Annotations: 6BNM

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6bnma1	All beta proteins	PH domain-like barrel	PH domain-like	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d6bnma2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF22697	e6bnmA1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF22697	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00169	PH domain (PH)	PH domain	PH stands for pleckstrin homology.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein	GTPase regulator activity enzyme regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity molecular function regulator activity enzyme activator activity GTPase activator activity molecular function activator activity	regulation of signaling regulation of biological process signaling biological regulation adult locomotory behavior behavior multicellular organismal process adult behavior locomotory behavior cellular response to stimulus regulation of cellular process response to stimulus intracellular signal transduction cell communication regulation of signaling regulation of biological process signaling biological regulation adult locomotory behavior behavior multicellular organismal process adult behavior locomotory behavior cellular response to stimulus regulation of cellular process response to stimulus intracellular signal transduction cell communication intracellular signaling cassette cellular process signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction small GTPase-mediated signal transduction regulation of small GTPase mediated signal transduction regulation of signal transduction regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication G protein-coupled receptor signaling pathway cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis dendrite development cell differentiation anatomical structure development cellular component organization or biogenesis system development developmental process plasma membrane bounded cell projection organization dendrite morphogenesis nervous system development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001849	Pleckstrin homology domain	Domain
A	IPR000591	DEP domain	Domain
A	IPR000219	Dbl homology (DH) domain	Domain
A	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
A	IPR036034	PDZ superfamily	Homologous Superfamily
A	IPR035899	Dbl homology (DH) domain superfamily	Homologous Superfamily
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR001478	PDZ domain	Domain
A	IPR037367	PREX2, DEP domain 1	Domain
A	IPR001331	Guanine-nucleotide dissociation stimulator, CDC24, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q70Z35	atypical teratoid rhabdoid tumor ductal breast carcinoma in situ large cell medulloblastoma malignant glioma ovarian cancer pilocytic astrocytoma bladder exstrophy glioblastoma lung adenocarcinoma medulloblastoma pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor colorectal cancer invasive ductal breast carcinoma lung carcinoma atypical teratoid rhabdoid tumor ductal breast carcinoma in situ large cell medulloblastoma malignant glioma ovarian cancer pilocytic astrocytoma bladder exstrophy glioblastoma lung adenocarcinoma medulloblastoma pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor colorectal cancer invasive ductal breast carcinoma lung carcinoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.