6BO7

Crystal structure of Plasmodium vivax hypoxanthine guanine phosphoribosyltransferase in complex with [3R,4R]-4-guanin-9-yl-3-((S)-2-hydroxy-2-phosphonoethyl)oxy-1-N-(phosphonopropionyl)pyrrolidine

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6bo7a1	Alpha and beta proteins (a/b)	PRTase-like	PRTase-like	Phosphoribosyltransferases (PRTases)	automated matches	malaria parasite P. vivax (Plasmodium vivax ) [TaxId: 5855 ],	SCOPe (2.08)
A	d6bo7a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	malaria parasite P. vivax (Plasmodium vivax ) [TaxId: 5855 ],	SCOPe (2.08)
B	d6bo7b1	Alpha and beta proteins (a/b)	PRTase-like	PRTase-like	Phosphoribosyltransferases (PRTases)	automated matches	malaria parasite P. vivax (Plasmodium vivax ) [TaxId: 5855 ],	SCOPe (2.08)
B	d6bo7b2	Artifacts	Tags	Tags	Tags	N-terminal Tags	malaria parasite P. vivax (Plasmodium vivax ) [TaxId: 5855 ],	SCOPe (2.08)
C	d6bo7c1	Alpha and beta proteins (a/b)	PRTase-like	PRTase-like	Phosphoribosyltransferases (PRTases)	automated matches	malaria parasite P. vivax (Plasmodium vivax ) [TaxId: 5855 ],	SCOPe (2.08)
C	d6bo7c2	Artifacts	Tags	Tags	Tags	N-terminal Tags	malaria parasite P. vivax (Plasmodium vivax ) [TaxId: 5855 ],	SCOPe (2.08)
D	d6bo7d_	Alpha and beta proteins (a/b)	PRTase-like	PRTase-like	Phosphoribosyltransferases (PRTases)	automated matches	malaria parasite P. vivax (Plasmodium vivax ) [TaxId: 5855 ],	SCOPe (2.08)
E	d6bo7e_	Alpha and beta proteins (a/b)	PRTase-like	PRTase-like	Phosphoribosyltransferases (PRTases)	automated matches	malaria parasite P. vivax (Plasmodium vivax ) [TaxId: 5855 ],	SCOPe (2.08)
H	d6bo7h_	Alpha and beta proteins (a/b)	PRTase-like	PRTase-like	Phosphoribosyltransferases (PRTases)	automated matches	malaria parasite P. vivax (Plasmodium vivax ) [TaxId: 5855 ],	SCOPe (2.08)
I	d6bo7i_	Alpha and beta proteins (a/b)	PRTase-like	PRTase-like	Phosphoribosyltransferases (PRTases)	automated matches	malaria parasite P. vivax (Plasmodium vivax ) [TaxId: 5855 ],	SCOPe (2.08)
J	d6bo7j_	Alpha and beta proteins (a/b)	PRTase-like	PRTase-like	Phosphoribosyltransferases (PRTases)	automated matches	malaria parasite P. vivax (Plasmodium vivax ) [TaxId: 5855 ],	SCOPe (2.08)
L	d6bo7l_	Alpha and beta proteins (a/b)	PRTase-like	PRTase-like	Phosphoribosyltransferases (PRTases)	automated matches	malaria parasite P. vivax (Plasmodium vivax ) [TaxId: 5855 ],	SCOPe (2.08)
F	d6bo7f1	Alpha and beta proteins (a/b)	PRTase-like	PRTase-like	Phosphoribosyltransferases (PRTases)	automated matches	malaria parasite P. vivax (Plasmodium vivax ) [TaxId: 5855 ],	SCOPe (2.08)
F	d6bo7f2	Artifacts	Tags	Tags	Tags	N-terminal Tags	malaria parasite P. vivax (Plasmodium vivax ) [TaxId: 5855 ],	SCOPe (2.08)
G	d6bo7g_	Alpha and beta proteins (a/b)	PRTase-like	PRTase-like	Phosphoribosyltransferases (PRTases)	automated matches	malaria parasite P. vivax (Plasmodium vivax ) [TaxId: 5855 ],	SCOPe (2.08)
K	d6bo7k_	Alpha and beta proteins (a/b)	PRTase-like	PRTase-like	Phosphoribosyltransferases (PRTases)	automated matches	malaria parasite P. vivax (Plasmodium vivax ) [TaxId: 5855 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Phosphoribosyltransferases (PRTases)	8069102	4000253	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	PRTase-like	8069103	3000060	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	PRTase-like	8069103	3000060	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	PRTase-like	8069103	3000060	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	PRTase-like	8069103	3000060	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	PRTase-like	8069103	3000060	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	PRTase-like	8069103	3000060	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	PRTase-like	8069103	3000060	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	PRTase-like	8069103	3000060	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	PRTase-like	8069103	3000060	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	PRTase-like	8069103	3000060	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	PRTase-like	8069103	3000060	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	PRTase-like	8069103	3000060	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00156	e6bo7A1	A: a/b three-layered sandwiches	X: PRTase-like (From Topology)	H: PRTase-like (From Topology)	T: PRTase-like	F: PF00156	ECOD (1.6)
B	PF00156	e6bo7B1	A: a/b three-layered sandwiches	X: PRTase-like (From Topology)	H: PRTase-like (From Topology)	T: PRTase-like	F: PF00156	ECOD (1.6)
C	PF00156	e6bo7C1	A: a/b three-layered sandwiches	X: PRTase-like (From Topology)	H: PRTase-like (From Topology)	T: PRTase-like	F: PF00156	ECOD (1.6)
D	PF00156	e6bo7D1	A: a/b three-layered sandwiches	X: PRTase-like (From Topology)	H: PRTase-like (From Topology)	T: PRTase-like	F: PF00156	ECOD (1.6)
E	PF00156	e6bo7E1	A: a/b three-layered sandwiches	X: PRTase-like (From Topology)	H: PRTase-like (From Topology)	T: PRTase-like	F: PF00156	ECOD (1.6)
H	PF00156	e6bo7H1	A: a/b three-layered sandwiches	X: PRTase-like (From Topology)	H: PRTase-like (From Topology)	T: PRTase-like	F: PF00156	ECOD (1.6)
I	PF00156	e6bo7I1	A: a/b three-layered sandwiches	X: PRTase-like (From Topology)	H: PRTase-like (From Topology)	T: PRTase-like	F: PF00156	ECOD (1.6)
J	PF00156	e6bo7J1	A: a/b three-layered sandwiches	X: PRTase-like (From Topology)	H: PRTase-like (From Topology)	T: PRTase-like	F: PF00156	ECOD (1.6)
L	PF00156	e6bo7L1	A: a/b three-layered sandwiches	X: PRTase-like (From Topology)	H: PRTase-like (From Topology)	T: PRTase-like	F: PF00156	ECOD (1.6)
F	PF00156	e6bo7F1	A: a/b three-layered sandwiches	X: PRTase-like (From Topology)	H: PRTase-like (From Topology)	T: PRTase-like	F: PF00156	ECOD (1.6)
G	PF00156	e6bo7G1	A: a/b three-layered sandwiches	X: PRTase-like (From Topology)	H: PRTase-like (From Topology)	T: PRTase-like	F: PF00156	ECOD (1.6)
K	PF00156	e6bo7K1	A: a/b three-layered sandwiches	X: PRTase-like (From Topology)	H: PRTase-like (From Topology)	T: PRTase-like	F: PF00156	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.2020	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
B	3.40.50.2020	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
C	3.40.50.2020	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
D	3.40.50.2020	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
E	3.40.50.2020	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
H	3.40.50.2020	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
I	3.40.50.2020	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
J	3.40.50.2020	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
L	3.40.50.2020	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
F	3.40.50.2020	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
G	3.40.50.2020	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
K	3.40.50.2020	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PF00156	Phosphoribosyl transferase domain (Pribosyltran)	Phosphoribosyl transferase domain	This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7, Swiss:P07672. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase Swiss:P51900. Hypoxanthine phosph ...	This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7, Swiss:P07672. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase Swiss:P51900. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8 Swiss:P36766. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1 Swiss:P09329. Amidophosphoribosyltransferase EC:2.4.2.14 Swiss:P00496. Orotate phosphoribosyl-transferase EC:2.4.2.10 Swiss:P11172. Uracil phosphoribosyl-transferase EC:2.4.2.9 Swiss:P25532. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22 Swiss:P00501. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	Hypoxanthine phosphoribosyltransferase	pentosyltransferase activity hypoxanthine phosphoribosyltransferase activity glycosyltransferase activity purine phosphoribosyltransferase activity transferase activity catalytic activity guanine phosphoribosyltransferase activity binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding small molecule binding cation binding pentosyltransferase activity hypoxanthine phosphoribosyltransferase activity glycosyltransferase activity purine phosphoribosyltransferase activity transferase activity catalytic activity guanine phosphoribosyltransferase activity binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding small molecule binding cation binding ion binding metal ion binding	IMP salvage IMP metabolic process purine ribonucleoside monophosphate biosynthetic process nucleotide biosynthetic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleoside monophosphate biosynthetic process purine nucleoside monophosphate metabolic process phosphate-containing compound metabolic process organic substance biosynthetic process small molecule metabolic process IMP salvage IMP metabolic process purine ribonucleoside monophosphate biosynthetic process nucleotide biosynthetic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleoside monophosphate biosynthetic process purine nucleoside monophosphate metabolic process phosphate-containing compound metabolic process organic substance biosynthetic process small molecule metabolic process phosphorus metabolic process ribose phosphate biosynthetic process cellular metabolic compound salvage nucleoside phosphate metabolic process cellular metabolic process primary metabolic process nucleotide metabolic process organic cyclic compound metabolic process biosynthetic process purine ribonucleotide salvage organophosphate biosynthetic process organic cyclic compound biosynthetic process nucleoside phosphate biosynthetic process metabolic process purine ribonucleotide metabolic process purine nucleotide biosynthetic process ribose phosphate metabolic process nucleotide salvage purine ribonucleoside monophosphate metabolic process purine nucleotide metabolic process organic substance metabolic process ribonucleotide metabolic process ribonucleoside monophosphate metabolic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process purine nucleotide salvage nucleoside monophosphate metabolic process carbohydrate derivative biosynthetic process organonitrogen compound metabolic process purine-containing compound salvage nucleobase-containing compound biosynthetic process nucleoside monophosphate biosynthetic process purine-containing compound metabolic process IMP biosynthetic process organophosphate metabolic process cellular process ribonucleoside monophosphate biosynthetic process glycosyl compound metabolic process nucleoside biosynthetic process purine ribonucleoside metabolic process glycosyl compound biosynthetic process small molecule biosynthetic process nucleoside salvage purine ribonucleoside biosynthetic process ribonucleoside biosynthetic process nucleoside metabolic process nucleobase-containing small molecule biosynthetic process purine ribonucleoside salvage purine nucleoside biosynthetic process purine nucleoside metabolic process ribonucleoside metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR005904	Hypoxanthine phosphoribosyl transferase	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR000836	Phosphoribosyltransferase domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR029057	Phosphoribosyltransferase-like	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.