6B9G

human ATL1 GTPase domain bound to GDP

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth B]	SCOP2B Superfamily	Ras-like P-loop GTPases	8019680	3002022	SCOP2B (2022-06-29)
B [auth C]	SCOP2B Superfamily	Ras-like P-loop GTPases	8019680	3002022	SCOP2B (2022-06-29)
C [auth D]	SCOP2B Superfamily	Ras-like P-loop GTPases	8019680	3002022	SCOP2B (2022-06-29)
D [auth A]	SCOP2B Superfamily	Ras-like P-loop GTPases	8019680	3002022	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	PF02263	e6b9gB1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF02263	ECOD (1.6)
B [auth C]	PF02263	e6b9gC1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF02263	ECOD (1.6)
C [auth D]	PF02263	e6b9gD1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF02263	ECOD (1.6)
D [auth A]	PF02263	e6b9gA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF02263	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth C], C [auth D], D [auth A]	PF02263	Guanylate-binding protein, N-terminal domain (GBP)	Guanylate-binding protein, N-terminal domain	Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth C], C [auth D], D [auth A]	Atlastin-1	binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity identical protein binding protein binding	cellular component organization organelle organization cellular process cellular component organization or biogenesis endoplasmic reticulum organization endomembrane system organization membrane organization endoplasmic reticulum membrane organization endoplasmic reticulum tubular network membrane organization endoplasmic reticulum tubular network organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization cellular component organization organelle organization cellular process cellular component organization or biogenesis endoplasmic reticulum organization endomembrane system organization membrane organization endoplasmic reticulum membrane organization endoplasmic reticulum tubular network membrane organization endoplasmic reticulum tubular network organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly protein homooligomerization multicellular organismal process axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development system development developmental process plasma membrane bounded cell projection organization nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development	membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure organelle subcompartment intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle endoplasmic reticulum cytoplasm endoplasmic reticulum tubular network Golgi apparatus membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure organelle subcompartment intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle endoplasmic reticulum cytoplasm endoplasmic reticulum tubular network Golgi apparatus Golgi membrane bounding membrane of organelle organelle membrane axon cell projection neuron projection plasma membrane bounded cell projection Golgi apparatus subcompartment Golgi cisterna Golgi cis cisterna Golgi stack nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum membrane endoplasmic reticulum tubular network membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth C], C [auth D], D [auth A]	IPR036543	Guanylate-binding protein, C-terminal domain superfamily	Homologous Superfamily
A [auth B], B [auth C], C [auth D], D [auth A]	IPR030386	GB1/RHD3-type guanine nucleotide-binding (G) domain	Domain
A [auth B], B [auth C], C [auth D], D [auth A]	IPR015894	Guanylate-binding protein, N-terminal	Domain
A [auth B], B [auth C], C [auth D], D [auth A]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth B], B [auth C], C [auth D], D [auth A]	Pharos: Q8WXF7	hereditary spastic paraplegia 3A neuropathy, hereditary sensory, type 1D peripheral neuropathy hereditary spastic paraplegia paraplegia primitive neuroectodermal tumor Spastic Paraplegia, Hereditary astrocytic tumor Charcot-Marie-Tooth disease large cell medulloblastoma medulloblastoma oligodendroglioma pilocytic astrocytoma psoriasis atypical teratoid rhabdoid tumor hereditary spastic paraplegia 3A neuropathy, hereditary sensory, type 1D peripheral neuropathy hereditary spastic paraplegia paraplegia primitive neuroectodermal tumor Spastic Paraplegia, Hereditary astrocytic tumor Charcot-Marie-Tooth disease large cell medulloblastoma medulloblastoma oligodendroglioma pilocytic astrocytoma psoriasis atypical teratoid rhabdoid tumor glioblastoma malignant ependymoma neurodegenerative disease ovarian cancer peripheral nervous system disease plantar fibromatosis Riley-Day syndrome breast cancer intellectual disability malignant glioma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.