Annotations: 6BM6

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6bm6a_	Alpha and beta proteins (a+b)	Methionine synthase activation domain-like	Methionine synthase activation domain-like	Methionine synthase SAM-binding domain	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Methionine synthase activation domain-like	8037194	3001398	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02965	e6bm6A1	A: a+b complex topology	X: Methionine synthase activation domain-like (From Topology)	H: Methionine synthase activation domain-like (From Topology)	T: Methionine synthase activation domain-like	F: PF02965	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.196.10	Alpha Beta	Roll	Cobalamin-dependent Methionine Synthase	domain 1	CATH (4.3.0)
A	1.10.288.10	Mainly Alpha	Orthogonal Bundle	Cobalamin-dependent Methionine Synthase	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02965	Vitamin B12 dependent methionine synthase, activation domain (Met_synt_B12)	Vitamin B12 dependent methionine synthase, activation domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Methionine synthase	vitamin binding binding cobalamin binding organic cyclic compound binding tetrapyrrole binding heterocyclic compound binding small molecule binding methionine synthase activity 5-methyltetrahydrofolate-dependent methyltransferase activity transferase activity, transferring one-carbon groups S-methyltransferase activity transferase activity methyltransferase activity catalytic activity vitamin binding binding cobalamin binding organic cyclic compound binding tetrapyrrole binding heterocyclic compound binding small molecule binding methionine synthase activity 5-methyltetrahydrofolate-dependent methyltransferase activity transferase activity, transferring one-carbon groups S-methyltransferase activity transferase activity methyltransferase activity catalytic activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding	homocysteine metabolic process organonitrogen compound metabolic process oxoacid metabolic process sulfur amino acid metabolic process cellular metabolic process carboxylic acid metabolic process amino acid metabolic process primary metabolic process organic acid metabolic process alpha-amino acid metabolic process non-proteinogenic amino acid metabolic process organic substance metabolic process metabolic process small molecule metabolic process homocysteine metabolic process organonitrogen compound metabolic process oxoacid metabolic process sulfur amino acid metabolic process cellular metabolic process carboxylic acid metabolic process amino acid metabolic process primary metabolic process organic acid metabolic process alpha-amino acid metabolic process non-proteinogenic amino acid metabolic process organic substance metabolic process metabolic process small molecule metabolic process cellular process sulfur compound metabolic process cellular biosynthetic process aspartate family amino acid biosynthetic process organonitrogen compound biosynthetic process aspartate family amino acid metabolic process organic acid biosynthetic process carboxylic acid biosynthetic process organic substance biosynthetic process methionine biosynthetic process small molecule biosynthetic process L-amino acid biosynthetic process methionine metabolic process L-amino acid metabolic process proteinogenic amino acid metabolic process amino acid biosynthetic process sulfur compound biosynthetic process biosynthetic process proteinogenic amino acid biosynthetic process sulfur amino acid biosynthetic process alpha-amino acid biosynthetic process organic cyclic compound metabolic process folic acid-containing compound metabolic process tetrahydrofolate metabolic process pteridine-containing compound metabolic process cellular modified amino acid metabolic process methylation tetrahydrofolate interconversion one-carbon metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR003759	Cobalamin (vitamin B12)-binding module, cap domain	Domain
A	IPR011005	Dihydropteroate synthase-like superfamily	Homologous Superfamily
A	IPR033706	Methionine synthase, B12-binding domain	Domain
A	IPR006158	Cobalamin (vitamin B12)-binding domain	Domain
A	IPR003726	Homocysteine-binding domain	Domain
A	IPR004223	Vitamin B12-dependent methionine synthase, activation domain	Domain
A	IPR036589	Homocysteine-binding domain superfamily	Homologous Superfamily
A	IPR000489	Pterin-binding domain	Domain
A	IPR036724	Cobalamin-binding domain superfamily	Homologous Superfamily
A	IPR011822	Cobalamin-dependent methionine synthase	Family
A	IPR036594	Methionine synthase domain	Homologous Superfamily
A	IPR037010	Vitamin B12-dependent methionine synthase, activation domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.