6AVA

Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6avaa1	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Short-chain scorpion toxins	automated matches	Lesser Asian scorpion (Mesobuthus eupeus ) [TaxId: 34648 ],	SCOPe (2.08)
A	d6avaa2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Lesser Asian scorpion (Mesobuthus eupeus ) [TaxId: 34648 ],	SCOPe (2.08)
B	d6avab1	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Short-chain scorpion toxins	automated matches	Lesser Asian scorpion (Mesobuthus eupeus ) [TaxId: 34648 ],	SCOPe (2.08)
B	d6avab2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Lesser Asian scorpion (Mesobuthus eupeus ) [TaxId: 34648 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Short-chain scorpion toxins	8077672	4003142	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Scorpion toxin-like	8077673	3000309	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Scorpion toxin-like	8077673	3000309	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF05294	e6avaA1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: PF05294	ECOD (1.6)
B	PF05294	e6avaB1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: PF05294	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF05294	Scorpion short toxin (Toxin_5)	Scorpion short toxin	This family contains various secreted scorpion short toxins and seems to be unrelated to Pfam:PF00451.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Insectotoxin-I1	channel regulator activity ion channel regulator activity molecular function regulator activity transporter regulator activity chloride channel regulator activity toxin activity	-	extracellular region cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036574	Knottin, scorpion toxin-like superfamily	Homologous Superfamily
A, B	IPR007958	Scorpion short chain toxin, chloride channel inhibitor	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.