6AUP

Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6aupa1	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Short-chain scorpion toxins	automated matches	Manchurian scorpion (Mesobuthus martensii ) [TaxId: 34649 ],	SCOPe (2.08)
A	d6aupa2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Manchurian scorpion (Mesobuthus martensii ) [TaxId: 34649 ],	SCOPe (2.08)
B	d6aupb1	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Short-chain scorpion toxins	automated matches	Manchurian scorpion (Mesobuthus martensii ) [TaxId: 34649 ],	SCOPe (2.08)
B	d6aupb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Manchurian scorpion (Mesobuthus martensii ) [TaxId: 34649 ],	SCOPe (2.08)
C	d6aupc1	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Short-chain scorpion toxins	automated matches	Manchurian scorpion (Mesobuthus martensii ) [TaxId: 34649 ],	SCOPe (2.08)
C	d6aupc2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Manchurian scorpion (Mesobuthus martensii ) [TaxId: 34649 ],	SCOPe (2.08)
D [auth F]	d6aupf1	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Short-chain scorpion toxins	automated matches	Manchurian scorpion (Mesobuthus martensii ) [TaxId: 34649 ],	SCOPe (2.08)
D [auth F]	d6aupf2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Manchurian scorpion (Mesobuthus martensii ) [TaxId: 34649 ],	SCOPe (2.08)
E [auth D]	d6aupd1	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Short-chain scorpion toxins	automated matches	Manchurian scorpion (Mesobuthus martensii ) [TaxId: 34649 ],	SCOPe (2.08)
E [auth D]	d6aupd2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Manchurian scorpion (Mesobuthus martensii ) [TaxId: 34649 ],	SCOPe (2.08)
G	d6aupg1	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Short-chain scorpion toxins	automated matches	Manchurian scorpion (Mesobuthus martensii ) [TaxId: 34649 ],	SCOPe (2.08)
G	d6aupg2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Manchurian scorpion (Mesobuthus martensii ) [TaxId: 34649 ],	SCOPe (2.08)
I	d6aupi1	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Short-chain scorpion toxins	automated matches	Manchurian scorpion (Mesobuthus martensii ) [TaxId: 34649 ],	SCOPe (2.08)
I	d6aupi2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Manchurian scorpion (Mesobuthus martensii ) [TaxId: 34649 ],	SCOPe (2.08)
J	d6aupj1	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Short-chain scorpion toxins	automated matches	Manchurian scorpion (Mesobuthus martensii ) [TaxId: 34649 ],	SCOPe (2.08)
J	d6aupj2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Manchurian scorpion (Mesobuthus martensii ) [TaxId: 34649 ],	SCOPe (2.08)
K	d6aupk1	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Short-chain scorpion toxins	automated matches	Manchurian scorpion (Mesobuthus martensii ) [TaxId: 34649 ],	SCOPe (2.08)
K	d6aupk2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Manchurian scorpion (Mesobuthus martensii ) [TaxId: 34649 ],	SCOPe (2.08)
L	d6aupl1	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Short-chain scorpion toxins	automated matches	Manchurian scorpion (Mesobuthus martensii ) [TaxId: 34649 ],	SCOPe (2.08)
L	d6aupl2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Manchurian scorpion (Mesobuthus martensii ) [TaxId: 34649 ],	SCOPe (2.08)
M	d6aupm1	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Short-chain scorpion toxins	automated matches	Manchurian scorpion (Mesobuthus martensii ) [TaxId: 34649 ],	SCOPe (2.08)
M	d6aupm2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Manchurian scorpion (Mesobuthus martensii ) [TaxId: 34649 ],	SCOPe (2.08)
N	d6aupn1	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Short-chain scorpion toxins	automated matches	Manchurian scorpion (Mesobuthus martensii ) [TaxId: 34649 ],	SCOPe (2.08)
N	d6aupn2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Manchurian scorpion (Mesobuthus martensii ) [TaxId: 34649 ],	SCOPe (2.08)
O	d6aupo1	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Short-chain scorpion toxins	automated matches	Manchurian scorpion (Mesobuthus martensii ) [TaxId: 34649 ],	SCOPe (2.08)
O	d6aupo2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Manchurian scorpion (Mesobuthus martensii ) [TaxId: 34649 ],	SCOPe (2.08)
P	d6aupp1	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Short-chain scorpion toxins	automated matches	Manchurian scorpion (Mesobuthus martensii ) [TaxId: 34649 ],	SCOPe (2.08)
P	d6aupp2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Manchurian scorpion (Mesobuthus martensii ) [TaxId: 34649 ],	SCOPe (2.08)
F [auth E]	d6aupe1	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Short-chain scorpion toxins	automated matches	Manchurian scorpion (Mesobuthus martensii ) [TaxId: 34649 ],	SCOPe (2.08)
F [auth E]	d6aupe2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Manchurian scorpion (Mesobuthus martensii ) [TaxId: 34649 ],	SCOPe (2.08)
H	d6auph1	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Short-chain scorpion toxins	automated matches	Manchurian scorpion (Mesobuthus martensii ) [TaxId: 34649 ],	SCOPe (2.08)
H	d6auph2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Manchurian scorpion (Mesobuthus martensii ) [TaxId: 34649 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Scorpion toxin-like	8073820	3000309	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Scorpion toxin-like	8073820	3000309	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Scorpion toxin-like	8073820	3000309	SCOP2B (2022-06-29)
D [auth F]	SCOP2B Superfamily	Scorpion toxin-like	8073820	3000309	SCOP2B (2022-06-29)
E [auth D]	SCOP2B Superfamily	Scorpion toxin-like	8073820	3000309	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Scorpion toxin-like	8073820	3000309	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Scorpion toxin-like	8073820	3000309	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Scorpion toxin-like	8073820	3000309	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Scorpion toxin-like	8073820	3000309	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Scorpion toxin-like	8073820	3000309	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	Scorpion toxin-like	8073820	3000309	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	Scorpion toxin-like	8073820	3000309	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	Scorpion toxin-like	8073820	3000309	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	Scorpion toxin-like	8073820	3000309	SCOP2B (2022-06-29)
F [auth E]	SCOP2B Superfamily	Scorpion toxin-like	8073820	3000309	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Scorpion toxin-like	8073820	3000309	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00451	e6aupA1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: PF00451	ECOD (1.6)
B	PF00451	e6aupB1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: PF00451	ECOD (1.6)
C	PF00451	e6aupC1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: PF00451	ECOD (1.6)
D [auth F]	PF00451	e6aupF1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: PF00451	ECOD (1.6)
E [auth D]	PF00451	e6aupD1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: PF00451	ECOD (1.6)
G	PF00451	e6aupG1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: PF00451	ECOD (1.6)
I	PF00451	e6aupI1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: PF00451	ECOD (1.6)
J	PF00451	e6aupJ1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: PF00451	ECOD (1.6)
K	PF00451	e6aupK1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: PF00451	ECOD (1.6)
L	PF00451	e6aupL1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: PF00451	ECOD (1.6)
M	PF00451	e6aupM1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: PF00451	ECOD (1.6)
N	PF00451	e6aupN1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: PF00451	ECOD (1.6)
O	PF00451	e6aupO1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: PF00451	ECOD (1.6)
P	PF00451	e6aupP1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: PF00451	ECOD (1.6)
F [auth E]	PF00451	e6aupE1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: PF00451	ECOD (1.6)
H	PF00451	e6aupH1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: PF00451	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D [auth F], E [auth D], A, B, C, D [auth F], E [auth D], F [auth E], G, H, I, J, K, L, M, N, O, P	PF00451	Scorpion short toxin, BmKK2 (Toxin_2)	Scorpion short toxin, BmKK2	Members of this family, which are found in various scorpion toxins, confer potassium channel blocking activity [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D [auth F], E [auth D], A, B, C, D [auth F], E [auth D], F [auth E], G, H, I, J, K, L, M, N, O, P	Potassium channel toxin gamma-KTx 2.2	molecular function inhibitor activity channel regulator activity transporter inhibitor activity ion channel inhibitor activity ion channel regulator activity molecular function regulator activity transporter regulator activity channel inhibitor activity potassium channel regulator activity toxin activity	-	extracellular region cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D [auth F], E [auth D], A, B, C, D [auth F], E [auth D], F [auth E], G, H, I, J, K, L, M, N, O, P	IPR036574	Knottin, scorpion toxin-like superfamily	Homologous Superfamily
A, B, C, D [auth F], E [auth D], A, B, C, D [auth F], E [auth D], F [auth E], G, H, I, J, K, L, M, N, O, P	IPR001947	Scorpion short chain toxin, potassium channel inhibitor	Family

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6AUP

Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Domain Annotation: ECOD Classification ECOD Database Homepage

Protein Family Annotation Pfam Database Homepage

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

InterPro: Protein Family Classification InterPro Database Homepage