Annotations: 6BX3

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth M]	SCOP2 Family	Dpy-30 motif-like	8088528	4005379	SCOP2 (2022-06-29)
C [auth M]	SCOP2 Superfamily	Dpy-30/Rlla-like	8104121	3001874	SCOP2 (2022-06-29)
D [auth N]	SCOP2B Superfamily	Dpy-30/Rlla-like	8104121	3001874	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth M]	PF05186	e6bx3M1	A: alpha duplicates or obligate multimers	X: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit (From Topology)	H: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit (From Topology)	T: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit	F: PF05186	ECOD (1.6)
D [auth N]	PF05186	e6bx3N1	A: alpha duplicates or obligate multimers	X: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit (From Topology)	H: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit (From Topology)	T: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit	F: PF05186	ECOD (1.6)
F [auth B]	PF00400	e6bx3B1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400	ECOD (1.6)
G [auth A]	PF00400	e6bx3A1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth E]	PF11764	COMPASS (Complex proteins associated with Set1p) component N (N-SET)	COMPASS (Complex proteins associated with Set1p) component N	The n-SET or N-SET domain is a component of the COMPASS complex, associated with SET1, conserved in yeasts and in other eukaryotes up to humans. The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for the silencing of genes ...	The n-SET or N-SET domain is a component of the COMPASS complex, associated with SET1, conserved in yeasts and in other eukaryotes up to humans. The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for the silencing of genes close to the telomeres of chromosomes [2]. This domain promotes trimethylation in conjunction with an RRM domain [4] and is necessary for binding of the Spp1 component of COMPASS into the complex [3].	Domain
A [auth E]	PF00856	SET domain (SET)	SET domain	-	Family
C [auth M], D [auth N]	PF05186	Dpy-30 motif (Dpy-30)	Dpy-30 motif	-	Motif
F [auth B]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
G [auth A]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth E]	Histone-lysine N-methyltransferase, H3 lysine-4 specific	protein-lysine N-methyltransferase activity histone H3 methyltransferase activity catalytic activity, acting on a protein transferase activity, transferring one-carbon groups transferase activity S-adenosylmethionine-dependent methyltransferase activity histone methyltransferase activity histone H3K4 methyltransferase activity lysine N-methyltransferase activity protein methyltransferase activity histone modifying activity N-methyltransferase activity histone H3K4 trimethyltransferase activity methyltransferase activity catalytic activity protein-lysine N-methyltransferase activity histone H3 methyltransferase activity catalytic activity, acting on a protein transferase activity, transferring one-carbon groups transferase activity S-adenosylmethionine-dependent methyltransferase activity histone methyltransferase activity histone H3K4 methyltransferase activity lysine N-methyltransferase activity protein methyltransferase activity histone modifying activity N-methyltransferase activity histone H3K4 trimethyltransferase activity methyltransferase activity catalytic activity	methylation metabolic process	intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome cellular anatomical entity non-membrane-bounded organelle membrane-bounded organelle protein-containing complex Set1C/COMPASS complex histone methyltransferase complex catalytic complex nucleus membrane-enclosed lumen intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome cellular anatomical entity non-membrane-bounded organelle membrane-bounded organelle protein-containing complex Set1C/COMPASS complex histone methyltransferase complex catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle transferase complex intracellular organelle lumen nucleoplasm organelle lumen methyltransferase complex nuclear lumen
B [auth K]	COMPASS component BRE2	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding	subtelomeric heterochromatin formation regulation of cellular process cellular biosynthetic process negative regulation of biological process telomere organization negative regulation of cellular metabolic process cellular component organization protein-DNA complex organization organic substance metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling cellular component organization or biogenesis subtelomeric heterochromatin formation regulation of cellular process cellular biosynthetic process negative regulation of biological process telomere organization negative regulation of cellular metabolic process cellular component organization protein-DNA complex organization organic substance metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation protein-containing complex organization epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process biological regulation chromosome organization regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organelle organization negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process cellular process negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process primary metabolic process DNA metabolic process nucleic acid metabolic process telomere maintenance nucleobase-containing compound metabolic process organic cyclic compound metabolic process	intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome chromosome, telomeric region cellular anatomical entity chromosomal region non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle protein-containing complex Set1C/COMPASS complex intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome chromosome, telomeric region cellular anatomical entity chromosomal region non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle protein-containing complex Set1C/COMPASS complex histone methyltransferase complex catalytic complex membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen nucleoplasm organelle lumen methyltransferase complex nuclear lumen
C [auth M], D [auth N]	COMPASS component SDC1	-	subtelomeric heterochromatin formation regulation of cellular process cellular biosynthetic process negative regulation of biological process telomere organization negative regulation of cellular metabolic process cellular component organization protein-DNA complex organization organic substance metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling cellular component organization or biogenesis subtelomeric heterochromatin formation regulation of cellular process cellular biosynthetic process negative regulation of biological process telomere organization negative regulation of cellular metabolic process cellular component organization protein-DNA complex organization organic substance metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation protein-containing complex organization epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process biological regulation chromosome organization regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organelle organization negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process cellular process negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process	intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome chromosome, telomeric region cellular anatomical entity chromosomal region non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle protein-containing complex Set1C/COMPASS complex intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome chromosome, telomeric region cellular anatomical entity chromosomal region non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle protein-containing complex Set1C/COMPASS complex histone methyltransferase complex catalytic complex membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen nucleoplasm organelle lumen methyltransferase complex nuclear lumen
E [auth F]	COMPASS component SPP1	protein-containing complex binding chromatin binding binding methylated histone binding protein binding modification-dependent protein binding histone binding methylation-dependent protein binding cation binding ion binding metal ion binding small molecule binding	regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process cellular process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process subtelomeric heterochromatin formation negative regulation of biological process telomere organization negative regulation of cellular metabolic process cellular component organization protein-DNA complex organization chromatin organization negative regulation of cellular process chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process heterochromatin formation protein-containing complex organization epigenetic regulation of gene expression negative regulation of metabolic process chromosome organization negative regulation of cellular biosynthetic process organelle organization negative regulation of gene expression constitutive heterochromatin formation negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of gene expression, epigenetic positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle process regulation of meiotic DNA double-strand break formation cell cycle regulation of cell cycle cell cycle process regulation of cell cycle process meiotic cell cycle DNA metabolic process meiotic DNA double-strand break formation meiosis I cell cycle process regulation of DNA metabolic process	membrane-bounded organelle protein-containing complex Set1C/COMPASS complex histone methyltransferase complex intracellular anatomical structure catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex intracellular organelle lumen intracellular organelle membrane-bounded organelle protein-containing complex Set1C/COMPASS complex histone methyltransferase complex intracellular anatomical structure catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle methyltransferase complex nuclear lumen cytoplasm cytosol intracellular non-membrane-bounded organelle chromosome chromosome, telomeric region chromosomal region non-membrane-bounded organelle
F [auth B]	COMPASS component SWD1	-	regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process cellular process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process subtelomeric heterochromatin formation negative regulation of biological process telomere organization negative regulation of cellular metabolic process cellular component organization protein-DNA complex organization chromatin organization negative regulation of cellular process chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process heterochromatin formation protein-containing complex organization epigenetic regulation of gene expression negative regulation of metabolic process chromosome organization negative regulation of cellular biosynthetic process organelle organization negative regulation of gene expression constitutive heterochromatin formation negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of gene expression, epigenetic DNA metabolic process telomere maintenance	intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome chromosome, telomeric region cellular anatomical entity chromosomal region non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle protein-containing complex Set1C/COMPASS complex intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome chromosome, telomeric region cellular anatomical entity chromosomal region non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle protein-containing complex Set1C/COMPASS complex histone methyltransferase complex catalytic complex membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen nucleoplasm organelle lumen methyltransferase complex nuclear lumen
G [auth A]	COMPASS component SWD3	protein binding binding histone binding	regulation of cellular process sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle process regulation of primary metabolic process nucleobase-containing compound metabolic process regulation of meiotic DNA double-strand break formation organic substance metabolic process regulation of nucleobase-containing compound metabolic process cell cycle regulation of cell cycle cell cycle process regulation of biological process regulation of cellular process sexual reproduction regulation of reproductive process reproductive process meiotic cell cycle process regulation of primary metabolic process nucleobase-containing compound metabolic process regulation of meiotic DNA double-strand break formation organic substance metabolic process regulation of nucleobase-containing compound metabolic process cell cycle regulation of cell cycle cell cycle process regulation of biological process regulation of cell cycle process meiotic cell cycle biological regulation primary metabolic process regulation of macromolecule metabolic process DNA metabolic process nucleic acid metabolic process organic cyclic compound metabolic process meiotic DNA double-strand break formation meiosis I cell cycle process metabolic process cellular process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process subtelomeric heterochromatin formation cellular biosynthetic process negative regulation of biological process telomere organization negative regulation of cellular metabolic process cellular component organization protein-DNA complex organization chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process regulation of biosynthetic process heterochromatin formation protein-containing complex organization epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process chromosome organization regulation of cellular metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organelle organization negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process telomere maintenance	intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome chromosome, telomeric region cellular anatomical entity chromosomal region non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle protein-containing complex Set1C/COMPASS complex intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome chromosome, telomeric region cellular anatomical entity chromosomal region non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle protein-containing complex Set1C/COMPASS complex histone methyltransferase complex catalytic complex membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen nucleoplasm organelle lumen methyltransferase complex nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth E]	IPR024657	COMPASS complex Set1 subunit, N-SET domain	Domain
A [auth E]	IPR024636	Histone lysine methyltransferase SET associated	Domain
A [auth E]	IPR048669	Histone-lysine N-methyltransferase SET1, RNA-binding domain	Domain
A [auth E]	IPR046341	SET domain superfamily	Homologous Superfamily
A [auth E]	IPR001214	SET domain	Domain
A [auth E]	IPR044570	Histone-lysine N-methyltransferase Set1-like	Family
A [auth E]	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
A [auth E]	IPR017111	Histone-lysine N-methyltransferase Set1, fungi	Family
A [auth E]	IPR003616	Post-SET domain	Domain
B [auth K]	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
B [auth K]	IPR043136	B30.2/SPRY domain superfamily	Homologous Superfamily
B [auth K]	IPR037353	Histone methyltransferase complex subunit ASH2	Family
B [auth K]	IPR003877	SPRY domain	Domain
C [auth M], D [auth N]	IPR007858	Dpy-30 motif	Conserved Site
C [auth M], D [auth N]	IPR049629	DPY30/SDC1, dimerization/docking domain	Domain
E [auth F]	IPR001965	Zinc finger, PHD-type	Domain
E [auth F]	IPR037869	Spp1/CFP1	Family
E [auth F]	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
E [auth F]	IPR019787	Zinc finger, PHD-finger	Domain
E [auth F]	IPR011011	Zinc finger, FYVE/PHD-type	Homologous Superfamily
E [auth F]	IPR019786	Zinc finger, PHD-type, conserved site	Conserved Site
F [auth B]	IPR001680	WD40 repeat	Repeat
F [auth B]	IPR019775	WD40 repeat, conserved site	Conserved Site
F [auth B]	IPR037850	Retinoblastoma-binding protein 5/Swd1	Family
F [auth B]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
F [auth B]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
G [auth A]	IPR001680	WD40 repeat	Repeat
G [auth A]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
G [auth A]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily