Annotations: 6BWI

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e6bwiA2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF00520	e6bwiA1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: PF00520	ECOD (1.6)
B	F_UNCLASSIFIED	e6bwiB2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF00520	e6bwiB1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: PF00520	ECOD (1.6)
C	F_UNCLASSIFIED	e6bwiC2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: F_UNCLASSIFIED	ECOD (1.6)
C	PF00520	e6bwiC1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: PF00520	ECOD (1.6)
D	F_UNCLASSIFIED	e6bwiD2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: F_UNCLASSIFIED	ECOD (1.6)
D	PF00520	e6bwiD1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: PF00520	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00520	Ion transport protein (Ion_trans)	Ion transport protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Transient receptor potential cation channel subfamily M member 4	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding calcium channel activity monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding calcium channel activity monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity ligand-gated calcium channel activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity ligand-gated monoatomic cation channel activity transmembrane transporter activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding sodium channel activity sodium ion transmembrane transporter activity protein binding calmodulin binding calcium-activated cation channel activity monoatomic ion-gated channel activity identical protein binding	heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation positive regulation of biological process positive regulation of heart rate positive regulation of blood circulation positive regulation of heart contraction circulatory system process regulation of blood circulation positive regulation of multicellular organismal process heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation positive regulation of biological process positive regulation of heart rate positive regulation of blood circulation positive regulation of heart contraction circulatory system process regulation of blood circulation positive regulation of multicellular organismal process regulation of multicellular organismal process regulation of biological quality heart contraction blood circulation regulation of heart rate positive regulation of cytosolic calcium ion concentration AV node cell action potential signaling cell-cell signaling involved in cardiac conduction membrane depolarization during cardiac muscle cell action potential cell communication membrane depolarization during AV node cell action potential cell communication involved in cardiac conduction AV node cell to bundle of His cell signaling membrane depolarization during action potential cell-cell signaling action potential AV node cell to bundle of His cell communication membrane depolarization cardiac conduction cellular process cardiac muscle cell action potential regulation of membrane potential response to stimulus immune response immune system process adaptive immune response regulation of tube diameter regulation of tube size positive regulation of vasoconstriction vascular process in circulatory system regulation of vasoconstriction blood vessel diameter maintenance vasoconstriction regulation of anatomical structure size developmental process regulation of developmental process connective tissue development adipose tissue development positive regulation of adipose tissue development animal organ development tissue development positive regulation of developmental process regulation of adipose tissue development anatomical structure development regulation of osteoblast differentiation regulation of cellular process cellular developmental process negative regulation of osteoblast differentiation negative regulation of developmental process negative regulation of biological process regulation of cell differentiation osteoblast differentiation ossification cell differentiation negative regulation of cellular process negative regulation of cell differentiation protein-containing complex organization protein homotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis organonitrogen compound metabolic process peptidyl-lysine modification primary metabolic process organic substance metabolic process protein sumoylation macromolecule modification peptidyl-amino acid modification metabolic process protein metabolic process macromolecule metabolic process protein modification process post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of actin filament-based process cardiac muscle cell action potential involved in contraction regulation of ventricular cardiac muscle cell action potential cardiac muscle contraction striated muscle contraction regulation of cardiac muscle cell action potential actin filament-based process cardiac muscle cell contraction regulation of action potential ventricular cardiac muscle cell action potential regulation of cardiac muscle contraction actin filament-based movement muscle contraction muscle system process regulation of muscle system process regulation of striated muscle contraction regulation of actin filament-based movement regulation of muscle contraction regulation of cardiac muscle cell contraction actin-mediated cell contraction cellular response to stimulus intracellular signal transduction calcium-mediated signaling intracellular signaling cassette signal transduction transmembrane transport localization transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport monoatomic ion transmembrane transport calcium ion transport metal ion transport monoatomic cation transmembrane transport monoatomic ion transport monoatomic cation transport calcium ion transmembrane transport cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation positive regulation of cellular process positive regulation of atrial cardiac muscle cell action potential regulation of atrial cardiac muscle cell action potential regulation of cardiac conduction atrial cardiac muscle cell to AV node cell signaling atrial cardiac muscle cell to AV node cell communication atrial cardiac muscle cell action potential positive regulation of action potential import into cell import across plasma membrane sodium ion import across plasma membrane sodium ion transmembrane transport inorganic cation import across plasma membrane inorganic ion import across plasma membrane sodium ion transport cell chemotaxis chemotaxis dendritic cell chemotaxis response to external stimulus leukocyte migration dendritic cell migration cellular response to chemical stimulus taxis response to chemical mononuclear cell migration cell migration cell motility leukocyte chemotaxis locomotion protein localization positive regulation of cell communication regulation of localization establishment of protein localization response to organic substance nitrogen compound transport positive regulation of establishment of protein localization carbohydrate homeostasis cellular macromolecule localization establishment of localization in cell positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of insulin secretion regulation of peptide hormone secretion regulation of hormone levels organic substance transport positive regulation of peptide hormone secretion establishment of protein localization to extracellular region intracellular glucose homeostasis protein secretion cellular response to oxygen-containing compound regulation of protein secretion regulation of secretion cellular response to carbohydrate stimulus chemical homeostasis response to glucose glucose homeostasis positive regulation of protein localization insulin secretion involved in cellular response to glucose stimulus cellular localization regulation of hormone secretion regulation of protein localization regulation of peptide secretion homeostatic process positive regulation of secretion by cell hormone secretion protein localization to extracellular region positive regulation of protein transport peptide secretion secretion by cell regulation of secretion by cell positive regulation of hormone secretion response to monosaccharide response to carbohydrate positive regulation of secretion amide transport signal release cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus cellular response to organic substance positive regulation of peptide secretion regulation of signaling secretion regulation of transport regulation of peptide transport regulation of establishment of protein localization export from cell response to oxygen-containing compound cellular response to glucose stimulus regulation of protein transport positive regulation of protein secretion peptide transport response to hexose cellular homeostasis positive regulation of transport protein transport regulation of cellular localization regulation of insulin secretion peptide hormone secretion macromolecule localization regulation of insulin secretion involved in cellular response to glucose stimulus hormone transport regulation of cell communication insulin secretion positive regulation of signaling Purkinje myocyte to ventricular cardiac muscle cell communication membrane depolarization during Purkinje myocyte cell action potential Purkinje myocyte action potential Purkinje myocyte to ventricular cardiac muscle cell signaling adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity regulation of immune effector process T cell mediated immunity T cell cytokine production cytokine production organic substance biosynthetic process leukocyte mediated immunity regulation of immune system process regulation of T cell mediated immunity regulation of cytokine production involved in immune response regulation of adaptive immune response cellular metabolic process regulation of cellular metabolic process immune effector process regulation of gene expression regulation of leukocyte mediated immunity biosynthetic process regulation of response to stimulus regulation of immune response regulation of macromolecule biosynthetic process regulation of production of molecular mediator of immune response regulation of metabolic process cellular biosynthetic process regulation of T cell cytokine production regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of cytokine production cytokine production involved in immune response production of molecular mediator of immune response regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of lymphocyte mediated immunity cellular response to nitrogen compound cellular response to ATP response to organonitrogen compound response to endogenous stimulus response to organophosphorus cellular response to organic cyclic compound response to nitrogen compound response to ATP response to purine-containing compound cellular response to endogenous stimulus cellular response to organonitrogen compound response to organic cyclic compound bundle of His cell to Purkinje myocyte signaling bundle of His cell to Purkinje myocyte communication bundle of His cell action potential membrane depolarization during bundle of His cell action potential positive regulation of signal transduction regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway regulation of signal transduction positive regulation of response to stimulus positive regulation of Wnt signaling pathway Wnt signaling pathway positive regulation of canonical Wnt signaling pathway cell surface receptor signaling pathway regulation of Wnt signaling pathway fat cell differentiation positive regulation of fat cell differentiation positive regulation of cell differentiation regulation of fat cell differentiation positive regulation of membrane depolarization regulation of membrane depolarization regulation of vascular associated smooth muscle cell membrane depolarization positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization regulation of heart rate by cardiac conduction negative regulation of biomineral tissue development regulation of biomineral tissue development regulation of bone mineralization negative regulation of bone mineralization multicellular organism development biomineral tissue development regulation of multicellular organismal development bone mineralization negative regulation of ossification negative regulation of multicellular organismal process regulation of ossification	membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane protein-containing complex sodium channel complex transmembrane transporter complex membrane protein complex cation channel complex transporter complex monoatomic ion channel complex membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane protein-containing complex sodium channel complex transmembrane transporter complex membrane protein complex cation channel complex transporter complex monoatomic ion channel complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen Golgi apparatus endomembrane system somatodendritic compartment cell body neuronal cell body endoplasmic reticulum

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR005821	Ion transport domain	Domain
A, B, C, D	IPR041491	TRPM, SLOG domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q8TD43	Brugada syndrome progressive familial heart block type IB prostate cancer malignant mesothelioma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia progressive familial heart block, type 1A Prostatic Neoplasms progressive familial heart block large cell medulloblastoma palmoplantar keratosis ulcerative colitis

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D	OPM	Transmembrane	Alpha-helical polytopic	Ion channel (VIC) superfamily	Transient receptor potential channels

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Channels: Transient Receptor Potential (TRP)	TRPM4 Ca²⁺-activated transient receptor potential channel, full length

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.