, C5HC2-type	Domain
C [auth E]	IPR036431	ARID DNA-binding domain superfamily	Homologous Superfamily
A, F [auth M], J [auth Q]	IPR019135	Polycomb protein, VEFS-Box	Domain
B	IPR003347	JmjC domain	Domain
B	IPR003349	JmjN domain	Domain
B	IPR001606	ARID DNA-binding domain	Domain
B	IPR004198	Zinc finger, C5HC2-type	Domain
B	IPR036431	ARID DNA-binding domain superfamily	Homologous Superfamily
D [auth K], L [auth C]	IPR048358	EZH1/2, MCSS domain	Domain
D [auth K], L [auth C]	IPR041343	Polycomb repressive complex 2 subunit EZH1/EZH2, tri-helical domain	Domain
D [auth K], L [auth C]	IPR046341	SET domain superfamily	Homologous Superfamily
D [auth K], L [auth C]	IPR001214	SET domain	Domain
D [auth K], L [auth C]	IPR045318	Histone-lysine N-methyltransferase EZH1/2-like	Family
D [auth K], L [auth C]	IPR033467	Tesmin/TSO1-like CXC domain	Domain
D [auth K], L [auth C]	IPR044439	EZH2, SET domain	Domain
D [auth K], L [auth C]	IPR026489	CXC domain	Domain
D [auth K], L [auth C]	IPR041355	Pre-SET CXC domain	Domain
D [auth K], L [auth C]	IPR001005	SANT/Myb domain	Domain
D [auth K], L [auth C]	IPR021654	Histone-lysine N-methyltransferase EZH1/EZH2	Family
E [auth L]	IPR019775	WD40 repeat, conserved site	Conserved Site
E [auth L]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
E [auth L]	IPR001680	WD40 repeat	Repeat
E [auth L]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
G [auth N]	IPR019775	WD40 repeat, conserved site	Conserved Site
G [auth N]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
G [auth N]	IPR022052	Histone-binding protein RBBP4, N-terminal	Domain
G [auth N]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
G [auth N]	IPR001680	WD40 repeat	Repeat
G [auth N]	IPR020472	G-protein beta WD-40 repeat	Repeat
I [auth P]	IPR013087	Zinc finger C2H2-type	Domain
I [auth P]	IPR036236	Zinc finger C2H2 superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C [auth E]	Pharos: Q92833	autism spectrum disorder osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia schizophrenia tuberculosis Autism Spectrum Disorders ovarian cancer plasma cell myeloma squamous cell carcinoma lung cancer pancreatic intraductal papillary-mucinous carcinoma psoriasis subependymal giant cell astrocytoma
A, F [auth M], J [auth Q]	Pharos: Q15022	malignant glioma schwannoma endometrioid stromal sarcoma melanoma neurofibroma cancer glioblastoma mixed glioma adenoma perineurioma endometrial carcinoma giant cell glioblastoma malignant peripheral nerve sheath tumor microcystic adenoma papillary adenoma malignant glioma schwannoma endometrioid stromal sarcoma melanoma neurofibroma cancer glioblastoma mixed glioma adenoma perineurioma endometrial carcinoma giant cell glioblastoma malignant peripheral nerve sheath tumor microcystic adenoma papillary adenoma follicular thyroid adenoma glioma melanocytic nevus Nerve Sheath Tumors breast cancer ovarian cancer cystic fibrosis Pick disease lung cancer myopathy astrocytic tumor oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma dermatomyositis plasma cell myeloma endometrium neoplasm malignant ependymoma medulloblastoma nerve sheath neoplasm neurofibromatosis osteosarcoma cutaneous melanoma peripheral nervous system neoplasm endometrial cancer progressive supranuclear palsy Weaver syndrome
B	Pharos: Q92833	autism spectrum disorder osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia schizophrenia tuberculosis Autism Spectrum Disorders ovarian cancer plasma cell myeloma squamous cell carcinoma lung cancer pancreatic intraductal papillary-mucinous carcinoma psoriasis subependymal giant cell astrocytoma
D [auth K], L [auth C]	Pharos: Q15910	Weaver syndrome follicular lymphoma osteosarcoma diffuse large B-cell lymphoma prostate cancer breast carcinoma myelodysplastic syndrome juvenile myelomonocytic leukemia primary myelofibrosis craniosynostosis Upper Extremity Deformities, Congenital endometrial carcinoma breast cancer malignant mesothelioma myelodysplastic/myeloproliferative Neoplasm Weaver syndrome follicular lymphoma osteosarcoma diffuse large B-cell lymphoma prostate cancer breast carcinoma myelodysplastic syndrome juvenile myelomonocytic leukemia primary myelofibrosis craniosynostosis Upper Extremity Deformities, Congenital endometrial carcinoma breast cancer malignant mesothelioma myelodysplastic/myeloproliferative Neoplasm non-small cell lung carcinoma inflammatory bowel disease ovarian cancer aleukemic leukemia invasive ductal breast carcinoma pilocytic astrocytoma lung disease psoriasis Sjogren syndrome chronic myelomonocytic leukemia cystic fibrosis malignant ependymoma ductal breast carcinoma in situ glioblastoma hepatocellular carcinoma myelofibrosis oligodendroglioma adrenal cortex carcinoma intellectual disability pancreatic intraductal papillary-mucinous carcinoma astrocytic tumor lung adenocarcinoma prostate disease breast disease lymphatic system disease congenital anemia trigonocephaly malignant glioma endometrial cancer malignant pancreatic neoplasm epithelioid sarcoma medulloblastoma hematologic disease nasopharyngeal carcinoma IgA glomerulonephritis interstitial cystitis pancreatic intraductal papillary-mucinous neoplasm atypical teratoid rhabdoid tumor large cell medulloblastoma primitive neuroectodermal tumor lung cancer cancer lymphoma sinusitis
E [auth L]	Pharos: O75530	schwannoma Cohen-Gibson syndrome malignant peripheral nerve sheath tumor perineurioma attention deficit hyperactivity disorder, inattentive type intellectual disability Nerve Sheath Tumors peripheral nervous system neoplasm Weaver syndrome epithelioid sarcoma cataract follicular lymphoma nerve sheath neoplasm
G [auth N]	Pharos: Q09028	medulloblastoma Pick disease osteosarcoma subependymal giant cell astrocytoma ovarian cancer
I [auth P]	Pharos: Q6ZN18	atypical teratoid rhabdoid tumor sarcoidosis juvenile dermatomyositis respiratory system disease

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
B	M3L	Parent Component: LYS RESID: AA0074 PSI-MOD : N6,N6,N6-trimethyl-L-lysine MOD:00083
K [auth Z]	UNK	RESID: AA0074