6B1T

Improved cryoEM structure of human adenovirus type 5 with atomic details of minor proteins VI and VII

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Group II dsDNA viruses VP	8038150	3001214	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Group II dsDNA viruses VP	8038153	3001214	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Group II dsDNA viruses VP	8038150	3001214	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Group II dsDNA viruses VP	8038153	3001214	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Group II dsDNA viruses VP	8038150	3001214	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Group II dsDNA viruses VP	8038153	3001214	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Group II dsDNA viruses VP	8038150	3001214	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Group II dsDNA viruses VP	8038153	3001214	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Group II dsDNA viruses VP	8038153	3001214	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Group II dsDNA viruses VP	8038150	3001214	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Group II dsDNA viruses VP	8038150	3001214	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Group II dsDNA viruses VP	8038153	3001214	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Group II dsDNA viruses VP	8038153	3001214	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Group II dsDNA viruses VP	8038150	3001214	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Group II dsDNA viruses VP	8038153	3001214	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Group II dsDNA viruses VP	8038150	3001214	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Group II dsDNA viruses VP	8038150	3001214	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Group II dsDNA viruses VP	8038153	3001214	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Group II dsDNA viruses VP	8038153	3001214	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Group II dsDNA viruses VP	8038150	3001214	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Group II dsDNA viruses VP	8038150	3001214	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Group II dsDNA viruses VP	8038153	3001214	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Group II dsDNA viruses VP	8038153	3001214	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Group II dsDNA viruses VP	8038150	3001214	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01065	e6b1tA2	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: PF01065	ECOD (1.6)
A	PF03678	e6b1tA1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: PF03678	ECOD (1.6)
B	PF01065	e6b1tB1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: PF01065	ECOD (1.6)
B	PF03678	e6b1tB2	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: PF03678	ECOD (1.6)
C	PF01065	e6b1tC1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: PF01065	ECOD (1.6)
C	PF03678	e6b1tC2	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: PF03678	ECOD (1.6)
D	PF01065	e6b1tD2	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: PF01065	ECOD (1.6)
D	PF03678	e6b1tD1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: PF03678	ECOD (1.6)
E	PF01065	e6b1tE2	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: PF01065	ECOD (1.6)
E	PF03678	e6b1tE1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: PF03678	ECOD (1.6)
F	PF01065	e6b1tF2	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: PF01065	ECOD (1.6)
F	PF03678	e6b1tF1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: PF03678	ECOD (1.6)
G	PF01065	e6b1tG2	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: PF01065	ECOD (1.6)
G	PF03678	e6b1tG1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: PF03678	ECOD (1.6)
H	PF01065	e6b1tH1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: PF01065	ECOD (1.6)
H	PF03678	e6b1tH2	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: PF03678	ECOD (1.6)
I	PF01065	e6b1tI1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: PF01065	ECOD (1.6)
I	PF03678	e6b1tI2	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: PF03678	ECOD (1.6)
J	PF01065	e6b1tJ2	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: PF01065	ECOD (1.6)
J	PF03678	e6b1tJ1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: PF03678	ECOD (1.6)
K	PF01065	e6b1tK1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: PF01065	ECOD (1.6)
K	PF03678	e6b1tK2	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: PF03678	ECOD (1.6)
L	PF01065	e6b1tL1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: PF01065	ECOD (1.6)
L	PF03678	e6b1tL2	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: PF03678	ECOD (1.6)
M	PF01686	e6b1tM2	A: beta sandwiches	X: jelly-roll	H: Jelly-roll domain in Adenovirus penton base protein (From Topology)	T: Jelly-roll domain in Adenovirus penton base protein	F: PF01686	ECOD (1.6)
M	PF01686	e6b1tM1	A: a+b complex topology	X: Insertion domain in Adenovirus penton base protein (From Topology)	H: Insertion domain in Adenovirus penton base protein (From Topology)	T: Insertion domain in Adenovirus penton base protein	F: PF01686	ECOD (1.6)
N	PF02455	e6b1tN2	A: alpha arrays	X: N-terminal domain of hexon-associated protein (IIIa) (From Topology)	H: N-terminal domain of hexon-associated protein (IIIa) (From Topology)	T: N-terminal domain of hexon-associated protein (IIIa)	F: PF02455	ECOD (1.6)
N	PF02455	e6b1tN1	A: alpha bundles	X: Middle domain of hexon-associated protein (IIIa) (From Topology)	H: Middle domain of hexon-associated protein (IIIa) (From Topology)	T: Middle domain of hexon-associated protein (IIIa)	F: PF02455	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PF01065	Hexon, adenovirus major coat protein, N-terminal domain (Adeno_hexon)	Hexon, adenovirus major coat protein, N-terminal domain	Hexon is the major coat protein from adenovirus type 2. Hexon forms a homo-trimer. The 240 copies of the hexon trimer are organised so that 12 lie on each of the 20 facets. The central 9 hexons in a facet are cemented together by 12 copies of polype ...	Hexon is the major coat protein from adenovirus type 2. Hexon forms a homo-trimer. The 240 copies of the hexon trimer are organised so that 12 lie on each of the 20 facets. The central 9 hexons in a facet are cemented together by 12 copies of polypeptide IX. The penton complex, formed by the peripentonal hexons and base hexon (holding in place a fibre), lie at each of the 12 vertices [1]. The N and C-terminal domains adopt the same PNGase F-like fold although they are significantly different in length.	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PF03678	Hexon, adenovirus major coat protein, C-terminal domain (Adeno_hexon_C)	Hexon, adenovirus major coat protein, C-terminal domain	Hexon is the major coat protein from adenovirus type 2. Hexon forms a homo-trimer. The 240 copies of the hexon trimer are organised so that 12 lie on each of the 20 facets. The central 9 hexons in a facet are cemented together by 12 copies of polype ...	Hexon is the major coat protein from adenovirus type 2. Hexon forms a homo-trimer. The 240 copies of the hexon trimer are organised so that 12 lie on each of the 20 facets. The central 9 hexons in a facet are cemented together by 12 copies of polypeptide IX. The penton complex, formed by the peripentonal hexons and base hexon (holding in place a fibre), lie at each of the 12 vertices [1]. The N and C-terminal domains adopt the same PNGase F-like fold although they are significantly different in length.	Domain
M	PF01686	Adenovirus penton base protein (Adeno_Penton_B)	Adenovirus penton base protein	-	Family
N	PF02455	Hexon-associated protein (IIIa) (Hex_IIIa)	Hexon-associated protein (IIIa)	-	Family
O, P	PF01310	Adenovirus hexon associated protein, protein VIII (Adeno_PVIII)	Adenovirus hexon associated protein, protein VIII	-	Family
Q, R, S, T	PF03955	Adenovirus hexon-associated protein (IX) (Adeno_PIX)	Adenovirus hexon-associated protein (IX)	-	Family
U, V, Y	PF02993	Minor capsid protein VI (MCPVI)	Minor capsid protein VI	-	Family
W	PF03228	Adenoviral core protein VII (Adeno_VII)	Adenoviral core protein VII	-	Family
X	PF02993	Minor capsid protein VI (MCPVI)	Minor capsid protein VI	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	Hexon protein	structural molecule activity	microtubule-dependent intracellular transport of viral material microtubule-dependent intracellular transport of viral material towards nucleus intracellular transport of virus viral process viral life cycle transport of virus transport of viral material towards nucleus biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host biological process involved in interaction with host biological process involved in symbiotic interaction	viral capsid virion component host intracellular membrane-bounded organelle host cellular component host intracellular part host cell part host intracellular region cellular anatomical entity host cell nucleus host intracellular organelle icosahedral viral capsid T=25 icosahedral viral capsid
M	Penton protein	structural molecule activity	import into cell receptor-mediated endocytosis of virus by host cell biological process involved in interspecies interaction between organisms transport viral life cycle establishment of localization vesicle-mediated transport biological process involved in interaction with host biological process involved in symbiotic interaction localization symbiont entry into host cell clathrin-dependent endocytosis viral process symbiont entry into host import into cell receptor-mediated endocytosis of virus by host cell biological process involved in interspecies interaction between organisms transport viral life cycle establishment of localization vesicle-mediated transport biological process involved in interaction with host biological process involved in symbiotic interaction localization symbiont entry into host cell clathrin-dependent endocytosis viral process symbiont entry into host cellular process clathrin-dependent endocytosis of virus by host cell receptor-mediated endocytosis endocytosis endocytosis involved in viral entry into host cell transport of virus virion attachment to host cell adhesion of symbiont to host cell adhesion of symbiont to host	viral capsid virion component host intracellular membrane-bounded organelle host cellular component host intracellular part host cell part host intracellular region cellular anatomical entity host cell nucleus host intracellular organelle icosahedral viral capsid T=25 icosahedral viral capsid
N	Pre-hexon-linking protein IIIa	-	-	viral capsid virion component host intracellular membrane-bounded organelle host cellular component host intracellular part host cell part host intracellular region cellular anatomical entity host cell nucleus host intracellular organelle viral capsid, decoration
O, P	Pre-hexon-linking protein VIII	hexon binding protein binding binding	-	viral capsid virion component host intracellular membrane-bounded organelle host cellular component host intracellular part host cell part host intracellular region cellular anatomical entity host cell nucleus host intracellular organelle
Q, R, S, T	Hexon-interlacing protein	hexon binding protein binding binding	biological process involved in interspecies interaction between organisms symbiont entry into host cell viral process symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction	host intracellular membrane-bounded organelle host cellular component host intracellular part host cell part host intracellular region cellular anatomical entity host cell nucleus host intracellular organelle viral capsid virion component viral capsid, decoration
U, V, Y	Pre-protein VI	-	microtubule-dependent intracellular transport of viral material microtubule-dependent intracellular transport of viral material towards nucleus intracellular transport of virus viral process viral life cycle transport of virus transport of viral material towards nucleus biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host lysis of host organelle involved in viral entry into host cell biological process involved in interaction with host biological process involved in symbiotic interaction protein localization microtubule-dependent intracellular transport of viral material microtubule-dependent intracellular transport of viral material towards nucleus intracellular transport of virus viral process viral life cycle transport of virus transport of viral material towards nucleus biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host lysis of host organelle involved in viral entry into host cell biological process involved in interaction with host biological process involved in symbiotic interaction protein localization establishment of protein localization cellular localization nitrogen compound transport transport organic substance transport protein transport along microtubule microtubule-based protein transport intracellular transport establishment of localization localization protein transport cellular macromolecule localization macromolecule localization establishment of localization in cell microtubule-based transport cellular process microtubule-based process transport along microtubule cytoskeleton-dependent intracellular transport microtubule-based movement intracellular protein transport exit from host cell viral release from host cell	viral capsid virion component viral procapsid host intracellular membrane-bounded organelle host cellular component host intracellular part host cell part host intracellular region cellular anatomical entity host cell nucleus host intracellular organelle host cell cytoplasm
W	Pre-histone-like nucleoprotein	DNA binding binding organic cyclic compound binding nucleic acid binding	biological process involved in interspecies interaction between organisms symbiont entry into host cell viral process symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction viral penetration into host nucleus intracellular transport of virus transport of virus	viral capsid virion component host intracellular membrane-bounded organelle host cellular component host intracellular part host cell part host intracellular region cellular anatomical entity host cell nucleus host cell nucleolus host cell nuclear part host intracellular organelle
X	Pre-protein VI	-	microtubule-dependent intracellular transport of viral material microtubule-dependent intracellular transport of viral material towards nucleus intracellular transport of virus viral process viral life cycle transport of virus transport of viral material towards nucleus biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host lysis of host organelle involved in viral entry into host cell biological process involved in interaction with host biological process involved in symbiotic interaction protein localization microtubule-dependent intracellular transport of viral material microtubule-dependent intracellular transport of viral material towards nucleus intracellular transport of virus viral process viral life cycle transport of virus transport of viral material towards nucleus biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host lysis of host organelle involved in viral entry into host cell biological process involved in interaction with host biological process involved in symbiotic interaction protein localization establishment of protein localization cellular localization nitrogen compound transport transport organic substance transport protein transport along microtubule microtubule-based protein transport intracellular transport establishment of localization localization protein transport cellular macromolecule localization macromolecule localization establishment of localization in cell microtubule-based transport cellular process microtubule-based process transport along microtubule cytoskeleton-dependent intracellular transport microtubule-based movement intracellular protein transport exit from host cell viral release from host cell	viral capsid virion component viral procapsid host intracellular membrane-bounded organelle host cellular component host intracellular part host cell part host intracellular region cellular anatomical entity host cell nucleus host intracellular organelle host cell cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR044942	Adenovirus Pll, hexon, subdomain 2	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR016107	Adenovirus Pll, hexon, N-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR016108	Adenovirus Pll, hexon, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR016112	Group II dsDNA virus coat/capsid protein	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR037542	Adenovirus hexon protein	Family
M	IPR002605	Adenovirus penton base protein	Family
N	IPR003479	Pre-hexon-linking protein IIIa	Family
N	IPR043053	Pre-hexon-linking protein IIIa, N-terminal	Homologous Superfamily
O, P	IPR000646	Pre-hexon-linking protein VIII	Family
Q, R, S, T	IPR005641	Hexon-associated protein IX	Family
U, V, Y	IPR004243	Minor capsid protein VI	Family
W	IPR004912	Adenoviral core protein VII	Family
X	IPR004243	Minor capsid protein VI	Family

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6B1T

Improved cryoEM structure of human adenovirus type 5 with atomic details of minor proteins VI and VII

External Resource: Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Domain Annotation: ECOD Classification ECOD Database Homepage

Protein Family Annotation Pfam Database Homepage

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

InterPro: Protein Family Classification InterPro Database Homepage