Annotations: 6BQN

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Proton-activated chloride channel extracellular domain-like	8106426	3002853	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Proton-activated chloride channel extracellular domain-like	8106427	3002853	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Proton-activated chloride channel extracellular domain-like	8106428	3002853	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00858	Amiloride-sensitive sodium channel (ASC)	Amiloride-sensitive sodium channel	-	Family
B	PF00858	Amiloride-sensitive sodium channel (ASC)	Amiloride-sensitive sodium channel	-	Family
C	PF00858	Amiloride-sensitive sodium channel (ASC)	Amiloride-sensitive sodium channel	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	SCNN1A	monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity ligand-gated sodium channel activity sodium channel activity sodium ion transmembrane transporter activity ligand-gated channel activity ligand-gated monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity ligand-gated sodium channel activity sodium channel activity sodium ion transmembrane transporter activity ligand-gated channel activity ligand-gated monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity ligand-gated monoatomic cation channel activity transmembrane transporter activity protein binding binding WW domain binding protein domain specific binding	sodium ion homeostasis inorganic ion homeostasis homeostatic process intracellular sodium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis multicellular organismal process system process circulatory system process sodium ion homeostasis inorganic ion homeostasis homeostatic process intracellular sodium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis multicellular organismal process system process circulatory system process regulation of blood pressure biological regulation regulation of biological quality blood circulation sensory perception of chemical stimulus sensory perception nervous system process sensory perception of taste sensory perception of sour taste cellular response to stimulus response to organic substance response to ketone response to lipid response to stimulus cellular response to mineralocorticoid stimulus response to mineralocorticoid cellular response to endogenous stimulus cellular response to aldehyde response to hormone response to steroid hormone cellular response to organic substance cellular response to ketone response to organic cyclic compound cellular response to steroid hormone stimulus cellular response to hormone stimulus cellular response to aldosterone response to aldosterone response to endogenous stimulus response to alcohol cellular response to organic cyclic compound response to oxygen-containing compound cellular response to oxygen-containing compound cellular response to corticosteroid stimulus response to corticosteroid cellular response to chemical stimulus cellular response to alcohol response to chemical cellular response to lipid cellular process cellular response to nitrogen compound cellular response to vasopressin response to organonitrogen compound response to peptide hormone cellular response to peptide hormone stimulus response to nitrogen compound response to vasopressin cellular response to organonitrogen compound response to pH cellular response to pH response to abiotic stimulus cellular response to acidic pH cellular response to abiotic stimulus response to acidic pH cellular response to environmental stimulus regulation of body fluid levels multicellular organismal-level homeostasis multicellular organismal-level water homeostasis multicellular organismal-level chemical homeostasis sensory perception of salty taste transport monoatomic ion transmembrane transport sodium ion transmembrane transport inorganic ion transmembrane transport establishment of localization metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport monoatomic cation transport sodium ion transport import into cell import across plasma membrane sodium ion import across plasma membrane inorganic cation import across plasma membrane inorganic ion import across plasma membrane	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane apical part of cell plasma membrane region apical plasma membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane apical part of cell plasma membrane region apical plasma membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol protein-containing complex sodium channel complex transmembrane transporter complex membrane protein complex cation channel complex transporter complex monoatomic ion channel complex cell projection sperm principal piece cilium 9+2 motile cilium sperm flagellum motile cilium plasma membrane bounded cell projection ciliary membrane bounding membrane of organelle organelle membrane cell projection membrane acrosomal vesicle intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle secretory granule secretory vesicle
B	SCNN1B	monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity ligand-gated sodium channel activity sodium channel activity sodium ion transmembrane transporter activity ligand-gated channel activity ligand-gated monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity ligand-gated sodium channel activity sodium channel activity sodium ion transmembrane transporter activity ligand-gated channel activity ligand-gated monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity ligand-gated monoatomic cation channel activity transmembrane transporter activity protein binding binding WW domain binding protein domain specific binding	response to stimulus response to chemical response to xenobiotic stimulus sodium ion homeostasis inorganic ion homeostasis homeostatic process intracellular sodium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis response to stimulus response to chemical response to xenobiotic stimulus sodium ion homeostasis inorganic ion homeostasis homeostatic process intracellular sodium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis multicellular organismal process system process circulatory system process regulation of blood pressure biological regulation regulation of biological quality blood circulation renal system process sensory perception of chemical stimulus sensory perception nervous system process sensory perception of taste sensory perception of sour taste neutrophil-mediated killing of symbiont cell biological process involved in interspecies interaction between organisms disruption of cell in another organism response to biotic stimulus myeloid leukocyte mediated immunity biological process involved in symbiotic interaction defense response to bacterium neutrophil mediated immunity response to stress response to bacterium leukocyte mediated immunity response to external biotic stimulus biological process involved in interaction with symbiont killing of cells of another organism neutrophil-mediated killing of bacterium neutrophil mediated cytotoxicity response to other organism defense response response to external stimulus defense response to symbiont leukocyte mediated cytotoxicity immune effector process killing by host of symbiont cells defense response to other organism immune system process cellular process disruption of anatomical structure in another organism cell killing localization epithelial fluid transport transport transepithelial transport fluid transport establishment of localization cellular response to stimulus response to organic substance response to ketone response to lipid cellular response to mineralocorticoid stimulus response to mineralocorticoid cellular response to endogenous stimulus cellular response to aldehyde response to hormone response to steroid hormone cellular response to organic substance cellular response to ketone response to organic cyclic compound cellular response to steroid hormone stimulus cellular response to hormone stimulus cellular response to aldosterone response to aldosterone response to endogenous stimulus response to alcohol cellular response to organic cyclic compound response to oxygen-containing compound cellular response to oxygen-containing compound cellular response to corticosteroid stimulus response to corticosteroid cellular response to chemical stimulus cellular response to alcohol cellular response to lipid cellular response to nitrogen compound cellular response to vasopressin response to organonitrogen compound response to peptide hormone cellular response to peptide hormone stimulus response to nitrogen compound response to vasopressin cellular response to organonitrogen compound response to pH cellular response to pH response to abiotic stimulus cellular response to acidic pH cellular response to abiotic stimulus response to acidic pH cellular response to environmental stimulus multicellular organismal-level homeostasis homeostasis of number of cells myeloid cell homeostasis erythrocyte homeostasis regulation of body fluid levels secretion by tissue secretion mucus secretion body fluid secretion multicellular organismal-level water homeostasis multicellular organismal-level chemical homeostasis sensory perception of salty taste monoatomic ion transmembrane transport sodium ion transmembrane transport inorganic ion transmembrane transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport monoatomic ion transport monoatomic cation transport sodium ion transport import into cell import across plasma membrane sodium ion import across plasma membrane inorganic cation import across plasma membrane inorganic ion import across plasma membrane organic substance metabolic process biosynthetic process cellular biosynthetic process cellular metabolic process organic substance biosynthetic process metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process potassium ion homeostasis regulation of hormone levels organic hydroxy compound metabolic process steroid metabolic process alcohol metabolic process primary metabolic process C21-steroid hormone metabolic process hormone metabolic process mineralocorticoid metabolic process organic cyclic compound metabolic process cellular ketone metabolic process aldosterone metabolic process cellular aldehyde metabolic process olefinic compound metabolic process small molecule metabolic process primary alcohol metabolic process lipid metabolic process regulation of tube diameter vascular associated smooth muscle contraction regulation of tube size muscle contraction muscle system process smooth muscle contraction artery smooth muscle contraction vascular process in circulatory system blood vessel diameter maintenance tonic smooth muscle contraction vasoconstriction regulation of anatomical structure size leukocyte activation involved in inflammatory response cell activation inflammatory response leukocyte activation developmental process multicellular organism growth developmental growth growth response to nutrient levels response to food neutrophil activation immune response cell activation involved in immune response myeloid leukocyte activation myeloid cell activation involved in immune response neutrophil activation involved in immune response leukocyte activation involved in immune response granulocyte activation	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane apical part of cell plasma membrane region apical plasma membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane apical part of cell plasma membrane region apical plasma membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle protein-containing complex sodium channel complex transmembrane transporter complex membrane protein complex cation channel complex transporter complex monoatomic ion channel complex intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle cytoplasm organelle membrane
C	EGFP-SCNN1G chimera	monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity ligand-gated sodium channel activity sodium channel activity sodium ion transmembrane transporter activity ligand-gated channel activity ligand-gated monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity ligand-gated sodium channel activity sodium channel activity sodium ion transmembrane transporter activity ligand-gated channel activity ligand-gated monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity ligand-gated monoatomic cation channel activity transmembrane transporter activity protein binding binding WW domain binding protein domain specific binding	sodium ion homeostasis inorganic ion homeostasis homeostatic process intracellular sodium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis multicellular organismal process system process circulatory system process sodium ion homeostasis inorganic ion homeostasis homeostatic process intracellular sodium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis multicellular organismal process system process circulatory system process regulation of blood pressure biological regulation regulation of biological quality blood circulation sensory perception of chemical stimulus sensory perception nervous system process sensory perception of taste sensory perception of sour taste cellular response to stimulus response to organic substance response to ketone response to lipid response to stimulus cellular response to mineralocorticoid stimulus response to mineralocorticoid cellular response to endogenous stimulus cellular response to aldehyde response to hormone response to steroid hormone cellular response to organic substance cellular response to ketone response to organic cyclic compound cellular response to steroid hormone stimulus cellular response to hormone stimulus cellular response to aldosterone response to aldosterone response to endogenous stimulus response to alcohol cellular response to organic cyclic compound response to oxygen-containing compound cellular response to oxygen-containing compound cellular response to corticosteroid stimulus response to corticosteroid cellular response to chemical stimulus cellular response to alcohol response to chemical cellular response to lipid cellular process cellular response to nitrogen compound cellular response to vasopressin response to organonitrogen compound response to peptide hormone cellular response to peptide hormone stimulus response to nitrogen compound response to vasopressin cellular response to organonitrogen compound response to pH cellular response to pH response to abiotic stimulus cellular response to acidic pH cellular response to abiotic stimulus response to acidic pH cellular response to environmental stimulus regulation of body fluid levels multicellular organismal-level homeostasis multicellular organismal-level water homeostasis multicellular organismal-level chemical homeostasis sensory perception of salty taste transport monoatomic ion transmembrane transport sodium ion transmembrane transport inorganic ion transmembrane transport establishment of localization metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport monoatomic cation transport sodium ion transport import into cell import across plasma membrane sodium ion import across plasma membrane inorganic cation import across plasma membrane inorganic ion import across plasma membrane	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane apical part of cell plasma membrane region apical plasma membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane apical part of cell plasma membrane region apical plasma membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle protein-containing complex sodium channel complex transmembrane transporter complex membrane protein complex cation channel complex transporter complex monoatomic ion channel complex intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen
D	7B1 fab	-	-	-
E	7B1 fab	-	-	-
F	10D4 fab	-	-	-
G	10D4 fab	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR020903	Epithelial sodium channel, conserved site	Conserved Site
A	IPR004724	Epithelial sodium channel, chordates	Family
A	IPR001873	Epithelial sodium channel	Family
B	IPR020903	Epithelial sodium channel, conserved site	Conserved Site
B	IPR004724	Epithelial sodium channel, chordates	Family
B	IPR001873	Epithelial sodium channel	Family
C	IPR020903	Epithelial sodium channel, conserved site	Conserved Site
C	IPR004724	Epithelial sodium channel, chordates	Family
C	IPR001873	Epithelial sodium channel	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P37088	cystic fibrosis hypertensive disorder bronchiectasis with or without elevated sweat chloride 2 Liddle syndrome autosomal recessive pseudohypoaldosteronism type 1 pseudohypoaldosteronism polycystic ovary syndrome autosomal dominant pseudohypoaldosteronism type 1 proteinuria lung disease preeclampsia germ cell tumor embryonal neoplasm pseudohypoaldosteronism type 1 glioblastoma cystic fibrosis hypertensive disorder bronchiectasis with or without elevated sweat chloride 2 Liddle syndrome autosomal recessive pseudohypoaldosteronism type 1 pseudohypoaldosteronism polycystic ovary syndrome autosomal dominant pseudohypoaldosteronism type 1 proteinuria lung disease preeclampsia germ cell tumor embryonal neoplasm pseudohypoaldosteronism type 1 glioblastoma Pulmonary Cystic Fibrosis Sjogren syndrome juvenile idiopathic arthritis lung cancer adenoma malignant glioma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma colorectal adenoma endometriosis pseudohypoaldosteronism type 2 idiopathic bronchiectasis spina bifida adrenal cortex carcinoma malignant pancreatic neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm colorectal cancer pituitary cancer interstitial cystitis Liddle syndrome 1 ankylosing spondylitis nasopharyngeal carcinoma nephrosclerosis pancreatic ductal adenocarcinoma celiac disease pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Crohn disease primary biliary cholangitis
B	Pharos: P51168	cystic fibrosis Liddle syndrome hypertensive disorder bronchiectasis with or without elevated sweat chloride 1 pseudohypoaldosteronism autosomal recessive pseudohypoaldosteronism type 1 autosomal dominant pseudohypoaldosteronism type 1 malignant ependymoma non-small cell lung carcinoma Pseudohypoaldosteronism, Type I, Autosomal Recessive renal tubular acidosis colorectal cancer esophageal adenocarcinoma idiopathic bronchiectasis Liddle syndrome 1 cystic fibrosis Liddle syndrome hypertensive disorder bronchiectasis with or without elevated sweat chloride 1 pseudohypoaldosteronism autosomal recessive pseudohypoaldosteronism type 1 autosomal dominant pseudohypoaldosteronism type 1 malignant ependymoma non-small cell lung carcinoma Pseudohypoaldosteronism, Type I, Autosomal Recessive renal tubular acidosis colorectal cancer esophageal adenocarcinoma idiopathic bronchiectasis Liddle syndrome 1 lung disease osteosarcoma pseudohypoaldosteronism type 1 ulcerative colitis interstitial cystitis lung adenocarcinoma nephrolithiasis pseudohypoaldosteronism type 2 gastric carcinoma lung carcinoma
C	Pharos: P51170	cystic fibrosis bronchiectasis with or without elevated sweat chloride 3 hypertensive disorder Liddle syndrome pseudohypoaldosteronism autosomal dominant pseudohypoaldosteronism type 1 autosomal recessive pseudohypoaldosteronism type 1 hypotensive disorder Peripheral Edema due to Chronic Heart Failure pseudohypoaldosteronism type 2 colorectal cancer idiopathic bronchiectasis Liddle syndrome 1 nasopharyngeal carcinoma Sjogren syndrome cystic fibrosis bronchiectasis with or without elevated sweat chloride 3 hypertensive disorder Liddle syndrome pseudohypoaldosteronism autosomal dominant pseudohypoaldosteronism type 1 autosomal recessive pseudohypoaldosteronism type 1 hypotensive disorder Peripheral Edema due to Chronic Heart Failure pseudohypoaldosteronism type 2 colorectal cancer idiopathic bronchiectasis Liddle syndrome 1 nasopharyngeal carcinoma Sjogren syndrome interstitial cystitis lung adenocarcinoma non-small cell lung carcinoma pseudohypoaldosteronism type 1 lung carcinoma

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Channels: Other Ion Channels	epithelial sodium channel ENaC

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.