Annotations: 6B4E

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	PF07817	e6b4eB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF07817	ECOD (1.6)
B [auth A]	PF07817	e6b4eA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF07817	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth B]	1.25.40.510	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	GLE1-like	CATH (4.3.0)
B [auth A]	1.25.40.510	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	GLE1-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth A]	PF07817	GLE1-like protein (GLE1)	GLE1-like protein	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth A]	Nucleoporin GLE1	enzyme regulator activity enzyme activator activity molecular function activator activity molecular function regulator activity protein binding binding translation initiation factor binding ion binding inositol hexakisphosphate binding alcohol binding anion binding small molecule binding phospholipid binding lipid binding	cellular localization nitrogen compound transport nucleocytoplasmic transport transport cellular biosynthetic process nuclear transport mRNA transport localization organic substance metabolic process mRNA export from nucleus establishment of localization in cell organic substance biosynthetic process RNA localization nuclear export cellular localization nitrogen compound transport nucleocytoplasmic transport transport cellular biosynthetic process nuclear transport mRNA transport localization organic substance metabolic process mRNA export from nucleus establishment of localization in cell organic substance biosynthetic process RNA localization nuclear export nucleobase-containing compound transport RNA transport organic substance transport cellular metabolic process nucleic acid transport poly(A)+ mRNA export from nucleus intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization cellular process metabolic process macromolecule metabolic process tRNA export from nucleus tRNA transport regulation of cellular process organonitrogen compound biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression translational initiation protein metabolic process regulation of biosynthetic process regulation of biological process organonitrogen compound metabolic process regulation of translational initiation regulation of protein metabolic process biological regulation regulation of cellular metabolic process primary metabolic process regulation of macromolecule metabolic process translation regulation of cellular biosynthetic process regulation of gene expression regulation of translation regulation of macromolecule biosynthetic process regulation of metabolic process protein localization establishment of protein localization protein transport cellular macromolecule localization regulation of cellular component organization protein-containing complex disassembly regulation of protein-containing complex disassembly cellular component organization translational termination cellular component organization or biogenesis cellular component disassembly protein-containing complex organization regulation of translational termination RNA metabolic process mRNA processing mRNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process RNA processing	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle organelle envelope nuclear envelope nucleus endomembrane system nuclear membrane membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle organelle envelope nuclear envelope nucleus endomembrane system nuclear membrane membrane organelle membrane protein-containing complex nuclear protein-containing complex nuclear pore nuclear pore cytoplasmic filaments
C, D	Nucleoporin NUP42	structural molecule activity structural constituent of nuclear pore	localization cellular localization nucleocytoplasmic transport transport nuclear transport establishment of localization in cell intracellular transport cellular process establishment of localization nitrogen compound transport cellular biosynthetic process mRNA transport organic substance metabolic process mRNA export from nucleus localization cellular localization nucleocytoplasmic transport transport nuclear transport establishment of localization in cell intracellular transport cellular process establishment of localization nitrogen compound transport cellular biosynthetic process mRNA transport organic substance metabolic process mRNA export from nucleus organic substance biosynthetic process RNA localization nuclear export nucleobase-containing compound transport RNA transport organic substance transport cellular metabolic process nucleic acid transport poly(A)+ mRNA export from nucleus gene expression macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization metabolic process macromolecule metabolic process protein localization establishment of protein localization NLS-bearing protein import into nucleus import into nucleus cellular macromolecule localization protein import into nucleus protein localization to nucleus establishment of protein localization to organelle protein transport protein localization to organelle intracellular protein transport cellular component organization organelle organization chromosome organization cellular component organization or biogenesis transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery cellular response to stimulus response to organic substance response to stimulus response to heat response to temperature stimulus cellular response to stress response to stress response to organic cyclic compound cellular response to heat response to nitrogen compound mRNA export from nucleus in response to heat stress response to chemical response to abiotic stimulus	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope nuclear pore nuclear membrane membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope nuclear pore nuclear membrane membrane organelle membrane nuclear pore central transport channel nuclear pore cytoplasmic filaments

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth A]	IPR012476	mRNA export factor GLE1-like	Family
A [auth B], B [auth A]	IPR038506	GLE1-like superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.